Hostname: page-component-76fb5796d-2lccl Total loading time: 0 Render date: 2024-04-29T06:16:07.731Z Has data issue: false hasContentIssue false
  • English
  • Français

Differences in intestinal protein synthesis and cellular proliferation in well-nourished rats consuming conventional laboratory diets

Published online by Cambridge University Press:  07 March 2008

Susan Southon ,
G. Livesey ,
Jennifer M. Gee  and
I. T. Johnson
Susan Southon
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
G. Livesey
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
Jennifer M. Gee
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
I. T. Johnson
Affiliation:
AFRC Food Research Institute, Colney Lane, Norwich NR4 7UA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Male Wistar rats (100 g) were given a commercial pellet feed or a semi-synthetic diet ad lib. Although the pellet-fed group grew slightly faster than the other group during the early part of the feeding period, there was no significant difference between the final weights of the groups.

2. The fractional rates of protein synthesis in jejunum, proximal ileum and liver were measured by a technique based on the determination of L-[4−3H]phenylalanine incorporation over a short time period. Protein synthesis was higher in both jejunum and ileum of the pellet-fed rats compared with those eating the semi-synthetic diet, but there was no difference between the rates of protein synthesis measured in the livers of the groups.

3. The rate of mucosal cell division was significantly faster in the ileal mucosa of the pellet-fed group compared with the other group, and there were significant differences in some aspects of mucosal morphology.

4. The maintenance of higher rates of cell turnover and protein synthesis in animals given commercial pellet feed is unexplained, but it may be related to the presence of non-absorbable polysaccharides or other complex plant materials in the pellet feed.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 53 , Issue 1 , January 1985 , pp. 87 - 95
Copyright
Copyright © The Nutrition Society 1985

References

REFERENCES

Bender, A. E. & Mohammidiha, H. (1981). Proceedings of the Nutrition Society 40, 66A.Google Scholar
Biol, M., Martin, A., Paulin, C., Hemming, F., Louisot, P. & Richard, M. (1984). Annals of Nutrition and Metabolism 28, 52–64.CrossRefGoogle Scholar
Brown, H. O., Levine, M. L. & Lipkin, M. (1963). American Journal of Physiology 205, 868–872.CrossRefGoogle Scholar
Clarke, R. M. (1970). Journal of Anatomy 107, 519–529.Google Scholar
Ecknauer, R., Sircar, B. & Johnson, L. R. (1981). Gastroenterology 81, 781–786.CrossRefGoogle Scholar
Englyst, H., Wiggins, H. S. & Cummings, J. H. (1982). Analyst 107, 307–318.CrossRefGoogle Scholar
Fairweather-Tait, S. J., Gee, J. M. & Johnson, I. T. (1983). British Journal of Nutrition 49, 303–312.CrossRefGoogle Scholar
Garlick, P. J., McNurlan, M. A. & Preedy, V. R. (1980). Biochemical Journal 192, 719–723.CrossRefGoogle Scholar
Kapadia, S. & Baker, S. J. (1976). Digestion 14, 256–268.CrossRefGoogle Scholar
Karasov, W. H. & Diamond, J. M. (1983). American Journal of Physiology 245, G443–G462.Google Scholar
McCance, R. A. & Walsham, C. M. (1948). British Journal of Nutrition 2, 26–37.CrossRefGoogle Scholar
McNurlan, M. A., Tomkins, A. M. & Garlick, P. J. (1979). Biochemical Journal 178, 373–379.CrossRefGoogle Scholar
Reeds, P. J., Haggarty, P., Wahle, W. J. & Fletcher, J. M. (1982). Biochemical Journal 204, 393–398.CrossRefGoogle Scholar
Roe, J. H. (1955). Journal of Biological Chemistry 212, 335–343.CrossRefGoogle Scholar
Sircar, B., Johnson, L. R. & Lichtenberger, L. M. (1983). American Journal of Physiology 244, G327–G335.Google Scholar
Southgate, D. A. T. & Durnin, J. V. G. A. (1970). British Journal of Nutrition 24, 517–535.CrossRefGoogle Scholar
Tasman-Jones, C., Owen, R. L. & Jones, A. L. (1982). Digestive Diseases and Sciences 27, 519–524.CrossRefGoogle Scholar
Walker, A. R. P. (1975). American Journal of Clinical Nutrition 28, 1161–1169.CrossRefGoogle Scholar
Wimber, D. E. & Lamerton, L. F. (1963). Radiation Research 18, 137–146.CrossRefGoogle Scholar
Younosjai, M. K., Adedoyin, M. & Ranshaw, J. (1978). Journal of Nutrition 108, 341–350.CrossRefGoogle Scholar