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Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance

  • Jennie Wickenberg (a1) (a2), Sandra Lindstedt (a3), Kerstin Berntorp (a4), Jan Nilsson (a1) (a2) and Joanna Hlebowicz (a1) (a2) (a5)...
Abstract

Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanicum on postprandial concentrations of plasma glucose, insulin, glycaemic index (GI) and insulinaemic index (GII) in subjects with impaired glucose tolerance (IGT). A total of ten subjects with IGT were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with placebo or C. zeylanicum capsules. Finger-prick capillary blood samples were taken for glucose measurements and venous blood for insulin measurements, before and at 15, 30, 45, 60, 90, 120, 150 and 180 min after the start of the OGTT. The ingestion of 6 g C. zeylanicum had no significant effect on glucose level, insulin response, GI or GII. Ingestion of C. zeylanicum does not affect postprandial plasma glucose or insulin levels in human subjects. The Federal Institute for Risk Assessment in Europe has suggested the replacement of C. cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost.

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Corresponding author
*Corresponding author: J. Hlebowicz, fax +46 40 92 32 72, email joanna.hlebowicz@med.lu.se
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1 CL Broadhurst , MM Polansky & RA Anderson (2000) Insulin-like biological activity of culinary and medicinal plant aqueous extracts in vitro. J Agric Food Chem 48, 849852.

4EJ Verspohl , K Bauer & E Neddermann (2005) Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicumin vivo and in vitro. Phytother Res 19, 203206.

7TPJ Solomon & AK Blannin (2007) Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab 9, 895901.

8TPJ Solomon & AK Blannin (2009) Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans. Eur J Appl Physiol 105, 969976.

9EC Hagan , WH Hansen , OG Fitzhugh , (1967) Food flavouring and compounds related structure. II. Subacute and chronic toxicity. Food Cosmet Toxicol 5, 141157.

10M Burian , J Freudenstein , M Tegtmeier , (2003) Single copy of variant CYP2A6 alleles does not confer susceptibility to liver dysfunction in patients treated with coumarin. Int J Clin Pharmacol Ther 41, 141147.

11HJ Schmeck-Lindenau , B Naser-Hijazi , EW Becker , (2003) Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study. Int J Clin Pharmacol Ther 41, 193199.

12W Vanscheidt , E Rabe , B Naser-Hijazi , (2002) The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomised study. Vasa 31, 185190.

14KG Miller , CF Poole & TMP Chichila (1995) Solvent-assisted supercritical fluid extraction for the isolation of semivolatile flavor compounds from the cinnamons of commerce and their separation by series-coupled column gas chromatography. J High Resol Chromatogr 18, 461471.

17American Diabetes Association (2007) Nutrition recommendations and interventions for diabetes. A position statement of the American Diabetes Association. Diabetes Care 30, S48S65.

19MA Abdul-Ghani , CP Jenkinson , DK Richardson , (2006) Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance. Results from the Veterans Administration Genetic Epidemiology Study. Diabetes 55, 14301435.

20J Tuomilehto , J Lindstrom , JG Eriksson , (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344, 13431350.

25G Feuer , L Golberg & KI Gibson (1996) Liver response tests. VII. Coumarin metabolism in relation to the inhibition of rat-liver glucose 6-phosphatase. Food Cosmet Toxicol 4, 157167.

27A Khan , M Safdar , MM Ali Khan , (2003) Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 26, 32153218.

28B Mang , M Wolters , B Schmitt , (2006) Effect of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 36, 340344.

32WLB Baker , G Gutiereez-Williams , CM White , (2008) The effect of cinnamon on glucose control and lipid parameters. Diabetes Care 31, 4143.

33JG Wang , RA Anderson , GM Graham , (2007) The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril 88, 240243.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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