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Modulatory effect of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects

  • Tania Reyes-Izquierdo (a1), Boris Nemzer (a2), Cynthia Shu (a1), Lan Huynh (a1), Ruby Argumedo (a1), Robert Keller (a3) and Zb Pietrzkowski (a1)...
Abstract

The present single-dose study was performed to assess the effect of whole coffee fruit concentrate powder (WCFC), green coffee caffeine powder (N677), grape seed extract powder (N31) and green coffee bean extract powder (N625) on blood levels of brain-derived neurotrophic factor (BDNF). Randomly assorted groups of fasted subjects consumed a single, 100 mg dose of each material. Plasma samples were collected at time zero (T0) and at 30 min intervals afterwards, up to 120 min. A total of two control groups were included: subjects treated with silica dioxide (as placebo) or with no treatment. The collected data revealed that treatments with N31 and N677 increased levels of plasma BDNF by about 31 % under these experimental conditions, whereas treatment with WCFC increased it by 143 % (n 10), compared with baseline. These results indicate that WCFC could be used for modulation of BDNF-dependent health conditions. However, larger clinical studies are needed to support this possibility.

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Corresponding author
*Corresponding author: T. Reyes-Izquierdo, fax +1 949 502 4987, email tania@abclinicaldiscovery.com
References
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1Fujinami A, Ohta K, Obayashi H, et al. (2008) Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance. Clin Biochem 41, 812817.
2Jones KR & Reichardt LF (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc Natl Acad Sci U S A 87, 80608064.
3Maisonpierre PC, Le Beau MM, Espinosa R III, et al. (1991) Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Genomics 10, 558568.
4Tessarollo L (1998) Pleiotropic functions of neurotrophins in development. Cytokine Growth Factor Rev 9, 125137.
5Yamamoto M, Sobue G, Yamamoto K, et al. (1996) Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res 21, 929938.
6Cunha C, Angelucci A, D'Antoni A, et al. (2009) Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiol Dis 33, 358368.
7Cunha C, Brambilla R & Thomas KL (2010) A simple role for BDNF in learning and memory? Front Mol Neurosci 3, 1.
8Grothe C & Unsicker K (1987) Neuron-enriched cultures of adult rat dorsal root ganglia: establishment, characterization, survival, and neuropeptide expression in response to trophic factors. J Neurosci Res 18, 539550.
9Kalcheim C & Gendreau M (1988) Brain-derived neurotrophic factor stimulates survival and neuronal differentiation in cultured avian neural crest. Brain Res 469, 7986.
10Snider WD (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell 77, 627638.
11Boulanger LM & Poo MM (1999) Presynaptic depolarization facilitates neurotrophin-induced synaptic potentiation. Nat Neurosci 2, 346351.
12Li W & Keifer J (2008) Coordinate action of pre- and postsynaptic brain-derived neurotrophic factor is required for AMPAR trafficking and acquisition of in vitro classical conditioning. Neuroscience 155, 686697.
13Tanaka J, Horiike Y, Matsuzaki M, et al. (2008) Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science (New York, NY) 319, 16831687.
14Han BH & Holtzman DM (2000) BDNF protects the neonatal brain from hypoxic–ischemic injury in vivo via the ERK pathway. J Neurosci 20, 57755781.
15Bifrare Y-D, Kummer J, Joss P, et al. (2005) Brain-derived neurotrophic factor protects against multiple forms of brain injury in bacterial meningitis. J Infect Dis 191, 4045.
16Brunoni AR, Lopes M & Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11, 11691180.
17Dwivedi Y (2009) Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat 5, 433449.
18Maina G, Rosso G, Zanardini R, et al. (2010) Serum levels of brain-derived neurotrophic factor in drug-naive obsessive-compulsive patients: a case–control study. J Affect Disord 122, 174178.
19Zuccato C & Cattaneo E (2009) Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol 5, 311322.
20Arancio O & Chao MV (2007) Neurotrophins, synaptic plasticity and dementia. Curr Opin Neurobiol 17, 325330.
21Fumagalli F, Racagni G & Riva MA (2006) Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease. Pharmacogenomics J 6, 95104.
22Chun HS, Son JJ & Son JH (2000) Identification of potential compounds promoting BDNF production in nigral dopaminergic neurons: clinical implication in Parkinson's disease. Neuroreport 11, 511514.
23Seifer DB, Feng B, Shelden RM, et al. (2002) Brain-derived neurotrophic factor: a novel human ovarian follicular protein. J Clin Endocrinol Metab 87, 655659.
24Pan W, Banks WA, Fasold MB, et al. (1998) Transport of brain-derived neurotrophic factor across the blood–brain barrier. Neuropharmacology 37, 15531561.
25Kramer AF, Colcombe SJ, McAuley E, et al. (2005) Fitness, aging and neurocognitive function. Neurobiol Aging 26, Suppl. 1, 124127.
26Colcombe SJ, Kramer AF, McAuley E, et al. (2004) Neurocognitive aging and cardiovascular fitness: recent findings and future directions. J Mol Neurosci 24, 914.
27Kramer AF, Hahn S, Cohen NJ, et al. (1999) Ageing, fitness and neurocognitive function. Nature 400, 418419.
28Connolly SK & Tamy (2010) Caffeine modulates CREB-dependent gene expression in developing cortical neurons. Biochem Biophys Res Commun 397, 152156.
29Costa MS, Botton PH, Mioranzza S, et al. (2008) Caffeine improves adult mice performance in the object recognition task and increases BDNF and TrkB independent on phospho-CREB immunocontent in the hippocampus. Neurochem Int 53, 8994.
30Alhaider IA, Aleisa AM, Tran TT, et al. (2011) Sleep deprivation prevents stimulation-induced increases of levels of P-CREB and BDNF: protection by caffeine. Mol Cell Neurosci 46, 742751.
31Heimbach JT, Marone PA, Hunter JM, et al. (2010) Safety studies on products from whole coffee fruit. Food Chem Toxicol 48, 25172525.
32Yashin YI, Nemzer BV, Ryzhnev VY, et al. (2010) Creation of a databank for content of antioxidants in food products by an amperometric method. Molecules 15, 74507466.
33Borecki IB, Higgins M, Schreiner PJ, et al. (1998) Evidence for multiple determinants of the body mass index: the National Heart, Lung, and Blood Institute Family Heart Study. Obes Res 6, 107114.
34Zolodz JAPA, Majerczak K, Grandys M, et al. (2008) Endurance training increases brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol S17, 59, 199–132.
35Piccini A, Marazziti D, Del Debbio A, et al. (2008) Diurnal variation of plasma brain-derived neurotrophic growth factor (BDNF) in humans. Chronobiol Int 25, 819826.
36Mullen W, Nemzer B, Ou B, et al. (2011) The antioxidant and chlorogenic acid profiles of whole coffee fruits are influenced by the extraction procedures. J Agric Food Chem 59, 37543762.
37International Organization for Standardization (ISO) (2005) Determination of Substances Characteristic of Green and Black Tea. Part 1: Content of Total Polyphenols in Tea – Colorimetric Method Using Folin–Ciocalteu Reagent. Geneva: ISO. ISO 14502-1.
38Chung HY, Choi HR, Park HJ, et al. (2001) Peroxynitrite scavenging and cytoprotective activity of 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether from the marine alga Symphyocladia latiuscula. J Agric Food Chem 49, 36143621.
39Huang D, Ou B, Hampsch-Woodill M, et al. (2002) High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate fluorescence reader in 96-well format. J Agric Food Chem 50, 44374444.
40Ou B, Hampsch-Woodill M, Flanagan J, et al. (2002) Novel fluorometric assay for hydroxyl radical prevention capacity using fluorescein as the probe. J Agric Food Chem 50, 27722777.
41Zhang L, Huang D, Kondo M, et al. (2009) Novel high-throughput assay for antioxidant capacity against superoxide anion. J Agric Food Chem 57, 26612667.
42Elzinga BM, Molendijk ML, Oude Voshaar RC, et al. (2011) The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. Psychopharmacology 214, 319328.
43Larsen MH, Mikkelsen JD, Hay-Schmidt A, et al. (2010) Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment. J Psychiatr Res 44, 808816.
44Advani T, Koek W & Hensler JG (2009) Gender differences in the enhanced vulnerability of BDNF+/ −  mice to mild stress. Int J Neuropsychopharmacol 12, 583588.
45Capiotti KM, Menezes FP, Nazario LR, et al. (2011) Early exposure to caffeine affects gene expression of adenosine receptors, DARPP-32 and BDNF without affecting sensibility and morphology of developing zebrafish (Danio rerio). Neurotoxicol Teratol 33, 680685.
46Bairam A, Kinkead R, Lajeunesse Y, et al. (2010) Neonatal caffeine treatment does not induce long-term consequences on TrkB receptors or BDNF expression in chemosensory organs of adult rats. Neurosci Lett 468, 292296.
47Xu J, Rong S, Xie B, et al. (2010) Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod. J Gerontol 65, 933940.
48Fraga CG & Oteiza PI (2011) Dietary flavonoids: role of ( − )-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med 51, 813823.
49Terra X, Pallares V, Ardevol A, et al. (2011) Modulatory effect of grape-seed procyanidins on local and systemic inflammation in diet-induced obesity rats. J Nutr Biochem 22, 380387.
50Narita K, Hisamoto M, Okuda T, et al. (2011) Differential neuroprotective activity of two different grape seed extracts. PloS one 6, e14575.
51Fu W, Lu C & Mattson MP (2002) Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. J Neurosci 22, 10, 710719.
52Niu C (2010) The neuroprotective signaling mechanisms of telomerase via the induction by brain-derived neurotrophic factor (BDNF) in nervous system injury. Postgraduate Thesis, University of Hong Kong.
53Wang CCLT, Liao WC, Yuan SC, et al. (2009) Cigarette smoking and cognitive impairment: a 10 year cohort study in Taiwan. Arch Gerontol Geriatr 1, 143148.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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