5 G Ravaglia , P Forti , F Maioli , et al. (2006) Apolipoprotein E e4 allele affects risk of hyperhomocysteinemia in the elderly. Am J Clin Nutr 84, 1473–1480.
6 PM Ueland , H Refsum , M Beresford , et al. (2000) The controversy over homocysteine and cardiovascular risk. Am J Clin Nut 72, 324–332.
7 LL Humphrey , R Fu , K Rogers , et al. (2008) Homocysteine level and coronary heart disease: a systematic review and meta-analysis. Mayo Clin Proc 83, 1203–1212.
8 MR Malinow , AG Bostom & RM Krauss (1999) Homocysteine, diet, and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association. Circulation 99, 178–182.
9 JB Ubbink (2001) What is a desirable homocysteine level? In Homocysteine in Health and Disease, pp. 485–490 [ R Carmel and DW Jacobsen , editors]. Cambridge: Cambridge University Press.
10 LA Kluijtmans , GH Boers , FJ Tribels , et al. (1997) Common 844INS68 insertion variant in the cystathionine beta-synthase gene. Biochem Mol Med 62, 23–27.
11 J Selhub (1999) Homocysteine metabolism. Ann Rev Nutr 19, 217–246.
12 NPB Dudman , X Guo , RB Gordon , et al. (1996) Human homocysteine catabolism: 3 major pathways and their relevance to the development of arterial occlusive disease. J Nutr 126, 4 Suppl., 1295S–1300S.
13 W Herrmann , R Obeid , H Schorr , et al. (2005) The usefulness of holotranscobalamin in predicting vitamin B12 status in different clinical settings. Curr Drug Meta 6, 47–53.
14 V Herbert & R Zalusky (1962) Interrelationship of vitamin B12 and folic acid metabolism: folic acid clearance studies. J Clin Invest 41, 1263–1276.
15 JM Noronha & M Silverman (1962) On folic acid, vitamin B12, methionine and formiminoglutamic acid. In Vitamin B12 and Intrinsic Factor 2. Europasches Symposion, p. 728 [ HC Heinrich , editor. Hamburg:, Enke.
16 JM Scott & DG Weir (1981) The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia. Lancet ii, 337–340.
17 I Chanarin , R Deacon , M Lumb , et al. (1985) Cobalamin–folate interrelations: a critical review. Blood 66, 478–489.
18 E Butensky , P Harmatz & B Lubin (2008) Nutritional Anemias. Nutrition in Paediatrics, 4th ed.,chapter 62. Hamilton, ON: BC Decker, Inc.
20 V Herbert (1994) Staging vitamin B12 (cobalamin) status in vegetarians. Am J Clin Nutr 59, Suppl. 1213S–1222S.
21 V Herbert & KC Das (1994) Folic Acid and Vitamin B12 Nutrition in Health and Disease, 8th ed., pp. 402–425. Philadelphia, PA: Lea and Febiger.
22 R Carmel , AH Rosenberg , KS Lau , et al. (1969) Vitamin B12 uptake by human small bowel homogenate and its enhancement by intrinsic factor. Gastroenterology 56, 548–555.
23 B Herzlich & V Herbert (1984) The role of pancreas in cobalamin (vitamin B12) absorption. Am J Gastroenterol 79, 489–493.
24 B Herzlich , T Schiano , E Moussa Zimbalist , et al. (1986) Decreased intrinsic factor secretion in AIDS: relation to parietal cell acid secretory capacity and vitamin B12 malabsorption. Am J Gastroenterol 87, 17811–17818.
25 V Herbert , GJ Subak-sharpe & D Hammock (1990) The Mount Sinai School of Medicine Complete Book of Nutrition. New York: St Martin's Press.
26 V Herbert (1992) Everyone should be tested for iron disorders. J Am Diet Assoc 92, 1502–1509.
27 A Simopoulos , V Herbert & B Jacobson (1993) Genetic Nutrition: Designing a Diet Based on Your Family Medical History. New York: Macmillan Press.
28 V Herbert (1994) Staging vitamin B12 status in vegetarians. Am J Clin Nutr 59, 1213s–1222s.
30 D Li (2011) Chemistry behind vegetarianism. J Agric Food Chem 59, 777–784.
32 MR Spiegel (1991) Statistics, pp. 88–189. New York: McGraw Hill.
33 FP Cappuccio , R Bell , IJ Perry , J Gilg , et al. (2002) Homocysteine levels in men and women of different ethnic and cultural background living in England. Atherosclerosis 164, 95–102.
34 EH Haddad , LS Berk , JD Kettering , et al. (1999) Dietary intake and biochemical, hematologic, and immune status of vegans compared with nonvegetarians. Am J Clin Nutr 70, 586S–593S.
35 L Bissoli , V Di Francesco , A Ballarin , et al. (2002) Effect of vegetarian diet on homocysteine levels. Ann Nutr Metab 46, 73–79.
36 W Herrmann , H Schorr , R Obeid , et al. (2003) Vitamin B-12 status, particularly holotranscobalamin “II” and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 78, 131–136.
37 C Koebnick , AL Garcia & PC Dagnelie (2005) Long-term consumption of a raw food diet is associated with favourable serum LDL cholesterol and triglycerides but also with elevated plasma homocysteine and low serum HDL cholesterol in humans. J Nutr 135, 2372–2378.
38 CE Yen , CH Yen , CH Cheng , et al. (2010) Vitamin B12 status is not associated with plasma homocysteine in parents and their preschool children: lacto–ovo, lacto, ovo vegetarians & omnivores. J Am Coll Nutr 29, 7–13.
39 NJ Mann , D Li , AJ Sinclair , et al. (1999) The effects of diet on plasma homocysteine in healthy male subjects. Eur J Clin Nutr 53, 895–899.
40 M Krajcovicova-Kudlackova , P Blazicek , J Kopvova , et al. (2000) Homocysteine levels in vegetarians versus omnivores. Ann Nutr Metab 44, 135–138.
41 W Herrmann , H Schorr , K Purschwitz , et al. (2001) Total homocysteine, vitamin B12 and total antioxidant status in vegetarians. Clin Chem 47, 1094–1101.
42 D Majchrzak , I Singer & M Manner (2006) B-Vitamin status and concentrations of homocysteine in Austrian omnivores, vegetarians and vegans. Ann Nutr Metab 50, 485–491.
43 YC Huang , SJ Chang , YT Chiu , et al. (2003) The status of plasma homocysteine and related to B-vitamins in healthy young vegetarians and non-vegetarians. Eur J Nutr 42, 84–90.
44 AC Antony (2001) Prevalence of cobalamin and folate deficiency in India. Am J Clin Nutr 74, 157–159.
45 H Refsum , CS Yajnik , M Gadkari , et al. (2001) Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nutr 74, 233–241.
46 A Waldmann , JW Koschizke , C Leitzmann , et al. (2003) Homocysteine and cobalamin status in German vegans. Public Health Nutr 74, 67–72.
47 TC Su , JS Jeng , JD Wang , et al. (2006) Homocysteine, circulating vascular cell adhesion molecule and carotid atherosclerosis in postmenopausal vegetarian women and omnivores. Atherosclerosis 184, 356–362.
48 E Karabudak , G Kiziltan & NA Cigerim (2008) A comparison of some of the cardiovascular risk factors in vegetarian and omnivorous Turkish females. J Hum Nutr Diet 21, 13–22.
49 Z Krivosikova , M Krajcovicova-Kudlackova , V Spustova , et al. (2010) The association between high plasma homocysteine levels and lower bone mineral density in Slovak women: the impact of vegetarian diet. Eur J Nutr 49, 147–153.
50 CJ Hung , PC Huang , SC Lu , et al. (2002) Plasma homocysteine levels in Taiwanese vegetarians are higher than those of omnivores. J Nutr 132, 152–158.
51 E Joosten , A van dem Berg , R Riezler , et al. (1993) Metabolic evidence that deficiencies of vitamin B12 (cobalamin), folate, and vitamin B6 occur commonly in elderly people. Am J Clin Nutr 58, 468–476.
52 W Herrmann , H Schorr , M Bodis , et al. (2000) Role of homocysteine, cystathionine and methylmalonic acid measurement for diagnosis of vitamin B12 deficiency in high-aged subjects. Eur J Clin Invest 30, 1083–1089.
53 A Dong & SC Scott (1982) Serum vitamin B12 and blood cell values in vegetarians. Ann Nut Met 26, 209–216.
54 V Herbert (1985) Biology of disease: megaloblastic anemia. Lab Invest 52, 3–19.
55 VI Mathan (1988) Tropical sprue in Southern India. Trans R Soc Trop Med Hyg 82, 10–14.
56 LN Balaji & A Dustagheer (2000) Nutrition scenario in India – implications of clinical practice. J Indian Med Assoc 98, 536–538, .
57 AMJ Gilsing , FL Crowe , TAB Sanders , et al. (2010) Serum concentrations of vitamin B12 and folate in British male omnivores, vegetarians and vegans: results from a cross-sectional analysis of the EPIC-Oxford cohort study. Eur J Clin Nutr 64, 933–939.
58The Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. J Am Med Ass 288, 2015–2022.
59 DS Wald , M Law & JK Morris (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325, 1202.
60 M Ward , H McNulty , J McPartlin , et al. (1997) Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. Q J Med 90, 519–528.
61The Heart Outcomes Prevention Evaluation (HOPE2) Investigators (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. New Eng J Med 354, 1567–1577.
62 BA Cooper & DS Rosenblatt (1987) Inherited defects of vitamin B12 metabolism. An Rev Nut 7, 291–320.
63 E Pezacka , R Green & DW Jacobsen (1990) Glutathionylcobalamin as a intermediate in the formation of cobalamin coenzymes. Biochem Biophys Res Commun 169, 443–450.
64 G Kelly (1997) The coenzyme forms of vitamin B12: towards an understanding of their therapeutic potential. Alt Med Rev 2, 459–471.
65 MG Crane (1994) Vitamin B12 studies in total vegetarians. J Nutr Med 4, 1–14.