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Docosahexaenoic acid-rich fish oil improves heart rate variability and heart rate responses to exercise in overweight adults

  • Daniel M. Ninio (a1), Alison M. Hill (a1) (a2), Peter R. Howe (a1) (a2) (a3), Jonathan D. Buckley (a2) and David A. Saint (a1)...
Abstract

Dietary fish oil supplementation and regular physical activity can improve outcomes in patients with established CVD. Exercise has been shown to improve heart rate variability (HRV), a predictor of cardiac death, but whether fish oil benefits HRV is controversial. Obese adults at risk of future coronary disease have impaired HRV and may benefit from these interventions. We evaluated the effect of DHA-rich tuna fish oil supplementation with and without regular exercise on HRV in sedentary, overweight adults with risk factors for coronary disease. In a randomised, double-blind, parallel comparison, sixty-five volunteers consumed 6 g fish oil/d (DHA 1·56 g/d, EPA 0·36 g/d) or sunflower-seed oil (placebo) for 12 weeks. Half of each oil group also undertook regular moderate physical activity (3 d/week for 45 min, at 75 % of age-predicted maximal heart rate (HR)). Resting HR and the HR response to submaximal exercise were measured at weeks 0, 6 and 12. In forty-six subjects, HRV was also assessed by power spectrum analysis of 20 min electrocardiogram recordings taken supine at baseline and 12 weeks. Fish oil supplementation improved HRV by increasing high-frequency power, representing parasympathetic activity, compared with placebo (P = 0·01; oil ×  time interaction). It also reduced HR at rest and during submaximal exercise (P = 0·008; oil ×  time interaction). There were no significant fish oil ×  exercise interactions. Dietary supplementation with DHA-rich fish oil reduced HR and modulated HRV in keeping with an improved parasympathetic–sympathetic balance in overweight adults with risk factors for future coronary disease.

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Corresponding author
*Corresponding author: Professor Peter R. C. Howe, fax +618 8302 2178, email peter.howe@unisa.edu.au
References
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1Kleiger RE, Miller JP, Bigger JT Jr & Moss AJ (1987) Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 59, 256262.
2Bigger JT Jr, Fleiss JL, Steinman RC, Rolnitzky LM, Kleiger RE & Rottman JN (1992) Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation 85, 164171.
3La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A & Schwartz PJ (1998) Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351, 478484.
4Tsuji H, Larson MG, Venditti FJ Jr, Manders ES, Evans JC, Feldman CL & Levy D (1996) Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation 94, 28502855.
5Dekker JM, Schouten EG, Klootwijk P, Pool J, Swenne CA & Kromhout D (1997) Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. Am J Epidemiol 145, 899908.
6Bang HO, Dyerberg J & Hjoorne N (1976) The composition of food consumed by Greenland Eskimos. Acta Med Scand 200, 6973.
7Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, Elwood PC & Deadman NM (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet ii, 757761.
8Anonymous (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. Lancet 354, 447455.
9Christensen JH (2003) n-3 Fatty acids and the risk of sudden cardiac death. Emphasis on heart rate variability. Dan Med Bull 50, 347367.
10Dallongeville J, Yarnell J, Ducimetiere P, et al. (2003) Fish consumption is associated with lower heart rates. Circulation 108, 820825.
11Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL & Katan MB (2005) Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation 112, 19451952.
12Christensen JH, Aaroe J, Knudsen N, Dideriksen K, Kornerup HJ, Dyerberg J & Schmidt EB (1998) Heart rate variability and n-3 fatty acids in patients with chronic renal failure – a pilot study. Clin Nephrol 49, 102106.
13Christensen JH, Christensen MS, Dyerberg J & Schmidt EB (1999) Heart rate variability and fatty acid content of blood cell membranes: a dose–response study with n-3 fatty acids. Am J Clin Nutr 70, 331337.
14Christensen JH, Gustenhoff P, Korup E, Aaroe J, Toft E, Moller J, Rasmussen K, Dyerberg J & Schmidt EB (1996) Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. BMJ 312, 677678.
15Holguin F, Tellez-Rojo MM, Lazo M, Mannino D, Schwartz J, Hernandez M & Romieu I (2005) Cardiac autonomic changes associated with fish oil vs. soy oil supplementation in the elderly. Chest 127, 11021107.
16Dyerberg J, Christensen JH, Eskesen D, Astrup A & Stender S (2006) Trans, and n-3 polyunsaturated fatty acids and vascular function – a yin yang situation? Atheroscler Suppl 7, 3335.
17Dyerberg J, Eskesen DC, Andersen PW, et al. (2004) Effects of trans- and n-3 unsaturated fatty acids on cardiovascular risk markers in healthy males. An 8 weeks dietary intervention study. Eur J Clin Nutr 58, 10621070.
18Geelen A, Zock PL, Swenne CA, Brouwer IA, Schouten EG & Katan MB (2003) Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects. Am Heart J 146, E4.
19Hamaad A, Kaeng Lee W, Lip GY & MacFadyen RJ (2006) Oral omega 3-PUFA therapy (Omacor) has no impact on indices of heart rate variability in stable post myocardial infarction patients. Cardiovasc Drugs Ther 20, 359364.
20Svensson M, Schmidt EB, Jorgensen KA & Christensen JH (2007) The effect of n-3 fatty acids on heart rate variability in patients treated with chronic hemodialysis. J Ren Nutr 17, 243249.
21Karason K, Molgaard H, Wikstrand J & Sjostrom L (1999) Heart rate variability in obesity and the effect of weight loss. Am J Cardiol 83, 12421247.
22Amano M, Kanda T, Ue H & Moritani T (2001) Exercise training and autonomic nervous system activity in obese individuals. Med Sci Sports Exerc 33, 12871291.
23Carter JB, Banister EW & Blaber AP (2003) The effect of age and gender on heart rate variability after endurance training. Med Sci Sports Exerc 35, 13331340.
24Jurca R, Church TS, Morss GM, Jordan AN & Earnest CP (2004) Eight weeks of moderate-intensity exercise training increases heart rate variability in sedentary postmenopausal women. Am Heart J 147, e8e15.
25Mori TA & Woodman RJ (2006) The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. Curr Opin Clin Nutr Metab Care 9, 95104.
26Hill AM, Buckley JD, Murphy KJ & Howe PRC (2007) Combining fish-oil supplements with regular aerobic exercise improves body composition and cardiovascular disease risk factors. Am J Clin Nutr 85, 12671274.
27Tanaka H, Monahan KD & Seals DR (2001) Age-predicted maximal heart rate revisited. J Am Coll Cardiol 37, 153156.
28Anonymous (1996) Heart rate variability: standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93, 10431065.
29Christensen JH, Korup E, Aaroe J, Toft E, Moller J, Rasmussen K, Dyerberg J & Schmidt EB (1997) Fish consumption n-3 fatty acids in cell membranes, and heart rate variability in survivors of myocardial infarction with left ventricular dysfunction. Am J Cardiol 79, 16701673.
30Christensen JH, Skou HA, Fog L, Hansen V, Vesterlund T, Dyerberg J, Toft E & Schmidt EB (2001) Marine n-3 fatty acids, wine intake, and heart rate variability in patients referred for coronary angiography. Circulation 103, 651657.
31Christensen JH, Skou HA, Madsen T, Torring I & Schmidt EB (2001) Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus. J Intern Med 249, 545552.
32Brouwer IA, Zock PL, van Amelsvoort LG, Katan MB & Schouten EG (2002) Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. Am J Cardiol 89, 629631.
33O'Keefe JJH, Abuissa H, Sastre A, Steinhaus DM & Harris WS (2006) Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. Am J Cardiol 97, 11271130.
34Mozaffarian D, Prineas RJ, Stein PK & Siscovick DS (2006) Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. J Am Coll Cardiol 48, 478484.
35Boutcher SH & Stein P (1995) Association between heart rate variability and training response in sedentary middle-aged men. Eur J Appl Physiol Occup Physiol 70, 7580.
36Wilmore JH, Stanforth PR, Gagnon J, Rice T, Mandel S, Leon AS, Rao DC, Skinner JS & Bouchard C (2001) Heart rate and blood pressure changes with endurance training: the HERITAGE Family Study. Med Sci Sports Exerc 33, 107116.
37Yamamoto K, Miyachi M, Saitoh T, Yoshioka A & Onodera S (2001) Effects of endurance training on resting and post-exercise cardiac autonomic control. Med Sci Sports Exerc 33, 14961502.
38Davy KP, Willis WL & Seals DR (1997) Influence of exercise training on heart rate variability in post-menopausal women with elevated arterial blood pressure. Clin Physiol 17, 3140.
39Figueroa A, Baynard T, Fernhall B, Carhart R & Kanaley J (2007) Endurance training improves post-exercise cardiac autonomic modulation in obese women with and without type 2 diabetes. Eur J Appl Physiol 100, 437444.
40Melanson EL & Freedson PS (2001) The effect of endurance training on resting heart rate variability in sedentary adult males. Eur J Appl Physiol 85, 442449.
41Tudor-Locke C, Bell RC, Myers AM, Harris SB, Ecclestone NA, Lauzon N & Rodger NW (2004) Controlled outcome evaluation of the First Step Program: a daily physical activity intervention for individuals with type II diabetes. Int J Obes Relat Metab Disord 28, 113119.
42Uusitalo ALT, Laitinen T, Vaisanen SB, Lansimies E & Rauramaa R (2002) Effects of endurance training on heart rate and blood pressure variability. Clin Physiol Funct Imaging 22, 173179.
43Okazaki K, Iwasaki K-I, Prasad A, Palmer M, Martini E, Fu Q, Arbab-Zadeh A, Zhang R & Levine B (2005) Dose–response relationship of endurance training for autonomic circulatory control in healthy seniors. J Appl Physiol 99, 10411049.
44Mehta JL, Lopez LM, Lawson D, Wargovich TJ & Williams LL (1988) Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease: effects on indices of platelet and neutrophil function and exercise performance. Am J Med 84, 4552.
45Vacek JL, Harris WS & Haffey K (1989) Short-term effects of omega-3 fatty acids on exercise stress test parameters, angina and lipoproteins. Biomed Pharmacother 43, 375379.
46Cole CR, Blackstone EH, Pashkow FJ, Snader CE & Lauer MS (1999) Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 341, 13511357.
47Metcalf RG, James MJ, Gibson RA, Edwards JRM, Stubberfield J, Stuklis R, Roberts-Thomson K, Young GD & Cleland LG (2007) Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr 85, 12221228.
48McLennan P, Barden L, Bridle T, Abeywardena M & Chenock J (1992) Dietary fat modultaion of left ventricular ejection fraction in the marmoset monkey due to enhanced filling. Cardiovasc Res 26, 871877.
49Pepe S & McLennan PL (2002) Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function. Circulation 105, 23032308.
50Grimsgaard S, Bonaa KH, Hansen JB & Myhre ES (1998) Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. Am J Clin Nutr 68, 5259.
51Mori TA, Bao DQ, Burke V, Puddey IB & Bellin LJ (1999) Decosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 34, 253260.
52Mori TA, Watts GF, Burke V, Hilme E, Puddey IB & Beilin LJ (2000) Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. Circulation 102, 12641269.
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