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Batool, Zehra Tabassum, Saiqa Siddiqui, Rafat Ali and Haider, Saida 2018. Dietary Supplementation of Almond Prevents Oxidative Stress by Advocating Antioxidants and Attenuates Impaired Aversive Memory in Male Rats. Plant Foods for Human Nutrition,
Xu, Jialin Yuan, Chunhui Wang, Guihua Luo, Jiaming Ma, Hang Xu, Li Mu, Yu Li, Yuanyuan Seeram, Navindra P. Huang, Xueshi and Li, Liya 2018. Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways. Journal of Agricultural and Food Chemistry, Vol. 66, Issue. 3, p. 571.
Rajaram, Sujatha Valls-Pedret, Cinta Cofán, Montserrat Sabaté, Joan Serra-Mir, Mercè Pérez-Heras, Ana M. Arechiga, Adam Casaroli-Marano, Ricardo P. Alforja, Socorro Sala-Vila, Aleix Doménech, Mónica Roth, Irene Freitas-Simoes, Tania M. Calvo, Carlos López-Illamola, Anna Haddad, Ella Bitok, Edward Kazzi, Natalie Huey, Lynnley Fan, Joseph and Ros, Emilio 2017. The Walnuts and Healthy Aging Study (WAHA): Protocol for a Nutritional Intervention Trial with Walnuts on Brain Aging. Frontiers in Aging Neuroscience, Vol. 8,
Jaroudi, Wafa Garami, Julia Garrido, Sandra Hornberger, Michael Keri, Szabolcs and Moustafa, Ahmed A. 2017. Factors underlying cognitive decline in old age and Alzheimer’s disease: the role of the hippocampus. Reviews in the Neurosciences, Vol. 28, Issue. 7,
Lv, Ying Wei, Kaihua Meng, Xiaoguang Huang, Yajuan Zhang, Tuo and Li, Zhen 2017. Separation and identification of iron-chelating peptides from defatted walnut flake by nanoLC-ESI–MS/MS and de novo sequencing. Process Biochemistry, Vol. 59, p. 223.
Gorji, Narjes Moeini, Reihaneh and Memariani, Zahra 2017. Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer’s disease: A neuropharmacological review of their bioactive constituents. Pharmacological Research,
Hamasaki, Hidetaka and Hamasaki, Yasuteru 2017. Nuts for Physical Health and Fitness: A Review. AIMS Medical Science, Vol. 4, Issue. 4, p. 441.
Hicyilmaz, Hicran Vural, Huseyin Delibas, Namik Sutcu, Recep Gultekin, Fatih and Yilmaz, Nigar 2017. The effects of walnut supplementation on hippocampal NMDA receptor subunits NR2A and NR2B of rats. Nutritional Neuroscience, Vol. 20, Issue. 3, p. 203.
Thangthaeng, Nopporn Poulose, Shibu M. Gomes, Stacey M. Miller, Marshall G. Bielinski, Donna F. and Shukitt-Hale, Barbara 2016. Tart cherry supplementation improves working memory, hippocampal inflammation, and autophagy in aged rats. AGE, Vol. 38, Issue. 5-6, p. 393.
Hayes, David Angove, Michael J. Tucci, Joe and Dennis, Christina 2016. Walnuts (Juglans regia) Chemical Composition and Research in Human Health. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. 8, p. 1231.
Galli, Rachel L. Carey, Amanda N. Luskin, Katharine A. Bielinski, Donna F. Shukitt-Hale, Barbara Seeram, Nadvindra P. and Shukkitt-Hale, Barbara 2016. Red raspberries can improve motor function in aged rats. Journal of Berry Research, Vol. 6, Issue. 2, p. 97.
Fisher, Derek R. Poulose, Shibu M. Bielinski, Donna F. and Shukitt-Hale, Barbara 2016. Serum metabolites from walnut-fed aged rats attenuate stress-induced neurotoxicity in BV-2 microglial cells. Nutritional Neuroscience, p. 1.
Zou, Juan Cai, Pei-shan Xiong, Chao-mei and Ruan, Jin-lan 2016. Neuroprotective effect of peptides extracted from walnut (Juglans Sigilata Dode) proteins on Aβ25-35-induced memory impairment in mice. Journal of Huazhong University of Science and Technology [Medical Sciences], Vol. 36, Issue. 1, p. 21.
Panth, Nisha Paudel, Keshav Raj and Karki, Rajendra 2016. Phytochemical profile and biological activity of Juglans regia. Journal of Integrative Medicine, Vol. 14, Issue. 5, p. 359.
Câmara, Cristiane Rodrigues Silva and Schlegel, Vicki 2016. A Review on the Potential Human Health Benefits of the Black Walnut: A Comparison with the English Walnuts and Other Tree Nuts. International Journal of Food Properties, Vol. 19, Issue. 10, p. 2175.
Guo, Shan-Shan Gao, Xiao-Fang Gu, Yan-Rong Wan, Zhong-Xiao Lu, A-Ming Qin, Zheng-Hong and Luo, Li 2016. Preservation of Cognitive Function byLepidium meyenii(Maca) Is Associated with Improvement of Mitochondrial Activity and Upregulation of Autophagy-Related Proteins in Middle-Aged Mouse Cortex. Evidence-Based Complementary and Alternative Medicine, Vol. 2016, p. 1.
Knight, Alissa Bryan, Janet and Murphy, Karen 2016. Is the Mediterranean diet a feasible approach to preserving cognitive function and reducing risk of dementia for older adults in Western countries? New insights and future directions. Ageing Research Reviews, Vol. 25, p. 85.
Aged rats show decrements in performance on motor and cognitive tasks that require the use of spatial learning and memory. Previously we have shown that these deficits can be reversed by the polyphenolics in fruits and vegetables. Walnuts, which contain the n-3 fatty acids α-linolenic acid and linoleic acid, are a dietary source of polyphenols, antioxidants and lipids. Thus, the present study examined the effects of walnut supplementation on motor and cognitive ability in aged rats. Fischer 344 rats, aged 19 months, were fed a control, or a 2, 6 or 9 % walnut diet for 8 weeks before motor and cognitive testing. Results for the motor testing showed that the 2 % walnut diet improved performance on rod walking, while the 6 % walnut diet improved performance on the medium plank walk; the higher dose of the 9 % walnut diet did not improve psychomotor performance and on the large plank actually impaired performance. All of the walnut diets improved working memory in the Morris water maze, although the 9 % diet showed impaired reference memory. These findings show for the first time that moderate dietary walnut supplementation can improve cognitive and motor performance in aged rats.
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