Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Open access
  • Cited by 3
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Al Tamimi, Jozaa Zaidan 2016. Effects of Almond Milk on Body Measurements and Blood Pressure. Food and Nutrition Sciences, Vol. 07, Issue. 06, p. 466.


    Boateng, J. Miller-Ceb, R. Shackelfor, L. and Verghese, M. 2016. Modifying Effects of Pistachio Nuts on Antioxidant Enzymes in Azoxymethane (AOM)-induced Formation of Aberrant Crypt Foci. International Journal of Cancer Research, Vol. 12, Issue. 3, p. 140.


    Grundy, Myriam Marie-Louise Lapsley, Karen and Ellis, Peter Rory 2016. A review of the impact of processing on nutrient bioaccessibility and digestion of almonds. International Journal of Food Science & Technology, Vol. 51, Issue. 9, p. 1937.


    ×

Effect of almond consumption on the serum fatty acid profile: a dose–response study

  • Stephanie Nishi (a1) (a2), Cyril W. C. Kendall (a1) (a2) (a3), Ana-Maria Gascoyne (a1) (a2), Richard P. Bazinet (a1), Balachandran Bashyam (a1) (a2), Karen G. Lapsley (a4), Livia S. A. Augustin (a2), John L. Sievenpiper (a1) (a2) (a5) (a6) (a7) and David J. A. Jenkins (a1) (a2) (a6) (a7) (a8)
  • DOI: http://dx.doi.org/10.1017/S0007114514001640
  • Published online: 20 August 2014
Abstract

Consumption of almonds has been shown to be associated with a decreased risk of CHD, which may be related to their fatty acid (FA) composition. However, the effect of almond consumption on the serum FA composition is not known. Therefore, in the present study, we investigated whether almond consumption would alter the serum FA profile and risk of CHD, as calculated using Framingham's 10-year risk score, in a dose-dependent manner in hyperlipidaemic individuals when compared with a higher-carbohydrate control group using dietary interventions incorporating almonds. A total of twenty-seven hyperlipidaemic individuals consumed three isoenergetic (mean 1770 kJ/d) supplements during three 1-month dietary phases: (1) full-dose almonds (50–100 g/d); (2) half-dose almonds with half-dose muffins; (3) full-dose muffins. Fasting blood samples were obtained at weeks 0 and 4 for the determination of FA concentrations. Almond intake (g/d) was found to be inversely associated with the estimated Framingham 10-year CHD risk score (P= 0·026). In both the half-dose and full-dose almond groups, the proportions of oleic acid (OA) and MUFA in the TAG fraction (half-almond: OA P= 0·003; MUFA P= 0·004; full-almond: OA P< 0·001; MUFA P< 0·001) and in the NEFA fraction (half-almond: OA P= 0·01; MUFA P= 0·04; full-almond: OA P= 0·12; MUFA P= 0·06) increased. The estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (P= 0·011) and MUFA (P= 0·016) content in the TAG fraction. The proportions of MUFA in the TAG and NEFA fractions were positively associated with changes in HDL-cholesterol concentrations. Similarly, the estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (P= 0·069) and MUFA content in the NEFA fraction (P= 0·009). In conclusion, the results of the present study indicate that almond consumption increases OA and MUFA content in serum TAG and NEFA fractions, which are inversely associated with CHD lipid risk factors and overall estimated 10-year CHD risk.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of almond consumption on the serum fatty acid profile: a dose–response study
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effect of almond consumption on the serum fatty acid profile: a dose–response study
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effect of almond consumption on the serum fatty acid profile: a dose–response study
      Available formats
      ×
Copyright
The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution-NonCommercial-ShareAlike licence http://creativecommons.org/licenses/by-nc-sa/3.0/. The written permission of Cambridge University Press must be obtained for commercial re-use.
Corresponding author
*Corresponding author: C. W. C. Kendall, fax +1 416 978 5310, email cyril.kendall@utoronto.ca
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1GE Frazer , J Sabate , WL Beeson , et al. (1992) A possible protective effect of nut consumption on risk of coronary heart disease. The Adventist Health Study. Arch Intern Med 152, 14161424.

2FB Hu , MJ Stampfer , JE Manson , et al. (1998) Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ 317, 13411345.

4CM Albert , JM Gaziano , WC Willett , et al. (2002) Nut consumption and decreased risk of sudden cardiac death in the Physicians' Health Study. Arch Intern Med 162, 13821387.

5 JSabate , KOda & ERos (2010) Nut consumption and blood lipid levels: a pooled analysis of 25 intervention trials. Arch Intern Med 170, 821827.

6R Estruch , E Ros , J Salas-Salvado , et al. (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368, 12791290.

7DJ Jenkins , CW Kendall , A Marchie , et al. (2002) Dose response of almonds on coronary heart disease risk factors: blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: a randomized, controlled, crossover trial. Circulation 106, 13271332.

8GA Spiller , DAJ Jenkins , O Bosello , et al. (1998) Nuts and plasma lipids: an almond-based diet lowers LDL-C while preserving HDL-C. J Am Coll Nutr 17, 285290.

10KS Robbins , EC Shin , RL Shewfelt , et al. (2011) Update on the healthful lipid constituents of commercially important tree nuts. J Agric Food Chem 59, 1208312092.

11PM Kris-Etherton (1999) Monounsaturated fatty acids and risk of cardiovascular disease. Circulation 100, 12531258.

12 SKSathe , NPSeeram , HHKshirsagar , et al. (2008) Fatty acid composition of California grown almonds. J Food Sci 73, C607C614.

13 LSMaguire , SMO'Sullivan , KGalvin , et al. (2004) Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut. Int J Food Sci Nutr 55, 171178.

14TA Sanders (2001) Olive oil and the Mediterranean diet. Int J Vitam Nutr Res 71, 179184.

15A Garg , A Bonnanome , SM Grundy , et al. (1988) Comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 319, 829834.

16 PWWilson , WPCastelli & WBKannel (1987) Coronary risk prediction in adults (the Framingham Heart Study). Am J Cardiol 59, 91G94G.

19 DJJenkins , CWKendall , DGPopovich , et al. (2011) Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism 50, 494503.

21 SNBhupathiraju & KLTucker (2011) Coronary heart disease prevention: nutrients, foods, and dietary patterns. Clin Chim Acta 412, 14931514.

22 CZizza (1997) The nutrient content of the Italian food supply 1961–1992. Eur J Clin Nutr 51, 259265.

25 PKris-Etherton , RHEckel , BVHoward , et al. (2001) AHA Science Advisory: Lyon Diet Heart Study. Benefits of a Mediterranean-style, National Cholesterol Education Program/American Heart Association Step I Dietary Pattern on Cardiovascular Disease. Circulation 103, 18231825.

28JM Martin-Moreno , P Boyle , L Gorgojo , et al. (1993) Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol 22, 512519.

30G Buckland , AL Mayen , A Agudo , et al. (2012) Olive oil intake and mortality within the Spanish population (EPIC-Spain). Am J Clin Nutr 96, 142149.

31NRT Damasceno , A Perez-Heras , M Serra , et al. (2011) Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers. Nutr Metab Cardiovasc Dis 21, S14S20.

32 REstruch , MAMartinez-Gonzalez , DCorella , et al. (2006) Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 145, 111.

33M Urpi-Sarda , R Casas , G Chiva-Blanch , et al. (2012) The Mediterranean diet pattern and its main components are associated with lower plasma concentrations of tumor necrosis factor receptor 60 in patients at high risk for cardiovascular disease. J Nutr 142, 10191025.

34 GASpiller , AMiller , KOlivera , et al. (2003) Effects of plant-based diets high in raw or roasted almonds, or roasted almond butter on serum lipoproteins in humans. J Am Coll Nutr 22, 195200.

35DJA Jenkins , L Chiavaroli , JMW Wong , et al. (2010) Adding monounsaturated fatty acids to a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. CMAJ 182, 19611967.

36 STsimikas , APhilis-Tsimikas , SAslexopoulos , et al. (1999) LDL isolated from Greek subjects on a typical diet or from American subjects on an oleate-supplemented diet induces less monocyte chemotaxis and adhesion when exposed to oxidative stress. Arterioscler Thromb Vasc Biol 19, 122130.



42PM Kris-Etherton , G Zhao , AE Binkoski , et al. (2001) The effects of nuts on coronary heart disease risk. Nutr Rev 59, 103111.


44BW Bolling , G Dolnikowski , JB Blumberg , et al. (2010) Polyphenol content and antioxidant activity of California almonds depend on cultivar and harvest year. Food Chem 122, 819825.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
UNKNOWN
Supplementary Materials

Nishi Supplementary Material
Table S1

 Unknown (38 KB)
38 KB
UNKNOWN
Supplementary Materials

Nishi Supplementary Material
Supplementary Material

 Unknown (117 KB)
117 KB