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Effect of blueberry feeding on plasma lipids in pigs

  • W. Kalt (a1), Kim Foote (a2), S. A. E. Fillmore (a1), Martha Lyon (a3), T. A. Van Lunen (a4) and K. B. McRae (a1)...
Abstract

Two feeding trials were conducted with pigs to determine the effects of blueberry supplementation on plasma lipid levels and other indices of cardiovascular benefit. In the first trial, where basal diets contained a high level of plant-based components (70 % soya, oats and barley), supplementation with 1, 2 and 4 % blueberries resulted in a decrease in total, LDL- and HDL-cholesterol. The greatest reduction was observed in the 2 % blueberry-fed pigs, where total, LDL- and HDL-cholesterol were reduced 11·7, 15·1 and 8·3 %, respectively. In the second trial where basal diets contained only 20 % (w/w) of soya, oats and barley, the lipid-modulating effect of blueberries was attenuated, so that supplementation with 1·5 % blueberries reduced total cholesterol by 8 %, which occurred only in pigs whose diets had been supplemented with cholesterol (0·08 %), NaCl (0·11 %) and fructose (9 %). In the first feeding trial, blueberry supplementation had no effect on blood platelet activity. Blueberry supplementation also had no effect on the susceptibility of leucocyte DNA to oxidation in the first trial and no effect on the susceptibility of LDL to oxidation in the second trial. Results of these two feeding trials are discussed in relation to the effects of basal diet composition on lipid-modulating effects of blueberries.

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Corresponding author
*Corresponding author: Dr W. Kalt, fax +1 902 679 2311, email kaltw@agr.gc.ca
References
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1Joshipura, KJ, Hu, FB, Manson, JE, et al. (2001) The effect of fruit and vegetable intake on risk of coronary heart disease. Ann Intern Med 134, 11061114.
2Fung, TT, Stampfer, MJ, Manson, JE, Rexrode, KM, Willett, WC & Hu, FB (2004) Prospective study of major dietary patterns and stroke risk in women. Stroke 35, 20142019.
3Manach, C, Mazur, A & Scalbert, A (2005) Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol 16, 7784.
4Castellani, W (2004) Metabolic and nutritional aspects of the atherogenic atypical lipoproteins: lipoprotein(a), remnant lipoproteins, and oxidized low-density lipoprotein. Nutr Res 24, 681693.
5Folts, JD (2002) Potential health benefits from the flavonoids in grape products on vascular disease. In Flavonoids in Cell Function, pp. 95111 [Buslig, B and Manthey, J, editors]. New York: Kluwer Academic/Plenum Publishing.
6Keevil, JG, Osman, HE, Reed, JD & Folts, JD (2000) Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J Nutr 130, 5356.
7Reed, J (2002) Cranberry flavonoids, atherosclerosis and cardiovascular health. Crit Rev Food Sci Nutr 42, 301316.
8Kurowska, EM & Manthey, JA (2004) Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. J Agric Food Chem 52, 28792886.
9Zern, TL, West, KL & Fernandez, ML (2003) Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. J Nutr 133, 22682272.
10Dufresne, CJ & Farnworth, ER (2001) A review of latest findings on the health promotion properties of tea. J Nutr Biochem 12, 404421.
11Steinberg, FM, Bearden, MM & Keen, CL (2003) Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc 103, 215223.
12Kris-Etherton, P & Keen, C (2002) Evidence for the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipidol 13, 4149.
13Kalt, W, MacKinnon, S, McDonald, J, Vinquist, M, Craft, C & Howell, A (2007) Phenolics of Vaccinium berries and other fruit crops. J Sci Food Agric (Epublication ahead of print version September 2007. http.//dx.doi.org/10.1002/jsfa.2991).
14Eck, P (1988) Blueberry Science, p. 81. New Brunswick, NJ: Rutgers University Press.
15Joseph, JA, Shukitt-Hale, B & Casadesus, G (2005) Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 81, Suppl. 1, 313S316S.
16Willis, L, Bickford, P, Zaman, V, Moore, A & Granholm, A-C (2005) Blueberry extract enhances survival of neural transplants of intra-ocular hippocampal transplants. Cell Transplant 14, 213223.
17Turk, JR & Laughlin, MH (2004) Physical activity and atherosclerosis: which animal model? Can J Appl Physiol 29, 657683.
18Moghadasian, MH, Frolich, JJ & McManum, BM (2001) Advances in experimental dyslipidemia and atherosclerosis. Lab Invest 81, 11731183.
19Goodman, S (1999) Sheep, pig and human-material interactions with model cardiovascular materials. J Biomed Mater Res 45, 240250.
20Kerckhoffs, DAJM, Brouns, F, Hornstra, G & Mensink, RP (2002) Effects on the human serum lipoprotein profile of β-glucan, soy protein and isoflavones, plant sterols and stanols, garlic and tocotrienols. J Nutr 132, 24942502.
21Subcommittee on Swine Nutrition, Committee in Animal Nutrition & National Research Council (1998) Nutrient Requirements of Swine, 10th revised ed.Washington, DC: National Academy Press.
22Kalt, W & McDonald, JE (1996) Chemical composition of lowbush blueberry cultivars. J Am Soc Hort Sci 121, 142146.
23Prior, RL, Cao, G, Martin, A, et al. (1998) Antioxidant capacity is influenced by total phenolic and anthocyanin content, maturity and variety of Vaccinium species. J Agric Food Chem 46, 26862693.
24Singleton, VL & Rossi, JA (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16, 144158.
25Lee, J, Durst, RW & Wrolstad, RE (2005) Determination of total monomeric anthocyanin pigment content of fruit juices, natural colorants, and wines, by the pH differential method: collaborative study. J AOAC Int 88, 12691278.
26Batel, R, Jakšić, Ž, Bihari, N, Hamer, B, Fafandel, M, Chauvin, C, Schröder, HC, Müller, WEG & Zahn, RF (1999) A microplate assay for DNA damage determination (Fast Micromethod) in cell suspensions and solid tissues. Anal Biochem 270, 195200.
27Vinson, JA, Proch, J & Pratima, B (1999) Determination of the quantity and quality of polyphenol antioxidants in foods and beverages. Methods Enzymol 335, 103114.
28Payne, RW (2003) The Guide to GenStat® Release 7.1; Statistics. Oxford, UK: VSN International Ltd.
29Kuller, LH (2006) Cholesterol, lipid and cardiovascular disease. Nutr Rev 64, S15S26.
30Franco, V & Oparil, S (2006) Salt sensitivity, a determinant of blood pressure, cardiovascular disease and survival. J Am Coll Nutr 25, 247S255S.
31Gaby, AR (2005) Adverse effects of dietary fructose. Altern Med Rev 10, 294306.
32Tsuda, T, Horio, F, Uchida, K, Aoki, H & Osawa, T (2003) Dietary cyanidin 3-O-β-d-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133, 21252130.
33Tsuda, T, Ueno, Y, Aoki, H, Koda, T, Horio, F, Takahashi, N, Kawada, T & Osawa, T (2004) Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Comm 316, 149157.
34Jayaprakasam, B, Vareed, SK, Olsen, LK & Nair, MG (2005) Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 53, 2831.
35Manach, C, Williamson, G, Morand, C, Scalbert, A & Remesy, C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S242S.
36Morazzoni, P & Magistretti, MJ (1990) Activity of Myrtocyan®, an anthocyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 61, 1321.
37Hubbard, GP, Wolffram, S, Lovegrove, JA & Gibbins, JM (2003) The role of polyphenolic compounds in the diet as inhibitors of platelet function. Proc Nutr Soc 62, 469478.
38Jenkins, DJ, Kendall, CW, Marchie, A, et al. (2005) Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. Am J Clin Nutr 81, 380387.
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British Journal of Nutrition
  • ISSN: 0007-1145
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