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The effect of dairy foods on CHD: a systematic review of prospective cohort studies

  • Robert A. Gibson (a1) (a2) (a3), Maria Makrides (a1) (a2) (a4), Lisa G. Smithers (a1) (a2) (a4) (a5), Melanie Voevodin (a6) and Andrew J. Sinclair (a7)...
Abstract

There is interest in the degree to which fats in dairy foods contribute to CHD. We undertook a systematic review to investigate the effect of dairy consumption on CHD using prospective cohort studies. A systematic search of electronic databases identified studies relating dairy food intake in adulthood to episodes or death from CHD, IHD and myocardial infarction. Included studies were assessed for quality based on study methodology, validity of dietary assessment, success of follow-up, standardised assessment of CHD, IHD or myocardial infarction end points and appropriateness of statistical adjustment. Data from twelve cohorts involving >280 000 subjects were included. Most studies had follow-up of >80 %, adjusted statistically for three or more confounders and used standard criteria to determine end points. About half the studies used a validated FFQ, administered the FFQ more than once or had follow-up of >20 years. Fewer than half the studies involved subjects representative of the general population. Four of the twelve cohorts found no association between dairy intake and CHD. Eight studies reported varying relationships between different dairy foods and CHD or differential associations based on race, sex or over time. Although dairy foods contribute to the SFA composition of the diet, this systematic review could find no consistent evidence that dairy food consumption is associated with a higher risk of CHD. This could be due to the limited sensitivity of the dietary assessment methods to detect an effect of a single food in a mixed diet on complex clinical outcomes.

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Corresponding author
*Corresponding author: Robert A. Gibson, fax +61 8 8303 7135, email robert.gibson@adelaide.edu.au
References
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1Lichtenstein AH, Appel LJ, Brands M, et al. (2006) Diet and lifestyle recommendations revision 2006: a scientific statement from the American heart association nutrition committee. Circulation 114, 8296.
2British Nutrition Foundation (2004) Heart Disease and Stroke (Cardiovascular Disease). http://www.nutrition.org.uk/home.asp?siteId = 43&sectionId = 404&subSectionId = 321&parentSection = 299&which = 1 (accessed January 2007).
3National Health and Medical Research Council of Australia (2003) Dietary Guidelines for Australians: A Guide to Healthy Eating. Canberra: Commonwealth of Australia.
4Mensink RP & Katan MB (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12, 911919.
5Gordon T (1988) The diet-heart idea. Outline of a history. Am J Epidemiol 127, 220225.
6Yu S, Derr J, Etherton TD, et al. (1995) Plasma cholesterol-predictive equations demonstrate that stearic acid is neutral and monounsaturated fatty acids are hypocholesterolemic. Am J Clin Nutr 61, 11291139.
7Whigham LD, Watrus AC & Schoeller DA (2007) Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr 85, 12031211.
8Bucher HC, Cook RJ, Guyatt GH, et al. (1996) Effects of dietary calcium supplementation on blood pressure. A meta-analysis of randomized controlled trials. JAMA 275, 10161022.
9Allender PS, Cutler JA, Follmann D, et al. (1996) Dietary calcium and blood pressure: a meta-analysis of randomized clinical trials. Ann Intern Med 124, 825833.
10Segall JJ (1977) Is milk a coronary health hazard? Br J Prev Soc Med 31, 8185.
11Hu FB & Willet WC (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 25692578.
12Nestel PJ, Chronopulos A & Cehun M (2005) Dairy fat in cheese raises LDL cholesterol less than that in butter in mildly hypercholesterolaemic subjects. Eur J Clin Nutr 59, 10591063.
13Fonollá J, López-Huertas E, Machado FJ, et al. (2008) Milk enriched with ‘healthy fatty acids’ improves cardiovascular risk markers and nutritional status in human volunteers. Nutrition 25, 408414.
14Biong AS, Muller H, Seljeflot I, et al. (2004) A comparison of the effects of cheese and butter on serum lipids, haemostatic variables and homocysteine. Br J Nutr 92, 791797.
15Fehily AM, Yarnell JWG, Sweetnam PM, et al. (1993) Diet and incident ischaemic heart disease: The Caerphilly Study. Br J Nutr 69, 303314.
16Hu F, Rimm E, Stampfer M, et al. (2000) Prospective study of major dietary patterns and risk of heart disease in men. Am J Clin Nutr 72, 912921.
17Oh K, Hu FB, Manson JE, et al. (2005) Dietary fat intake and risk of coronary heart disease in women: 20 years of follow-up of the Nurses' Health Study. Am J Epidemiol 161, 672679.
18Shimazu T, Kuriyama S, Hozawa A, et al. (2007) Dietary patterns and cardiovascular disease mortality in Japan: a prospective cohort study. Int J Epidemiol 36, 600609.
19Tanasescu M, Cho E, Manson JE, et al. (2004) Dietary fat and cholesterol and the risk of cardiovascular disease among women with type 2 diabetes. Am J Clin Nutr 79, 9991005.
20Waijers PM, Ocke MC, van Rossum CT, et al. (2006) Dietary patterns and survival in older Dutch women. Am J Clin Nutr 83, 11701176.
21Brown L, Rosner B, Willett W, et al. (1999) Red meat, eggs, and dairy food consumption in relation to risk of coronary heart disease in pravastatin-treated patients with myocardial infarction. Am J Epidemiol 149, 11 Suppl., S32.
22Hsia J, Heiss G, Ren H, et al. (2007) Calcium/vitamin D supplementation and cardiovascular events. Circulation 115, 846854.
23Gramenzi A, Gentile A, Fasoli M, et al. (1990) Association between certain foods and risk of acute myocardial infarction in women. Br Med J 300, 771773.
24Rastogi T, Reddy KS, Vaz M, et al. (2004) Diet and risk of ischemic heart disease in India. Am J Clin Nutr 79, 582592.
25Sun Q, Ma J, Campos H, et al. (2007) Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease. Am J Clin Nutr 86, 929937.
26Elwood PC, Pickering JE, Hughes J, et al. (2004) Milk drinking, ischaemic heart disease and ishcaemic stroke II. Evidence from cohort studies. Eur J Clin Nutr 58, 718724.
27Hu FB & Willett WC (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 25692578.
28Iestra JA, Kromhout D, van der Schouw YT, et al. (2005) Effect size estimates of lifestyle and dietary changes on all-cause mortality in coronary artery disease patients: a systematic review. Circulation 112, 924934.
29Tholstrup T (2006) Dairy products and cardiovascular disease. Curr Opin Lipidol 17, 110.
30Tucker KL (2004) Dietary intake and coronary heart disease: a variety of nutrients and phytochemicals are important. Curr Treat Options Cardiovasc Med 6, 291302.
31Abbott RD, Curb JD, Rodriguez BL, et al. (1996) Effect of dietary calcium and milk consumption on risk of thromboembolic stroke in older middle-aged men: The Honolulu Heart Program. Stroke 27, 813818.
32He K, Merchant A, Rimm EB, et al. (2003) Dietary fat intake and risk of stroke in male US healthcare professionals: 14-year prospective cohort study. Br Med J 327, 777782.
33Iso H, Hennekens CH, Stampfer MJ, et al. (1999) Prospective study of aspirin use and risk of stroke in women. Stroke 30, 17641771.
34Al-Delaimy WK, Rimm E, Willett WC, et al. (2003) A prospective study of calcium intake from diet and supplements and risk of ischaemic heart disease among men. Am J Clin Nutr 77, 814818.
35Bostick RM, Kushi LH, Wu Y, et al. (1999) Relation of calcium, vitamin D and dairy food intake to ischaemic heart disease mortality among postmenopausal women. Am J Epidemiol 149, 151161.
36Elwood PC, Pickering JE, Fehily AM, et al. (2004) Milk drinking, ischaemic heart disease and ischaemic stroke I. Evidence from Caerphilly cohort. Eur J Clin Nutr 58, 711717.
37Gartside PS, Wang P & Glueck CJ (1998) Prospective assessment of coronary heart disease risk factors: the NHANES I epidemiologic follow-up study (MHEFS) 16-year follow-up. J Am Coll Nutr 17, 263269.
38Hu FB, Stampfer MJ, Manson JE, et al. (1999) Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am J Clin Nutr 70, 10011008.
39Mann JI, Appleby PN, Key TJ, et al. (1997) Dietary determinants of ischaemic heart disease in health conscious individuals. Heart 78, 450455.
40Menotti A, Kromhout D, Blackburn H, et al. (1999) Food intake patterns and 25-year mortality from coronary heart disease: cross cultural correlations in the Seven Countries Study. Eur J Epidemiol 15, 507515.
41Ness AR, Davey Smith G & Hart C (2001) Milk, coronary heart disease and mortality. J Epidemiol Community Health 55, 379382.
42Shaper AG, Wannamethee G & Walker M (1991) Milk, butter and heart disease. Br Med J 302, 785786.
43Snowdon DA, Phillips RL & Fraser GE (1984) Meat consumption and fatal ischemic heart disease. Prev Med 13, 490500.
44Umesawa M, Iso H, Date C, et al. (2006) Dietary intake of calcium in relation to mortality from cardiovascular disease: The JACC Study. Stroke 37, 2026.
45Van der Vijver LPL, van der Waal MAE, Weterings KGC, et al. (1992) Calcium intake and 28-year cardiovascular and coronary heart disease mortality in Dutch civil servants. Int J Epidemiol 21, 3639.
46Kelemen LE, Kushi LH, Jacobs DR Jr, et al. (2005) Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women. Am J Epidemiol 161, 239249.
47Elwood PC, Strain JJ, Robson PJ, et al. (2005) Milk consumption, stroke, and heart attack risk: evidence from the Caerphilly cohort of older men. J Epidemiol Community Health 59, 502505.
48Appleby PN, Thorogood M, Mann JI, et al. (1999) The Oxford Vegetarian Study: an overview. Am J Clin Nutr 70, Suppl. 3, 525S531S.
49Walker M, Whincup PH & Shaper AG (2004) The British Regional Heart Study 1975–2004. Int J Epidemiol 33, 11851192.
50McGee DL, Reed DM, Yano K, et al. (1984) Ten-year incidence of coronary heart disease in the Honolulu Heart Program. Relationship to nutrient intake. Am J Epidemiol 119, 667676.
51Moss M & Freed D (2003) The cow and the coronary: epidemiology, biochemistry and immunology. Int J Cardiol 87, 203216.
52Sanchez-Villegas A, Martinez JA, Prattala RS, et al. (2003) A systematic review of socioeconomic differences in food habits in Europe: consumption of cheese and milk. Eur J Clin Nutr 57, 917929.
53Lopez-Azpiazu I, Sanchez-Villegas A, Johansson L, et al. (2003) Disparities in food habits in Europe: systematic review of educational and occupational differences in the intake of fat. J Hum Nutr Diet 16, 349364.
54Prattala RS, Groth MV, Oltersdorf US, et al. (2003) Use of butter and cheese in 10 European countries: a case of contrasting educational differences. Eur J Public Health 13, 124132.
55Tholstrup T, Hoy C-E, Andersen LN, et al. (2004) Does fat in milk, butter and cheese affect blood lipids and cholesterol differently? J Am Coll Nutr 23, 169176.
56Sun Q, Ma J, Campos H, et al. (2007) Plasma and erythrocyte biomarkers of dairy fat intake and risk of ischemic heart disease. Am J Clin Nutr 86, 929937.
57Agerholm-Larsen L, Bell ML, Grunwald GK, et al. (2000) The effect of a probiotic milk product on plasma cholesterol: a meta-analysis of short-term intervention studies. Eur J Clin Nutr 54, 856860.
58Jauhiainen T & Korpela R (2007) Milk peptides and blood pressure. J Nutr 137, 3 Suppl. 2, 825S829S.
59Groziak SM & Miller GD (2000) Natural bioactive substances in milk and colostrum: effects on the arterial blood pressure system. Br J Nutr 84, Suppl. 1, S119S125.
60Liu E, McKeown NM, Newby PK, et al. (2009) Cross-sectional association of dietary patterns with insulin-resistant phenotypes among adults without diabetes in the Framingham Offspring Study. Br J Nutr (Epublication ahead of print version 16 February 2009).
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