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Effect of dietary protein concentration on responses to Escherichia coli endotoxin in broiler chickens

Published online by Cambridge University Press:  09 March 2007

Kazuaki Takahashi ,
Shinichi Yodogawa ,
Yukio Akiba  and
Keiji Tamura
Kazuaki Takahashi
Affiliation:
Department of Animal Science, Faculty of Agriculture, Tohoku University, Sendai-shiJapan981
Shinichi Yodogawa
Affiliation:
Department of Animal Science, Faculty of Agriculture, Tohoku University, Sendai-shiJapan981
Yukio Akiba
Affiliation:
Department of Animal Science, Faculty of Agriculture, Tohoku University, Sendai-shiJapan981
Keiji Tamura
Affiliation:
Saikin Kagaku Institute, Sendai-shiJapan981
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Abstract

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The effect of dietary protein concentration on stress responses against injection of Escherichia coli lipopolysaccharide (LPS) was studied in male broiler chickens. Chickens (7 d of age) were fed on a 100 (low-protein; LP) or 300 g protein/kg (high-protein; HP) diet for 2 weeks. LPS was injected intraperitoneally every 2 d during the final 6 d, or once 16 h before the end of the experiment, at a concentration of 900 μg/chick. The LPS injection did not affect body-weight gain, feed intake, gain:intake ratio, or plasma Fe concentration. The single injection of LPS reduced plasma Zn concentration, but the repeated injections did not. Feeding the HP diet increased the response of plasma Zn concentration to the single injection of LPS. Plasma albumin concentration was reduced by LPS injection. Feeding the HP diet resulted in a higher plasma α 1-acid glycoprotein (AGP) concentration than feeding the LP diet, in chicks untreated with LPS. An increase in plasma AGP concentration observed after LPS injection in chicks fed on the LP diet was greater than that seen in chicks fed on the HP diet. No significant changes in plasma AGP concentration in response to repeated injections of LPS were observed in chicks fed on the HP diet. Plasma interleukin-1 (IL-l)-like activity was greater in chicks fed on the LP diet than in those fed on the HP diet, when LPS was injected. The response of plasma IL-1-like activity to the single injection of LPS in chicks fed on the LP diet was the greatest among the treatment groups. These results suggest that acute-phase responses to LPS injection are much greater in chicks fed on a LP diet than in those fed on a HP diet, and multiple injection of LPS weakens the responses.

Keywords

Acute-phase responseDietary proteinLipopolysaccharide
Type
Effects of dietary protein in chickens
Information
British Journal of Nutrition , Volume 74 , Issue 2 , August 1995 , pp. 173 - 182
Copyright
Copyright © The Nutrition Society 1995

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