Skip to main content Accessibility help
×
×
Home

Effect of oat intake on glycaemic control and insulin sensitivity: a meta-analysis of randomised controlled trials

  • Lei Bao (a1), Xiaxia Cai (a1), Meihong Xu (a1) and Yong Li (a1)
Abstract

The present meta-analysis of randomised controlled trials (RCT) aimed to investigate the effect of oat intake on glycaemic control and insulin sensitivity. A literature search was carried out in PubMed, ScienceDirect Online and The Cochrane Library (up to October 2013) for RCT that assessed the effect of oat intake on glucose control and insulin sensitivity. A total of fifteen articles with 673 subjects met the inclusion criteria. A random-effects model was used when the overall pooled studies exhibited significant heterogeneity. Otherwise, a fixed-effects model was used. Compared with controls, oat intake significantly reduced the concentrations of fasting insulin by − 6·29 (95 % CI − 12·32, − 0·27) pmol/l (P= 0·04) and the values of glucose AUC (GAUC; 0–120 min) by − 30·23 (95 % CI − 43·65, − 16·81) min × mmol/l (P< 0·0001). There was a slight decrease in fasting glucose concentrations, glycated Hb concentrations and homeostatic model assessment-insulin resistance values in subjects who consumed oats, but the difference was not significant. In conclusion, oat intake significantly lowers fasting insulin concentrations and GAUC values. To further investigate the effect of oat intake on fasting glucose concentrations, additional long-term and high-quality RCT with a parallel design are required.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of oat intake on glycaemic control and insulin sensitivity: a meta-analysis of randomised controlled trials
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Effect of oat intake on glycaemic control and insulin sensitivity: a meta-analysis of randomised controlled trials
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Effect of oat intake on glycaemic control and insulin sensitivity: a meta-analysis of randomised controlled trials
      Available formats
      ×
Copyright
Corresponding author
* Corresponding author: Professor Y. Li, fax +86 10 82801177, email liyongbmu@163.com
References
Hide All
1 Danaei, G, Finucane, MM, Lu, Y, et al. (2011) National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 378, 3140.
2 Shaw, JE, Sicree, RA & Zimmet, PZ (2010) Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract 87, 414.
3 Rathmann, W & Giani, G (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 25682569.
4 The Diabetes Control and Complications Trial Research Group (1995) The effect of intensive diabetes therapy on the development and progression of neuropathy. Ann Intern Med 122, 561568.
5 Nathan, DM, Cleary, PA, Backlund, JY, et al. (2005) Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 353, 26432653.
6 Li, G, Zhang, P, Wang, J, et al. (2008) The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet 371, 17831789.
7 Ramachandran, A, Snehalatha, C, Mary, S, et al. (2006) The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia 49, 289297.
8 Sadiq Butt, M, Tahir-Nadeem, M, Khan, MK, et al. (2008) Oat: unique among the cereals. Eur J Nutr 47, 6879.
9 Haboubi, NY, Taylor, S & Jones, S (2006) Coeliac disease and oats: a systematic review. Postgrad Med J 82, 672678.
10 Battilana, P, Ornstein, K, Minehira, K, et al. (2001) Mechanisms of action of beta-glucan in postprandial glucose metabolism in healthy men. Eur J Clin Nutr 55, 327333.
11 Tappy, L, Gügolz, E & Würsch, P (1996) Effects of breakfast cereals containing various amounts of beta-glucan fibers on plasma glucose and insulin responses in NIDDM subjects. Diabetes Care 19, 831834.
12 Tapola, N, Karvonen, H, Niskanen, L, et al. (2005) Glycemic responses of oat bran products in type 2 diabetic patients. Nutr Metab Cardiovasc Dis 15, 255261.
13 Pick, ME, Hawrysh, ZJ, Gee, MI, et al. (1996) Oat bran concentrate bread products improve long-term control of diabetes: a pilot study. J Am Diet Assoc 96, 12541261.
14 Nazare, JA, Normand, S, Oste Triantafyllou, A, et al. (2009) Modulation of the postprandial phase by beta-glucan in overweight subjects: effects on glucose and insulin kinetics. Mol Nutr Food Res 53, 361369.
15 Beck, EJ, Tapsell, LC, Batterham, MJ, et al. (2010) Oat beta-glucan supplementation does not enhance the effectiveness of an energy-restricted diet in overweight women. Br J Nutr 103, 12121222.
16 Braaten, JT, Wood, PJ, Scott, FW, et al. (1991) Oat gum, a soluble fiber which lowers glucose and insulin in normal individuals after an oral glucose load: comparison with guar gum. Am J Clin Nutr 53, 14251430.
17 Panahi, S, Ezatagha, A, Temelli, F, et al. (2007) β-Glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosity. J Am Coll Nutr 26, 639644.
18 Liljeberg, HG, Granfeldt, YE & Björck, IM (1996) Products based on a high fiber barley genotype, but not on common barley or oats, lower postprandial glucose and insulin responses in healthy humans. J Nutr 126, 458466.
19 McGeoch, SC, Johnstone, AM, Lobley, GE, et al. (2013) A randomized crossover study to assess the effect of an oat-rich diet on glycaemic control, plasma lipids and postprandial glycaemia, inflammation and oxidative stress in Type 2 diabetes. Diabet Med 30, 13141323.
20 Cugnet-Anceau, C, Nazare, JA, Biorklund, M, et al. (2010) A controlled study of consumption of beta-glucan-enriched soups for 2 months by type 2 diabetic free-living subjects. Br J Nutr 103, 422428.
21 Biorklund, M, Holm, J & Onning, G (2008) Serum lipids and postprandial glucose and insulin levels in hyperlipidemic subjects after consumption of an oat beta-glucan-containing ready meal. Ann Nutr Metab 52, 8390.
22 Oremus, M, Wolfson, C, Perrault, A, et al. (2001) Interrater reliability of the modified Jadad quality scale for systematic reviews of Alzheimer's disease drug trials. Dement Geriatr Cogn Disord 12, 232236.
23 Whitehead, A (2002) Meta-analysis of Controlled Clinical Trials. pp. 601204. Chichester: John Wiley & Sons.
24 Higgins, JP, Thompson, SG, Deeks, JJ, et al. (2003) Measuring inconsistency in meta-analyses. BMJ 327, 557560.
25 Egger, M, Davey, SG, Schneider, M, et al. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629634.
26 Saltzman, E, Das, SK, Lichtenstein, AH, et al. (2001) An oat-containing hypocaloric diet reduces systolic blood pressure and improves lipid profile beyond effects of weight loss in men and women. J Nutr 131, 14651470.
27 Davy, BM, Davy, KP, Ho, RC, et al. (2002) High-fiber oat cereal compared with wheat cereal consumption favorably alters LDL-cholesterol subclass and particle numbers in middle-aged and older men. Am J Clin Nutr 76, 351358.
28 Biorklund, M, van Rees, A, Mensink, RP, et al. (2005) Changes in serum lipids and postprandial glucose and insulin concentrations after consumption of beverages with beta-glucans from oats or barley: a randomised dose-controlled trial. Eur J Clin Nutr 59, 12721281.
29 Maki, KC, Galant, R, Samuel, P, et al. (2007) Effects of consuming foods containing oat beta-glucan on blood pressure, carbohydrate metabolism and biomarkers of oxidative stress in men and women with elevated blood pressure. Eur J Clin Nutr 61, 786795.
30 Queenan, KM, Stewart, ML, Smith, KN, et al. (2007) Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. Nutr J 6, 6.
31 Reyna-Villasmil, N, Bermudez-Pirela, V, Mengual-Moreno, E, et al. (2007) Oat-derived beta-glucan significantly improves HDLC and diminishes LDLC and non-HDL cholesterol in overweight individuals with mild hypercholesterolemia. Am J Ther 14, 203212.
32 Granfeldt, Y, Nyberg, L & Bjorck, I (2008) Muesli with 4 g oat beta-glucans lowers glucose and insulin responses after a bread meal in healthy subjects. Eur J Clin Nutr 62, 600607.
33 Liatis, S, Tsapogas, P, Chala, E, et al. (2009) The consumption of bread enriched with betaglucan reduces LDL-cholesterol and improves insulin resistance in patients with type 2 diabetes. Diabetes Metab 35, 115120.
34 Juvonen, KR, Salmenkallio-Marttila, M, Lyly, M, et al. (2011) Semisolid meal enriched in oat bran decreases plasma glucose and insulin levels, but does not change gastrointestinal peptide responses or short-term appetite in healthy subjects. Nutr Metab Cardiovasc Dis 21, 748756.
35 Zhang, PP, Hu, XZ, Zhen, HM, et al. (2012) Oat β-glucan increased ATPases activity and energy charge in small intestine of rats. J Agric Food Chem 60, 98229827.
36 Hlebowicz, J (2009) Postprandial blood glucose response in relation to gastric emptying and satiety in healthy subjects. Appetite 53, 249252.
37 Behall, KM, Scholfield, DJ, Hallfrisch, JG, et al. (2006) Consumption of both resistant starch and beta-glucan improves postprandial plasma glucose and insulin in women. Diabetes Care 29, 975981.
38 Drzikova, B, Dongowski, G & Gebhardt, E (2005) Dietary fibre-rich oat-based products affect serum lipids, microbiota, formation of short-chain fatty acids and steriods in rats. Br J Nutr 94, 10121025.
39 Lv, N, Song, MY, Lee, YR, et al. (2009) Dihydroavenanthramide D protects pancreatic beta-cells from cytokine and streptozotocin toxicity. Biochem Biophys Res Commun 387, 97102.
40 Ren, Y, Yang, X, Niu, X, et al. (2011) Chemical characterization of the avenanthramide-rich extract from oat and its effect on d-galactose-induced oxidative stress in mice. J Agric Food Chem 59, 206211.
41 Choi, JS, Kim, H, Jung, MH, et al. (2010) Consumption of barley beta-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet. Mol Nutr Food Res 54, 10041013.
42 Shen, RL, Cai, FL, Dong, JL, et al. (2011) Hypoglycemic effects and biochemical mechanisms of oat products on streptozotocin-induced diabetic mice. J Agric Food Chem 59, 88958900.
43 Tiwari, U & Cummins, E (2011) Meta-analysis of the effect of β-glucan intake on blood cholesterol and glucose levels. Nutrition 27, 10081016.
44 Shewry, PR, Piironen, V, Lampi, AM, et al. (2008) Phytochemical and fiber components in oat varieties in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 97779784.
45 Andersson, AA, Lampi, AM, Nyström, L, et al. (2008) Phytochemical and fiber components in barley varieties in the HEALTHGRAIN Diversity Screen. J Agric Food Chem 56, 97679776.
46 Ma, X, Gu, J, Zhang, Z, et al. (2013) Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial. Eur J Clin Nutr 67, 12911297.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed