Skip to main content
×
×
Home

Effect of postprandial modulation of glucose availability: short- and long-term analysis

  • Julie-Anne Nazare (a1) (a2) (a3) (a4) (a5) (a6), Alexis de Rougemont (a1) (a2) (a3) (a4) (a5) (a6), Sylvie Normand (a1) (a2) (a3) (a4) (a5) (a6), Valérie Sauvinet (a1) (a2) (a3) (a4) (a5) (a6), Monique Sothier (a1) (a2) (a3) (a4) (a5) (a6), Sophie Vinoy (a7), Michel Désage (a1) (a2) (a3) (a4) (a5) (a6) and Martine Laville (a1) (a2) (a3) (a4) (a5) (a6)...
Abstract

Low glycaemic index (LGI) foods have been proposed as potential means to decrease postprandial glucose excursions and thus to improve diabetes management. We modulated glucose availability of cereal products and thus their glycaemic index to study the metabolic effect of LGI foods on daylong glucose control acutely and in the long term following a 5-week GI intervention diet in free-living subjects. In this randomised, parallel trial, two groups of nineteen overweight subjects followed an ad libitum 5-week intervention diet in which usual starch was replaced by either LGI or high GI (HGI) starch. During the exploration days (days 1 and 36), subjects ate their assigned 13C-labelled test breakfast (LGI or HGI), and total and exogenous glucose kinetics (using stable isotopes), postprandial concentrations of glucose, insulin, lipid profile and nutrient oxidation were assessed after the test breakfast and a standardised lunch. At day 1, LGI breakfast significantly decreased post-breakfast glycaemic response with a parallel decrease in exogenous and total glucose appearance (P < 0·05). Post-lunch and post-breakfast glycaemic responses were positively correlated (r 0·79, P < 0·0001). Following the 5-week diet, difference between the groups in terms of glucose kinetics and response was maintained (no significant interaction group × time) but tended to decrease over time for the post-breakfast glycaemic response. Post-lunch and post-breakfast glycaemic responses remained positively correlated (r 0·47, P = 0·004). Modulation of postprandial glucose availability at breakfast decreased plasma exogenous glucose appearance and improved glucose control at the subsequent lunch. After 5 weeks, these effects were maintained in healthy subjects but remained to be confirmed in the longer term.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of postprandial modulation of glucose availability: short- and long-term analysis
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Effect of postprandial modulation of glucose availability: short- and long-term analysis
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Effect of postprandial modulation of glucose availability: short- and long-term analysis
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor Martine Laville, fax +33 4 78 86 44 62, email martine.laville@chu-lyon.fr
References
Hide All
1 Coutinho M, Gerstein HC, Wang Y, et al. (1999) The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12·4 years. Diabetes Care 22, 233240.
2 Jenkins DJ, Kendall CW, Augustin LS, et al. (2002) Glycemic index: overview of implications in health and disease. Am J Clin Nutr 76, 266S273S.
3 Salmeron J, Manson JE, Stampfer MJ, et al. (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 277, 472477.
4 Augustin LS, Franceschi S, Jenkins DJ, et al. (2002) Glycemic index in chronic disease: a review. Eur J Clin Nutr 56, 10491071.
5 Livesey G, Taylor R, Hulshof T, et al. (2008) Glycemic response and health – a systematic review and meta-analysis: relations between dietary glycemic properties and health outcomes. Am J Clin Nutr 87, 258S268S.
6 Wolever TM, Jenkins DJ, Ocana AM, et al. (1988) Second-meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response. Am J Clin Nutr 48, 10411047.
7 Liljeberg HG, Akerberg AK & Bjorck IM (1999) Effect of the glycemic index and content of indigestible carbohydrates of cereal-based breakfast meals on glucose tolerance at lunch in healthy subjects. Am J Clin Nutr 69, 647655.
8 Liljeberg H & Bjorck I (2000) Effects of a low-glycaemic index spaghetti meal on glucose tolerance and lipaemia at a subsequent meal in healthy subjects. Eur J Clin Nutr 54, 2428.
9 Nilsson A, Granfeldt Y, Ostman E, et al. (2006) Effects of GI and content of indigestible carbohydrates of cereal-based evening meals on glucose tolerance at a subsequent standardised breakfast. Eur J Clin Nutr 60, 10921099.
10 Brighenti F, Benini L, Del Rio D, et al. (2006) Colonic fermentation of indigestible carbohydrates contributes to the second-meal effect. Am J Clin Nutr 83, 817822.
11 Miles JM (2008) A role for the glycemic index in preventing or treating diabetes? Am J Clin Nutr 87, 12.
12 Brand-Miller JC, Petocz P & Colagiuri S (2003) Meta-analysis of low-glycemic index diets in the management of diabetes: response to Franz. Diabetes care 26, 33633364.
13 Wolever TM, Mehling C, Chiasson JL, et al. (2008) Low glycaemic index diet and disposition index in type 2 diabetes (the Canadian trial of carbohydrates in diabetes): a randomised controlled trial. Diabetologia 51, 16071615.
14 Jenkins DJ, Wolever TM, Taylor RH, et al. (1982) Slow release dietary carbohydrate improves second meal tolerance. Am J Clin Nutr 35, 13391346.
15 Schenk S, Davidson CJ, Zderic TW, et al. (2003) Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue. Am J Clin Nutr 78, 742748.
16 Englyst KN, Englyst HN, Hudson GJ, et al. (1999) Rapidly available glucose in foods: an in vitro measurement that reflects the glycemic response. Am J Clin Nutr 69, 448454.
17 McMillan-Price J, Petocz P, Atkinson F, et al. (2006) Comparison of 4 diets of varying glycemic load on weight loss and cardiovascular risk reduction in overweight and obese young adults: a randomized controlled trial. Arch Intern Med 166, 14661475.
18 de Rougemont A, Normand S, Nazare JA, et al. (2007) Beneficial effects of a 5-week low-glycaemic index regimen on weight control and cardiovascular risk factors in overweight non-diabetic subjects. Br J Nutr 98, 12881298.
19 Foster-Powell K, Holt SH & Brand-Miller JC (2002) International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76, 556.
20 Arock M, Desnault H, Viars P, et al. (1985) Determination of total nitrogen in biological milieux by chemoluminescence: a comparison with the reference method. Ann Biol Clin (Paris) 43, 872874.
21 Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37, 287301.
22 Tissot S, Normand S, Guilluy R, et al. (1990) Use of a new gas chromatograph isotope ratio mass spectrometer to trace exogenous 13C labelled glucose at a very low level of enrichment in man. Diabetologia 33, 449456.
23 Bier DM, Arnold KJ, Sherman WR, et al. (1977) In vivo measurement of glucose and alanine metabolism with stable isotopic tracers. Diabetes 26, 10051015.
24 Dejongh DC & Hanessian S (1965) Characterization of amino sugars by mass spectrometry. J Am Chem Soc 87, 37443751.
25 Thivend P MC & Guilbot A (1972) Determination of starch with glucoamylase. In Methods in Carbohydrate Chemistry, pp. 100105 [Whisler RL, editor]. New York/London: Academic Press.
26 Normand S, Pachiaudi C, Khalfallah Y, et al. (1992) 13C appearance in plasma glucose and breath CO2 during feeding with naturally 13C-enriched starchy food in normal humans. Am J Clin Nutr 55, 430435.
27 De Bodo RC, Steele R, Altszuler N, et al. (1963) On the hormonal regulation of carbohydrate metabolism: studies with 14C glucose. Recent Prog Horm Res 19, 4548.
28 Proietto J, Rohner-Jeanrenaud F, Ionescu E, et al. (1987) Non-steady-state measurement of glucose turnover in rats by using a one-compartment model. Am J Physiol 252, E77E84.
29 Goldberg GR, Black AE, Jebb SA, et al. (1991) Critical evaluation of energy intake data using fundamental principles of energy physiology: 1. Derivation of cut-off limits to identify under-recording. Eur J Clin Nutr 45, 569581.
30 Englyst KN, Hudson GJ & Englyst HN (2000) Starch analysis in food. In Encyclopedia of Analytical Chemistry, pp. 42464262 [Meyers R, editor]. Chichester: John Wiley & Sons Ltd.
31 Seal CJ, Daly ME, Thomas LC, et al. (2003) Postprandial carbohydrate metabolism in healthy subjects and those with type 2 diabetes fed starches with slow and rapid hydrolysis rates determined in vitro. Br J Nutr 90, 853864.
32 Garsetti M, Vinoy S, Lang V, et al. (2005) The glycemic and insulinemic index of plain sweet biscuits: relationships to in vitro starch digestibility. J Am Coll Nutr 24, 441447.
33 Nazare J-A, Normand S, Triantafyllou AO, et al. (2007) Modulation of the postprandial phase by beta-glucan in overweight subjects: effects on glucose and insulin kinetics. Mol Nutr Food Res 53, 361369.
34 Nilsson AC, Ostman EM, Granfeldt Y, et al. (2008) Effect of cereal test breakfasts differing in glycemic index and content of indigestible carbohydrates on daylong glucose tolerance in healthy subjects. Am J Clin Nutr 87, 645654.
35 Howarth NC, Saltzman E & Roberts SB (2001) Dietary fiber and weight regulation. Nutr Rev 59, 129139.
36 Jenkins DJ, Wolever TM, Buckley G, et al. (1988) Low-glycemic-index starchy foods in the diabetic diet. Am J Clin Nutr 48, 248254.
37 Brand JC, Colagiuri S, Crossman S, et al. (1991) Low-glycemic index foods improve long-term glycemic control in NIDDM. Diabetes Care 14, 95101.
38 Wolever TM, Jenkins DJ, Vuksan V, et al. (1992) Beneficial effect of low-glycemic index diet in overweight NIDDM subjects. Diabetes Care 15, 562564.
39 Food and Drug Administration (2006) Food labeling: health claims; soluble dietary fiber from certain foods and coronary heart disease. Final rule. Fed Regist 71, 2924829250.
40 Brand-Miller JC, Holt SH, Pawlak DB, et al. (2002) Glycemic index and obesity. Am J Clin Nutr 76, 281S285S.
41 Wee SL, Williams C, Tsintzas K, et al. (2005) Ingestion of a high-glycemic index meal increases muscle glycogen storage at rest but augments its utilization during subsequent exercise. J Appl Physiol 99, 707714.
42 Diaz EO, Galgani JE & Aguirre CA (2006) Glycaemic index effects on fuel partitioning in humans. Obes Rev 7, 219226.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 17
Total number of PDF views: 201 *
Loading metrics...

Abstract views

Total abstract views: 366 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 20th February 2018. This data will be updated every 24 hours.