Skip to main content
×
Home

Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials

  • Jia-Yi Dong (a1), Ignatius M. Y. Szeto (a2), Kimmo Makinen (a3), Qiutao Gao (a2), Junkuan Wang (a2), Li-Qiang Qin (a1) and Youyou Zhao (a2)...
Abstract

Previous studies have suggested that probiotic fermented milk may possess blood pressure (BP)-lowering properties. In the present study, we aimed to systematically examine the effect of probiotic fermented milk on BP by conducting a meta-analysis of randomised controlled trials. PubMed, Cochrane library and the ClinicalTrials.gov databases were searched up to March 2012 to identify eligible studies. The reference lists of the obtained articles were also reviewed. Either a fixed-effects or a random-effects model was used to calculate the combined treatment effect. Meta-analysis of fourteen randomised placebo-controlled trials involving 702 participants showed that probiotic fermented milk, compared with placebo, produced a significant reduction of 3·10 mmHg (95 % CI − 4·64, − 1·56) in systolic BP and 1·09 mmHg (95 % CI − 2·11, − 0·06) in diastolic BP. Subgroup analyses suggested a slightly greater effect on systolic BP in hypertensive participants than in normotensive ones ( − 3·98 v. − 2·09 mmHg). Analysis of trials conducted in Japan showed a greater reduction than those conducted in European countries for both systolic BP ( − 6·12 v. − 2·08 mmHg) and diastolic BP ( − 3·45 v. − 0·52 mmHg). Some evidence of publication bias was present, but sensitivity analysis excluding small trials that reported extreme results only affected the pooled effect size minimally. In summary, the present meta-analysis suggested that probiotic fermented milk has BP-lowering effects in pre-hypertensive and hypertensive subjects.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials
      Available formats
      ×
Copyright
Corresponding author
*Corresponding authors: L.-Q. Qin, email qinliqiang@suda.edu.cn; Y. Zhao, fax +86 10 5987 1301, email youyou.zhao@rd.nestle.com
References
Hide All
1Ebringer L, Ferencík M & Krajcovic J (2008) Beneficial health effects of milk and fermented dairy products – review. Folia Microbiol (Praha) 53, 378394.
2Tong X, Dong JY, Wu ZW, et al. (2011) Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur J Clin Nutr 65, 10271031.
3Sonestedt E, Wirfalt E, Wallstrom P, et al. (2011) Dairy products and its association with incidence of cardiovascular disease: the Malmo diet and cancer cohort. Eur J Epidemiol 26, 609618.
4Dalmeijer GW, Struijk EA, van der Schouw YT, et al. (2012) Dairy intake and coronary heart disease or stroke – a population-based cohort study. Int J Cardiol (Epublication ahead of print version 4 April 2012).
5Guo Z, Liu XM, Zhang QX, et al. (2011) Influence of consumption of probiotics on the plasma lipid profile: a meta-analysis of randomised controlled trials. Nutr Metab Cardiovasc Dis 21, 844850.
6Hata Y, Yamamoto M, Ohni M, et al. (1996) A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 64, 767771.
7Agerholm-Larsen L, Raben A, Haulrik N, et al. (2000) Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases. Eur J Clin Nutr 54, 288297.
8Kawase M, Hashimoto H, Hosoda M, et al. (2000) Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci 83, 255263.
9Inoue K, Shirai T, Ochiai H, et al. (2003) Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 57, 490495.
10Seppo L, Jauhiainen T, Poussa T, et al. (2003) A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77, 326330.
11Mizushima S, Ohshige K, Watanabe J, et al. (2004) Randomized controlled trial of sour milk on blood pressure in borderline hypertensive men. Am J Hypertens 17, 701706.
12Tuomilehto J, Lindstrom J, Hyyrynen J, et al. (2004) Effect of ingesting sour milk fermented using Lactobacillus helveticus bacteria producing tripeptides on blood pressure in subjects with mild hypertension. J Hum Hypertens 18, 795802.
13Aihara K, Kajimoto O, Hirata H, et al. (2005) Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension. J Am Coll Nutr 24, 257265.
14Jauhiainen T, Vapaatalo H, Poussa T, et al. (2005) Lactobacillus helveticus fermented milk lowers blood pressure in hypertensive subjects in 24-h ambulatory blood pressure measurement. Am J Hypertens 18, 16001605.
15Engberink MF, Schouten EG, Kok FJ, et al. (2008) Lactotripeptides show no effect on human blood pressure: results from a double-blind randomized controlled trial. Hypertension 51, 399405.
16van der Zander K, Jakel M, Bianco V, et al. (2008) Fermented lactotripeptides-containing milk lowers daytime blood pressure in high normal-to-mild hypertensive subjects. J Hum Hypertens 22, 804806.
17Jauhiainen T, Ronnback M, Vapaatalo H, et al. (2010) Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects. Eur J Clin Nutr 64, 424431.
18Usinger L, Ibsen H, Linneberg A, et al. (2010) Human in vivo study of the renin–angiotensin–aldosterone system and the sympathetic activity after 8 weeks daily intake of fermented milk. Clin Physiol Funct Imaging 30, 162168.
19Moher D, Liberati A, Tetzlaff J, et al. (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151, 264269.
20Higgins J & Green S (2011) Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0. The Cochrane Collaboration. http://www.cochrane-handbook.org (accessed 9 March 2012).
21Higgins JP & Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21, 15391558.
22Egger M, Davey Smith G, Schneider M, et al. (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629634.
23Duval S & Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56, 455463.
24Lewington S, Clarke R, Qizilbash N, et al. (2002) Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360, 19031913.
25Appel LJ, Moore TJ, Obarzanek E, et al. (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med 336, 11171124.
26Wang H, Livingstone KA, Mayer J, et al. (2012) Yogurt consumption, blood pressure and incident hypertension: a longitudinal study in the Framingham Heart Study. Presented at the American Heart Association High Blood Pressure Research Scientific Sessions, 21 September 2012, Washington, DC (Abstract 188).
27Usinger L, Ibsen H & Jensen LT (2009) Does fermented milk possess antihypertensive effect in humans? J Hypertens 27, 11151120.
28Qin LQ, Xu JY, Dong JY, et al. (2013) Lactotripeptides intake and blood pressure management: a meta-analysis of randomised controlled clinical trials. Nutr Metab Cardiovasc Dis 23, 395402.
29Kato N (2012) Ethnic differences in genetic predisposition to hypertension. Hypertens Res 35, 574581.
30Xu JY, Qin LQ, Wang PY, et al. (2008) Effect of milk tripeptides on blood pressure: a meta-analysis of randomized controlled trials. Nutrition 24, 933940.
31Ricci I, Artacho R & Olalla M (2010) Milk protein peptides with angiotensin I-converting enzyme inhibitory (ACEI) activity. Crit Rev Food Sci Nutr 50, 390402.
32Cicero AF, Gerocarni B, Laghi L, et al. (2011) Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta-analysis of current available clinical trials. J Hum Hypertens 25, 425436.
33Research Group of γ-Aminobutyric Acid in Tokyo (1960) Clinical aspects on the use of gamma-aminobutyric acid. In Inhibition in the Nervous System and Gamma-aminobutyric Acid. Proceedings of an International Symposium, 22–24 May 1959, City of Hope Medical Center, Duarte, CA, pp. 579–581. Oxford: Pergamon Press.
34Cani PD & Delzenne NM (2009) The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 15, 15461558.
35Sawada H, Furushiro M, Hirai K, et al. (1990) Purification and characterization of an antihypertensive compound from Lactobacillus casei. Agric Biol Chem 54, 32113219.
36Nakajima K, Hata Y, Osono Y, et al. (1995) Antihypertensive effect of extract of Lactobacillus casei in patients with hypertension. J Clin Biochem Nutr 18, 181187.
37Naruszewicz M, Johansson ML, Zapolska-Downar D, et al. (2002) Effect of Lactobacillus plantarum 299v on cardiovascular disease risk factors in smokers. Am J Clin Nutr 76, 12491255.
38McGrane MM, Essery E, Obbagy J, et al. (2011) Dairy consumption, blood pressure, and risk of hypertension: an evidence-based review of recent literature. Curr Cardiovasc Risk Rep 5, 287298.
39Steffen LM, Kroenke CH, Yu X, et al. (2005) Associations of plant food, dairy product, and meat intakes with 15-y incidence of elevated blood pressure in young black and white adults: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Clin Nutr 82, 11691177.
40Wang L, Manson JE, Buring JE, et al. (2008) Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women. Hypertension 51, 10731079.
41Engberink MF, Geleijnse JM, de Jong N, et al. (2009) Dairy intake, blood pressure, and incident hypertension in a general Dutch population. J Nutr 139, 582587.
42Engberink MF, Hendriksen MA, Schouten EG, et al. (2009) Inverse association between dairy intake and hypertension: the Rotterdam Study. Am J Clin Nutr 89, 18771883.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Type Description Title
WORD
Supplementary Materials

Dong Supplementary Material
Table S2

 Word (51 KB)
51 KB
WORD
Supplementary Materials

Dong Supplementary Material
Table S1

 Word (79 KB)
79 KB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 39
Total number of PDF views: 367 *
Loading metrics...

Abstract views

Total abstract views: 654 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th November 2017. This data will be updated every 24 hours.