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Effect of the LoBAG30 diet on blood glucose control in people with type 2 diabetes

  • Frank Q. Nuttall (a1) (a2), Kelly Schweim (a1), Heidi Hoover (a1) and Mary C. Gannon (a1) (a2) (a3)
Abstract

In subjects with untreated type 2 diabetes, we previously determined that a weight-maintenance, non-ketogenic diet containing 30 % protein, 50 % fat and 20 % carbohydrate (30:50:20) decreased the percentage total glycohaemoglobin (%tGHb) by 2·2 % glycohaemoglobin over 5 weeks compared to a diet recommended for the American public (protein–fat–carbohydrate 15:30:55). Both the fasting and postprandial glucose were decreased. The objective of the present study was to determine if increasing the carbohydrate content from 20 to 30 % at the expense of fat would still provide a similar effect on %tGHb, fasting and postprandial glucose concentration. Eight men with untreated type 2 diabetes were studied over a 5-week period. Results at the beginning (standard diet) and end of the 5-week study were analysed. Body weight was stable. Fasting glucose concentration decreased by 40 %; 24 h glucose area response decreased by 45 %. Insulin did not change. Mean %tGHb decreased by 1·7 (from 10·8 to 9·1 %), and was still decreasing linearly at 5 weeks. In conclusion, a high-protein, 30 % carbohydrate diet could be a patient-empowering method of improving the hyperglycaemia of type 2 diabetes without pharmacologic intervention. Long-term effects and general applicability of this diet remain to be determined.

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Corresponding author
*Corresponding author: Dr Frank Q. Nuttall, fax +1 612 725 2273, email nutta001@umn.edu
References
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1Gannon MC, Nuttall FQ, Saeed A, Jordan K & Hoover H (2003) An increase in dietary protein improves the blood glucose response in persons with type 2 diabetes. Am J Clin Nutr 78, 734741.
2Gannon MC & Nuttall FQ (2004) Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. Diabetes 53, 23752382.
3Nuttall FQ, Khan M & Gannon MC (2000) Peripheral glucose appearance rate following fructose ingestion in normal subjects. Metabolism 49, 15651571.
4Gannon MC, Khan MA & Nuttall FQ (2001) Glucose appearance rate after the ingestion of galactose. Metabolism 50, 9398.
5Khan M, Gannon MC & Nuttall FQ (1992) Glucose appearance rate following protein ingestion in normal subjects. J Am Coll Nutr 11, 701706.
6Gannon MC, Nuttall JA, Damberg G, Gupta V & Nuttall FQ (2001) Effect of protein ingestion on the glucose appearance rate in people with type 2 diabetes. J Clin Endocrinol Metab 86, 10401047.
7Nuttall FQ, Mooradian AD, Gannon MC, Billington C & Krezowski PA (1984) Effect of protein ingestion on the glucose and insulin response to a standardized oral glucose load. Diabetes Care 7, 465470.
8Nuttall FQ & Gannon MC (1988) The quantitative importance of dietary constituents other than carbohydrate or protein as insulin secretagogues in type 2 diabetes. Diabetes Care 11, 7276.
9Gannon MC, Nuttall FQ, Neil BJ & Westphal SA (1988) The insulin and glucose responses to meals of glucose plus various proteins in type 2 diabetic subjects. Metabolism 37, 10811088.
10Nuttall FQ & Gannon MC (1991) Plasma glucose and insulin response to macronutrients in non-diabetic and NIDDM subjects. Diabetes Care 14, 824838.
11American Diabetes Association (2005) Standards of medical care in diabetes. Diabetes Care 28, Suppl. 1, S4S36.
12US Department of Agriculture (1992) The Food Guide Pyramid. Washington, DC: US Government Printing Office.
13US Department of Agriculture (1995) Nutrition and Your Health: Dietary Guidelines for Americans. Hysattsville, MD: US Department of Agriculture, Human Nutrition Information Service.
14American Heart Association (1986) Dietary guidelines for healthy American adults. A statement for physicians and health professionals by the Nutrition Committee. Circulation 74, 1465A1468A.
15Nuttall FQ, Schweim K, Hoover H & Gannon MC (2006) Metabolic effect of a LoBAG30 diet in men with type 2 diabetes. Am J Physiol Endocrinol Metab 291, E786E791.
16Rech ME (1996) Observations on the decay of glycated hemoglobin HbA1c in diabetic patients. Exp Clin Endocrinol Diabetes 104, 102105.
17Nuttall FQ (1998) Comparison of percent total GHb with percent HbA1c in people with and without known diabetes. Diabetes Care 21, 14751480.
18Nilsson LH, Furst P & Hultman E (1973) Carbohydrate metabolism of the liver in normal man under varying dietary conditions. Scand J Clin Lab Invest 32, 331337.
19Unger RH & Orci L (1976) Physiology and pathophysiology of glucagon. Physiol Rev 56, 778825.
20Garg A, Bantle JP, Henry RR, Coulston AM, Griver KA, Raatz SK, Brinkley L, Chen Y-D, Grundy SM, Huet BA & Reaven GM (1994) Effects of varying carbohydrate content of diet in patients with non-insulin-dependent diabetes mellitus. JAMA 271, 14211428.
21Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL & Buring JE (1997) Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation 96, 25202525.
22Glasnapp DR & Poggio JP (1985) Essentials of Statistical Analysis for the Behavioral Sciences. Columbus, OH: Charles E. Merrill.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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