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Effect of the LoBAG30 diet on blood glucose control in people with type 2 diabetes

  • Frank Q. Nuttall (a1) (a2), Kelly Schweim (a1), Heidi Hoover (a1) and Mary C. Gannon (a1) (a2) (a3)
  • DOI: http://dx.doi.org/10.1017/S0007114507819155
  • Published online: 01 March 2008
Abstract

In subjects with untreated type 2 diabetes, we previously determined that a weight-maintenance, non-ketogenic diet containing 30 % protein, 50 % fat and 20 % carbohydrate (30:50:20) decreased the percentage total glycohaemoglobin (%tGHb) by 2·2 % glycohaemoglobin over 5 weeks compared to a diet recommended for the American public (protein–fat–carbohydrate 15:30:55). Both the fasting and postprandial glucose were decreased. The objective of the present study was to determine if increasing the carbohydrate content from 20 to 30 % at the expense of fat would still provide a similar effect on %tGHb, fasting and postprandial glucose concentration. Eight men with untreated type 2 diabetes were studied over a 5-week period. Results at the beginning (standard diet) and end of the 5-week study were analysed. Body weight was stable. Fasting glucose concentration decreased by 40 %; 24 h glucose area response decreased by 45 %. Insulin did not change. Mean %tGHb decreased by 1·7 (from 10·8 to 9·1 %), and was still decreasing linearly at 5 weeks. In conclusion, a high-protein, 30 % carbohydrate diet could be a patient-empowering method of improving the hyperglycaemia of type 2 diabetes without pharmacologic intervention. Long-term effects and general applicability of this diet remain to be determined.

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*Corresponding author: Dr Frank Q. Nuttall, fax +1 612 725 2273, email nutta001@umn.edu
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2MC Gannon & FQ Nuttall (2004) Effect of a high-protein, low-carbohydrate diet on blood glucose control in people with type 2 diabetes. Diabetes 53, 23752382.

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11American Diabetes Association (2005) Standards of medical care in diabetes. Diabetes Care 28, Suppl. 1, S4S36.

15FQ Nuttall , K Schweim , H Hoover & MC Gannon (2006) Metabolic effect of a LoBAG30 diet in men with type 2 diabetes. Am J Physiol Endocrinol Metab 291, E786E791.

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21JM Gaziano , CH Hennekens , CJ O'Donnell , JL Breslow & JE Buring (1997) Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation 96, 25202525.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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