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Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial

  • Jordi Salas-Salvadó (a1), Xavier Farrés (a2), Xavier Luque (a3), Silvia Narejos (a4), Manel Borrell (a5), Josep Basora (a6), Anna Anguera (a7), Ferran Torres (a8), Mònica Bulló (a1), Rafel Balanza (a1) and for the Fiber in Obesity-Study Group...

The aim of the study was to compare the effect of the administration of a mixture of fibres on body weight-loss, satiety, lipid profile and glucose metabolism. We included 200 overweight or obese patients in a parallel, double-blind, placebo-controlled clinical trial, who were randomised to receive, in the context of an energy-restricted diet for a period of 16 weeks, a mixed fibre dose (3 g Plantago ovata husk and 1 g glucomannan) twice (b.i.d. group) or three times daily (t.i.d. group) or placebo. Weight change was the primary efficacy endpoint. Satiety, dietary compliance, lipid profile, glucose tolerance, insulin resistance and high-sensitivity C-reactive protein were secondary endpoints. Weight loss tended to be higher after both doses of fibre ( − 4·52 (sd 0·56) and − 4·60 (sd 0·55) kg) than placebo ( − 0·79 (sd 0·58) kg); the differences in changes between groups were not statistically significant. Postprandial satiety increased in both fibre groups compared to the placebo. The differences between groups in LDL-cholesterol levels were significant (P = 0·03), with greater reductions in the two fibre-supplemented groups ( − 0·38 (sd 0·10) and − 0·24 (sd 0·09) mmol/l in the b.i.d. and t.i.d. groups v. − 0·06 (sd 0·09) mmol/l in placebo group). A similar pattern was observed for changes in total cholesterol:HDL-cholesterol and HDL-cholesterol:LDL-cholesterol ratios. Interventions were well tolerated and had no effects on HDL-cholesterol, glucose and insulin concentrations, glucose tolerance or high-sensitivity C-reactive protein. In conclusion, a 16-week dietary supplement of soluble fibre in overweight or obese patients was well tolerated, induced satiety and had beneficial effects on some CVD risk factors, the most important of which was a significant decrease in plasma LDL-cholesterol concentrations.

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      Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial
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*Corresponding author: Dr J. Salas-Salvadó, fax +34 977 75 93 22, email
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1Newby PK, Tucker KL & Wolk A (2005) Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women. Am J Clin Nutr 81, 12671274.
2Alfieri MA, Pomerleau J, Grace DM & Anderson L (1995) Fiber intake of normal weight, moderately obese and severely obese subjects. Obes Res 3, 541547.
3Ludwig DS, Pereira MA, Kroenke CH, Hilner JE, Van Horn L, Slattery ML & Jacobs DR Jr (1999) Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA 282, 15391546.
4Slavin JL (2005) Dietary fiber and body weight. Nutrition 21, 411418.
5Jenkins DJA, Kendall CWC, Axelsen M, Augustin LSA & Vuksan V (2000) Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 11, 4956.
6Schneeman BO (2002) Gastrointestinal physiology and functions. Br J Nutr 88, Suppl. 2, S159S163.
7Baer DJ, Rumpler WV, Miles CW & Fahey GC Jr (1997) Dietary fiber decreases the metabolizable energy content and nutrient digestibility of mixed diets fed to humans. J Nutr 127, 579586.
8Salas-Salvadó J, Bulló M, Pérez-Heras A & Ros E (2006) Dietary fiber, nuts and cardiovascular diseases. Br J Nutr 96, Suppl. 2, S45S51.
9Pittler MH & Ernst E (2001) Guar gum for body weight reduction: meta-analysis of randomized trials. Am J Med 110, 724730.
10Rodriguez-Moran M, Guerrero-Romero F & Lazcano-Burciaga G (1998) Lipid- and glucose-lowering efficacy of Plantago Psyllium in type II diabetes. J Diabetes Complications 12, 273278.
11Birketvedt GS, Aaseth J, Florholmen JR & Ryttig K (2000) Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects. Acta Medica (Hradec Kralove) 43, 129132.
12Rossner S, Andersson IL & Ryttig K (1988) Effects of a dietary fibre supplement to a weight reduction programme on blood pressure. A randomized, double-blind, placebo-controlled study. Acta Med Scand 223, 353357.
13Howarth NC, Saltzman E & Roberts SB (2001) Dietary fiber and weight regulation. Nutr Rev 59, 129139.
14Jacobs ET, Giuliano AR, Roe DJ, Guillen-Rodriguez JM, Hess LM, Alberts DS & Martinez ME (2002) Intake of supplemental and total fiber and risk of colorectal adenoma recurrence in the wheat bran fiber trial. Cancer Epidemiol Biomarkers Prev 11, 906914.
15National Heart Lung and Blood Institute: Obesity Education Initiative Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (1998) Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res 6, S51S210.
16Salas-Salvadó J, Rubio MA, Barbany M, Moreno B & Grupo Colaborativo de la SEEDO (2007) SEEDO 2007 Consensus for the evaluation of overweight and obesity and the establishment of therapeutic intervention criteria. Med Clin (Barc) 10; 128, 184196.
17Tuomilehto J, Voutilainen E, Huttunen J, Vinni S & Homan K (1980) Effect of guar gum on body weight and serum lipids in hypercholesterolemic females. Acta Med Scand 208, 4548.
18Ryttig KR, Tellnes G, Haegh L, Boe E & Fagerthun H (1989) A dietary fibre supplement and weight maintenance after weight reduction: a randomized, double-blind, placebo-controlled long-term trial. Int J Obes 13, 165171.
19Rigaud D, Ryttig KR, Angel LA & Apfelbaum M (1990) Overweight treated with energy restriction and a dietary fibre supplement: a 6-month randomized, double-blind, placebo-controlled trial. Int J Obes 14, 763769.
20Makkonen M, Simpanen AL, Saarikoski S, Uusitupa M, Penttila I, Silvasti M & Korhonen P (1993) Endocrine and metabolic effects of guar gum in menopausal women. Gynecol Endocrinol 7, 135141.
21Brown L, Rosner B, Willett WW & Sacks FM (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69, 3042.
22Hylander B & Rossner S (1983) Effects of dietary fiber intake before meals on weight loss and hunger in a weight-reducing club. Acta Med Scand 213, 217220.
23Birketvedt GS, Shimshi M, Erling T & Florholmen J (2005) Experiences with three different fiber supplements in weight reduction. Med Sci Monit 11, I5I8.
24Walsh DE, Yaghoubian V & Behforooz A (1984) Effect of glucomannan on obese patients: a clinical study. Int J Obes 8, 289293.
25Biancardi G, Palmiero L & Ghirardi PE (1989) Glucomannan in the treatment of overweight patients with osteoarthrosis. Curr Ther Res 46, 908912.
26Cairella M & Marchini G (1995) Evaluation of the action of glucomannan on metabolic parameters and on the sensation of satiation in overweight and obese patients. Clin Ter 146, 269274.
27Vita PM, Restelli A, Caspani P & Klinger R (1992) Chronic use of glucomannan in the dietary treatment of severe obesity. Minerva Med 83, 135139.
28Anderson JW, Allgood LD, Lawrence A, Altringer LA, Jerdack GR, Hengehold DA & Morel JG (2000) Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 71, 472479.
29Salmeron J, Manson JE, Stampfer MJ, Colditz GA, Wing AL & Willett WC (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. JAMA 277, 472477.
30Montonen J, Knekt P, Jarvinen R, Aromaa A & Reunanen A (2003) Whole-grain and fiber intake and the incidence of type 2 diabetes. Am J Clin Nutr 77, 622629.
31Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ & Willett WC (1996) Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men. JAMA 275, 447451.
32Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy SM & Brinkley LJ (2000) Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med 342, 13921398.
33Wursch P & Pi-Sunyer FX (1997) The role of viscous soluble fiber in the metabolic control of diabetes. A review with special emphasis on cereals rich in beta-glucan. Diabetes Care 20, 17741780.
34Ma Y, Griffith J, Chasan-Taber G, Olendzki B, Jackson E, Stanek E, et al. (2006) Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr 83, 760766.
35Ajani U, Ford E & Mokdad A (2004) Dietary fiber and C-reactive protein: findings from national health and nutrition examination survey data. J Nutr 134, 11811185.
36Jensen M, Koh-Banerjee P, Franz M, Sampson L, Gronbaek M & Rimm E (2006) Whole grains, bran, and germ in relation to homocysteine and markers of glycemic control, lipids and inflammation. Am J Clin Nutr 83, 275283.
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