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Effects of long-term administration of a cocoa polyphenolic extract (Acticoa powder) on cognitive performances in aged rats

  • Jean-François Bisson (a1), Amine Nejdi (a1), Pascale Rozan (a1), Sophie Hidalgo (a1), Robert Lalonde (a2) and Michaël Messaoudi (a1)...
Abstract

Numerous studies have indicated that increased vulnerability to oxidative stress may be the main factor involved in functional declines during normal and pathological ageing, and that antioxidant agents, such as polyphenols, may improve or prevent these deficits. We examined whether 1-year administration of a cocoa polyphenolic extract (Acticoa powder), orally delivered at the dose of 24 mg/kg per d between 15 and 27 months of age, affects the onset of age-related cognitive deficits, urinary free dopamine levels and lifespan in old Wistar-Unilever rats. Acticoa powder improved cognitive performances in light extinction and water maze paradigms, increased lifespan and preserved high urinary free dopamine levels. These results suggest that Acticoa powder may be beneficial in retarding age-related brain impairments, including cognitive deficits in normal ageing and perhaps neurodegenerative diseases. Further studies are required to elucidate the mechanisms of cocoa polyphenols in neuroprotection and to explore their effects in man.

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Corresponding author
*Corresponding author: Dr Michaël Messaoudi, fax +33 383 446 441, email etap@etap-lab.com
References
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1Biesalski HK (2000) The role of antioxidants in nutritional support. Nutrition 16, 593596.
2Huber A, Stuchbury G, Burkle A, Burnell J & Munch G (2006) Neuroprotective therapies for Alzheimer's disease. Curr Pharm Des 12, 705717.
3Egashira T, Takayama F & Yamanaka Y (1996) Effects of bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries. Jpn J Pharmacol 72, 5765.
4Gould TJ & Bickford P (1997) Age-related deficits in the cerebellar b-adrenergic signal transduction cascade in Fischer 344 rats. J Pharmacol Exp Ther 281, 965971.
5Levine MS & Cepeda C (1998) Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum. Adv Pharmacol 42, 724729.
6Hertog MG, Feskens EJM, Hollman PC, Martijn MB & Kromhout D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen Elderly Study. Lancet 342, 10071011.
7Hertog MG, Kromhout D, Aravanis C, et al. (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Studies. Arch Intern Med 155, 381386.
8Steinmetz KA & Potter JD (1991) Vegetables, fruit and cancer. 1. Epidemiology. Cancer Causes Control 2, 325357.
9Keli SO, Hertog MG, Feskens EJ & Kromhout D (1996) Dietary flavonoids, antioxidant vitamins, and incidence of stroke: the Zutphen study. Arch Intern Med 156, 637642.
10Scalbert A, Johnson I & Saltmarsh M (2005) Polyphenols: antioxidant and beyond. Am J Clin Nutr 81, Suppl. 1, 215S217S.
11Sies H & Stahl W (1995) Vitamins E and C, beta-carotene, and other carotenoids as antioxidants. Am J Clin Nutr 62, Suppl. 1, 1315S1321S.
12Adamson GE, Lazarus SA, Mitchel AE, et al. (1999) HPLC method for the quantification of procyanidins in cocoa and chocolate samples and correlation to total antioxidant capacity. J Agric Food Chem 47, 773781.
13Lazarus SA, Hammerstone JF & Schmitz HH (1999) Chocolate contains additional flavanoids not found in tea. Lancet 354, 1825.
14Natsume M, Osakabe N, Yamagishi M, Takizawa T, Nakamura T, Miyatake H, Hanato T & Yoshida T (2000) Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal phase HPLC. Biosci Biotechnol Biochem 64, 25812587.
15Hammerstone JF, Lazarus SA, Mitchell AE, Rucker R & Schmitz HH (1999) Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem 47, 490496.
16Hammerstone JF, Lazarus SA & Schmitz HH (2000) Procyanidin content and variation in some commonly consumed foods. J Nutr 130, Suppl. 85, 2086S2092S.
17Arteel GE & Sies H (1999) Protection against peroxynitrite in cocoa polyphenols oligomers. FEBS Lett 462, 167170.
18Holt RR, Lazarus SA, Sullards MC, Zhu QY, Schramm DD, Hammerstone JF, Fraga CG, Schmitz HH & Keen CL (2002) Procyanidin dimer B2 [epicatechin-(4beta-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa. Am J Clin Nutr 76, 798804.
19Kondo K, Hirano R, Matsumoto A, Igarashi O & Itakura H (1996) Inhibition of LDL oxidation by cocoa. Lancet 348, 1514.
20Rein D, Paglieroni TG, Wun T, Pearson DA, Schmitz HH, Gosselin R & Keen CL (2000) Cocoa inhibits platelet activation and function. Am J Clin Nutr 72, 3035.
21Lotito SB & Fraga CG (2000) Catechins delay lipid oxidation and alpha-tocopherol and beta-carotene depletion following ascorbate depletion in human plasma. Proc Soc Exp Biol Med 225, 3238.
22Miura Y, Chiba T, Miura S, Tomita I, Umegaki K, Ikeda M & Tomita T (2000) Green Tea polyphenols (flavan 3-ols) prevent oxidative modification of low densitylipoproteins – an ex vivo study in humans. J Nutr Biochem 11, 216222.
23Miura Y, Chiba T, Tomita I, Koizumi H, Miura S, Umegaki K, Hara Y & Tomita T (2001) Tea catechins prevent the development of artheroscerosis in apoprotein E-deficent mice. J Nutr 131, 2732.
24Joseph JA, Shukitt-Hale B, Denisova N, Bielinski DF, Martin A, McEwen JJ & Bickford PC (1999) Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavorial deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 19, 81148121.
25Pan T, Jankovic J & Le WD (2003) Potential therapeutic properties of green tea polyphenols in Parkinson's disease. Drugs Aging 20, 711721.
26Schroeter H, Williams JR, Matin R, Iverson L & Rice-Evans CA (2000) Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein. Free Radic Biol Med 29, 12221233.
27Kim HK, Kim M, Kim S, Kim M & Chung JH (2004) Effects of green tea polyphenol on cognitive and acetylcholinesterase activities. Biosci Biotechnol Biochem 68, 19771979.
28Mandel S, Weinreb O, Amit T & Youdim MBH (2004) Cell signalling pathways in the neuroprotective actions of the green tea polyphenols ( − )-epigallocatechin-3-gallate: implications for neurodegenerative diseases. J Neurochem 88, 15551569.
29Benton D, Ruffin MP, Lassel T, Nabb S, Messaoudi M, Vinoy S, Desor D & Lang V (2003) The delivery rate of dietary carbohydrates affects cognitive performances in both rats and humans. Psychopharmocology 166, 8690.
30Messaoudi M, Tricoire A, Lalonde R, Canini F & Minn A (1996) Effects of MPTP on lever-pressing for light extinction in rats. Eur J Pharmacol 299, 1720.
31Messaoudi M, Desor D, Grasmuck V, Joyeux M, Langlois A & Roman FJ (1999) Behavioral evaluation of visceral pain in a rat model of colonic inflammation. Neuroreport 10, 11371141.
32Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11, 4760.
33Armando I, Nowicki S, Aguirre J & Barontini M (1995) A decreased tubular uptake of dopa results in defective renal dopamine production in aged rats. Am J Physiol 268, 10871092.
34Bisson JF, Guardia-Llorens MA, Hidalgo S, Rozan P & Messaoudi M (2007) Protective effect of Acticoa powder, a cocoa polyphenolic extract, on prostate carcinogenesis in Wistar-Unilever rats. Eur J Cancer Prev, (In the Press).
35Siegel S & Castellan NJ Jr (1988) Nonparametric Statistics for the Behavioural Sciences, 2nd ed.New York: McGraw-Hill.
36Kaplan EL & Meier P (1958) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53, 457481.
37Lalonde R & Badescu R (1995) Exploratory drive, frontal lobe function and adipsia in aging. Gerontology 41, 134144.
38Rai GS, Shovlin C & Wesnes KA (1991) A double-blind placebo controlled study of ginkgo biloba extract (‘tanakan’) in elderly outpatients with mild moderate memory impairment. Curr Med Res Opin 12, 350355.
39Kleijnen J & Knipschild P (1992) Ginkgo biloba for cerebral insufficiency. Br J Clin Pharmacol 34, 352358.
40Oyama Y, Fuchs PA, Katayama N & Noda K (1994) Myricetin and quercetin, the flavonoid constituents of Ginkgo biloba extract, greatly reduce oxidative metabolism in both resting and Ca2+-loaded brain neurons. Brain Res 635, 125129.
41Kanowski S, Herrmann WM, Stephan K, Wierich W & Horr R (1996) Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29, 4756.
42Sastre J, Lloret A, Borras C, Pereda G, Garcia-Sala D, Droy-Lefaix MT, Pallardo FV & Vita J (2002) Ginkgo biloba extract EGb 761 protects against mitochondrial aging in the brain and in the liver. Cell Mol Biol 48, 685692.
43Moriguchi T, Saito H & Nishiyama N (1997) Anti-aging effect of aged garlic extract in the inbred brain atrophy mouse model. Clin Exp Pharmacol Physiol 24, 235242.
44Nishiyama N, Morigushy T & Saito H (1997) Beneficial effects of aged garlic extract on learning and memory impairment in the senescence-accelerated mouse. Exp Gerontol 32, 149160.
45Cao G, Sofic E & Prior RL (1997) Antioxidant and prooxidant behaviour of flavonoids: structure–activity relationships. Free Radic Biol Med 22, 749760.
46Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA & Joseph J (2004) Modulation of hippocampal plasticity and cognitive behaviour by short-term blueberry supplementation in aged rats. Nutr Neurosci 7, 309316.
47Lau FC, Shukitt L & Joseph JA (2005) The beneficial effects of fruits polyphenols on brain aging. Neurobiol Aging 26, Suppl. 1, 128132.
48Matsuoka Y, Kitamura Y, Tsukahara T, Terai K, Tooyama I, Kimura H & Taniguchi T (1995) Neuroprotective effects of NBQX on hypoxia-induced neuronal damage in rat hippocampus. Neuroreport 6, 22052208.
49Lee S, Suh S & Kim S (2000) Protective effects of the green tea polyphenol ( − )-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 287, 191194.
50Ishige K, Shubert D & Sagara Y (2001) Flavonoids protect neuronal cells from oxidative stress by three distinct mechanisms. Free Radic Biol Med 30, 433446.
51Crowley TJ, Hoehn MM, Rutledge CO, Stallings MA, Heaton RK, Sundell S & Stilson D (1978) Dopamine excretion and vulnerability to drug-induced Parkinsonism in schizophrenic patients. Arch Gen Psychiatry 35, 97104.
52Hoehn MM, Crowley TJ & Rutledge CO (1977) The Parkinsonian syndrome and its dopamine correlates. Adv Exp Med Biol 90, 243254.
53Pan T, Fei J, Zhou XD, Jankovic J & Le WD (2003) Effects of green tea polyphenols on dopamine uptake and on MMP+-induced dopamine neuron injury. Life Sci 72, 10731083.
54Levites Y, Weinreb O, Maor G, Youdim MB & Mandel S (2001) Green tea polyphenol ( − )-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78, 10731082.
55Mercer LD, Kelly BL, Horne MK & Beart PM (2005) Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol 69, 339345.
56Osakabe N, Yamagishi M, Sanbongi C, Natsume M, Takizawa T & Osawa T (1998) The antioxidative substances in cacao liquor. J Nutr Sci Vitaminol 44, 313321.
57Cropley VL, Fujita M, Innis RB & Nathan PJ (2006) Molecular imaging of the dopaminergic system and its association with human cognitive function. Biol Psychiatry 59, 898907.
58Lieberman A (2006) Depression in Parkinson's disease – a review. Acta Neurol Scand 113, 18.
59Richard IH (2005) Anxiety disorders in Parkinson's disease. Adv Neurol 96, 4255.
60Seutin V (2005) Dopaminergic neurones: much more than dopamine? Br J Pharmacol 146, 167169.
61Shook SK, Franz EA, Higginson CI, Wheelock VL & Sigvardt KA (2005) Dopamine dependency of cognitive switching and response repetition effects in Parkinson's patients. Neuropsychologia 43, 19901999.
62Baba S, Osakabe N, Natsume M, Yasuda A, Takizawa T, Nakamura T & Terao J (2000) Cocoa powder enhances the level of antioxidative activity in rat plasma. Br J Nutr 84, 673680.
63Rozan P, Hidalgo S, Nejdi A, Bisson JF, Lalonde R & Messaoudi M (2007) Preventive antioxidant effects of cocoa polyphenolic extract on free radical production and cognitive performances after heat exposure in Wistar rats. J Food Sci 72, S203S206.
64Wang JF, Schramm DD, Holt RR, Ensunsa JL, Fraga CG, Schmitz HH & Keen CL (2000) Dose–response effect from chocolate consumption on plasma epicatechin and oxidative damage. J Nutr 130, Suppl. 85, 2115S2119S.
65Lee KW, Kim YJ, Lee HJ & Lee CY (2003) Cocoa has more phenolic phytochemicals and a higher antioxidant capacity than teas and red wine. J Agric Food Chem 51, 72927295.
66Heiss C, Dejam A, Kleinbongard T, Schewe P, Sies H & Kelm M (2003) Vascular effects of cocoa rich in flavan-3-ols. JAMA 290, 10301031.
67Sies H, Schewe T, Heiss C & Kelm M (2005) Cocoa polyphenols and inflammatory mediators. Am J Clin Nutr 81, Suppl. 1, 304S312S.
68Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH & Kelm M (2006) ( − )-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103, 10241029.
69Pearson DA, Schmitz HH, Lazarus SA & Keen CL (2001) Inhibition of in vitro low-density lipoprotein oxidation by oligomeric procyanidins present in chocolate and cocoas. Methods Enzymol 335, 350360.
70Wan Y, Vinson JA, Etherton TD, Proch J, Lazarus S & Kris-Etherton P (2001) Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentrations in humans. Am J Clin Nutr 74, 596602.
71Karim M, McCormick K & Kappagoda CT (2000) Effects of cocoa extracts on endothelium-dependent relaxation. J Nutr 130, Suppl. 85, 2105S2108S.
72Mao TK, Powell JJ, Van de Water J, Keen CL, Schmitz HH, Hammerstone JF & Gershwin ME (2000) The effect of cocoa procyanidins on the transcription and secretion of interleukin-1β in peripheral blood mononuclear cells. Life Sci 66, 13771386.
73Sanbongi C, Suzuki N & Sakane T (1997) Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro. Cell Immunol 177, 129136.
74Schramm DD, Wang JF, Holt RR, Ensunsa JL, Gonsalves JL, Lazarus SA, Schmitz HH, German JB & Keen CL (2001) Chocolate procyanidins decrease the leukotriene–prostacyclin ratio in humans and human aortic endothelial cells. Am J Clin Nutr 73, 3640.
75Murphy KJ, Chronopoulos AK, Singh I, Francis MA, Moriarty H, Pike MJ, Turner AH, Mann NJ & Sinclair AJ (2003) Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function. Am J Clin Nutr 77, 466473.
76Vita J (2005) Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 81, Suppl. 1, 292S297S.
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