1Grundy, SM, Brewer, HB Jr, Cleeman, JI, et al. (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109, 433–438.
2Tamakoshi, K, Yatsuya, H, Kondo, T, et al. (2003) The metabolic syndrome is associated with elevated circulating C-reactive protein in healthy reference range, a systemic low-grade inflammatory state. Int J Obes Relat Metab Disord 27, 443–449.
3Pickup, JC, Mattock, MB, Chusney, GD, et al. (1997) NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40, 1286–1292.
4Hotamisligil, GS, Arner, P, Caro, JF, et al. (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95, 2409–2415.
5Ford, ES (2003) The metabolic syndrome and C-reactive protein, fibrinogen, and leukocyte count: findings from the Third National Health and Nutrition Examination Survey. Atherosclerosis 168, 351–358.
6Azadbakht, L, Mirmiran, P, Esmaillzadeh, A, et al. (2005) Dairy consumption is inversely associated with the prevalence of the metabolic syndrome in Tehranian adults. Am J Clin Nutr 82, 523–530.
7Beydoun, MA, Gary, TL, Caballero, BH, et al. (2008) Ethnic differences in dairy and related nutrient consumption among US adults and their association with obesity, central obesity, and the metabolic syndrome. Am J Clin Nutr 87, 1914–1925.
8Elwood, PC, Pickering, JE & Fehily, AM (2007) Milk and dairy consumption, diabetes and the metabolic syndrome: the Caerphilly prospective study. J Epidemiol Community Health 61, 695–698.
9Lutsey, PL, Steffen, LM & Stevens, J (2008) Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study. Circulation 117, 754–761.
10Mennen, LI, Lafay, L, Feskens, EJM, et al. (2000) Possible protective effect of bread and dairy products on the risk of the metabolic syndrome. Nutr Res 20, 335–347.
11Pereira, MA, Jacobs, DR Jr, Van Horn, L, et al. (2002) Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA 287, 2081–2089.
12Ruidavets, JB, Bongard, V, Dallongeville, J, et al. (2007) High consumptions of grain, fish, dairy products and combinations of these are associated with a low prevalence of metabolic syndrome. J Epidemiol Community Health 61, 810–817.
13Zemel, MB & Sun, X (2008) Dietary calcium and dairy products modulate oxidative and inflammatory stress in mice and humans. J Nutr 138, 1047–1052.
14van Meijl, LE & Mensink, RP (2010) Low-fat dairy consumption reduces systolic blood pressure, but does not improve other metabolic risk parameters in overweight and obese subjects. Nutr Metab Cardiovasc Dis .
15Plat, J & Mensink, RP (2000) Vegetable oil based versus wood based stanol ester mixtures: effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects. Atherosclerosis 148, 101–112.
16Barash, J, Dushnitzki, D, Barak, Y, et al. (2003) Tumor necrosis factor (TNF)alpha and its soluble receptor (sTNFR) p75 during acute human parvovirus B19 infection in children. Immunol Lett 88, 109–112.
17Zemel, MB (2003) Mechanisms of dairy modulation of adiposity. J Nutr 133, 252S–256S.
18Pocock, SJ (1983) Clinical Trials. A Practical Approach. Hoboken, NJ: John Wiley & Sons.
19Eckel, RH, Grundy, SM & Zimmet, PZ (2005) The metabolic syndrome. Lancet 365, 1415–1428.
20Fernandez-Real, JM & Ricart, W (2003) Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 24, 278–301.
21Hotamisligil, GS, Shargill, NS & Spiegelman, BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 87–91.
22Uysal, KT, Wiesbrock, SM, Marino, MW, et al. (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389, 610–614.
23Plomgaard, P, Bouzakri, K, Krogh-Madsen, R, et al. (2005) Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation. Diabetes 54, 2939–2945.
24Gonzalez-Gay, MA, De Matias, JM, Gonzalez-Juanatey, C, et al. (2006) Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis. Clin Exp Rheumatol 24, 83–86.
25Kiortsis, DN, Mavridis, AK, Vasakos, S, et al. (2005) Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis. Ann Rheum Dis 64, 765–766.
26Tam, LS, Tomlinson, B, Chu, TT, et al. (2007) Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol 26, 1495–1498.
27Bernstein, LE, Berry, J, Kim, S, et al. (2006) Effects of etanercept in patients with the metabolic syndrome. Arch Intern Med 166, 902–908.
28Dominguez, H, Storgaard, H, Rask-Madsen, C, et al. (2005) Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes. J Vasc Res 42, 517–525.
29Paquot, N, Castillo, MJ, Lefebvre, PJ, et al. (2000) No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients. J Clin Endocrinol Metab 85, 1316–1319.
30Fernandez-Real, JM, Broch, M, Ricart, W, et al. (1998) Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes 47, 1757–1762.
31Moon, YS, Kim, DH & Song, DK (2004) Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents. Metabolism 53, 863–867.
32Zahorska-Markiewicz, B, Olszanecka-Glinianowicz, M, Janowska, J, et al. (2008) The effect of weight loss on serum concentrations of FAS and tumour necrosis factor alpha in obese women. Endokrynol Pol 59, 18–22.
33Warzocha, K & Salles, G (1998) The tumor necrosis factor signaling complex: choosing a path toward cell death or cell proliferation. Leuk Lymphoma 29, 81–92.
34Aderka, D, Englemann, H, Hornik, V, et al. (1991) Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients. Cancer Res 51, 5602–5607.
35Van Zee, KJ, Kohno, T, Fischer, E, et al. (1992) Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci U S A 89, 4845–4849.
36Zhu, Y, Mahon, BD, Froicu, M, et al. (2005) Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease. Eur J Immunol 35, 217–224.
37Tomsig, JL, Sohma, H & Creutz, CE (2004) Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine. Biochem J 378, 1089–1094.
38Wennersberg, MH, Smedman, A, Turpeinen, AM, et al. (2009) Dairy products and metabolic effects in overweight men and women: results from a 6-mo intervention study. Am J Clin Nutr 90, 960–968.
39Sun, X & Zemel, MB (2007) Calcium and 1,25-dihydroxyvitamin D3 regulation of adipokine expression. Obesity (Silver Spring) 15, 340–348.
40Sun, X & Zemel, MB (2008) Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. J Nutr Biochem 19, 392–399.
41Ardizzone, S, Cassinotti, A, Trabattoni, D, et al. (2009) Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: an in vitro study. Int J Immunopathol Pharmacol 22, 63–71.
42Prabhu Anand, S, Selvaraj, P & Narayanan, PR (2009) Effect of 1,25 dihydroxyvitamin D3 on intracellular IFN-gamma and TNF-alpha positive T cell subsets in pulmonary tuberculosis. Cytokine 45, 105–110.
43Tang, J, Zhou, R, Luger, D, et al. (2009) Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 182, 4624–4632.
44Zemel, MB, Sun, X, Sobhani, T, et al. (2010) Effects of dairy compared with soy on oxidative and inflammatory stress in overweight and obese subjects. Am J Clin Nutr 91, 16–22.