Skip to main content
×
Home
    • Aa
    • Aa

Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components

  • Nuria Laso (a1), Emma Brugué (a2), Josep Vidal (a2), Emilio Ros (a2), Joan Albert Arnaiz (a3), Xavier Carné (a3), Sergi Vidal (a4), Sergi Mas (a1), Ramon Deulofeu (a5) and Amalia Lafuente (a1)...
Abstract

The effects of conjugated linoleic acid (CLA) on body weight and body composition in man are controversial. The aim of this study was to investigate the effects of milk supplementation with CLA on body composition and on the biochemical parameters of the metabolic syndrome. This was a randomised, double-blind, placebo-controlled trial. Subjects were randomised to a daily intake of 500 ml milk supplemented with 3 g CLA (using a mixture of the bioactive isomers cis-9, trans-11 and trans-10, cis-12, marketed as Tonalin®, Naturlinea; Central Lechera Asturiana) or placebo for 12 weeks. Sixty healthy men and women (aged 35–65 years) with signs of the metabolic syndrome participated (BMI 25–35 kg/m2). Dual-energy X-ray absorptiometry was used to measure body composition (week 0 baseline and week 12). Total fat mass in the CLA-milk subgroup with a BMI ≤ 30 kg/m2 decreased significantly while no changes were detected in the placebo group (~2 %, P = 0·01). Trunk fat mass showed a trend towards reduction (~3 %, P = 0·05). CLA supplementation had no significant effect on the parameters of the metabolic syndrome, nor was it associated with changes in haematological parameters or renal function. The supplementation of milk with 3 g CLA over 12 weeks results in a significant reduction of fat mass in overweight but not in obese subjects. CLA supplementation was not associated with any adverse effects or biological changes.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Effects of milk supplementation with conjugated linoleic acid (isomers cis-9, trans-11 and trans-10, cis-12) on body composition and metabolic syndrome components
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Amalia Lafuente, fax +34 934035881, email amalialafuente@ub.edu
References
Hide All
MW Pariza , Y Park & ME Cook (1999) Conjugated linoleic acid and the control of cancer and obesity. Toxicol Sci 52, 107110.

M Pariza , S Ashoor , F Chu & D Lund (1979) Effects of temperature and time on mutagen formation in pan-fried hamburger. Cancer Lett 7, 6369.

HX Zu & HA Schut (1992) Inhibition of 2-amino-3-methylimidazol (4,5-f) quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid. Food Chem Toxicol 30, 916.

C Liew , HA Schut , SF Chin , MW Pariza & RH Dashwood (1995) Protection of conjugated linoleic acids against 2-amino-3-methylimidazol (4,5-f) quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis 16, 30373043.

KN Lee , D Kritchevsky & MW Pariza (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108, 1925.

C Miller , Y Park , MW Pariza & M Cook (1994) Feeding conjugated linoleic acid to animals partially overcomes catabolic responses due to endotoxin injection. Biochem Biophys Res Commun 198, 11071112.

Y Park , KJ Allbright , W Liu , JM Storkson , ME Cooj & MW Pariza (1997) Effects of conjugated linoleic acid on body composition in mice. Lipids 32, 853858.

JB German , CJ Dilard & RE Ward (2002) Bioactive components in milk. Curr Opin Clin Nutr Metab Care 5, 653658.

L Yu , D Adams & BA Watkins (2003) Comparison of commercial supplements containing conjugated linoleic acids. J Food Composit Anal 16, 419428.

K Nagao & T Yanagita (2005) Conjugated fatty acids in food and their health benefits. J Biosci Bioeng 100, 152157.

JM Gaullier , G Berven , H Blankson & O Gudmundsen (2002) Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids 37, 10191025.

A Smedman & B Vessby (2001) Conjugated linoleic acid supplementation in humans – metabolic effects. Lipids 36, 773781.

E Thom , J Wadstein & O Gudmunsen (2001) Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 29, 392396.

U Riserús , P Arner , K Brismar & B Vessby (2002) Treatment with dietary trans-10 cis-12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with metabolic syndrome. Diabetes Care 25, 15161521.

G Berven , A Bye , O Hals & OA Karlsen (2000) Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol 102, 455462.

KL Zambell , NL Keim , MD Van Loan , B Gale , P Benito , DS Kelley & GJ Nelson (2000) Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids 35, 777782.

U Riserús , L Berglund & B Vessby (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord 25, 11291135.

MM Kamphuis , MP Lejeune , WH Saris & MS Westerterp-Plantenga (2003) The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. Int J Obes Relat Metab Disord 27, 840847.

C Malpuech-Brugere , WP Verboeket-van de Venne , RP Mensink , MA Arnal , B Morio , M Brandolini , A Saebo , TS Lassel , JM Chardigny , JL Sebedio & B Beaufrere (2004) Effects of two conjugated linoleic acid isomers on body fat mass in overweight humans. Obes Res 12, 591598.

CL Craig , Al Marshall , M Sjostrom , AE Bauman , ML Booth , BE Ainsworth , M Pratt , U Ekelund , A Yngve , JF Sallis & P Oja (2003) International Physical Activity Questionnaire (IPAQ): 12-country reliability and validity. Med Sci Sports Exer 35, 13811395.

MW Pariza , Y Park & ME Cook (2001) The biologically active isomers of conjugated linoleic acid. Prog Lipid Res 40, 283298.

Y Park , JM Storckson , KJ Albright , W Liu & MW Pariza (1999) Evidence that the trans-10,cis-12 isomers of conjugated linoleic acid induces body composition changes in mice. Lipids 34, 235241.

M Evans , C Geigerman , J Cook , L Curtis , B Kuebler & M McIntosh (2000) Conjugated acid linoleic suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35, 899910.

Y Park & MW Pariza (2001) The effects of dietary conjugated nonadecadienoic acid and body composition in mice. Biochim Biophys Acta 1533, 171174.

C Kallen & M Lazar (1996) Antidiabetic thiazolidinediones inhibit leptin on gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 93, 57935796.

L Granlud , L Juvet , J Pedersen & H Nebb (2003) Trans 10, cis 12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res 44, 14411452.

B Szymczyk , PM Pisulewski , W Szczurek & P Hanczakowski (2001) Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br J Nutr 85, 465473.

J Salas-Salvado , F Marquez-Sandoval & M Bullo (2006) Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism. Crit Rev Food Sci Nutr 46, 479488.

EJ Noone , HM Roche , AP Nugent & MJ Gibney (2002) The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 88, 243251.

S Basu , U Riserús , A Turpeinen & B Vessby (2000) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci 99, 511516.

S Basu , A Smedman & B Vessby (2000) Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Lett 468, 3336.

N Tsuboyama-Kasaoka , M Takahashi , K Tanemura , HJ Kim , T Tange , H Okuyama , M Kasai , S Ikemoto & O Ezaki (2000) Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49, 15341542.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 12
Total number of PDF views: 131 *
Loading metrics...

Abstract views

Total abstract views: 286 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th October 2017. This data will be updated every 24 hours.