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Effects of synbiotic supplementation on insulin resistance in subjects with the metabolic syndrome: a randomised, double-blind, placebo-controlled pilot study

  • Tannaz Eslamparast (a1) (a2), Farhad Zamani (a3), Azita Hekmatdoost (a1), Maryam Sharafkhah (a2), Sareh Eghtesad (a2), Reza Malekzadeh (a2) and Hossein Poustchi (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114514000919
  • Published online: 22 May 2014
Abstract

To evaluate the effects of synbiotic supplementation on insulin resistance and lipid profile in individuals with the metabolic syndrome, we conducted a randomised, double-blind, placebo-controlled pilot study on thirty-eight subjects with the metabolic syndrome; they were supplemented with either synbiotic capsules containing 200 million of seven strains of friendly bacteria plus fructo-oligosaccharide or placebo capsules twice a day for 28 weeks. Both the synbiotic (G1) and the placebo (G2) groups were advised to follow an energy-balanced diet and physical activity recommendations. Parameters related to the metabolic syndrome and insulin resistance were measured every 7 weeks during the course of the study. After 28 weeks of treatment, the levels of fasting blood sugar and insulin resistance improved significantly in the G1 group (P< 0·001). Both the G1 and G2 groups exhibited significant reductions in TAG levels ( − 71·22 v. − 10·47 mg/dl ( − 0·80 v. − 0·12 mmol/l) respectively; P< 0·001) and total cholesterol levels ( − 21·93 v. − 14·2 mg/dl ( − 0·57 v. − 0·37 mmol/l) respectively; P= 0·01), as well as increases in HDL levels (+7·7 v. +0·05 mg/dl (+0·20 v. +>0·01 mmol/l) respectively; P< 0·001). The mean differences observed were greater in the G1 group. No significant changes were observed in LDL levels, waist circumference, BMI, metabolic equivalent of task and energy intake between the groups. The present results indicate that synbiotic supplementation increases the efficacy of diet therapy in the management of the metabolic syndrome and insulin resistance.

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*Corresponding authors: A. Hekmatdoost, fax +98 2122360657, email a_hekmat2000@yahoo.com; H. Poustchi, fax +98 2182415400, email: h.poustchi@gmail.com
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1SM Grundy (2004) Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 89, 25952600.

2G Musso , R Gambino & M Cassader (2010) Gut microbiota as a regulator of energy homeostasis and ectopic fat deposition: mechanisms and implications for metabolic disorders. Curr Opin Lipidol 21, 7683.

3H Tilg (2010) Obesity, metabolic syndrome, and microbiota: multiple interactions. J Clin Gastroenterol 44, S16S18.

4PJ Turnbaugh (2009) A core gut microbiome in obese and lean twins. Nature 457, 480484.

5RE Ley (2010) Obesity and the human microbiome. Curr Opin Gastroenterol 26, 511.

6OS Al-Attas , NM Al-Daghri , K Al-Rubeaan , et al. (2009) Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies. Cardiovasc Diabetol 8, 20.

7 HGhanim (2009) Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal: implications for insulin resistance. Diabetes Care 32, 22812287.

8M Wendel , R Paul & AR Heller (2007) Lipoproteins in inflammation and sepsis. II. Clinical aspects. Intens Care Med 33, 2535.

9T Vasiljevic & NP Shah (2008) Probiotics – from Metchnikoff to bioactives. Int Dairy J 18, 714728.

10PD Cani (2006) Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55, 14841490.

11AS Andreasen (2010) Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr 104, 18311838.

12 CSBBogsan , ACRFlorence , NPerina , et al. (2011) Probiotics intake and metabolic syndrome: a proposal. Trends Food Sci Technol 22, 457464.

13J Frece , B Kos , IK Svetec , et al. (2009) Synbiotic effect of Lactobacillus helveticus M92 and prebiotics on the intestinal microflora and immune system of mice. J Dairy Res 76, 98104.

14 DLWorthley , RKLe Leu , VLWhitehall , et al. (2009) A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. Am J Clin Nutr 90, 578586.

16 ZLi , SYang , HLin , et al. (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37, 343350.

17JJ Chen , R Wang , X-F Li , et al. (2011) Bifidobacterium longum supplementation improved high-fat-fed-induced metabolic syndrome and promoted intestinal Reg I gene expression. Exp Biol Med 236, 823831.

18M Malaguarnera , M Vacante , T Antic , et al. (2012) Bifidobacterium longum with fructo-oligosaccharides in patients with non alcoholic steatohepatitis. Dig Dis Sci 57, 545553.

19The National Heart Lung and Blood Institute Expert Panel on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults (1998) Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. J Am Diet Assoc 98, 11781191.

23R Hardy , D Kuh , C Langenberg , et al. (2003) Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort. Lancet 362, 11781183.

25BE Ainsworth , WL Haskell , MC Whitt , et al. (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32, 498504.

26D Matthews , J Hosker , A Rudenski , et al. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.

27 JHřebíček , VJanout , JMalinčíková , et al. (2002) Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab 87, 144147.

29 AMO'Hara & FShanahan (2006) The gut flora as a forgotten organ. EMBO Rep 7, 688693.

30 ASNeish (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136, 6580.

31 JCPickup (2004) Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27, 813823.

32NN Mehta , FC McGillicuddy , PD Anderson , et al. (2010) Experimental endotoxemia induces adipose inflammation and insulin resistance in humans. Diabetes 59, 172181.

33D Compare , P Coccoli , A Rocco , et al. (2012) Gut-liver axis: the impact of gut microbiota on non alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis 22, 471476.

34P Peraldi & B Spiegelman (1998) TNF-α and insulin resistance: summary and future prospects. Mol Cell Biochem 182, 169175.

35 HYadav , SJain & PRSinha (2007) Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition 23, 6268.

36X Ma , J Hua & Z Li (2008) Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol 49, 821830.

37G Kiessling , J Schneider & G Jahreisl (2002) Original Communication. Long-term consumption of fermented dairy products over 6 months increases HDL cholesterol. Eur J Clin Nutr 56, 843849.

38S Khalatbari Soltani , R Jamaluddin , H Tabibi , et al. (2012) Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. Hemodial Int 17, 275281.

39G Schaafsma , W Meuling , W Van Dokkum , et al. (1998) Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr 52, 436440.

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