Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 137
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Emara, Mohamed H. Elhawari, Soha A. Yousef, Salem Radwan, Mohamed I. and Abdel-Aziz, Hesham R. 2016. Emerging Role of Probiotics in the Management ofHelicobacter PyloriInfection: Histopathologic Perspectives. Helicobacter, Vol. 21, Issue. 1, p. 3.

    Fernandes, Ricardo Beserra, Bruna T. S. Mocellin, Michel C. Kuntz, Marilyn G. F. da Rosa, Julia S. de Miranda, Rafaella C. D. Schreiber, Cristina S. O. Fröde, Tânia S. Nunes, Everson A. and Trindade, Erasmo B. S. M. 2016. Effects of Prebiotic and Synbiotic Supplementation on Inflammatory Markers and Anthropometric Indices After Roux-en-Y Gastric Bypass. Journal of Clinical Gastroenterology, Vol. 50, Issue. 3, p. 208.

    Gamallat, Yaser Meyiah, Abdo Kuugbee, Eugene D. Hago, Ahmed Musa Chiwala, Gift Awadasseid, Annoor Bamba, Djibril Zhang, Xin Shang, Xueqi Luo, Fuwen and Xin, Yi 2016. Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model. Biomedicine & Pharmacotherapy, Vol. 83, p. 536.

    Liu, Dun Jiang, Xiao-Ying Zhou, Lan-Shu Song, Ji-Hong and Zhang, Xuan 2016. Effects of Probiotics on Intestinal Mucosa Barrier in Patients With Colorectal Cancer after Operation. Medicine, Vol. 95, Issue. 15, p. e3342.

    Oh, Jung Hwan 2016. Helicobacter pyloriand Gastric Microbiota. The Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol. 16, Issue. 2, p. 59.

    Perlamutrov, Yuri N. Olhovskaya, Kira B. and Zakirova, Svetlana A. 2016. Double-blind controlled randomised study of lactulose and lignin hydrolysed combination in complex therapy of atopic dermatitis. Microbial Ecology in Health & Disease, Vol. 27,

    Wang, Bao-gui Wu, Yaoping Qiu, Liang Shah, Nagendra P. Xu, Feng and Wei, Hua 2016. Integration of genomic and proteomic data to identify candidate genes in HT-29 cells after incubation with Bifidobacterium bifidum ATCC 29521. Journal of Dairy Science,

    Yoo, Ji and Kim, Sung 2016. Probiotics and Prebiotics: Present Status and Future Perspectives on Metabolic Disorders. Nutrients, Vol. 8, Issue. 3, p. 173.

    Jung, Ji-Yun Shin, Ji-Sun Lee, Suel-Gie Rhee, Young Kyoung Cho, Chang-Won Hong, Hee-Do and Lee, Kyung-Tae 2015. Lactobacillus sakei K040706 evokes immunostimulatory effects on macrophages through TLR 2-mediated activation. International Immunopharmacology, Vol. 28, Issue. 1, p. 88.

    Marlow, Gareth Han, Dug Yeo Wickens, Kristin Stanley, Thorsten Crane, Julian Mitchell, Edwin A. Dekker, James Barthow, Christine Fitzharris, Penny Ferguson, Lynnette R. and Morgan, Angharad R. 2015. Differential effects of two probiotics on the risks of eczema and atopy associated with single nucleotide polymorphisms to Toll-like receptors. Pediatric Allergy and Immunology, Vol. 26, Issue. 3, p. 262.

    O'Brien, Teresa Thomas, David G. Morel, Patrick C.H. and Rutherfurd-Markwick, Kay J. 2015. Moderate dietary supplementation with vitamin E enhances lymphocyte functionality in the adult cat. Research in Veterinary Science, Vol. 99, p. 63.

    Pei, Ruisong Martin, Derek A. DiMarco, Diana M. and Bolling, Bradley W. 2015. Evidence for the Effects of Yogurt on Gut Health and Obesity. Critical Reviews in Food Science and Nutrition, p. 00.

    Ashraf, Rabia and Shah, Nagendra P. 2014. Immune System Stimulation by Probiotic Microorganisms. Critical Reviews in Food Science and Nutrition, Vol. 54, Issue. 7, p. 938.

    Dimitrijevic, Rajna Ivanovic, Nevena Mathiesen, Geir Petrusic, Vladimir Zivkovic, Irena Djordjevic, Brizita and Dimitrijevic, Ljiljana 2014. Effects of Lactobacillus rhamnosus LA68 on the immune system of C57BL/6 mice upon oral administration. Journal of Dairy Research, Vol. 81, Issue. 02, p. 202.

    El-Bakry, Hanan A. Zahran, Wafaa M. Anter, Shaimaa A. and Zahran, Ahmed S. 2013. Role of some selected Bifidobacterium strains in modulating immunosenescence of aged albino rats. The Journal of Basic & Applied Zoology, Vol. 66, Issue. 5, p. 255.

    Galdeano, C. Maldonado Dogi, C.A. Bonet, M.E. Bibas de Moreno de LeBlanc, A. and Perdigón, G. 2013. Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease.

    He, Dan Wang, Hai-Yang Feng, Jing-Yan Zhang, Ming-Ming Zhou, Yong and Wu, Xiao-Ting 2013. Use of pro-/synbiotics as prophylaxis in patients undergoing colorectal resection for cancer: A meta-analysis of randomized controlled trials. Clinics and Research in Hepatology and Gastroenterology, Vol. 37, Issue. 4, p. 406.

    Heinritz, Sonja N. Mosenthin, Rainer and Weiss, Eva 2013. Use of pigs as a potential model for research into dietary modulation of the human gut microbiota. Nutrition Research Reviews, Vol. 26, Issue. 02, p. 191.

    Kiseleva, E.P. Mikhailopulo, K.I. Novik, G.I. Szwajcer Dey, E. Zdorovenko, E.L. Shashkov, A.S. and Knirel, Y.A. 2013. Isolation and structural identification of glycopolymers ofBifidobacterium bifidumBIM B-733D as putative players in pathogenesis of autoimmune thyroid diseases. Beneficial Microbes, Vol. 4, Issue. 4, p. 375.

    Makino, Seiya Ikegami, Shuji Nagai, Takayuki and Yamada, Haruki 2013. Probiotics.


Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019)

  • H. S. Gill (a1) (a2), K. J. Rutherfurd (a1) (a2), J. Prasad (a2) and P. K. Gopal (a1)
  • DOI:
  • Published online: 01 March 2007

In order to study the mechanism by which increasing unsaturation of dietary fat lowers HDL-cholesterol levels, we studied various measures of HDL metabolism in hamsters fed with fats with different degrees of saturation. Hamsters were fed on a cholesterol-enriched (1 g/kg) semipurified diet containing 200 g/kg of maize oil, olive oil, or palm oil for 9 weeks. Increasing saturation of dietary fat resulted in increasing concentrations of total plasma cholesterol (4·29 (SD 0·51), 5·30 (sd 0·67) and 5·58 (sd 0·76) mmol/l respectively, n 12) and HDL-cholesterol (3·31 (sd 0·50), 3·91 (sd 0·12) and 3·97 (sd 0·43) mmol/l) and these concentrations were significantly higher (P < 0·05) in the palm-oil and olive-oil-fed hamsters compared with the maize-oil group. Total plasma triacylglycerol levels also increased with increasing fat saturation (1·01 (sd 0·59), 1·56 (sd 0·65) and 2·75 (sd 1·03) mmol/l) and were significantly higher (P < 0·05) in the palm-oil group compared with the olive-oil and maize-oil-fed hamsters. The three diets did not have differential effects on plasma activity levels of lecithin: cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP). Levels of phospholipid transfer protein (PLTP) tended to be higher with increasing fat saturation but this effect was not significant. The capacity of liver membranes to bind human HDL3 was significantly higher (P < 0·05) in the hamsters fed with maize oil (810 (sd 100) ng HDL3 protein/mg membrane protein, n 4) compared with those fed on palm oil (655 (sd 56) ng/mg), whereas the olive-oil group had intermediate values (674 (sd 26) ng/mg). The affinity of HDL3 for the binding sites was not affected by the type of dietary fat. Hepatic lipase (EC activity, measured in liver homogenates, increased with increasing fat saturation. We conclude that dietary maize oil, when compared with either olive oil or palm oil, may lower HDL-cholesterol concentrations by enhancing HDL binding to liver membranes.

    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019)
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019)
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019)
      Available formats
Corresponding author
*Corresponding author: Professor H. S. Gill, fax +64 6 350 5446, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

ML Cross and HS Gill (1999) Modulation of immune function by a modified bovine whey protein concentrate. Immunology and Cell Biology 77, 288296.

C De Simone , R Vesely , R Negri , B Bianchi Salvadori , S Zanzoglu , A Cilli and L Lucci (1987) Enhancement of immune response of murine Peyer's patches by a diet supplemented with yoghurt .Immunopharmacology and Immunotoxicology 9, 87100.

HS Gill (1998) Stimulation of the immune system by lactic cultures. International Dairy Journal 8, 535544.

JS Goodwin (1995) Decreased immunity and increased morbidity in the elderly Nutrition Reviews 53, S41S46.

E Isolauri , J Joensus , H Suomalainen , M Luomala and T Vesikari (1995) Improved immunogenicity of oral DxRRX reabsorbant rotavirus vaccine by Lactobacillus casei GG. Vaccine 13, 310312.

S Johann Blümel G, M Lipp and Förster R (1995) A versatile flow cytometry-based assay for the determination of short- and long-term natural killer cell activity. Journal of Immunological Methods 185, 209216.

DN Khansari , AJ Murgo and AE Faith (1990) Effects of stress on the immune system. Immunology Today 11, 170175.

L Lefrancois (1994) Basic aspects of intraepithelial lymphocyte immunobiology. In Handbook of Mucosal Immunology, pp. 287290 [PL Ogra , J Mestecky , ME Lamm , W Strober , JR McGhee and J Bienenstock , editors]. San Diego, CA: Academic Press.

H Link-Amster , F Rochat , KY Saudan , O Mignot and JM Aeschlimann (1994) Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake FEMS Immunology and Medical Microbiology 10, 5564.

JB Lloyd , HS Gill and AJ Husband (1995) The effect of storage on immunophenotyping of sheep lymphocyte by flow cytometry. Veterinary Immunology and Immunopathology 47, 131142.

H Majamaa , E Isolauri , M Saxelin and T Vesikari (1995) Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. Journal of Pediatric Gastroenterology and Nutrition 20, 333338.

YA Mekori (1996) Introduction to allergic diseases. Critical Reviews in Food Science and Nutrition 36, S1S18.

Z Mikes , M Ferenicik , E Jahnova , L Ebringer and I Ciznar (1995) Hypocholesterolemic and immunostimulatory effects of orally applied. Enterococcus faecium M-74 in man Folia Microbiologica 40, 639646.

TR Mossmann and RL Coffman (1989) Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annual Review of Immunology 7, 145173.

HW Murray (1988) Interferon-gamma, the activated macrophages, and host defense against microbial challenge .Annals of International Medicine 108, 595608.

ME Nader de Macias , MC Apella , NC Romero , SN Gonzalez and G Oliver (1992) Inhibition of Shigella sonnei by Lactobacillus casei and Lactobacillus acidophilus. Journal of Applied Bacteriology 73, 407411.

G Pawelec , M Adibzadeh , H Pohla and K Schaudt (1995) Immunosenescence: aging of the immune system. Immunology Today 16, 420422.

J Prasad , HS Gill , JB Smart and PK Gopal (1999) Selection and characterisation of Lactobacillus and >Bifidobacterium strains for use as probiotics. International Dairy Journal 8, 9931002.

JJ Ryan (1997) Interleukin-4 and its receptors: essential mediators of the allergic response. Journal of Allergy and Clinical Immunology 99, 16.

S Salminen , AC Ouwehand and E Isolauri (1998) Clinical applications of Probiotic bacteria. International Dairy Journal 8, 563572.

K Shida , K Makino , A Morishita , K Takamizawa , S Hachimura , A Ametani , T Sato , Y Kumagai , S Habu and S Kaminogawa (1998) Lactobacillus casei inhibits antigen-induced IgE secretion through regulation of cytokine production in murine splenocyte cultures. International Archives of Allergy and Immunology 115, 278287.

G Thyphronitis , GC Tsokos , CH June , AD Levine and FD Finkelmen (1989) IgE secretion by Epstein-Bar virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon γ .Proceedings of the National Academy of Sciences USA 86, 55805584.

CP Wan , CS Park and BHS Lau (1993) A rapid and simple microfluorometric phagocytosis assay. Journal of Immunological Methods 162, 17.

B Woodward (1998) Protein, calories and immune defenses. Nutrition Reviews 56, S84S92.

J Xu-Amano , RJ Jackson , K Fujihashi , H Kiyono , HF Staats and JR McGhee (1994) Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin .Vaccine 12, 903911.

H Yasui , A Mike and M Ohwaki (1989) Immunogenicity of Bifidobacterium breve and change in antibody production in Peyer's patches after oral administration. Journal of Dairy Science 72, 3035.

RM Zinkernagal and H Hengartner (1997) Antiviral immunity. Immunology Today 18, 258259.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *