Skip to main content Accessibility help
×
×
Home

Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years

  • Kirsi Laitinen (a1) (a2), Marko Kalliomäki (a1), Tuija Poussa (a3), Hanna Lagström (a4) and Erika Isolauri (a1) (a5)...
Abstract

Current research into dietary factors contributing to the development of allergic diseases is directed towards new active approaches instead of passive elimination diets. The present study aimed to investigate the explanatory role of the diet in a probiotic intervention study on the appearance of atopic eczema (AE) in childhood and the safety of perinatal supplementation with probiotics (Lactobacillus rhamnosus strain GG; ATCC 53 103). A prospective follow-up study from birth to 48 months of children (n 159) with a family history of allergic disease was carried out. Outcome measures included growth, dietary intake assessed with 4 d food diaries and their association with AE by logistic regression models. Increased intakes of retinol, Ca and Zn, with perinatal administration of probiotics, reduced the risk of AE, whilst an increase in intake of ascorbic acid increased the likelihood of AE. Perinatal administration of probiotics was safe, as it did not influence the height (mean difference 0·04 (95 % CI −0·33, 0·40) sd scores, P=0·852) or the weight-for-height (mean difference −3·35 (95 % CI −7·07, 0·37)%, P=0·077) of the children at 48 months with and without perinatal administration of probiotics. Up to 48 months, AE did not affect height (mean difference −0·05 (95 % CI −0·42, 0·33) sd scores, P=0·815), but mean weight-for-height in children with AE was −5·1 % (95 % CI −8·9, −1·2 %) lower compared with children without (P=0·010). The joint effects of nutrients and probiotics need to be considered in active prevention and management schemes for allergic diseases.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Evaluation of diet and growth in children with and without atopic eczema: follow-up study from birth to 4 years
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Kirsi Laitinen, fax +358 2 333 6862, email kirsi.laitinen@utu.fi
References
Hide All
Aberg, N, Hesselmar, B, Aberg, B & Eriksson, B (1995) Increase of asthma, allergic rhinitis and eczema in Swedish schoolchildren between 1979 and 1991. Clin Exp Allergy 25, 815819.
Agostoni, C, Grandi, F, Scaglioni, S, Gianni, ML, Torcoletti, M, Radaelli, G, Fiocchi, A & Riva, E (2000) Growth pattern of breastfed and nonbreastfed infants with atopic dermatitis in the first year of life. Pediatrics 106, e73.
Albers, R, Bol, M, Bleumink, R, Willems, AA & Pieters, RHH (2003) Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. Nutrition 19, 940946.
Arora, P, Kumar, V & Batra, S (2002) Vitamin A status in children with asthma. Pediatr Allergy Immunol 13, 223226.
Barker, DJP (1995) Fetal origins of coronary heart disease. BMJ 311, 171174.
Bjelakovic, G, Nikolova, D, Simonetti, RG & Gluud, C (2004) Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 364, 12191228.
Bodner, C, Godden, D, Brown, K, Little, J, Ross, S & Seaton, A on behalf of Aberdeen WHEASE Study Group (1999) Antioxidant intake and adult-onset wheeze: a case–control study. Eur Respir J 13, 2230.
Brook, CGD (1971) Determination of body composition of children from skinfold measurements. Arch Dis Child 46, 182184.
Chang, KC, Miklich, DR, Barwise, G, Chai, H & Miles-Lawrence, R (1982) Linear growth of chronic asthmatic children: the effects of the disease and various forms of steroid therapy. Clin Allergy 12, 369378.
Christie, L, Hine, RJ, Parker, JG & Burks, W (2002) Food allergies in children affect nutrient intake and growth. J Am Diet Assoc 102, 16481651.
Dunstan, JA, Mori, TA, Barden, A, Beilin, LJ, Taylor, AL, Holt, PG & Prescott, SL (2003) Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy. Clin Exp Allergy 33, 442448.
Eggesbo, M, Botten, G & Stigum, H (2001) Restricted diets in children with reactions to milk and egg perceived by their parents. J Pediatr 139, 583587.
Ferguson, AC, Murray, AB & Tze, WJ (1982) Short stature and delayed skeletal maturation in children with allergic disease. J Allergy Clin Immunol 69, 461466.
Fiocchi, A, Bouygue, GR, Martelli, A, Terracciano, L & Sarratud, T (2004) Dietary treatment of childhood atopic eczema/dermatitis syndrome (AEDS). Allergy 59, Suppl., 7885.
Hakala, P, Marniemi, J, Knuts, L-R, Kumpulainen, J, Tahvonen, R & Plaami, S (1996) Calculated vs analysed nutrient composition of weight reduction diets. Food Chem 57, 7175.
Halevy, O & Sklan, D (1987) Inhibition of arachidonic acid oxidation by β-carotene, retinol, and α-tocopherol. Biochim Biophys Acta 918, 304307.
Hanifin, JM (1991) Atopic dermatitis in infants and children. Pediatr Clin North Am 38, 763789.
Harik-Khan, RI, Muller, DC & Wise, RA (2004) Serum vitamin levels and the risk of asthma in children. Am J Epidemiol 159, 351357.
Harizi, H, Juzan, M, Pitard, V, Moreau, J-F & Gualde, N (2002) Cyclooxygenase-2-issued prostaglandin E 2 enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J Immunol 168, 22552263.
Hijazi, N, Abalkhail, B & Seaton, A (2000) Diet and childhood asthma in a society in transition: a study in urban and rural Saudi Arabia. Thorax 55, 775779.
Hoppu, U, Rinne, M, Salo-Väänänen, P, Lampi, A-M, Piironen, V & Isolauri, E (2005) Vitamin C in breast milk may reduce the risk of atopy in the infant. Eur J Clin Nutr 59, 123128.
Isolauri, E, Sütas, Y, Salo, MK, Isosomppi, R & Kaila, M (1998) Elimination diet in cow's milk allergy: risk for impaired growth in young children. J Pediatr 132, 10041009.
Kalliomäki, M, Salminen, S, Arvilommi, H, Kero, P, Koskinen, P & Isolauri, E (2001) Probiotics in primary prevention of atopic disease: a randomised, placebo-controlled trial. Lancet 357, 10761079.
Kalliomäki, M, Salminen, S, Poussa, T, Arvilommi, H & Isolauri, E (2003) Probiotics and prevention of atopic disease – a 4-year follow-up of a randomised placebo-controlled trial. Lancet 361, 18691871.
Kankaanpää, PE, Salminen, S, Isolauri, E & Lee, YK (2001) The influence of polyunsaturated fatty acids on probiotic growth and adhesion. FEMS Microbiol Lett 194, 149153.
Kardinaal, AFM, van't Veer, P, Brants, HAM, van den Berg, H, Van Schoonhoven, J & Hermus, RJJ (1995) Relations between antioxidant vitamins in adipose tissue, plasma, and diet. Am J Epidemiol 141, 440450.
Kristmundsdottir, F & David, TJ (1987) Growth impairment in children with atopic eczema. J R Soc Med 80, 912.
Lagström, H, Jokinen, E, Seppänen, R (1997) Nutrient intakes by young children in a prospective randomized trial of a low-saturated fat, low-cholesterol diet. The STRIP baby project. Arch Pediatr Adolesc Med 151, 181188.
Massarano, AA, Hollis, S, Devlin, J & David, TJ (1993) Growth in atopic eczema. Arch Dis Child 68, 677679.
Mathieu, C, Van Etten, E, Decallone, B, Guilietti, A, Gysemans, C, Bouillon, R & Overbergh, L (2004) Vitamin D and 1,25-dihydroxyvitamin D 3 as modulators in the immune system. J Steroid Biochem Mol Biol 89–90 449452.
Miller, ER, Pastor-Barriuso, R, Dalal, D, Riemersma, RA, Appel, L & Guallar, E (2004) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 142, 3746.
Milner, JD, Stein, DM, McCarter, R & Moon, RY (2004) Early infant multivitamin supplementation is associated with increased risk for food allergy and asthma. Pediatrics 114, 2732.
Nagel, G, Nieters, A, Becker, N & Linseisen, J (2003) The influence of the dietary intake of fatty acids and antioxidants on hay fever in adults. Allergy 58, 12771284.
Newberry, RD, Stenson, WF & Lorenz, RG (1999) Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nat Med 5, 900906.
Ninan, TK & Russell, G (1992) Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ 304, 873875.
Nordic Working Group on Diet and Nutrition (1996) Nordic Nutrition Recommendations. Scand J Nut 40, 161165.
Omata, N, Tsukahara, H, Ito, S et al. , (2001) Increased oxidative stress in childhood atopic dermatitis. Life Sci 69, 223228.
Patel, L, Clayton, PE, Jenney, MEM, Ferguson, JE & David, TJ (1997) Adult height in patients with childhood onset atopic dermatitis. Arch Dis Child 76, 505508.
Picado, C, Deulofeu, R, Lleonart, R, Agusti, M, Mullol, J, Quinto, L & Torra, M (2001) Dietary micronutrients/antioxidants and their relationship with bronchial asthma severity. Allergy 56, 4349.
Powell, CVE, Nash, AA, Powers, HJ & Primhak, RA (1994) Antioxidant status in asthma. Pediatr Pulmonol 18, 3438.
Rakoff-Nahoum, S, Paglino, J, Eslami-Varzaneh, F, Edberg, S & Medzhitov, R (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229241.
Räsänen, L, Ylönen, K (1992) Food consumption and nutrient intake of one- to two-year-old Finnish children. Acta Paediatr 81, 711.
Rietjens, IMCM, Boersma, MG, de Haan, L, Spenkelink, B, Awad, HM, Cnubben, NHP, Van Zanden, JJ, van der Woude, H, Alink, GM & Koeman, JH (2002) The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids. Environ Toxicol Pharmacol 11, 321333.
Rocklin, RE & Thistle, L (1986) Reduced prostaglandin E 2 (PGE 2 ) receptors on atopic T lymphocytes. Cell Immunol 99, 294299.
Rocklin, RE, Thistle, L & Audera, C (1985) Decreased sensitivity of atopic mononuclear cells to prostaglandin E 2 (PGE 2 ) and prostaglandin D 2 (PGD 2 ). J Immunol 135, 20332039.
Saavedra, JM, Abi-Hanna, A, Moore, N & Yolken, RH (2004) Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety. Am J Clin Nutr 79, 261267.
Shoseyov, D, Bibi, H, Biesalski, H & Reifen, R (2002) Repeated allergen challenge in rats increases vitamin A consumption. Chest 122, 14071411.
Siri, WE (1961) Body volume measurements by gas dilution. In Techniques for Measuring Body Composition, pp. 108117 [Brozek, J and Henschel, A, editors]. Washington, DC: National Academy of Sciences.
Sorva, R, Perheentupa, J & Tolppanen, EM (1984) A novel format for growth chart. Acta Paediatr 73, 527529.
Soutar, A, Seaton, A & Brown, K (1997) Bronchial reactivity and dietary antioxidants. Thorax 52, 166170.
Stephensen, CB (2001) Vitamin A, infection, and immune function. Annu Rev Nutr 21, 167192.
Stone, WL, LeClair, I, Ponder, T, Baggs, G & Barret, Reis B (2003) Infants discriminate between natural and synthetic vitamin E. Am J Clin Nutr 77, 899906.
Tiainen, JM, Nuutinen, OM & Kalavainen, MP (1995) Diet and nutritional status in children with cow's milk allergy. Eur J Clin Nutr 49, 605612.
Ukabam, SO, Mann, RJ & Cooper, BT (1984) Small intestinal permeability to sugars in patients with atopic eczema. Br J Dermatol 110, 649652.
Worm, M, Herz, U, Krah, JM, Renz, H & Henz, BM (2001) Effects of retinoids on in vitro and in vivo IgE production. Int Arch Allergy Immunol 124, 233236.
Zeiger, RS & Heller, S (1995) The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J Allergy Clin Immunol 95, 11791190.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed