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Experimental nutritional folate deficiency in the baboon (Papio cynocephulus)

Published online by Cambridge University Press:  24 July 2007

R. C. Siddons
R. C. Siddons
Affiliation:
Wellcome Trust Research Laboratories, PO Box 43640, Nairobi, Kenya
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Abstract

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1. Folate deficiency was produced in baboons by feeding them on a diet which was deficient in folic acid.

2. Loss of body-weight, anorexia, asthenia, gingivitis and diarrhoea were common features of the deficiency.

3. Haematologically, the deficiency was characterized by leucopenia with a greater proportional decrease in the polymorphonuclear neutrophils, thrombocytopenia and in some baboons macrocytic anaemia.

4. Deficient baboons had low serum, erythrocyte and liver folate levels and excreted increased amounts of formiminoglutamic acid. The fall in the serum folate level was more rapid than that of the erythrocytes, occurring mainly during the 1st month of deficiency, while erythrocyte levels decreased gradually over a 5-month period.

5. Serum and liver vitamin B12 levels and methylmalonic acid excretion were normal in deficient baboons.

Type
Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 32 , Issue 3 , November 1974 , pp. 579 - 587
Copyright
Copyright © The Nutrition Society 1974

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