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Experimental protein and energy deficiencies: effects on brain free amino acid composition in rats

Published online by Cambridge University Press:  09 March 2007

M. Kaladhar
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad-500007, India
B. S. Narasinga Rao
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad-500007, India
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Abstract

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  1. 1. The effects of protein-energy malnutrition on brain free amino acids of acidic and neutral groups were investigated in experimental rats.

  2. 2. Severe energy restriction did not modify the free amino acid composition of the brain while protein deficiency affected certain amino acids of the brain in opposite directions. Significant decreases in the levels of aspartic acid, threonine and tyrosine were observed in the protein-deficient rats.

  3. 3. These changes in brain amino acids appear to be specific to protein deficiency and not affected by energy deficiency.

Type
Short Papers
Copyright
Copyright © The Nutrition Society 1977

References

Anthony, L. E. & Edozien, J. C. (1975). J. Nutr. 105, 631.CrossRefGoogle Scholar
Badger, T. M. & Tumbleson, M. E. (1974). J. Nutr. 104, 1329.Google Scholar
Cravioto, J. & De Licardie, E. (1968). In Malnutrition, Learning and Behaviour, pp. 252269 [Scrimshaw, N. S. and Gordon, J. E., editors]. Cambridge, Mass.: M.I.T. Press.Google Scholar
De Feudis, F. V. (1975). Ann. Rev. Pharmacol, Palo Alto, Calif. 5, 105.Google Scholar
Enwonwu, C. O. & Worthington, B. S. (1973). J. Neurochem. 21, 799.CrossRefGoogle Scholar
Frankova, S. & Barnes, R. H. (1968 a). J. Nutr. 96, 477.Google Scholar
Frankova, S. & Barnes, R. H. (1968 b). J. Nutr. 96, 485.CrossRefGoogle Scholar
Horwitz, W. (editor)(1965). Official Methods of Analysis, 10th ed, p. 779. Washington, D.C.: Association of Official Agriculture Chemistry.Google Scholar
Lajtha, A. (1968). In Progress in Brain Research, Vol. 29, pp. 201216 [Lajtha, A. & Ford, D. H., editors]. Amsterdam: Elsevier.Google Scholar
Levitsky, D. & Barnes, R. H. (1970). Nature, Lond. 225, 465.Google Scholar
McIlwain, H. & Bachelard, H. S. (1971). In Biochemistry and the Central Nervous System, 4th ed., pp. 266307. Edinburgh: Churchill-Livingstone.Google Scholar
Monckeberg, F. (1968). In Malnutrition, Learning and Behaviour, pp. 269278. [Scrimshaw, N. S. & Gordon, J. E., editors]. Cambridge, Mass.: M.I.T. Press.Google Scholar
Ramanadham, M. & Kaplay, S. S. (1975). Nutr. Rep. Int. 12, 93.Google Scholar
Scrimshaw, N. S. (1967). Am. J. Clin. Nutr. 20, 493.Google Scholar
Shoemaker, W. J. & Wurtman, R. J. (1973). J. Nutr. 103, 1357.CrossRefGoogle Scholar