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Exploring the influence of the gut microbiota and probiotics on health: a symposium report

  • Linda V. Thomas (a1), Theo Ockhuizen (a2) and Kaori Suzuki (a3)

The present report describes the presentations delivered at the 7th International Yakult Symposium, ‘The Intestinal Microbiota and Probiotics: Exploiting Their Influence on Health’, in London on 22–23 April 2013. The following two themes associated with health risks were covered: (1) the impact of age and diet on the gut microbiota and (2) the gut microbiota's interaction with the host. The strong influence of the maternal gut microbiota on neonatal colonisation was reported, as well as rapid changes in the gut microbiome of older people who move from community living to residential care. The effects of dietary changes on gut metabolism were described and the potential influence of inter-individual microbiota differences was noted, in particular the presence/absence of keystone species involved in butyrate metabolism. Several speakers highlighted the association between certain metabolic disorders and imbalanced or less diverse microbiota. Data from metagenomic analyses and novel techniques (including an ex vivo human mucosa model) provided new insights into the microbiota's influence on coeliac, obesity-related and inflammatory diseases, as well as the potential of probiotics. Akkermansia muciniphila and Faecalibacterium prausnitzii were suggested as targets for intervention. Host–microbiota interactions were explored in the context of gut barrier function, pathogenic bacteria recognition, and the ability of the immune system to induce either tolerogenic or inflammatory responses. There was speculation that the gut microbiota should be considered a separate organ, and whether analysis of an individual's microbiota could be useful in identifying their disease risk and/or therapy; however, more research is needed into specific diseases, different population groups and microbial interventions including probiotics.

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*Corresponding author: Dr L. V. Thomas, fax +44 20 8839 3250, email
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1 H Tsuji , R Oozeer , K Matsuda , et al. (2012) Molecular monitoring of the development of intestinal microbiota in Japanese infants. Benef Microbes 3, 113125.

2 J Penders , C Thijs , C Vink , et al. (2006) Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 118, 511521.

3 MG Dominguez-Bello , EK Costello , M Contreras , et al. (2010) Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A 107, 1197111975.

4 S Schloissnig , M Arumugam , S Sunagawa , et al. (2013) Genomic variation landscape of the human gut microbiome. Nature 493, 4550.

5 H Makino , A Kushiro , E Ishikawa , et al. (2011) Transmission of intestinal Bifidobacterium longum subsp. longum strains from mother to infant, determined by multilocus sequencing typing and amplified fragment length polymorphism. Appl Environ Microbiol 77, 67886793.

6 T Mitsuoka (1982) Recent trends in research on intestinal flora. Bifido Microflora 1, 324.

7 E Woodmansey (2007) Intestinal bacteria and ageing. J Appl Microbiol 102, 11781186.

8 MJ Claesson , O O'Sullivan , Q Wang , et al. (2009) Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLOS ONE 4, e6669.

10 Ó O'Sullivan , M Coakely , B Lakshiminarayanan , et al. (2011) Correlation of rRNA gene amplicon pyrosequencing and bacterial culture for microbial compositional analysis of faecal samples from elderly Irish subjects. J Appl Microbiol 111, 467473.

11 MJ Claesson , S Cusak , O O'Sullivan , et al. (2011) Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A 108, Suppl. 1, 45864591.

13 O O'Sullivan , M Coakley , B Lashminarayanan , et al. (2013) Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy. J Antimicrob Chemother 68, 214221.

14 MC Rea , O O'Sullivan , F Shanahan , et al. (2011) Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J Clin Microbiol 50, 867875.

15 AW Walker , J Ince , SH Duncan , et al. (2011) Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J 5, 220230.

16 HJ Flint , KP Scott , SH Duncan , et al. (2012) Microbial degradation of complex carbohydrates in the gut. Gut Microbes 3, 289306.

17 P Louis , SH Duncan , SI McCrae , et al. (2004) Restricted distribution of the butyrate kinase pathway among butyrate-producing bacteria from the human colon. J Bacteriol 186, 20992106.

19 P Louis , P Young , G Holtrop , et al. (2010) Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol 12, 304314.

20 SH Duncan , A Belengeuer , G Holtrop , et al. (2007) Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 73, 10731078.

22 AW Walker , SH Duncan , EC McWilliam Leitch , et al. (2005) pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon. Appl Environ Microbiol 71, 36923700.

23 SH Duncan , P Louis , JM Thomson , et al. (2009) The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol 11, 21122122.

24 HJ Flint , SH Duncan , KP Scott , et al. (2007) Interactions and competition within the microbial community of the human colon: links between diet and health. Environ Microbiol 9, 11011111.

25 MT Khan , SH Duncan , AJ Stams , et al. (2012) The gut anaerobe Faecalibacterium prausnitzii uses an extracellular electron shuttle to grow at oxic–anoxic interphases. ISME J 6, 15781585.

26 KP Scott , JC Martin , G Campbell , et al. (2006) Whole-genome transcription profiling reveals genes up-regulated by growth on fucose in the human gut bacterium “Roseburia inulinivorans. J Bacteriol 188, 43404349.

28 X Ze , F Le Mougen , SH Duncan , et al. (2013) Some are more equal than others. The role of “keystone” species in the degradation of recalcitrant substrates. Gut Microbes 4, 236240.

29 AW Walker , SH Duncan , HJ Harmsen , et al. (2008) The species composition of the human intestinal microbiota differs between particle-associated and liquid phase communities. Environ Microbiol 10, 32753283.

30 WR Russell , SH Duncan , L Scobbie , et al. (2013) Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein. Mol Nutr Food Res 57, 523535.

32 PB Eckburg , EM Bik , CN Bernstein , et al. (2005) Diversity of the human intestinal microbial flora. Science 308, 16351638.

34 J-F Bach (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347, 911920.

35 H Okada , C Kuhn , H Feillet , et al. (2010) The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update. Clin Exp Immunol 160, 19.

37 C Manichanh , CE Chapple , L Frangeul , et al. (2008) A comparison of random sequence reads versus 16S rDNA sequences for estimating the biodiversity of a metagenomic library. Nucleic Acids Res 36, 51805188.

38 SR Gill , M Pop , RT DeBoy , et al. (2006) Metagenomic analysis of the human distal gut microbiome. Science 312, 13551359.

39 K Kurokawa , T Itoh , T Kuwahara , et al. (2007) Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Res 14, 169181.

40 A Mullard (2008) Microbiology: the inside story. Nature 453, 578580.

41 J Qin , R Li , J Raes , et al. (2010) A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 5965.

43 H Sokol , B Pigneur , L Watterlot , et al. (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 105, 1673116736.

44 P Lepage , MC Leclerc , M Joossens , et al. (2013) A metagenomic insight into our gut's microbiome. Gut 62, 146158.

47 A Spor , O Koren & R Ley (2011) Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol 9, 279289.

49 O Lakhdari , A Cultrone , J Tap , et al. (2010) Functional metagenomics: a high throughput screening method to decipher microbiota-driven NF-κB modulation in the human gut. PLOS ONE 5, e13092.

50 G Kaci , O Lakhdari , J Doré , et al. (2011) Inhibition of the NF-κB pathway in human intestinal epithelial cells by commensal Streptococcus salivarius. Appl Environ Microbiol 77, 46814684.

51 O Lakhdari , J Tap , F Béguet-Crespel , et al. (2011) Identification of NF-κB modulation capabilities within human intestinal commensal bacteria. J Biomed Biotechnol 2011, 282356.

53 M Nepelska , A Cultrone , F Béguet-Crespel , et al. (2012) Butyrate produced by commensal bacteria potentiates phorbol esters induced AP-1 response in human intestinal epithelial cells. PLOS ONE 7, e52869.

54 PD Cani , J Amar , MA Iglesias , et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 17611772.

55 PD Cani , AM Neyrinck , F Fava , et al. (2007) Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 50, 23742383.

56 NM Delzenne , AM Neyrinck , F Bäckhed , et al. (2011) Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat Rev Endocrinol 7, 639646.

57 PD Cani , R Bilbiloni , C Knauf , et al. (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 14701481.

58 PD Cani , S Possemiers , T Van de Wiele , et al. (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58, 10911103.

60 PD Cani , E Lecourt , EM Dewulf , et al. (2009) Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 90, 12361243.

61 GG Muccioli , D Naslain , F Bäckhed , et al. (2010) The endocannabinoid system links gut microbiota to adipogenesis. Mol Syst Biol 6, 392.

62 A Everard , V Lazarevic , M Derrien , et al. (2011) Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes 60, 27752786.

63 A Everard , C Belzer , L Geurts , et al. (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A 110, 90669071.

64 B Owens (2013) Gut microbes may fight obesity and diabetes. Nature doi:10.1038/nature.2013.12975.

65 F Bäckhed , H Ding , T Wang , et al. (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 101, 1571815723.

66 RE Ley , PJ Turnbaugh , S Klein , et al. (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 10221023.

68 PJ Turnbaugh , M Hamady , T Yatsunenko , et al. (2009) A core gut microbiome in obese and lean twins. Nature 457, 480484.

69 J Qin , Y Li , Z Cai , et al. (2012) A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 5560.

70 FH Karlsson , V Tremaroli , I Nookaew , et al. (2013) Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 498, 99103.

71 FH Karlsson , F Fåk , I Nookaew , et al. (2012) Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun 3, 1245.

72 R Caesar , CS Reigstad , HK Bäckhed , et al. (2012) Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice. Gut 61, 17011707.

73 DJ Drucker (2007) The role of gut hormones in glucose homeostasis. J Clin Invest 117, 2432.

74 T Inagaki , M Choi , A Moschetta , et al. (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2, 217225.

75 SI Sayin , A Wahlström , J Felin , et al. (2013) Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab 17, 225235.

76 PB Hylemon , H Zhou , WM Pandak , et al. (2009) Bile acids as regulatory molecules. J Lipid Res 50, 15091520.

77 K Van Wijck , K Lenaerts , LJC van Loon , et al. (2011) Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men. PLOS ONE 6, e22366.

78 L Guerts , AM Neyrinck , NM Delzenne , et al. (2014) Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Benef Microbes 5, 317.

79 J Grootjans , G Thuijls , F Verdam , et al. (2010) Non-invasive assessment of barrier integrity and function of the human gut. World J Gastrointest Surg 2, 6169.

82 S Bischoff (2011) ‘Gut health’: a new objective in medicine? BMC Med 9, 24.

84 L Zhao (2013) The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol 11, 639647.

85 SJ Lahtinen , E Davis & AC Ouwehand (2012) Lactobacillus species causing obesity in humans: where is the evidence? Benef Microbes 3, 171174.

87 FJ Verdam , JWM Greve , S Roosta , et al. (2011) Small intestinal alterations in severely obese hyperglycemic subjects. J Clin Endocrinol Metab 96, E379E383.

88 S Wagnerberger , A Spruss , G Kanuri , et al. (2012) Lactobacillus casei Shirota protects from fructose-induced liver steatosis: a mouse model. J Nutr Biochem 24, 531538.

89 U Dobrindt , B Hocchut , U Hentschel , et al. (2004) Genomic islands in pathogenic and environmental microorganisms. Nat Rev Microbiol 2, 414424.

90 H Schmidt & M Hensel (2004) Pathogenicity islands in bacterial pathogenesis. Clin Microbiol Rev 17, 1456.

91 GN Schroeder & H Hilbi (2008) Molecular pathogenesis of Shigella spp.: controlling host cell signalling, invasion, and death by type III secretion. Clin Microbiol Rev 21, 134156.

92 TH Mogensen (2009) Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev 22, 240273.

93 FY Liew , D Xu , EK Brint , et al. (2005) Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol 5, 446458.

95 P Broz , MB Ohlson & DM Monack (2012) Innate immune response to Salmonella typhimurium, a model enteric pathogen. Gut Microbes 3, 6270.

98 LR Muniz , C Knosp & G Yeretssian (2012) Intestinal antimicrobial peptides during homeostasis, infection, and disease. Front Immunol 3, 310.

99 L Pirofski & A Casadevall (2012) Q and A: What is a pathogen? A question that begs the point. BMC Biol 10, 6.

102 S Sato , S Kaneto , N Shibata , et al. (2012) Transcription factor Spi-B-dependent and -independent pathways for the development of Peyer's patch M cells. Mucosal Immunol 6, 838846.

104 W De Lau , P Kujala , K Schneeberger , et al. (2012) Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured ‘miniguts’. Mol Cell Biol 32, 36393647.

105 T Kanaya , K Hase , D Takahashi , et al. (2012) The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells. Nat Immunol 13, 729736.

109 GF Sonnenberg , LA Monticelli , T Alenghat , et al. (2012) Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336, 13211325.

112 L Bry , PG Falk , T Midtvedt , et al. (1996) A model of host–microbial interactions in an open mammalian ecosystem. Science 273, 13801383.

114 B Chassaing & A Darfeuille-Michaud (2011) The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140, 17201728.

115 DN Frank , AL St Amand , RA Feldman , et al. (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 104, 1378013785.

116 E Papa , M Docktor , C Smillie , et al. (2012) Non-invasive mapping of the gastrointestinal microbiota identifies children with inflammatory bowel disease. PLOS ONE 7, e39242.

117 SH Duncan , GL Hold , HJM Harmsen , et al. (2002) Growth requirements and fermentation products of Fusobacterium prausnitzii, and a proposal to reclassify it as Faecalibacterium prausnitzii gen. nov., comb. nov. Int J Syst Evol Microbiol 52, 21412146.

118 MEV Johansson , JK Gustafsson , KE Sjöberg , et al. (2010) Bacteria penetrate the inner mucus layer before inflammation in the dextran sulphate colitis model. PLOS ONE 5, e12238.

120 S Miquel , R Martin , O Rossi , et al. (2013) Faecalibacterium prausnitzii and human intestinal health. Curr Opin Microbiol 16, 17.

121 M Rescigno & A Di Sabatino (2009) Dendritic cells in intestinal homeostasis and disease. J Clin Invest 119, 24412450.

122 M Chieppa , M Rescigno , AYC Huang , et al. (2006) Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. J Exp Med 203, 28412852.

123 E Mileti , G Matteoli , ID Iliev , et al. (2009) Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy. PLOS ONE 4, e7056.

124 K Tsilingiri & M Rescigno (2013) Postbiotics: what else? Benef Microbes 4, 101107.

125 K Tsilingiri , T Barbosa , G Penna , et al. (2012) Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model. Gut 61, 10071015.

126 K Tsilingiri & M Rescigno (2012) Should probiotics be tested on ex vivo organ culture models? Gut Microbes 3, 442448.

128 SD McLaughlin , AW Walker , C Churcher , et al. (2010) The bacteriology of pouchitis: a molecular phylogenetic analysis using 16S rRNA gene cloning and sequencing. Ann Surg 252, 9098.

129 R Hansen , RK Russell , C Reiff , et al. (2012) Microbiota of de-novo pediatric IBD: increased Faecalibacterium prausnitzii and reduced bacterial diversity in Crohn's but not in ulcerative colitis. Am J Gastroenterol 107, 19131922.

130 XC Morgan , TL Tickle , H Sokol , et al. (2012) Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol 13, R79.

131 KT Thia , U Mahadevan , BG Feagan , et al. (2009) Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn's disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis 15, 1724.

132 P Rutgeerts , M Hiele , K Geboes , et al. (1995) Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology 108, 16171621.

133 W Kruis , J Frič , J Poktrotnieks , et al. (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53, 16171623.

134 A Sood , V Midha , GK Makharia , et al. (2009) The probiotic preparation, VSL#3 induces remission in patients with mild-to-moderately active ulcerative colitis. Clin Gastroenterol Hepatol 7, 12021209.

136 JL Benjamin , CR Hedin , A Koutsoumpas , et al. (2011) Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut 60, 923929.

137 AL Hart , K Lammers , P Brigidi , et al. (2004) Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 53, 16021609.

139 D Rachmilewitz , K Katakura , F Karmeili , et al. (2004) Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterol 126, 520528.

141 D Bernardo , B Sanchez , HO Al-Hassi , et al. (2012) Microbiota/host crosstalk biomarkers: regulatory response of human intestinal dendritic cells exposed to Lactobacillus extracellular encrypted peptide. PLOS ONE 7, e36262.

144 TD Lawley , S Clare , AW Walker , et al. (2012) Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog 8, e1002995.

147 J Landy , HO Al-Hassi , E Ronde , et al. (2013) P591 A prospective controlled pilot study of faecal microbiota transplantation for chronic refractory pouchitis. J Crohn's Colitis 7, S247S248.

148 G Solis , CG de Los Reyes-Gavilan , N Fernandez , et al. (2010) Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut. Anaerobe 16, 307310.

150 K Mårild , O Stephansson , S Montogmery , et al. (2012) Pregnancy outcome and risk of celiac disease in offspring: a nationwide case–control study. Gastroenterology 142, 3945.

151 B Jabri & LM Sollid (2009) Tissue-mediated control of immunopathology in coeliac disease. Nat Rev Immunol 9, 858870.

152 LC Stene , MC Honeyman , EJ Hoffenberg , et al. (2006) Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol 101, 23332340.

153 I Nadal , E Donant , C Ribes-Koninckx , et al. (2007) Imbalance in the composition of the duodenal microbiota of children with coeliac disease. J Med Microbiol 56, 16691674.

154 MC Collado , E Donat , C Ribes-Koninckx , et al. (2009) Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease. J Clin Pathol 62, 264269.

155 E Sánchez , JM Laparra & Y Sanz (2012) Discerning the role of Bacteroides fragilis in celiac disease pathogenesis. Appl Environ Microbiol 78, 65076515.

156 CL Sears (2009) Enterotoxigenic Bacteroides fragilis: a rogue among symbiotes. Clin Microbiol Rev 22, 349369.

157 P Wacklin , K Kaukinen , E Tuovinen , et al. (2013) The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestation of the disease. Inflamm Bowel Dis 19, 934941.

158 P Margaritte-Jeannin , MC Babron , M Bourgey , et al. (2004) HLA-DQ relative risks for coeliac disease in European populations: a study of the European Genetics Cluster on Coeliac Disease. Tissue Antigens 63, 562567.

159 E Sánchez , C Ribes-Koninckx , M Calabuig , et al. (2012) Intestinal Staphylococcus spp. and virulent features associated with coeliac disease. J Clin Pathol 65, 830834.

160 J Cinova , G De Palma , R Stepankova , et al. (2011) Role of intestinal bacteria in gliadin-induced changes in intestinal mucosa: study in germ-free rats. PLOS ONE 6, e16169.

161 TG De Meij , AE Budding , ME Grasman , et al. (2013) Composition and diversity of the duodenal mucosa-associated microbiome in children with untreated coeliac disease. Scand J Gastroenterol 48, 530536.

163 S Schippa , V Iebba , M Barbato , et al. (2010) A distinctive ‘microbial signature’ in celiac pediatric patients. BMC Microbiol 10, 175.

164 R Di Cagno , M De Angelis , I De Pasquale , et al. (2011) Duodenal and faecal microbiota of celiac children: molecular, phenotype and metabolome characterization. BMC Microbiol 11, 219.

165 G De Palma , A Capilla , E Nova , et al. (2012) Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study. PLOS ONE 7, e30791.

166 A Myléus , O Hernell , L Gothefors , et al. (2012) Early infections are associated with increased risk for celiac disease: an incident case-referent study. BMC Pediatr 12, 194.

167 K Mårild , W Ye , B Lebwohl , et al. (2013) Antibiotic exposure and the development of coeliac disease: a nationwide case–control study. BMC Gastroenterol 13, 109.

169 AL Nau , L Fayad , C Lazzarotto , et al. (2013) Prevalence and clinical features of celiac disease in patients with hepatitis B virus infection in Southern Brazil. Rev Soc Bras Med Trop 46, 397402.

171 MS Riddle , JA Murray , BD Cash , et al. (2013) Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness: a retrospective cohort study. Dig Dis Sci 58, 32423245.

172 AR Tjernberg & JF Ludvigsson (2014) Children with celiac disease are more likely to have attended hospital for prior respiratory syncytial virus infection. Dig Dis Sci (Epublication ahead of print version).

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