Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 29
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Burkina, Viktoriia Zlabek, Vladimir Halsne, Ruth Ropstad, Erik and Zamaratskaia, Galia 2016. In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish. Biochemical Pharmacology, Vol. 110-111, p. 109.


    Blount, Jack W. Redan, Benjamin W. Ferruzzi, Mario G. Reuhs, Bradley L. Cooper, Bruce R. Harwood, John S. Shulaev, Vladimir Pasinetti, Giulio and Dixon, Richard A. 2015. Synthesis and Quantitative Analysis of Plasma-Targeted Metabolites of Catechin and Epicatechin. Journal of Agricultural and Food Chemistry, Vol. 63, Issue. 8, p. 2233.


    Ding, Fei and Peng, Wei 2015. Biological activity of natural flavonoids as impacted by protein flexibility: an example of flavanones. Mol. BioSyst., Vol. 11, Issue. 4, p. 1119.


    Gardana, Claudio Canzi, Enrica and Simonetti, Paolo 2014. R(-)-O-desmethylangolensin is the main enantiomeric form of daidzein metabolite produced by human in vitro and in vivo. Journal of Chromatography B, Vol. 953-954, p. 30.


    Khan, Muhammad Kamran Zill-E-Huma, and Dangles, Olivier 2014. A comprehensive review on flavanones, the major citrus polyphenols. Journal of Food Composition and Analysis, Vol. 33, Issue. 1, p. 85.


    Tomás-Navarro, María Vallejo, Fernando and Tomás-Barberán, Francisco A. 2014. Polyphenols in Human Health and Disease.


    Mäkynen, Kittana Jitsaardkul, Sritanaporn Tachasamran, Pansiree Sakai, Nathaporn Puranachoti, Supitcha Nirojsinlapachai, Natthapat Chattapat, Vipaporn Caengprasath, Natarin Ngamukote, Sathaporn and Adisakwattana, Sirichai 2013. Cultivar variations in antioxidant and antihyperlipidemic properties of pomelo pulp (Citrus grandis [L.] Osbeck) in Thailand. Food Chemistry, Vol. 139, Issue. 1-4, p. 735.


    Seger, Christoph Sturm, Sonja and Stuppner, Hermann 2013. Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques – state of the art in natural product HPLC-MS, HPLC-NMR, and CE-MS hyphenations. Natural Product Reports, Vol. 30, Issue. 7, p. 970.


    Chanet, Audrey Milenkovic, Dragan Manach, Claudine Mazur, Andrzej and Morand, Christine 2012. Citrus Flavanones: What Is Their Role in Cardiovascular Protection?. Journal of Agricultural and Food Chemistry, Vol. 60, Issue. 36, p. 8809.


    Ding, Fei Diao, Jian-Xiong Sun, Ye and Sun, Ying 2012. Bioevaluation of Human Serum Albumin–Hesperidin Bioconjugate: Insight into Protein Vector Function and Conformation. Journal of Agricultural and Food Chemistry, Vol. 60, Issue. 29, p. 7218.


    Kobayashi, Shoko Nagai, Toshitada Konishi, Yutaka Tanabe, Soichi Morimoto, Kaori and Ogihara, Takuo 2012. Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes. Journal of Pharmacy and Pharmacology, Vol. 64, Issue. 1, p. 52.


    Lee, Young-Su Huh, Ji-Young Nam, So-Hyun Moon, Sung-Kwon and Lee, Soo-Bok 2012. Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: Enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori. Food Chemistry, Vol. 135, Issue. 4, p. 2253.


    LIU, Wen-Yuan ZHOU, Chen YAN, Cui-Min XIE, Shuang-Lu FENG, Feng WU, Chun-Yong and XIE, Ning 2012. Characterization and simultaneous quantification of multiple constituents in Aurantii Fructus Immaturus extracts by HPLC-DAD-ESI-MS/MS. Chinese Journal of Natural Medicines, Vol. 10, Issue. 6, p. 456.


    Srirangam, Ramesh Hippalgaonkar, Ketan Avula, Bharathi Khan, Ikhlas A. and Majumdar, Soumyajit 2012. Evaluation of the Intravenous and Topical Routes for Ocular Delivery of Hesperidin and Hesperetin. Journal of Ocular Pharmacology and Therapeutics, p. 120713092119007.


    Urpi-Sarda, Mireia Rothwell, Joseph Morand, Christine and Manach, Claudine 2012. Flavonoids and Related Compounds.


    Bojić, Mirza Debeljak, Željko Tomičić, Maja Medić-Šarić, Marica and Tomić, Siniša 2011. Evaluation of antiaggregatory activity of flavonoid aglycone series. Nutrition Journal, Vol. 10, Issue. 1,


    González, R. Ballester, I. López-Posadas, R. Suárez, M. D. Zarzuelo, A. Martínez-Augustin, O. and Medina, F. Sánchez De 2011. Effects of Flavonoids and other Polyphenols on Inflammation. Critical Reviews in Food Science and Nutrition, Vol. 51, Issue. 4, p. 331.


    Herath, Wimal and Khan, Ikhlas Ahmad 2011. Microbial metabolism. Part 13. Metabolites of hesperetin. Bioorganic & Medicinal Chemistry Letters, Vol. 21, Issue. 19, p. 5784.


    Sato, Nanako Seiwa, Chika Uruse, Michihiro Yamamoto, Masahiro Tanaka, Kayoko Kawakita, Takuya Komatsu, Yasuhiro Yasukawa, Akio Takao, Masakatsu Kudo, Chiaki Hasegawa, Atsuhiko Ishige, Atushi Watanabe, Kenji and Asou, Hiroaki 2011. Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination. Evidence-Based Complementary and Alternative Medicine, Vol. 2011, p. 1.


    Brand, Walter Padilla, Beatriz van Bladeren, Peter J. Williamson, Gary and Rietjens, Ivonne M. C. M. 2010. The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers. Molecular Nutrition & Food Research, Vol. 54, Issue. 6, p. 851.


    ×

Flavanone plasma pharmacokinetics from blood orange juice in human subjects

  • Claudio Gardana (a1), Serena Guarnieri (a1), Patrizia Riso (a1), Paolo Simonetti (a1) and Marisa Porrini (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114507699358
  • Published online: 01 July 2007
Abstract

Some blood orange juice (BOJ) flavanones may have antioxidant, anti-inflammatory, anti-allergic, hypolipidaemic, vasoprotective and anticarcinogenic properties. The aim of the present study was to evaluate the pharmacokinetics of hesperetin and naringenin in human subjects after BOJ intake. In a cross-over study, seven healthy female volunteers consumed 150 and 300 ml BOJ corresponding to about 51–102 mg hesperetin and to 6–12 mg naringenin, respectively. Plasma samples were collected before, each hour for 8 h and 24 h after BOJ administration and analysed for their content of hesperetin and naringenin by liquid chromatography–MS/MS. The plasma concentrations of these compounds were dose dependent and the peak concentration (Cmax) was reached in 5·1 (sd 0·6) h after BOJ intake. The Cmax of hesperetin was 43·4 (sd 32·4) and 79·8 (sd 60·1) ng/ml after 150 and 300 ml intake, respectively. For naringenin the plasma peak was 16·4 (sd 11·9) and 34·0 (sd 20·6) ng/ml. Moreover, the conjugated forms of these flavanones represent more than 95 % of the plasma concentration. The results indicate that both hesperetin and naringenin are bioavailable after BOJ intake; naringenin seemingly more so than hesperetin.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Flavanone plasma pharmacokinetics from blood orange juice in human subjects
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Flavanone plasma pharmacokinetics from blood orange juice in human subjects
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Flavanone plasma pharmacokinetics from blood orange juice in human subjects
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor Paolo Simonetti, fax +39 02 50316071, email Paolo.Simonetti@unimi.it
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

R Choudhury , G Chowrimootoo , K Srai , E Debnam & CA Rice-Evans (1999) Interactions of the flavonoid naringenin in the gastrointestinal tract and the influence of glycosylation. Biochem Biophys Res Commun 265, 410415.

AJ Day , FJ Canada & JC Diaz (2000) Dietary flavonoid and isoflavone glycosides are hydrolyzed by the lactase site of lactase phlorizin hydrolase. FEBS Lett 468, 166170.

AJ Day , MS DuPont & S Ridley (1998) Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver-glucosidase activity. FEBS Lett 436, 7175.

KM Edmunds , AC Holloway , DJ Crankshaw , SK Agarwal & WG Foster (2005) The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells. Repr Nutr Dev 45, 709720.

AA Franke , RV Cooney , SM Henning & LJ Custer (2005) Bioavailability and antioxidant effects of orange juice components in humans. J Agric Food Chem 53, 51705178.

HJ Heo , DO Kim , SC Shin , MJ Kim , BG Kim & DH Shin (2004) Effect of antioxidant flavanone, naringenin, from Citrus junos on neuroprotection. J Agric Food Chem 52, 15201525.

PC Hollman , MN Bijsman , Y van Gameren , EP Cnossen , JH de Vries & MB Katan (1999) The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Rad Res 31, 569573.

K Ishii , T Furuta & Y Kasuya (2000) Mass spectrometric identification and high-performance liquid chromatographic determination of a flavonoid glycoside naringin in human urine. J Agric Food Chem 48, 5659.

U Justesen , P Knuthsen & T Leth (1997) Determination of plant polyphenols in Danish foodstuffs by HPLC-UV and LC-MS detection. Cancer Lett 114, 165167.

FI Kanaze , MI Bounartzi , M Georgarakis & I Niopas (2006) Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects. Eur J Clin Nutr, Published online: 18 October 2006; DOI:10.1038/sj.ejcn.1602543.

J Kuhnau (1976) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 24, 117191.

EM Kurowska & JA Manthey (2004) Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hyper-cholesterolemia. J Agric Food Chem 52, 28792886.

C Manach , A Mazur & A Scalbert (2005 a) Polyphenols and prevention of cardiovascular diseases. Curr Opinion Lipidology 16, 7784.

C Manach , C Morand , A Gil-Izquierdo , C Bouteloup-Demange & C Remesy (2003) Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. Eur J Clin Nutr 57, 235242.

H Matsumoto , Y Ikoma , M Sugiura , M Yano & Y Hasegawa (2004) Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma. J Agric Food Chem 52, 66536659.

BK Matuszewski , ML Constanzer & CM Chavez-Eng (2003) Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 75, 30193030.

C Morrissey & RW Watson (2003) Phytoestrogens and prostate cancer. Curr Drug Targets 4, 231241.

S Passamonti , U Vrhovsek , A Vanzo & F Mattivi (2003) The stomach as a site for anthocyanins absorption from food. FEBS Lett 544, 210213.

PG Pietta , P Simonetti , C Roggi , A Brusamolino , N Pellegrini , L Maccarini & G Testolin (1996) Dietary flavonoids and oxidative stress. In Natural Antioxidants and Food Quality in Atherosclerosis and Cancer Prevention, pp. 249255 [JT Kumpulainen and JT Salonen , editors]. Cambridge: Royal Society of Chemistry.

P Riso , F Visioli , C Gardana , S Grande , A Brusamolino , F Galvano , G Galvano & M Porrini (2005) Effects of blood orange juice intake on antioxidant bioavailability and on different markers related to oxidative stress. J Agric Food Chem 53, 941947.

K Robards , X Li , M Antolovich & S Boyd (1997) Characterization of citrus by chromatographic analysis of flavonoids. J Sci Food Agric 75, 87101.

AE Rotelli , T Guardia , AO Juarez , NE de la Rocha & LE Pelzer (2003) Comparative study of flavonoids in experimental models of inflammation. Pharm Res 48, 601606.

L Sampson , E Rimm , PC Hollman , JH de Vries & MB Katan (2002) Flavonol and flavone intakes in US health professionals. J Am Diet Assoc 102, 14141420.

A Scalbert , C Manach , C Morand , C Remesy & L Jimenez (2005) Dietary polyphenols and the prevention of diseases. Critical Rev Food Sci Nutr 45, 287306.

SC Shen , CH Ko , SW Tseng , SH Tsai & YC Chen (2004) Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species production. Toxicol App Pharm 197, 8495.

JP Spencer , G Chowrimootoo , R Choudhury , ES Debnam , SK Srai & C Rice-Evans (1999) The small intestine can both absorb and glucuronidate luminal flavonoids. FEBS Lett 458, 224230.

FA Tomas-Barberan & MN Clifford (2000) Flavanones, chalcones and dihydrochalcones – nature, occurrence and dietary burden. J Sci Food Agric 80, 10731080.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: