1 Pagliassotti, MJ, Gayles, EC & Hill, JO (1997) Fat and energy balance. Ann N Y Acad Sci 827, 431–448.
2 Triscari, J, Nauss-Karol, C, Levin, BE & Sullivan, AC (1985) Changes in lipid metabolism in diet-induced obesity. Metabolism 34, 580–587.
3 Bhathena, SJ & Velasquez, MT (2002) Beneficial role of dietary phytoestrogens in obesity and diabetes. Am J Clin Nutr 76, 1191–1201.
4 Thompson, LU, Rickard, SE, Cheung, F, Kenaschuk, EO & Obermeyer, WR (1997) Variability in anticancer lignan levels in flaxseed. Nutr Cancer 27, 26–30.
5 Cunnane, SC, Ganguli, S, Menard, C, et al. (1993) High alpha-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humans. Br J Nutr 69, 443–453.
6 Romans, JR, Johnson, RC, Wulf, DM, Libal, GW & Costello, WJ (1995) Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: I. Dietary level of flaxseed. J Anim Sci 73, 1982–1986.
7 Axelson, M, Sjovall, J, Gustafsson, BE & Setchell, KD (1982) Origin of lignans in mammals and identification of a precursor from plants. Nature 298, 659–660.
8 Nesbitt, PD, Lam, Y & Thompson, LU (1999) Human metabolism of mammalian lignan precursors in raw and processed flaxseed. Am J Clin Nutr 69, 549–555.
9 Wang, L, Chen, J & Thompson, LU (2005) The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenografts is attributed to both its lignan and oil components. Int J Cancer 116, 793–798.
10 Prasad, K (1997) Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed. Mol Cell Biochem 168, 117–123.
11 Prasad, K (1999) Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation 99, 1355–1362.
12 Li, D, Yee, JA, Thompson, LU & Yan, L (1999) Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice. Cancer Lett 142, 91–96.
13 Prasad, K (2001) Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat. J Lab Clin Med 138, 32–39.
14 Prasad, K, Mantha, SV, Muir, AD & Westcott, ND (2000) Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism. Mol Cell Biochem 206, 141–149.
15 Hu, E, Liang, P & Spiegelman, BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271, 10697–10703.
16 Matsuzawa, Y, Funahashi, T & Nakamura, T (1999) Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 892, 146–154.
17 Yamauchi, T, Kamon, J, Waki, H, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7, 941–946.
18 Johnsson, P, Kamal-Eldin, A, Lundgren, LN & Aman, P (2000) HPLC method for analysis of secoisolariciresinol diglucoside in flaxseeds. J Agric Food Chem 48, 5216–5219.
19 Fritsche, J, Angoelal, R & Dachtler, M (2002) On-line liquid-chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry coupling for the separation and characterization of secoisolariciresinol diglucoside isomers in flaxseed. J Chromatogr 972, 195–203.
20 Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497–509.
21 Shoji, T, Kobori, M, Shinmoto, H, Yanagida, A, Kanda, T & Tsushida, T (2000) Inhibitory effects of apple polyphenols on differentiation of 3T3-L1 cells into adipocytes. Food Sci Technol Res 6, 119–121.
22 Dyck, DJ, Heigenhauser, GJ & Bruce, CR (2006) The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity. Acta Physiol (Oxf) 186, 5–16.
23 Armoni, M, Kritz, N, Harel, C, Bar-Yoseph, F, Chen, H, Quon, MJ & Karnieli, E (2003) Peroxisome proliferator-activated receptor-gamma represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect. J Biol Chem 278, 30614–30623.
24 Hollenberg, AN, Susulic, VS, Madura, JP, Zhang, B, Moller, DE, Tontonoz, P, Sarraf, P, Spiegelman, BM & Lowell, BB (1997) Functional antagonism between CCAAT/enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem 272, 5283–5290.
25 Iwaki, M, Matsuda, M, Maeda, N, Funahashi, T, Matsuzawa, Y, Makishima, M & Shimomura, I (2003) Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655–1663.
26 Kota, BP, Huang, TH & Roufogalis, BD (2005) An overview on biological mechanisms of PPARs. Pharmacol Res 51, 85–94.
27 Marx, N, Duez, H, Fruchart, JC & Staels, B (2004) Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells. Circ Res 94, 1168–1178.
28 Plasad, K (2000) Flaxseed: a source of hypercholetsterolemic and antiatherogenic agent. Drug News Perspect 13, 99–104.
29 Mandasescu, S, Mocanu, V, Dascalita, AM, Haliga, R, Nestian, I, Stitt, PA & Luca, V (2005) Flaxseed supplementation in hyperlipidemic patients. Rev Med Chir Soc Med Nat Iasi 109, 502–506.
30 Bhathena, SJ, Ali, AA, Haudenschild, C, et al. (2003) Dietary flaxseed meal is more protective than soy protein concentrate against hypertriglyceridemia and steatosis of liver in an animal model of obesity. J Am Coll Nutr 22, 157–164.
31 Kim, HJ, Takahashi, M & Ezaki, O (1999) Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic enzyme mRNAs. J Biol Chem 274, 25892–25898.
32 Fujita, H, Fujishima, H, Koshimura, J, Hosoba, M, Yoshioka, N, Shimotomai, T, Morii, T, Narita, T, Kakei, M & Ito, S (2005) Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice. Endocr J 52, 427–433.
33 Brown, NF, Hill, JK, Esser, V, Kirkland, JL, Corkey, BE, Foster, DW & McGarry, JD (1997) Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes. Biochem J 327, Pt 1, 225–231.
34 Rosen, ED, Walkey, CJ, Puigserver, P & Spiegelman, BM (2000) Transcriptional regulation of adipogenesis. Genes Dev 14, 1293–1307.
35 Clavel, T, Henderson, G, Engst, W, Dore, J & Blaut, M (2006) Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside. FEMS Microbiol Ecol 55, 471–478.
36 Lehmann, JM, Moore, LB, Smith-Oliver, TA, Wilkison, WO, Willson, TM & Kliewer, SA (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270, 12953–12956.