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Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome

  • Helga Refsum (a1)
  • DOI: http://dx.doi.org/10.1049/BJN2000302
  • Published online: 01 March 2007
Abstract

Increased folate intake reduces the risk of neural tube defects, other malformations and also possibly, pregnancy complications. Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. In India, the majority of the population adheres to a vegetarian diet known to be deficient in vitamin B12. In such a population, increased folate intake may offer minimal protection against birth defects, whereas vitamin B12 administration should be considered. In this review, is described the metabolism of and interrelations between folate, vitamin B12 and homocysteine. This is followed by a brief discussion of some of the proposed mechanisms for their biological effects in relation to birth defects and pregnancy outcome.

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Corresponding author
Corresponding author: Prof Helga Refsum, tel +47 55974680, fax +47 55974605, email helga.refsum@farm.uib.no
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Jr Adams MJ , MJ Khoury , KS Scanlon , RE Stevenson , GJ Knight , JE Haddow , GC Sylvester , JE Cheek , JP Henry & SP Stabler et al.(1995) Elevated midtrimester serum methylmalonic acid levels as a risk factor for neural tube defects. Teratology 51, 311317.

PJ Bagley & J Selhub (1998) A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proceedings of the National Academy of Sciences of the United States of America 95, 1321713220.

BC Blount , MM Mack , CM Wehr , JT MacGregor , RA Hiatt , G Wang , SN Wickramasinghe , RB Everson & BN Ames (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proceedings of the National Academy of Sciences of the United States of America 94, 32903295.

LD Botto , CA Moore , MJ Khoury & JD Erickson (1999) Neural-tube defects. New England Journal of Medicine 341, 15091519.

JC Chambers , A McGregor , J Jean-Marie , OA Obeid & JS Kooner (1999) Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation 99, 11561160.

B Christensen , L Arbour , P Tran , D Leclerc , N Sabbaghian , R Platt , BM Gilfix , DS Rosenblatt , RA Gravel , P Forbes & R Rozen (1999) Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. American Journal of Medical Genetics 84, 151157.

AE Czeizel & I Dudas (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. New England Journal of Medicine 327, 18321835.

AE Czeizel (1993) Prevention of congenital abnormalities by periconceptional multivitamin supplementation. British Medical Journal 306, 16451648.

ST Davidge (1998) Oxidative stress and altered endothelial cell function in preeclampsia. Seminars in Reproductive Endocrinology 16, 6573.

M Fenech , C Aitken & J Rinaldi (1998) Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 19, 11631171.

AB Guttormsen , PM Ueland , I Nesthus , O Nygård , J Schneede , SE Vollset & H Refsum (1996) Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (≥40 μmol/L). The Hordaland Homocysteine Study. Journal of Clinical Investigation 98, 21742183.

V Herbert & R Zalusky (1962) Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies. Journal of Clinical Investigation 41, 12631276.

M Leeda , N Riyazi , JI de Vries , C Jakobs , HP van Geijn & GA Dekker (1998) Effects of folic acid and vitamin B6 supplementation on women with hyperhomocysteinemia and a history of preeclampsia or fetal growth restriction. American Journal of Obstetrics and Gynaecology 179, 135139.

MD Lucock , J Wild , CH Lumb , M Oliver , R Kendall , I Daskalakis , CJ Schorah & MI Levene (1997) Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate:homocysteine methyltransferase. Biochemical and Molecular Medicine 61, 2840.

JG Ray & CA Laskin (1999) Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 20, 519529.

H Refsum , PM Ueland , O Nygård & SE Vollset (1998) Homocysteine and cardiovascular disease. Annual Review of Medicine 49, 3162.

GM Shaw , EM Velie & DM Schaffer (1997) Is dietary intake of methionine associated with a reduction in risk for neural tube defect-affected pregnancies? Teratology 56, 295299.

DC Shields , PN Kirke , JL Mills , D Ramsbottom , AM Molloy , H Burke , DG Weir , JM Scott & AS Whitehead (1999) The ‘thermolabile’ variant of methylenetetrahydrofolate reductase and neural tube defects: an evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. American Journal of Human Genetics 64, 10451055.

RPM Steegers-Theunissen , GHJ Boers , HJ Blom , FJM Trijbels & TKAB Eskes (1992) Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 339, 11221123.

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