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Folic acid under scrutiny

  • Hilary J Powers (a1)
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Abstract
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References
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1 Scientific Advisory Committee on Nutrition (2006) Folate and Disease Prevention. London: The Stationery Office.
2 Wright AJ, Dainty JR & Finglas PM (2007) Folic acid metabolism in humans revisited: potential implications for proposed mandatory folic acid fortification in the UK. Brit J Nutr in press.
3 Winkels EM, Brouwer IA, Siebelink E, Katan MB & Verhoef P (2007) Bioavailability of food folates is 80 % of that of folic acid. Am J ClinNutr 85, 465473.
4 Rogers LM, Pfeiffer CM, Bailey LB & Gregory JF (1997) A dual stable-isotope protocol for determination of plasma folate bioavailability in humans: evaluation of urinary excretion and plasma folate kinetics of intravenous and oral doses of (13C5) and (2H2) folic acid. J Nutr 127, 23212327.
5 Wright AJ, Finglas PM, Dainty JR, Wolfe CA, Hart DJ, Wright DM & Gregory JF (2005) Differential kinetic behaviour and distribution for pteroylglutamic acid and reduced folates: a revised hypothesis of primary site of PteGlu metabolism in humans. J Nutr 135, 619623.
6 Whitehead VM, Kamen BA & Beaulieu D (1987) Levels of dihydrofolate reductase in livers of birds, animals, primates and man. Cancer Drug Delivery 4, 185189.
7 Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH & Jacques PF (2002) Folic acid intake from fortification in United States exceeds predictions. J Nutr 132, 27922798.
8 Radimer K, Bindwald B, Hughes J, Ervin B, Swanson C & Picciano MF (2004) Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000. Am J Epidemiol 160, 339349.
9 Troen AM, Mitchell B, Sorensen B, Wener MH, Johnston A, et al. (2006) Unmetabolised folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 136, 189194.
10 Kelly P, McPartlin J, Goggins M, Weir DG & Scott JM (1997) Unmetabolised folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 65, 17901795.
11 Sweeney MR, McPartlin J, Weir J, Daly S & Scott J (2006) Post-prandial serum folic acid response to multiple doses of folic acid in fortified bread. Brit J Nutr 94, 18.
12 Sweeney MR, McPartlin J & Scott J (2007) Folic acid fortification and public health: Report on threshold doses above which unmetabolised folic acid appears in serum. BMC Public Health 7, 4147.
13 Reynolds EH (2002) Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiat 72, 567571.
14 Morris MS, Jacques PF, Rosenberg I & Selhub J (2007) Folate and vitamin B12 status in relation to anaemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 85, 193200.
15 Song J, Medline A, Mason JB, Gallinger S & Kim YI (2000) Effects of dietary folate on intestinal tumorigenesis in the ApcMin mouse. Cancer Res 60, 54345440.
16 Song J, Sohn KJ, Medline A, Ash C, Gallinger S & Kim YI (2000) Chemopreventive effects of dietary folate on intestinal polyps in Apc-/-Msh2-/- mice. Cancer Res 60, 31913199.
17 Van Guelpen B, Hultdin J, Johansson I, Hallmans G, Stenling R, Riboli E, Winkvist A & Palmqvist R (2006) Low folate levels may protect against colorectal cancer. Gut 55, 14611466.
18 De Vogel S, van Engeland M, Luchtenborg M, et al. (2006) Dietary folate and APC mutations in sporadic colorectal cancer. J Nutr 136, 30153021.
19 Cole BF, Baron JA, Sandler RS, et al. (2007) Folic acid for the prevention of colorectal adenomas: a randomised clinical trial. JAMA 297, 23512359.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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