Skip to main content Accesibility Help
×
×
Home

Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males

  • Mark J. Dekker (a1), Jenny E. Gusba (a1), Lindsay E. Robinson (a1) and Terry E. Graham (a1)
Abstract

Acute caffeine ingestion increases serum NEFA and plasma adrenaline and decreases insulin sensitivity. Although frequently suggested, it is not known if a tolerance to these alterations in glucose homeostasis is developed in habitual caffeine consumers. Our objective was to determine whether acute caffeine ingestion continued to alter insulin, glucose, NEFA and adrenaline during an oral glucose tolerance test (OGTT) following 14 d of caffeine consumption. Twelve caffeine-naive young males underwent four OGTTs over a 4-week period. Subjects ingested a gelatin-filled placebo (PLA) capsule on the first trial day and 5 mg caffeine/kg body weight on the remaining three trial days (day 0, day 7, day 14) before a 2 h OGTT. Following day 0 and day 7, subjects were given six dosages of 5 mg caffeine/kg to consume per d between trials. Serum insulin and blood glucose area under the curve (AUC) were significantly elevated (P < 0·05) v. PLA on day 0 (36 and 103 %, respectively) and were not different from PLA on day 7. On day 14, insulin AUC was 29 % greater than PLA (P < 0·05), and glucose was greater (P < 0·05) during the first hour, although the 50 % elevation in glucose AUC was not different from PLA. Before the OGTT, caffeine resulted in greater (P < 0·05) serum NEFA and plasma adrenaline concentrations in all three caffeine trials, but both NEFA and adrenaline concentrations were decreased (P < 0·05) on day 14 v. day 0. Although 14 d of caffeine consumption by previously caffeine-naive subjects reduced its impact on glucose homeostasis, carbohydrate metabolism remained disrupted.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Glucose homeostasis remains altered by acute caffeine ingestion following 2 weeks of daily caffeine consumption in previously non-caffeine-consuming males
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Mark J. Dekker, fax +1 519 763 5902, email mdekker@uoguelph.ca
References
Hide All
Greenberg, JA, Boozer, CN & Geliebter, A (2006) Coffee, diabetes, and weight control. Am J Clin Nutr 84, 682693.
Battram, DS, Graham, TE, Richter, EA & Dela, F (2005) The effect of caffeine on glucose kinetics in humans – influence of adrenaline. J Physiol 569, 347355.
Greer, F, Hudson, R, Ross, R & Graham, T (2001) Caffeine ingestion decreases glucose disposal during a hyperinsulinemic–euglycemic clamp in sedentary humans. Diabetes 50, 23492354.
Lee, S, Hudson, R, Kilpatrick, K, Graham, TE & Ross, R (2005) Caffeine ingestion is associated with reductions in glucose uptake independent of obesity and type 2 diabetes before and after exercise training. Diabetes Care 28, 566572.
Thong, FS, Derave, W, Kiens, B, Graham, TE, Urso, B, Wojtaszewski, JF, Hansen, BF & Richter, EA (2002) Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise. Diabetes 51, 583590.
Keijzers, GB, De Galan, BE, Tack, CJ & Smits, P (2002) Caffeine can decrease insulin sensitivity in humans. Diabetes Care 25, 364369.
Battram, DS, Arthur, R, Weekes, A & Graham, TE (2006) The glucose intolerance induced by caffeinated coffee ingestion is less pronounced than that due to alkaloid caffeine in men. J Nutr 136, 12761280.
Graham, TE, Sathasivam, P, Rowland, M, Marko, N, Greer, F & Battram, D (2001) Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can J Physiol Pharmacol 79, 559565.
Robinson, LE, Savani, S, Battram, DS, McLaren, DH, Sathasivam, P & Graham, TE (2004) Caffeine ingestion before an oral glucose tolerance test impairs blood glucose management in men with type 2 diabetes. J Nutr 134, 25282533.
Thong, FS & Graham, TE (2002) Caffeine-induced impairment of glucose tolerance is abolished by β-adrenergic receptor blockade in humans. J Appl Physiol 92, 23472352.
Rosengren, A, Dotevall, A, Wilhelmsen, L, Thelle, D & Johansson, S (2004) Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study. J Intern Med 255, 8995.
Tuomilehto, J, Hu, G, Bidel, S, Lindstrom, J & Jousilahti, P (2004) Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA 291, 12131219.
van Dam, RM & Hu, FB (2005) Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 294, 97104.
van Dam, RM, Willett, WC, Manson, JE & Hu, FB (2006) Coffee, caffeine, and risk of type 2 diabetes: a prospective cohort study in younger and middle-aged U.S. women. Diabetes Care 29, 398403.
Salazar-Martinez, E, Willett, WC, Ascherio, A, Manson, JE, Leitzmann, MF, Stampfer, MJ & Hu, FB (2004) Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med 140, 18.
van Dam, RM, Dekker, JM, Nijpels, G, Stehouwer, CD, Bouter, LM & Heine, RJ (2004) Coffee consumption and incidence of impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes: the Hoorn Study. Diabetologia 47, 21522159.
Bidel, S, Hu, G, Sundvall, J, Kaprio, J & Tuomilehto, J (2006) Effects of coffee consumption on glucose tolerance, serum glucose and insulin levels – a cross-sectional analysis. Horm Metab Res 38, 3843.
Arnlov, J, Vessby, B & Riserus, U (2004) Coffee consumption and insulin sensitivity. JAMA 291, 11991201.
Wu, T, Willett, WC, Hankinson, SE & Giovannucci, E (2005) Caffeinated coffee, decaffeinated coffee, and caffeine in relation to plasma C-peptide levels, a marker of insulin secretion, in U.S. women. Diabetes Care 28, 13901396.
Yamaji, T, Mizoue, T, Tabata, S, Ogawa, S, Yamaguchi, K, Shimizu, E, Mineshita, M & Kono, S (2004) Coffee consumption and glucose tolerance status in middle-aged Japanese men. Diabetologia 47, 21452151.
Watson, J, Deary, I & Kerr, D (2002) Central and peripheral effects of sustained caffeine use: tolerance is incomplete. Br J Clin Pharmacol 54, 400406.
Debrah, K, Haigh, R, Sherwin, R, Murphy, J & Kerr, D (1995) Effect of acute and chronic caffeine use on the cerebrovascular, cardiovascular and hormonal responses to orthostasis in healthy volunteers. Clin Sci 89, 475480.
Farag, NH, Vincent, AS, Sung, BH, Whitsett, TL, Wilson, MF & Lovallo, WR (2005) Caffeine tolerance is incomplete: persistent blood pressure responses in the ambulatory setting. Am J Hypertens 18, 714719.
Farag, NH, Vincent, AS, McKey, BS, Whitsett, TL & Lovallo, WR (2005) Hemodynamic mechanisms underlying the incomplete tolerance to caffeine's pressor effects. Am J Cardiol 95, 13891392.
Lovallo, WR, Wilson, MF, Vincent, AS, Sung, BH, McKey, BS & Whitsett, TL (2004) Blood pressure response to caffeine shows incomplete tolerance after short-term regular consumption. Hypertension 43, 760765.
Kruszynska, YT, Worrall, DS, Ofrecio, J, Frias, JP, Macaraeg, G & Olefsky, JM (2002) Fatty acid-induced insulin resistance: decreased muscle PI3K activation but unchanged Akt phosphorylation. J Clin Endocrinol Metab 87, 226234.
Itani, SI, Ruderman, NB, Schmieder, F & Boden, G (2002) Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51, 20052011.
Han, DH, Hansen, PA, Nolte, LA & Holloszy, JO (1998) Removal of adenosine decreases the responsiveness of muscle glucose transport to insulin and contractions. Diabetes 47, 16711675.
Crist, GH, Xu, B, Lanoue, KF & Lang, CH (1998) Tissue-specific effects of in vivo adenosine receptor blockade on glucose uptake in Zucker rats. FASEB J 12, 13011308.
Fisher, SM, McMurray, RG, Berry, M, Mar, MH & Forsythe, WA (1986) Influence of caffeine on exercise performance in habitual caffeine users. Int J Sports Med 7, 276280.
Dodd, SL, Brooks, E, Powers, SK & Tulley, R (1991) The effects of caffeine on graded exercise performance in caffeine naive versus habituated subjects. Eur J Appl Physiol Occup Physiol 62, 424429.
Robertson, D, Wade, D, Workman, R, Woosley, RL & Oates, JA (1981) Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67, 11111117.
McLean, C & Graham, TE (2002) Effects of exercise and thermal stress on caffeine pharmacokinetics in men and eumenorrheic women. J Appl Physiol 93, 14711478.
Van Soeren, MH, Sathasivam, P, Spriet, LL & Graham, TE (1993) Caffeine metabolism and epinephrine responses during exercise in users and nonusers. J Appl Physiol 75, 805812.
Fredholm, BB (1982) Adenosine actions and adenosine receptors after 1 week treatment with caffeine. Acta Physiol Scand 115, 283286.
Holtzman, SG, Mante, S & Minneman, KP (1991) Role of adenosine receptors in caffeine tolerance. J Pharmacol Exp Ther 256, 6268.
Zhang, Y & Wells, JN (1990) The effects of chronic caffeine administration on peripheral adenosine receptors. J Pharmacol Exp Ther 254, 757763.
Biaggioni, I, Paul, S, Puckett, A & Arzubiaga, C (1991) Caffeine and theophylline as adenosine receptor antagonists in humans. J Pharmacol Exp Ther 258, 588593.
Lynge, J & Hellsten, Y (2000) Distribution of adenosine A1, A2A and A2B receptors in human skeletal muscle. Acta Physiol Scand 169, 283290.
Aldridge, A, Aranda, JV & Neims, AH (1979) Caffeine metabolism in the newborn. Clin Pharmacol Ther 25, 447453.
Matsuda, M & DeFronzo, RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22, 14621470.
Denaro, CP, Brown, CR, Jacob, P III & Benowitz, NL (1991) Effects of caffeine with repeated dosing. Eur J Clin Pharmacol 40, 273278.
Van Soeren, M, Mohr, T, Kjaer, M & Graham, TE (1996) Acute effects of caffeine ingestion at rest in humans with impaired epinephrine responses. J Appl Physiol 80, 9991005.
Battram, DS, Bugaresti, J, Gusba, J & Graham, TE (2007) Acute caffeine ingestion does not impair glucose tolerance in persons with tetraplegia. J Appl Physiol 102, 374381.
Espinal, J, Challiss, RA & Newsholme, EA (1983) Effect of adenosine deaminase and an adenosine analogue on insulin sensitivity in soleus muscle of the rat. FEBS Lett 158, 103106.
Vergauwen, L, Hespel, P & Richter, EA (1994) Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J Clin Invest 93, 974981.
Lane, JD, Barkauskas, CE, Surwit, RS & Feinglos, MN (2004) Caffeine impairs glucose metabolism in type 2 diabetes. Diabetes Care 27, 20472048.
van Dam, RM, Pasman, WJ & Verhoef, P (2004) Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers. Diabetes Care 27, 29902992.
Shearer, J, Farah, A, de Paulis, T, Bracy, DP, Pencek, RR, Graham, TE & Wasserman, DH (2003) Quinides of roasted coffee enhance insulin action in conscious rats. J Nutr 133, 35293532.
Lopez-Garcia, E, van Dam, RM, Rajpathak, S, Willett, WC, Manson, JE & Hu, FB (2006) Changes in caffeine intake and long-term weight change in men and women. Am J Clin Nutr 83, 674680.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed