Skip to main content
×
Home
    • Aa
    • Aa

Green tea (Camellia sinensis) catechins and vascular function

  • Rosalind J. Moore (a1), Kim G. Jackson (a1) and Anne M. Minihane (a1)
Abstract

The health benefits of green tea (Camellia sinensis) catechins are becoming increasingly recognised. Amongst the proposed benefits are the maintenance of endothelial function and vascular homeostasis and an associated reduction in atherogenesis and CVD risk. The mounting evidence for the influential effect of green tea catechins on vascular function from epidemiological, human intervention and animal studies is subject to review together with exploration of the potential mechanistic pathways involved. Epigallocatechin-3-gallate, one of the most abundant and widely studied catechin found in green tea, will be prominent in the present review. Since there is a substantial inconsistency in the published data with regards to the impact of green tea catechins on vascular function, evaluation and interpretation of the inter- and intra-study variability is included. In conclusion, a positive effect of green tea catechins on vascular function is becoming apparent. Further studies in animal and cell models using physiological concentrations of catechins and their metabolites are warranted in order to gain some insight into the physiology and molecular basis of the observed beneficial effects.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Green tea (Camellia sinensis) catechins and vascular function
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Green tea (Camellia sinensis) catechins and vascular function
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Green tea (Camellia sinensis) catechins and vascular function
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Anne M. Minihane, fax +44 118 931 0080, email a.m.minihane@reading.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1 JV Higdon & B Frei (2003) Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit Rev Food Sci Nutr 43, 89143.

3 T Miyazawa (2000) Absorption, metabolism and antioxidative effects of tea catechin in humans. Biofactors 13, 5559.

7 C Li , MJ Lee , SQ Sheng , (2000) Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion. Chem Res Toxicol 13, 177184.

8 H Lu , XF Meng & CS Yang (2003) Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by ( − )-epigallocatechin gallate. Drug Metab Dispos 31, 572579.

9 G Kuhnle , JP Spencer , H Schroeter , (2000) Epicatechin and catechin are O-methylated and glucuronidated in the small intestine. Biochem Biophys Res Commun 277, 507512.

10 WY Feng (2006) Metabolism of green tea catechins: an overview. Curr Drug Metab 7, 755809.

11 H Lu , XF Meng , C Li , (2003) Glucuronides of tea catechins: enzymology of biosynthesis and biological activities. Drug Metab Dispos 31, 452461.

12 JD Lambert , JE Rice , J Hong , (2005) Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives. Bioorg Med Chem Lett 15, 873876.

13 F Nanjo , M Mori , K Goto , (1999) Radical scavenging activity of tea catechins and their related compounds. Biosci Biotechnol Biochem 63, 16211623.

15 MI Cybulsky & MA Gimbrone Jr (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788791.

16 LE Rohde , RT Lee , J Rivero , (1998) Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis. Arterioscler Thromb Vasc Biol 18, 17651770.

17 ZM Dong , SM Chapman , AA Brown , (1998) The combined role of P- and E-selectins in atherosclerosis. J Clin Invest 102, 145152.

18 RG Collins , R Velji , NV Guevara , (2000) P-selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191, 189194.

19 V Schachinger , MB Britten & AM Zeiher (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101, 18991906.

20 TJ Anderson , A Uehata , MD Gerhard , (1995) Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 26, 12351241.

21 T Heitzer , T Schlinzig , K Krohn , (2001) Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104, 26732678.

22 JPJ Halcox , WH Schenke , G Zalos , (2002) Prognostic value of coronary vascular endothelial dysfunction. Circulation 106, 653658.

23 U Landmesser , B Hornig & H Drexler (2004) Endothelial function – a critical determinant in atherosclerosis? Circulation 109, 2733.

24 NN Chan , HM Colhoun & P Vallance (2001) Cardiovascular risk factors as determinants of endothelium-dependent and endothelium-independent vascular reactivity in the general population. J Am Coll Cardiol 38, 18141820.

25 K Imai & K Nakachi (1995) Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ 310, 693696.

26 J Sano , S Inami , K Seimiya , (2004) Effects of green tea intake on the development of coronary artery disease. Circ J 68, 665670.

27 S Sasazuki , H Kodama , K Yoshimasu , (2000) Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Ann Epidemiol 10, 401408.

28 R Hirano , Y Momiyama , R Takahashi , (2002) Comparison of green tea intake in Japanese patients with and without angiographic coronary artery disease. Am J Cardiol 90, 11501153.

29 S Kuriyama , T Shimazu , K Ohmori , (2006) Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan: the Ohsaki study. JAMA 296, 12551265.

30 K Nakachi , S Matsuyama , S Miyake , (2000) Preventive effects of drinking green tea on cancer and cardiovascular disease: epidemiological evidence for multiple targeting prevention. Biofactors 13, 4954.

31 ME Widlansky , NM Hamburg , E Anter , (2007) Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr 26, 95102.

32 OH Ryu , J Lee , KW Lee , (2006) Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients. Diabetes Res Clin Pract 71, 356358.

33 W Kim , MH Jeong , SH Cho , (2006) Effect of green tea consumption on endothelial function and circulating endothelial progenitor cells in chronic smokers. Circ J 70, 10521057.

34 FJ Tinahones Madueño , MA Rubio , L Garrido Sánchez , (2007) Green tea reduces LDL oxidability and improves vascular function. Atheroscler Suppl 8, 166.

35 W Lee , WK Min , S Chun , (2005) Long-term effects of green tea ingestion on atherosclerotic biological markers in smokers. Clin Biochem 38, 8487.

37 N Nagaya , H Yamamoto , M Uematsu , (2004) Green tea reverses endothelial dysfunction in healthy smokers. Heart 90, 14851486.

38 N Alexopoulos , C Vlachopoulos , K Aznaouridis , (2008) The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil 15, 300305.

39 M Antonello , D Montemurro , M Bolognesi , (2007) Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts. Am J Hypertens 20, 13211328.

40 MA Potenza , FL Marasciulo , M Tarquinio , (2007) EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab 292, E1378E1387.

41 KY Chyu , SM Babbidge , X Zhao , (2004) Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice. Circulation 109, 24482453.

43 L Song , MWL Koo , CP Lau , (2008) Effects of green tea on lipids, blood pressure and vasorelaxation in rats with hypercholesterolaemia-induced hypertension. Int J Cardiol 125, Suppl. 1, S64.

44 F Sanae , Y Miyaichi , H Kizu , (2002) Effects of catechins on vascular tone in rat thoracic aorta with endothelium. Life Sci 71, 25532562.

45 M Ajay , AU Gilani & MR Mustafa (2003) Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci 74, 603612.

46 DF Fitzpatrick , SL Hirschfield , T Ricci , (1995) Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol 26, 9095.

47 DY Lim , ES Lee , HG Park , (2003) Comparison of green tea extract and epigallocatechin gallate on blood pressure and contractile responses of vascular smooth muscle of rats. Arch Pharm Res 26, 214223.

48 M Lorenz , S Wessler , E Follmann , (2004) A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J Biol Chem 279, 61906195.

49 JZ Shen , XF Zheng , EQ Wei , (2003) Green tea catechins evoke a phasic contraction in rat aorta via H2O2-mediated multiple-signalling pathways. Clin Exp Pharmacol Physiol 30, 8895.

50 E Alvarez , M Campos-Toimil , H Justiniano-Basaran , (2006) Study of the mechanisms involved in the vasorelaxation induced by ( − )-epigallocatechin-3-gallate in rat aorta. Br J Pharmacol 147, 269280.

51 U Pfeffer , N Ferrari , R Dell'Eva , (2005) Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res 591, 198211.

53 T Schewe , Y Steffen & H Sies (2008) How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys 476, 102106.

54 Y Steffen , C Gruber , T Schewe , (2008) Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch Biochem Biophys 469, 209219.

55 M Mizugaki , F Ishizawa , T Yamazaki , (2000) Epigallocatechin gallate increase the prostacyclin production of bovine aortic endothelial cells. Prostaglandins Other Lipid Mediat 62, 157164.

56 M Yamakuchi , C Bao , M Ferlito , (2008) Epigallocatechin gallate inhibits endothelial exocytosis. Biol Chem 389, 935941.

57 A Ludwig , M Lorenz , N Grimbo , (2004) The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem Biophys Res Commun 316, 659665.

58 RH Boger (2003) Asymmetric dimethylarginine (ADMA) modulates endothelial function – therapeutic implications. Vasc Med 8, 149151.

60 WJ Tang , CP Hu , MF Chen , (2006) Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level. Can J Physiol Pharmacol 84, 163171.

61 L Actis-Goretta , JI Ottaviani & CG Fraga (2006) Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 54, 229234.

62 JB Paquay , GR Haenen , G Stender , (2000) Protection against nitric oxide toxicity by tea. J Agric Food Chem 48, 57685772.

66 SJ Duffy , JF Keaney Jr, M Holbrook , (2001) Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 104, 151156.

68 SB Lotito & B Frei (2006) Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 41, 17271746.

69 EL Da Silva , M Piskula & J Terao (1998) Enhancement of antioxidative ability of rat plasma by oral administration of ( − )-epicatechin. Free Radic Biol Med 24, 12091216.

70 IF Benzie , YT Szeto , JJ Strain , (1999) Consumption of green tea causes rapid increase in plasma antioxidant power in humans. Nutr Cancer 34, 8387.

71 R Leenen , AJ Roodenburg , LB Tijburg , (2000) A single dose of tea with or without milk increases plasma antioxidant activity in humans. Eur J Clin Nutr 54, 8792.

72 D Erba , P Riso , A Bordoni , (2005) Effectiveness of moderate green tea consumption on antioxidative status and plasma lipid profile in humans. J Nutr Biochem 16, 144149.

74 JA Kim , G Formoso , Y Li , (2007) Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem 282, 1373613745.

75 CC Wu , MC Hsu , CW Hsieh , (2006) Upregulation of heme oxygenase-1 by epigallocatechin-3-gallate via the phosphatidylinositol 3-kinase/Akt and ERK pathways. Life Sci 78, 28892897.

78 ME Waltner-Law , XL Wang , BK Law , (2002) Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem 277, 3493334940.

79 RA Anderson & MM Polansky (2002) Tea enhances insulin activity. J Agric Food Chem 50, 71827186.

80 LY Wu , CC Juan , LT Ho , (2004) Effect of green tea supplementation on insulin sensitivity in Sprague–Dawley rats. J Agric Food Chem 52, 643648.

82 E Ramesh , R Elanchezhian , M Sakthivel , (2008) Epigallocatechin gallate improves serum lipid profile and erythrocyte and cardiac tissue antioxidant parameters in Wistar rats fed an atherogenic diet. Fundam Clin Pharmacol 22, 275284.

83 TT Yang & MW Koo (1997) Hypocholesterolemic effects of Chinese tea. Pharmacol Res 35, 505512.

84 S Kono , K Shinchi , K Wakabayashi , (1996) Relation of green tea consumption to serum lipids and lipoproteins in Japanese men. J Epidemiol 6, 128133.

85 S Tokunaga , IR White , C Frost , (2002) Green tea consumption and serum lipids and lipoproteins in a population of healthy workers in Japan. Ann Epidemiol 12, 157165.

86 SI Koo & SK Noh (2007) Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. J Nutr Biochem 18, 179183.

87 TTC Yang & MWL Koo (2000) Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci 66, 411423.

89 A Bu-Abbas , MN Clifford , C Ioannides , (1995) Stimulation of rat hepatic UDP-glucuronosyl transferase activity following treatment with green tea. Food Chem Toxicol 33, 2730.

90 S Khokhar & SG Magnusdottir (2002) Total phenol, catechin, and caffeine contents of teas commonly consumed in the United Kingdom. J Agric Food Chem 50, 565570.

91 RJ Green , AS Murphy , B Schulz , (2007) Common tea formulations modulate in vitro digestive recovery of green tea catechins. Mol Nutr Food Res 51, 11521162.

92 HHS Chow , IA Hakim , DR Vining , (2005) Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of Polyphenon E in healthy individuals. Clin Cancer Res 11, 46274633.

93 DD Schramm , M Karim , HR Schrader , (2003) Food effects on the absorption and pharmacokinetics of cocoa flavanols. Life Sci 73, 857869.

96 S Nagar , JJ Zalatoris & RL Blanchard (2004) Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics 14, 487499.

97 K Sai , Y Saito , M Itoda , (2008) Genetic variations and haplotypes of ABCC2 encoding MRP2 in a Japanese population. Drug Metab Pharmacokinet 23, 139147.

98 S Gawande , A Kale & S Kotwal (2008) Effect of nutrient mixture and black grapes on the pharmacokinetics of orally administered ( − )epigallocatechin-3-gallate from green tea extract: a human study. Phytother Res 22, 802808.

100 D Del Rio , AJ Stewart , W Mullen , (2004) HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea. J Agric Food Chem 52, 28072815.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 36
Total number of PDF views: 302 *
Loading metrics...

Abstract views

Total abstract views: 390 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 25th May 2017. This data will be updated every 24 hours.