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Growth, development and differentiation: a functional food science approach

  • B. Koletzko (a1), P. J. Aggett (a2), J. G. Bindels (a3), P. Bung (a4), P. Ferré (a5), A. Gil (a6), M. J. Lentze (a7), M. Roberfroid (a8) and S. Strobel (a9)...

Few other aspects of food supply and metabolism are of greater biological importance than the feeding of mothers during pregnancy and lactation, and of their infants and young children. Nutritional factors during early development not only have short-term effects on growth, body composition and body functions but also exert long-term effects on health, disease and mortality risks in adulthood, as well as development of neural functions and behaviour, a phenomenon called ‘metabolic programming’. The interaction of nutrients and gene expression may form the basis of many of these programming effects and needs to be investigated in more detail. The relation between availability of food ingredients and cell and tissue differentiation and its possible uses for promoting health and development requires further exploration. The course of pregnancy, childbirth and lactation as well as human milk composition and the short- and long-term outcome of the child are influenced by the intake of foods and particularly micronutrients, e.g. polyunsaturated fatty acids, Fe, Zn and I. Folic acid supplementation from before conception through the first weeks of pregnancy can markedly reduce the occurrence of severe embryonic malformations; other potential benefits of modulating nutrient supply on maternal and child health should be further evaluated. The evaluation of dietary effects on child growth requires epidemiological and field studies as well as evaluation of specific cell and tissue growth. Novel substrates, growth factors and conditionally essential nutrients (e.g. growth factors, amino acids, polyunsaturated fatty acids) may be potentially useful as ingredients in functional foods and need to be assessed carefully. Intestinal growth, maturation, and adaptation as well as long-term function may be influenced by food ingredients such as oligosaccharides, gangliosides, high-molecular-mass glycoproteins, bile salt-activated lipase, pre- and probiotics. There are indications for some beneficial effects of functional foods on the developing immune response, for example induced by antioxidant vitamins, trace elements, fatty acids, arginine, nucleotides, and altered antigen contents in infant foods. Peak bone mass at the end of adolescence can be increased by dietary means, which is expected to be of long-term importance for the prevention of osteoporosis at older ages. Future studies should be directed to the combined effects of Ca and other constituents of growing bone, such as P, Mg and Zn, as well as vitamins D and K, and the trace elements F and B. Pregnancy and the first postnatal months are critical time periods for the growth and development of the human nervous system, processes for which adequate substrate supplies are essential. Early diet seems to have long-term effects on sensory and cognitive abilities as well as behaviour. The potential beneficial effects of a balanced supply of nutrients such as I, Fe, Zn and polyunsaturated fatty acids should be further evaluated. Possible long-term effects of early exposure to tastes and flavours on later food choice preferences may have a major impact on public health and need to be further elucidated. The use of biotechnology and recombinant techniques may offer the opportunity to include various bioactive substances in special dietary products, such as human milk proteins, peptides, growth factors, which may have beneficial physiological effects, particularly in infancy and early childhood.

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*Professor B. Koletzko, fax +49 89 5 160 3336, email:
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C Agostoni , S Trojan , R Bellu , E Riva & M Giovannini (1995) Neurodevelopmental quotient of healthy term infants at 4 months and feeding practice: the role of long-chain polyunsaturated fatty acids. Pediatric Research 38, 262266.

B Anderson , O Porras , LA Hanson , T Lagergård & C Svanborg-Edén (1986) Inhibition of attachment of Streptococcus pneumoniae and Hemophilus influenzae by human milk and receptor oligo-saccharides. Journal of Infectious Diseases 153, 232237.

J Antras-Feny , P Robin , D Robin & C Forest (1995) Fatty acids and fibrates are potent inducers of transcription of the phosphoenolpyruvate carboxykinase gene in adipocytes. European Journal of Biochemistry 234, 390396.

HS Baldwin (1996) Early embryonic vascular development. Cardiovascular Research 31, E34–E45.

LR Ballou , SJ Laulederkind , EF Rosloniec & R Raghow (1996) Ceramide signalling and the immune response. Biochimica et Biophysica Acta 1301, 273287.

AA Barnett , AP Weis , MV Sotillo , M Skurovich & J Cravioto (1978) Abnormal auditory evoked potentials in early human malnutrition. Science 201, 450452.

PR Bartel , E Robinson , JM Conradie & JG Prinsloo (1986) Brainstem auditory evoked potentials in severely malnourished children with kwashiorkor. Neuropediatrics 17, 178182.

JL Beard , JR Connor & BC Jones (1993) Iron in the brain. Nutrition Reviews 51, 157170.

J Bhatia , DK Rassin , MC Cerreto & DE Bee (1991) Effect of protein–energy ratio on growth and behaviour of premature infants: preliminary findings. Journal of Pediatrics 119, 103110.

NJ Bishop , SL Dahlenburg , MS Fewtrell , R Morley & A Lucas (1995) Early diet of preterm infants and bone mineralization at age five years. Acta Pediatricia 85, 230236.

G Boivin , J Dupuis & PJ Meunier (1993) Fluoride and osteoporosis. World Review of Nutrition and Dietetics 73, 80103.

G Brem , P Hartl , U Besenfelder , E Wolf , N Zinovieva & R Pfaller (1994) Expression of synthetic cDNA sequences encoding human insulin like growth factor-q (IGF1) in the mammary gland of transgenic rabbits. Gene 149, 351355.

RK Buddington & JM Diamond (1989) Ontogenetic development of intestinal nutrient transporters. Annual Review of Physiology 51, 601619.

P Bung , C Stein , R Prinz , K Pietrzik , H Schlebusch , O Bauer & D Krebs (1993) Folsäureversorgung in der Schwangerschaft–Ergebnisse einer prospektiven Longitudinalstudie (Folic acid provision in pregnancy: results of a prospective longitudinal study). Geburtsh u Frauenheilk 53, 9299.

JP Buts & M Nyakabasa (1985) Role of dietary protein to adaptation at weaning in the development of the rat gastro-intestinal tract. Pediatric Research 19, 857862.

CE Butterworth & A Bendich (1996) Folic acid and the prevention of birth defects. Annual Review of Nutrition 16, 7397.

DB Buxton , SM Robertson & MS Olson (1986) Stimulation of glycogenolysis by adenine nucleotides in the perfused rat liver. Biochemical Journal 237, 773780.

SE Carlson , RJ Cooke , PG Rhodes , SH Werkman , JM Peeples & EA Tolley (1991) Long term feeding of formulas high in linolenic acid and marine oil to very low birth weight infantsd: phospholipids fatty acids. Pediatric Researvh 30, 404412.

SE Carlson , RJ Cooke , SH Werkman & JM Peeples (1992) First year growth of preterm infants fed standard compared to marine oil n−3 supplemented formula. Lipids 27, 901907.

SE Carlson & SH Werkman (1996) A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. Lipids 31, 8590.

SE Carlson , SH Werkman , JM Peeples , RJ Cooke & EA Tolley (1993) Arachidonic acid status correlates with first year growth in preterm infants. Proceedings of the National Academy of Sciences USA 90, 10731077.

GM Chan , K Hoffman & M McMurry (1995) Effects of dairy products on bone and body composition in pubertal girls. Journal of Pediatrics 126, 551556.

RK Chandra , S Puri & A Hamed (1989 a) Influence of maternal diet during lactation and use of formula feeds on development of atopic eczema in high risk infants. British Medical Journal 299, 228230 (published erratum appears in British Medical Journal299, 896).

RK Chandra , S Puri , C Suraiya & PS Cheema (1986) Influence of maternal food antigen avoidance during pregnancy and lactation on incidence of atopic eczema in infants. Clinical Allergy 16, 563569.

R Cheung , J Karjalainen , J Vandermeulen , DP Singal & HM Dosch (1994) T cells from children with IDDM are sensitized to bovine serum albumin. Scandinavian Journal of Immunology 40, 623628.

G Chirico , M Marconi , A Colombo , A Chiara , G Rondini & AG Ugazio (1983) Deficiency of neutrophil phagocytosis in premature infants: effects of vitamin E supplementation. Acta Paediatrica Scandinavia 72, 521524.

SD Clarke (1994) Dietary polyunsaturated fatty acid regulation of gene transcription. Annual Review of Nutrition 14, 8398.

DE Cole , CM Gundberg , LJ Stirk , SA Atkinson , DA Hanley , LM Ayer & LS Baldwin (1987) Changing osteocalcin concentration during pregnancy and lactation: implications for maternal mineral metabolism. Journal of Clinical Endocrinology and Metabolism 65, 290.

D Cosman (1994) A family of ligands for the TNF receptor superfamily. Stem Cells 12, 440455.

A Coutsoudis , RA Bobat , HM Coovadia , L Kuhn , WY Tsai & ZA Stein (1995) The effects of vitamin A supplementation on the morbidity of children born to HIV-infected women. American Journal of Public Health 85, 10761081.

A Coutsoudis , P Kiepiela , HM Coovadia & M Broughton (1992) Vitamin A supplementation enhances specific IgG antibody levels and total lymphocyte numbers while improving morbidity in measles. Pediatric Infectious Disease Journal 11, 203209.

A Cravioto , A Tello , H Villafán , J Ruiz , S Del Vedovo & JR Neeser (1991) Inhibition of localized adhesion of enteropathogenic Escherichia coli to Hep-2 cells by immunoglobulin and oligosaccharide fractions of human colostrum and breast milk. Journal of Infectious Diseases 163, 12471255.

L Cynober (1994) Can arginine and ornithine support gut functions? Gut 35, Suppl. 1, S42–S45.

A Dahlqvist & T Lindberg (1965) Fetal development of the small-intestinal disaccharidase and alkaline phosphatase in the human. Biology of the Neonate 9, 2432.

JM Daly , J Reynolds , RK Sigal , J Shou & MD Liberman (1990) Effect of dietary protein and amino acids on immune function. Critical Care Medicine 18, S86–S93.

EM Danielsen , H Skovberg , O Norén & H Sjöström (1984) Biosynthesis of intestinal microvillar proteins. Intracellular processing of lactase–phlorizin hydrolase. Biochemical and Biophysical Research Communications 122, 8290.

EM Danielsen , H Skovbjerg , O Noré & H Sjöström (1981) Biosynthesis of intestinal proteins. Nature of precursor forms of microvillar enzymes from Ca2+ -precipitated enterocyte membranes. FEBS Letters 132, 197200.

T Decsi & B Koletzko (1995) Growth, fatty acid composition of plasma lipid classes, and plasma retinol and α-tocopherol concentrations in full-term infants fed formula enriched with ω-6 and ω-3 long-chain polyunsaturated fatty acids. Acta Paediatrica 84, 725732.

C De-Lucchi , ML Pita , MJ Faus , JA Molina , R Uauy & A Gil (1987) Effects of dietary nucleotides on the fatty acid composition of erythrocyte membrane lipids in term infants. Journal of Pediatric Gastroenterology and Nutrition 6, 568574.

S Demirini & RC Tsang (1995) Calcium and phosphorus nutrition in infants. Journal of Pediatric Gastroenterology and Nutrition 21, 367373.

H Demmelmair , U von Schenck , E Behrendt , T Sauerwald & B. Koletzko (1995) Estimation of arachidonic acid synthesis in fullterm neonates using natural variation of 13C-abundance. Journal of Pediatric Gastroenterology and Nutrition 21, 3136.

M Dragunow & K Preston (1995) The role of inducible transcription factors in apoptotic nerve cell death. Brain Research Reviews 21, 128.

H Egge , A Dell & H von Nicolai (1983) Fucose containing oligosaccharides from human milk. Archives of Biochemistry and Biophysics 224, 235253.

S Endres (1996) n−3 Polyunsaturated fatty acids and human cytokine synthesis. Lipids 31, S239–S242.

RB Evans-Storms & JA Cidlowski (1995) Regulation of apoptosis by steroid hormones. Journal of Steroid Biochemistry and Molecular Biology 53, 18.

K Fälth-Magnusson & NI Kjellman (1992) Allergy prevention by maternal elimination diet during late pregnancy – a 5-year follow-up of a randomized study. Journal of Allergy and Clinical Immunology 89, 709713.

K Fälth-Magnusson , H Oman & NI Kjellman (1987) Maternal abstention from cow milk and egg in allergy risk pregnancies. Effect on antibody production in the mother and the newborn. Allergy 42, 6473.

J Farquharson , F Cockburn , WA Patrick , EC Jamieson & RW Logan (1992) Infant cerebral cortex phospholipid fatty–acid composition and diet. Lancet 340, 810813.

G Fernandes , J Venkatraman , A Khare , GJ Horbach & W Friedrichs (1990) Modulation of gene expression in autoimmune disease and aging by food restriction and dietary lipids. Proceedings of the Society for Experimental Biology and Medicine 193, 1622.

S Fievre , JM Wieruszeski , JC Michalski , J Lemoine , J Montreuil & G Strecker (1991) Primary structure of trisialylated oligosaccharide from human milk. Biochemical and Biophysical Research Communications 177, 720724.

JM Finch & RJ Turner (1996) Effects of selenium and vitamin E on the immune responses of domestic animals. Research in Veterinary Science 60, 97106.

TR Fleming & DL DeMets (1996) Surrogate endpoints in clinical trials: are we being misled? Annuls of Internal Medicine 125, 605613.

K Folkers , M Morita & J McRee Jr (1993) The activities of coenzyme QlO and vitamin B6 for immune responses. Biochemical and Biophysical Research Communications 193, 8892.

SJ Fomon (1991) Reference data for assessing growth of infants. Journal of Pediatrics 119, 415416.

JV Formica & W Regelson (1995) Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology 33, 10611080.

F Foufelle , J Girard & P Ferré (1996) Regulation of lipogenic enzyme expression by glucose in liver and adipose tissue: a review of the potential cellular and molecular mechanisms. Advances in Enzyme Regulation 36, 199226.

JK Friel , WL Andrews , JD Matthew , DR Long , AM Cornel , M Cox , E McKim & GO Zerbe (1993) Zinc supplementation in very low birth weight infants. Journal of Pediatric Gastroenterology and Nutrition 17, 97104.

T Fujisawa , J Riby & N Kretchmer (1991) Intestinal absorption of fructose in the rat. Gastroenterology 101, 360367.

PJ Garlick & MA McNurlan (1994) Protein metabolism in the cancer patient. Biochimie 76, 713717.

GE Gaull , DK Rassin , NCR Raiha & K Heinonen (1977) Milk protein quantity and quality in low-birth weight infants: III. Effects on sulfur amino acids in plasma and urine. Journal of Pediatrics 90, 348355.

KJ Gebhard , DS Gridley , DR Stickney & TD Shulz (1990) Enhancement of immune status by high levels of dietary vitamin B-6 without growth inhibition of human malignant melanoma in athymic nude mice. Nutrition and Cancer 14, 1526.

HC Gerstein (1994) Cow's milk exposure and type I diabetes mellitus. A critical overview of the clinical literature. Diabetes Care 17, 1319.

H Gerster & U Moser (1988) Is high-dose vitamin C intake associated with systemic conditioning? Nutrition Research 8, 13271332.

E Ghigo , E Arvat , L Gianotti , M Nicolosi , MR Valetto , S Avagnina , D Bellitti , M Rolla , EE Muller & F Camanni (1994) Arginine but not pyridostigmine, a cholinesterase inhibitor, enhances the GHRH-induced GH rise in patients with anorexia nervosa. Biological Psychiatry 36, 689695.

A Gil & R Uauy (1995 a) Nucleotides and related compounds in human and bovine milks. In Handbook of Milk Composition, pp. 436464 [ RG Jensen , editor]. San Diego, CA: Academic Press.

V Gilsanz , TF Roe , S Mora , G Costin & WG Goodman (1991) Changes in vertebral bone density in black girls and white girls during childhood and puberty. New England Journal of Medicine 325, 15971600.

PA Grimaldi , SM Knobel , RR Whitesell & NA Abumrad (1992) Induction of aP2 gene expression by nonmetabolized long-chain fatty acids. Proceedings of the National Academy of Sciences USA 89, 1093010934.

M Gunnes & EH Lehman (1995) Dietary calcium, saturated fat, fiber and vitamin C as predictors of forearm cortical and trabecular bone density in healthy children and adolescents. Acta Paeditrica 84, 388392.

F Güttler (1984) Phenylketonuria: 50 years since Follings discovery and still expanding our clinical and biochemical knowledge. Acta Paediatrica Scandinavia 73, 705716.

F Güttler & P Guldberg (1996) The influence of mutations of enzyme activity and phenylalanine tolerance in phenylalanine hydroxylase deficiency. European Journal of Pediatrics 155, Suppl. 1, S6–S10.

DL Hadsell , NM Greenberg , JM Fligger , CR Baumrucker & JM Rosen (1996) Targeted expression of des(1–3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression. Endocrinology 137, 321330.

ES Halas , HH Sanstead (1975) Some effects of prenatal zinc deficiency on behavior of the adult rat. Pediatric Research 9, 9497.

AJ Hale , CA Smith , LC Sutherland , VE Stoneman , VL Longthorne , AC Culhane & GT Williams (1996) Apoptosis: molecular regulation of cell death. European Journal of Biochemistry 236, 126.

S Halken , A Host , LG Hansen & O Osterballe (1993 a) Preventive effect of feeding high-risk infants a casein hydrolysate formula or an ultrafiltrated whey hydrolysate formula. A prospective, randomized, comparative clinical study. Pediatric Allergy and Immunology 4, 173181.

S Halken , A Host , LG Hansen & O Osterballe (1993 b) Safety of a new, ultrafiltrated whey hydrolysate formula in children with cow milk allergy: a clinical investigation. Pediatric Allergy and Immunology 4, 5359.

L Hall , DC Emery , MS Davies , D Parker & RK Craig (1987) Organization and sequence of the human α-lactalbumin gene. Biochemical Journal 242, 735742.

HP Hauri , A Quaroni & KJ Isselbacher (1980) Monoclonal antibodies to sucrase–isomaltase: probes for the study of postnatal development and biogenesis of the intestinal microvillus membrane. Proceedings of the National Academy of Sciences USA 77, 66296633.

HP Hauri , EE Sterchi , D Bienz , JAW Fransen & A Marxer (1986) Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cell. Journal of Cellular Biology 101, 838851.

MK Hellerstein , K Wu , M McGrath , D Faix , D George , CH Shackleton , W Horn , R Hoh & RA Neese (1996) Effects of dietary n−3 fatty acid supplementation in men with weight loss associated with the acquired immune deficiency syndrome: relation to indices of cytokine production. Journal of Acquired Immune Deficiency Syndromes: Human Retrovirology 11, 258270.

H Hemila (1996) Vitamin C and common cold incidence: a review of studies with subjects under heavy physical stress. Interna– tional Journal of Sports Medicine 17, 379383.

RC Henderson & PRL Hayes (1994) Bone mineralisation in children and adolescents with a milk allergy. Bone and Mineral 27, 112.

R Hernández-Muñoz , M Díaz-Muñoz , J Suárez & V Chagoya de Sánchez (1990) Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats. Hepatology 12, 242248.

A Herskovics , A Quaroni , B Bugge & K Kirsch (1981) Partial characterization of the carbohydrate units of rat intestinal sucrase–isomaltase. Biochemical Journal 197, 511514.

KC Houscham & JFK Devilliers (1987) Computed tomography in severe protein–energy malnutrition. Archives of Disease in Childhood 62, 589592.

DA Hughes , AJA Wright , PM Finglas , ACJ Peerless , AL Bailey , SB Astley , AC Pinder & S Southon (1996) Beta-carotene supplementation enhances the expression of functionally associated molecules on human monocytes. Biochemical Society Transactions 24, 388S.

PR Huttenlocher , C de Courten , LJ Garey & H van der Loos (1982) Synaptogenesis in the human visual cortex–evidence for synapse elimination during normal development. Neuroscience Letters 33, 247252.

P Igarashi (1994) Transcription factors and apoptosis in kidney development. Current Opinion in Nephrology and Hypertension 3, 308317.

E Isolauri , M Kaila , H Mykkanen , WH Ling & S Salminen (1994) Oral bacteriotherapy for viral gastroenteritis. Digestive Diseases and Sciences 39, 25952600.

M Jacobson (1991) Developmental Neurobiology. New York: Plenum Press.

V Jirsova , O Koldovsky , A Heringova , J Hoskova , J Jirasek & J Uher (19651966) The development of the functions of the small intestine of the human fetus. Biology of the Neonate 9, 4449.

CC Johnston , JZ Miller , CW Slemenda , TK Reister , S Hui , JC Christian & M Peacock (1992) Calcium supplementation and increase in bone mineral density in children. New England Journal of Medicine 327, 8287.

HL Jørgensen , J Schøller , JC Sand , M Bjuring , C Hassager & C Christiansen (1996) Relation of common allelic variation at vitamin D receptor locus to bone mineral density and postmenopausal bone loss: cross sectional and longitudinal population study. British Medical Journal 313, 586590.

M Kaila , E Isolauri , E Soppi , E Virtanen , S Laine & H Arvilommi (1992) Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatric Research 32, 141144.

ER Kandel , JH Schwartz & TM Jessell (1995) Essentials of Neural Science. East Nonvalk, CT: Appleton & Lange.

WH Karasov , RS Pond III, DH Solberg & JM Diamond (1983) Regulation of proline and glucose transport in mouse intestine by dietary substrate levels. Proceedings of the National Academy of Sciences USA 80, 76747678.

M Kawata (1995) Roles of steroid hormones and their receptors in structural organization in the nervous system. Neuroscience Research 24, 146.

M Kemen , M Senkal , HH Homann , A Mumme , AK Dauphin , J Baier , J Windeler , H Neumann & V Zumtobel (1995) Early postoperative enteral nutrition with arginine- omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: An immunologic evaluation of Impact(R). Critical Care Medicine 23, 652659.

JE Kerstetter (1995) Do dairy products improve bone density in adolescent girls? Nutrition Reviews 53, 328332.

PJ Kilshaw & AJ Cant (1984) The passage of maternal dietary proteins into human breast milk. International Archives of Allergy and Applied Immunology 75, 815.

L Kiremidjian Schumacher & G Stotzky (1987) Selenium and immune responses. Environmental Research 42, 277303.

H Kitagawa , H Nakada , S Fukui , I Funakoshi , T Kawasaki & I Yamashira (1991) Novel oligosaccharides with the sialyl- Le structure in human milk. Biochemistry 30, 28692876.

H Kitajima , Y Sumida , R Tanaka , N Yuki , H Takayama & M Fujimura (1997) Early administration of bifidobacterium breve to preterm infants: randomised controlled trial. Archives of Disease in Childhood 76, F101–F107.

O Koldovsky & V Strbak (1995) Hormones and growth factors in human milk. In Handbook of Milk Composition, pp. 428436 [ RG Jensen , editor]. San Diego, CA: Academic Press.

B Koletzko & M Braun (1991) Arachidonic acid and early human growth: is there a relation? Annals of Nutrition and Metabolism 35, 128131.

B Koletzko & J Müller (1990) Cis- and trans-isomeric fatty acids in plasma lipids of newborn infants and their mothers. Biology of the Neonate 57, 172178.

B Koletzko , I Thiel & PO Abiodun (1992) The fatty acid composition of human milk in Europe and Africa. Journal of Pediatrics 120, S62–S70.

PH Krammer , I Behrmann , P Daniel , J Dhein & KM Debatin (1994) Regulation of apoptosis in the immune system. Current Opinion in Immunology 6, 279289.

KA Kudsk , G Minard , MA Croce , RO Brown , TS Lowrey , FE Pritchard , RN Dickerson & TC Fabian (1996) A randomized trial of isonitrogenous enteral diets after severe trauma. An immune-enhancing diet reduces septic complications. Annals of Surgery 531540; discussion 540543.

AD Kulkarni , WC Fanslow , FB Rudolph & CT Van Buren (1992) Immunohemopoietic effects of dietary nucleotide restriction in mice. Transplantation 53, 467472.

JM Lacey & DW Wilmore (1990) Is glutamine a conditionally essential amino acid? Nutrition Reviews 48, 297309.

A Laegrid , ABK Otnaess & J. Fugelsang (1986) Human and bovine milks: comparison of ganglioside compositions and enterotoxin inhibitory activity. Pediatric Research 20, 416420.

CI Lanting , V Fidler , M Huisman , BCL Touwen & ER Boersma (1994) Neurological differences between 9-year-old children fed breast-milk or formula-milk as babies. Lancet 344, 13191322.

NS LeLeiko , AD Bronstein , S Baliga & HN Muno (1983) De novo purine nucleotide synthesis in the rat small and large intestine: effect of dietary protein and purines. Journal of Pediatric Gastroenterology and Nutrition 2, 313319.

NS LeLeiko , BA Martin , MJ Walsh , P Kazlow , S Rabinowitz & K Sterling (1987) Tissue specific gene expression results from a purine and pyrimidine -free diet and 6-mercaptopurine in the rat small intestine and colon. Gastroenterology 93, 10141020.

C Levy Marchal , J Karjalainen , F Dubois , W Karges , P Czernichow & HM Dosch (1995) Antibodies against bovine albumin and other diabetes markers in French children. Diabetes Care 18, 10891094.

DS Lewis , HA Bertrand , CA McMahan , HC McGill , KD Carey & EJ Masaro (1986) Preweaning food intake influences the adiposity of young adult baboons. Journal of Clinical Investigation 78, 899905.

B Liang , L Lane & RR Watson (1995) Vitamin E stimulation of disease resistance and immune function. Expert Opinion on Investigational Drugs 4, 201211.

B Liang & RR Watson (1996) Vitamin E and immunomodulation for cancer and AIDS resistance. Expert Opinion on Investigational Drugs 5, 12211225.

Q Liang & T Richardson (1993) Expression and characterization of human lactofemn in yeast, Saccharomyces cerevisiae. Journal of Agriculture and Food Chemistry 41, 18001807.

AA Licata (1993) Monitoring calcium intake and absorption. World Review of Nutrition and Dietetics 73, 2752.

G Lilja , A Dannaeus , T Foucard , LV Graff , SG Johansson & H Oman (1989) Effects of maternal diet during late pregnancy and lactation on the development of atopic diseases in infants up to 18 months of age – in-vivo results. Clinical and Experimental Allergy 19, 473479.

JM Limonta , FO Castro , R Martinez , P Puentes , B Ramos , A Aguilar , RL Lleonart & J delaFuente (1995) Transgenic rabbits as bioreactors for the production of human growth hormone. Journal of Biotechnology 40, 4958.

A Lindfors & E Enocksson (1988) Development of atopic disease after early administration of cow milk formula. Allergy 43, 1116.

D Llewellyn-Jones (1965) Severe anaemia in pregnancy. Australian and New Zealand Journal of Obstetrics and Gynaecology 5, 191197.

T Lloyd , MB Andon , N Rollings , JK Martel , JR Landis , LM Demers , DF Eggli , K Kieselhorst & HE Kulin (1993) Calcium supplementation and bone mineral density in adolescent girls. Journal of the American Medical Association 270, 841844.

S Loche , D Carta , AC Muntoni , R Corda & C Pintor (1993) Oral administration of arginine enhances the growth hormone response to growth hormone releasing hormone in short children. Acta Paediatrica 82, 883884.

AT López-Navarro , MA Ortega , J Peragon , JD Bueno , A Gil & A Sanchez-Pozo (1996) Deprivation of dietary nucleotides decreases protein synthesis in the liver and small intestine in rats. Gastroenterology 110, 17601769.

B Lozoff , AW Wolf & E Jiminez (1996) Iron-deficiency anemia and infant development: effects of extended oral iron therapy. Journal of Pediatrics 129, 382389.

A Lucas , R Morley , TJ Cole , G Lister & C Leeson-Payne (1992) Breast milk and subsequent intelligence quotient in children born preterm. Lancet 339, 261264.

AM Mackinnon & DJ Deller (1973) Purine nucleotides biosynthesis in gastrointestinal mucosa. Biochimica et Biophysica Acta 319, 14.

EA Maga , GB Anderson , CH Mei & JD Murray (1994) Expression of human lysozyme mRNA in the mammary gland of transgenic mice. Transgenic Research 3, 3642.

H Majamaa & E Isolauri (1997) Probiotics: a novel approach in the management of food allergy. Journal of Allergy and Clinical Immunology 99, 179185.

M Makrides , M Neumann , K Simmer , J Pater & R Gibson (1995) Are long chain polyunsaturated fatty acids essential nutrients in infancy? Lancet 345, 14631468.

J Mandl , G Banhegy , M Kapalos , T Garzo (1995) Increased oxidation and decreased conjugation of drugs in the liver caused by starvation, altered metabolism of certain aromatic compounds and acetone. Chemicobiological Interactions 96, 87101.

E Mastrmatteo & F Sullivan (1994) Summary: international symposium on the health effects of boron and its compounds. Environmental Health Perspectives 102, Suppl. 7, 139141.

C Mathieu , M Waer , J Laureys , O Rutgeerts & R Bouillon (1994) Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 37, 552558.

W Meikrantz & R Schlegel (1995) Apoptosis and the cell cycle. Journal of Cell Biochemistry 58, 160174.

B Melnik , G Plewig & T Tschung (1991) Are deficiencies of prostaglandin-E-mediated immunoregulation involved in increased IgE synthesis of atopic mononuclear cells in vitro? Allergy 46, 502506.

JA Mennella & GK Beauchamp (1991) The transfer of alcohol to human milk effects on flavor and the infant's behavior. New England Journal of Medicine 325, 981985.

JA Mennella & GK Beauchamp (1993) The effects of repeated exposure to garlic-flavored milk on the nursling's behavior. Pediatric Research 34, 805808.

M Messer & KR Keny (1967) Intestinal digestion of maltotriose in man. Biochimica et Biophysica Acta 132, 432443.

M Messina & V Messina (1996) Nutritional implications of dietary phytochemicals. Advances in Experimental Medicine and Biology 401, 207212.

MR Millar , C Bacon , SL Smith , V Walker & MA Hall (1993) Enteral feeding of premature infants with Lactobacillus GG. Archives of Disease in Childhood 69, 483487.

JB Miller , S Bull , J Miller & P McVeagh (1994) The oligosaccharide composition of human milk: temporal and individual variations in the monosaccharide components. Journal of Pediatric Gastroenterology and Nutrition 19, 371376.

LT Miller & NI Kerkvliet (1990) Effect of vitamin B6 on immunocompetence in the elderly. Annals of the New York Academy of Sciences 587, 4954.

JA Milner (1990) Trace minerals in the nutrition of children. Journal of Pediatrics 117, S147–S155.

J Morillas , L Moltó , R Robles , A Gil & A Sánchez-Pozo (1994) Lipoprotein changes in small-for-gestational-age infants fed nucleotide-supplemented milk formula. Acta Paediatrica 83, 481485.

R Morley & A Lucas (1993) Early diet and outcome in prematurely born children. Clinical Nutrition 12, Suppl., 611.

RL Naeye , MM Diener & WS Dellinger (1989) Urban poverty: effects on prenatal nutritition. Science 166, 1026.

S Nagata (1997) Apoptosis by death factor. Cell 88, 355365.

HY Naim , J Roth , EE Sterchi , MJ Lentze , PJ Milla , J Schmitz & HP Hauri (1988) Sucrase–isomaltase deficiency in humans. Different mutations disrupt intracellular transport, processing and function of an intestinal brush border enzyme. Journal of Clinical Investigation 82, 667679.

HY Naim , T Niermann , U Kleinhans , CP Hollenberg & AWM Strasser (1991) Strikung structural and functional similarities suggest that intestinal sucrase–isomaltase, human lysosomal α-glucosidase, and Schwanniomyces occidentalis glucoamylase are derived from common ancestral gene. FEBS Letters 294, 109112.

J Navarro , A RuizBravo , M JimenezValera & A Gil (1996) Modulation of antibody-forming cell and mitogen-driven lym-phoproliferative responses by dietary nucleotides in mice. Immunology Letters 53, 141145.

YH Neggers , GR Cutter , JO Alvarez , RL Goldenberg , R Acton , RC Go & JM Roseman (1991) The relationship between maternal serum zinc levels during pregnancy and birthweight. Early Human Development 25, 7585.

DS Newburg & SH Neubauer (1995) Carbohydrates in milks: analysis, quantities and significance. In Handbook of Milk Composition, pp. 273349 [ RG Jensen , editor]. San Diego, CA: Academic Press.

DS Newburg , LK Pickering , RH McCluer & TG Cleary (1990) Fucosylated oligosaccharides of human milk protect suckling mice from heat stable enterotoxin of Escherichia coli. Journal of Infections and Diseases 162, 10751080.

EA Newsholme & AL Carrié (1994) Quantitative aspects of glucose and glutamine metabolism by intestinal cells. Gut 35, Suppl. 1, S13–S17.

M Niv , W Levy & NM Greenstein (1963) Yogurt in the treatment of infantile diarrhoea. Clinical Pediatrics 2, 407411.

S Ogoshi , M Iwasa , S Kitagawa , Y Ohmori , S Mizobuchi , Y Iwasa & T Tamiya (1988) Effects of total parenteral nutrition with nucleoside and nucleotide mixture on D -galactosamine-induced liver injury in rats. Journal of Parenteral and Enteral Nutrition 12, 5357.

S Ogoshi , M Iwasa , T Yonezawa & T Tamiya (1985) Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy. Journal of Parenteral and Enteral Nutrition 9, 339342.

H Ohyanagi , S Nishimatsu , Y Kanbara , M Usami & Y Saitoh (1989) Effects of nucleosides and a nucleotide on DNA and RNA syntheses by the salvage and de novo pathway in primary monolayer cultures of hepatocytes and hepatoma cells. Journal of Parenteral and Enteral Nutrition 13, 5158.

G Oldaeus , K Anjou , B Björksten , JR Moran & NIM Kjellmann (1997) Extensively and partially hydrolysed infant formulas for allergy prophylaxis. Archives of Disease in Childhood 77, 410.

SF Olsen , JD Soerensen , NJ Secher , M Hedegaard , TB Henriksen , HS Hansen & A Grant (1992) Randomized controlled trial of the effect of fish-oil supplementation on pregnancy duration. Lancet 339, 10031007.

JL Onwude , RJ Lilford , H Hjartardottir , A Staines & D Tuffnell (1995) A randomised double blind placebo controlled trial of fish oil in high risk pregnancy. British Journal of Obstetrics and Gynaecology 102, 95100.

C Osmond , DJP Barker , PD Winter , CHD Fall & SJ Simmonds (1993) Early growth and death from cardiovascular disease in women. British Medical Journal 307, 15191524.

S Patton , S Gendler & AP Spicer (1995) The epithelial mucin, MUC1, of milk mammary gland and other tissues. Biochimica et Biophysica Acta 1241, 407424.

ND Penn , L Purkins , J Kelleher , RV Heatley , BH MascieTaylor & PW Belfield (1991) The effect of dietary supplementation with vitamins A, C and E on cell-mediated immune function in elderly long-stay patients: a randomized controlled trial. Age and Ageing 20, 169174.

DP Peters (1979) Effects of prenatal malnutrition on learning and motivation in rats. Physiology and Behaviour 22, 10671070.

SR Pfeffer & JE Rothman (1987) Biosynthetic protein transport and sorting by the endoplasmic reticulum and Golgi. Annual Review of Biochemistry 56, 829852.

K Pietrzik , R Prinz , K Reusch , P Bung , P Mallmann & A Chronides (1992) Folate status and pregnancy outcome. Annals of the New York Academy of Sciences 669, 371373.

ML Pita , MR Fernández , C DeLucchi , A Medina , A Martínez-Valverde , R Uauy & A Gil (1988) Changes in fatty acids pattern of red blood cell phospholipids induced by type of milk. Dietary nucleotide supplementation and postnatal age in preterm infants. Journal of Pediatric Gastroenterology and Nutrition 7, 740747.

RP Pizzini , S Kumar , AD Kulkarni , FB Rudolph & CT Van Buren (1990) Dietary nucleotides reverse malnutrition and starvation-induced immunosuppression. Archives of Surgery 125, 8690.

NA Pocock , JA Eisman , JL Hopper , MG Yeates , PN Sambrook & S Eberl (1987) Genetic determinants of bone mass in adults: a twin study. Journal of Clinical Investigation 80, 706710.

E Politt (1993) Iron deficiency and cognitive function. Annual Review of Nutrition 13, 521537.

R Quan & GM Gray (1993) Sucrase-α-dextrinase in the rat. Journal of Clinical Investigation 91, 27852790.

LC Rall & SN Meydani (1993) Vitamin B6 and immune competence. Nutrition Reviews 51, 217225.

KM Rasmussen (1992) The influence of maternal nutrition on lactation. Annual Review of Nutrition 12, 103117.

GP Ravelli , ZA Stein & MW Susser (1976) Obesity in young men after famine exposure in utero and early infancy. New England Journal of Medicine 295, 349353.

J Rigo , K Nyamugabo , M De Curtis & J Senterre (1996) Bone mineralization during the first year of life. In Recent Developments of Infant Nutrition, pp. 98111 [ JG Bindels , AC Goedhart and HKA Visser , editors]. Dordrecht, Boston and London: Kluwer Academic Publishers.

DA Rodeberg , MS Chaet , RC Bass , MS Arkovitz & VF Garcia (1995) Nitric oxide: an overview. American Journal of Surgery 170, 292303.

CD Roskelley , A Srebrow & MJ Bissell (1995) A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Current Opinion in Cell Biology 7, 736747.

JM Saavedra , NA Bauman , I Oung , JA Perman & RH Yolken (1994) Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet 344, 10461049.

L Sachs (1996) The control of hematopoiesis and leukemia: from basic biology to the clinic. Proceedings of the National Academy of Sciences USA 93, 47424749.

A Sánchez-Pozo , J Morillas , L Moltó , R Robles & A Gil (1994) Dietary nucleotides influence lipoprotein metabolism in newborn infants. Pediatric Research 35, 112116.

A Sánchez-Pozo , M Ramirez , A Gil , J Maldonado , JP Van Biervliet & M Rosseneu (1995) Dietary nucleotides enhance plasma lecithin cholesterol acyl transferase activity and apolipoprotein A-IV concentration in preterm newborn infants. Pediatric Research 37, 328333.

EJ Sanders & MA Wride (1995) Programmed cell death in development. International Review of Cytology 163, 105173.

E Savilahti , VM Tainio , L Salmenperä , MA Siimes & J Perheentupa (1987) Prolonged exclusive breast feeding and heredity as determinants in infantile atopy. Archives of Disease in Childhood 62, 269273.

EJ Schiffrin , F Rochat , H Link Amster , JM Aeschlimann & A Donnet Hughes (1995) Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. Journal of Dairy Science 78, 491497.

H Schroten , R Plogmann , FG Hanisch , J Hacker , R Nobis-Bosch & V Wahn (1993) Inhibition of adhesion of S-fimbriated E. coli to buccal epithelial cells by human skim milk is predominantly mediated by mucins and depends on the period of lactation. Acta Paediatrica 82, 611.

GG Schwartz (1992) Multiple sclerosis and prostate cancer: what do their similar geographies suggest? Neuroepidemiology 11, 244254.

CR Scriver (1991) Phenylketonuria – genotypes and phenotypes. New England Journal of Medicine 324, 12801281.

CR Scriver & CL Clow (1980) Phenylketonuria: epitome of human biochemical genetics. New England Journal of Medicine 303, 13361342.

NJ Secher & SF Olsen (1990) Fish oil and preeclampsia. British Journal of Obstetrics and Gynaecology 97, 10771079.

Y Sei , L Vitkovic & MM Yokoyama (1995) Cytokines in the central nervous system: regulatory roles in neuronal function, cell death and repair. Neuroimmunomodulation 2, 121133.

E Seidman , N LeLeiko , M Ament , W Berman , D Caplan , J Evans , S Kocoshis , A Lake , K Motil & J Sutphen (1991) Nutritional issues in pediatric inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition 12, 424438.

NJ Shaw & NJ Bishop (1995) Mineral accretion in growing bones - a framework for the future? Archives of Disease in Childhood 72, 177179.

NF Sheard (1994) Iron deficiency and infant development. Nutrition Reviews 52, 137140.

M Shiner , VN Nichols , JP Banish & BL Nichols (1990) Pathogenesis of small-intestinal mucosal lesions in chronic diarrhea of infancy: 11. An electron microscopic study. Journal of Pediatric Gastroenterology and Nutrition 11, 464480.

G Shor Posner , MJ Miguez Burbano , Y Lu , D Feaster , M Fletcher , H Sauberlich & MK Baum (1995) Elevated IgE level in relationship to nutritional status and immune parameters in early human immunodeficiency virus-1 disease. Journal of Allergy and Clinical Immunology 95, 886892.

BM Sibai , MA Villar , E Bray (1989) Magnesium supplementation during pregnancy: a double blind randomized controlled clinical trial. American Journal of Obstetrics and Gynecology 161, 115.

JL Smart (1974) Activity and exploratory behavior of adult offspring of undernourished mother rats. Developmental Psychobiology 7, 315321.

L Spatling & G Spatling (1988) Magnesium supplementation in pregnancy: a double-blind study. British Journal of Obstetrics and Gynaecology 95, 120125.

R Speck & B Lauterburg (1991) Fish oil protects mice against acetaminophen hepatotoxicity in vivo. Hepatology 13, 557561.

EM Stansbridge , V Walker , MA Hall , MR Millar , C Bacon & S Chen (1993) Effects of feeding premature infants with Lactobacillus GG on gut fermentation. Archives of Disease in Childhood 69, 488492.

S Stephens (1986) Development of secretory immunity in breast fed and bottle fed infants. Archives of Disease in Childhood 61, 263269.

S Stephens , MK Brenner , SW Duffy , PK Lakhani , CR Kennedy & J Farrant (1986 a) The effect of breast-feeding on proliferation by infant lymphocytes in vitro. Pediatric Research 20, 227231.

MB Stoch , PM Smythe , AD Moodie & O Bradshaw (1982) Psychosocial outcome and CT findings after gross undernourishment during infancy: a 20-year developmental study. Developmental Medicine and Child Neurology 24, 419436.

KM Stowell , TA Rado , WD Funk & JW Tweedie (1991) Expression of cloned human lactofemn in baby hamster kidney cells. Biochemical Journal 276, 349355.

A Suarez , MJ Faus & A Gil (1996 a) Dietary long-chain poly-unsaturated fatty acids modify heart, kidney, and lung fatty acid composition in weanling rats. Lipids 31, 345348.

A Suarez , MJ Faus & A Gil (1996 b) Dietary supplementation with long-chain polyunsaturated fatty acids increases susceptibility of weanling rat tissue lipids to in vitro lipid peroxidation. Journal of Nutritional Biochemistry 7, 252260.

H Suzuki , M Menegazzi , A Carcereri de Prati , S Mariotto & U Armato (1995) Nitric oxide in the liver: physiopathological roles. Advances in Neuroimmunology 5, 379410.

EM Taylor & EH Morgan (1990) Developmental changes in transferrin and iron uptake by the brain in the rat. Developmental Brain Research 55, 3542.

RP Tengerdy (1990) The role of vitamin E in immune response and disease resistance. Annals of the New York Academy of Sciences 587, 2433.

D Thépot , E Devinoy , ML Fontaine , MG Stinnakre , M Massoud , G Kann & LM Houdébine (1995) Rabbit whey acidic protein gene upstream region controls high-level expression of bovine growth hormone in the mammary gland of trans-genic mice. Molecular Reproduction and Development 42, 261267.

A Tixier-Vidal , R Picart , C Loudes & AF Bauman (1986) Effects of polyunsaturated fatty acids and hormones on synaptogenesis in serum-free medium cultures of mouse fetal hypothalamic cells. Neuroscience 17, 115132.

P Trivedi , J Risteli , L Risteli , PC Hindmarsh , CG Brook & AP Mowat (1991) Serum concentration of the type I and III procollagen propeptides as biochemical markers of growth velocity in healthy infants and children and in children with growth disorders. Pediatric Research 30, 276280.

R Troncone , A Scarcella , A Donatiello , P Cannataro , A Tarabuson & S Auricchio (1987) Passage of gliadin into human breast milk. Acta Paediatrica Scandinavica 76, 453456.

R Uauy , DG Birch , EE Birch , JE Tyson & DR Hoffman (1990) Effect of dietary omega-3 fatty acids on retinal function of very-low-birth-weight neonates. Pediatric Research 28, 485492.

O Vaarala , P Klemetti , E Savilahti , H Reijonen , J Ilonen & HK Akerblom (1996) Cellular immune response to cow's milk beta-lactoglobulin in patients with newly diagnosed IDDM. Diabetes 45, 178182.

CT Van Buren , AD Kulkarni , WC Fanslow & FB Rudolph (1985) Dietary nucleotides: a requirement for helperhnducer T lymphocytes. Transplantation 40, 694697.

CT Van Buren , AD Kulkarni , VB Schandle & FB Rudolph (1983) The influence of dietary nucleotide on cell-mediated immunity. Transplantation 36, 350352.

Y Vandenplas , B Hauser , C Van Den Borre , C Clybouw , T Mahler , S HachimiIdrissi , L Deraeve , A Malfroot & I Dab (1995) The long-term effect of a partial whey hydrolysate formula on the prophylaxis of atopic disease. European Journal of Pediatrics 154, 488494.

DL Vaux & A Strasser (1996) The molecular biology of apoptosis. Proceedings of the National Academy of Sciences USA 93, 22392244.

SM Virtanen , L Räsänen , A Aro , J Lindström , H Sippola , R Lounamaa , L Toivanen , J Tuomilehto & HK Akerblom (1991) Infant feeding in Finnish children <7 yr of age with newly diagnosed IDDM. Diabetes Care 14, 415417.

D Viverge , L Grimmonprez , G Cassanas , L Bardet & M Solere (1990) Variations in oligosaccharides and lactose in human milk during the first week of lactation. Journal of Pediatric Gastroenterology and Nutrition 11, 361364.

MJ Walsh , A Sánchez-Pozo & NS LeLeiko (1990) A regulatory element is characterized by purine-mediated and cell type specific gene transcription. Molecular Cell Biology 10, 43564364.

X Wang , R Sato , MS Brown , X Hua & JL Goldstein (1994) SREBP-1, a membrane bound transcription factor released by sterol-regulated proteolysis. Cell 77, 5362.

PP Ward , JY Lo , M Duke , GS May , DR Headon & OM Conneely (1992 b) Production of biologically active recombinant human lactofenin in Aspergillus oryzae. BioTechnology 10, 784789.

PP Ward , GS May , DR Headon & OM Conneely (1992 b) An inducible expression system for the production of human lactofenin in Aspergillus nidulans. Gene 122, 219223.

JO Warner (1980) Food allergy in fully breast fed infants. Clinical Allergy 10, 133136.

JL Wells , DK James , R Luxton & CA Pennock (1987) Maternal leukocyte zinc deficiency at start of third trimester as a predictor of fetal growth retardation. British Medical Journal 294, 1054.

JK Welply , JL Keene , JJ Schmuke & SC Howard (1994) Selectins as potential targets of therapeutic intervention in inflammatory diseases. Biochimica et Biophysica Acta 1197, 215226.

AO Welsh (1993) Uterine cell death during implantation and early placentation. Microscopy Research and Technique 25, 223245.

M Winick (1970) Fetal malnutrition. Clinical Obstetrics and Gynecology 13, 526.

JZ Yetiv (1988) Clinical applications of fish oils [see comments]. Journal of the American Medical Association 260, 665670.

Z Zakeri & RA Lockshin (1994) Physiological cell death during development and its relationship to aging. Annals of the New York Academy of Sciences 719, 212229.

RS Zeiger & S Heller (1995) The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. Journal of Allergy Clinical Immunology 95, 11791190.

RS Zeiger , S Heller , MH Mellon , AB Forsythe , RD O'Connor , RN Hamburger & M Schatz (1989) Effect of combined maternal and infant food-allergen avoidance on development of atopy in early infancy: a randomized study [published erratum appears in Journal of Allergy and Clinical Immunology (1989) 84 (5 Pt 1), 677]. Journal of Allergy and Clinical Immunology 84, 7289.

RS Zeiger , S Heller , MH Mellon , JF Halsey , RN Hamburger & HA Sampson (1992) Genetic and environmental factors affecting the development of atopy through age 4 in children of atopic parents: a prospective, randomized study of food allergen avoidance. Pediatric Allergy and Immunology 3, 110127.

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