Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 3
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Orekhov, Alexander N. Melnichenko, Alexandra A. and Sobenin, Igor A. 2014. Approach to Reduction of Blood Atherogenicity. Oxidative Medicine and Cellular Longevity, Vol. 2014, p. 1.

    Tseng, Yen-Hsun and Pease, Leonard F. 2014. Electrospray differential mobility analysis for nanoscale medicinal and pharmaceutical applications. Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 10, Issue. 8, p. 1591.

    Hernes, Sigrunn Cabo, Rona N. Mansoor, Mohammad Azam and Haugen, Margaretha 2012. Eating patterns are associated with biomarkers in a selected population of university students and employees. Journal of Nutritional Science, Vol. 1,


High disaccharide intake associates with atherogenic lipoprotein profile


Increased plasma concentrations of small LDL particles denote an atherogenic lipoprotein phenotype (ALP) that is correlated with increased circulating TAG and reduced HDL-cholesterol. Principal component analyses of subfraction concentrations have previously been used in the Swedish population-based Malmö Diet and Cancer (MDC) cohort to identify three independent components, one pattern representing the ALP. The aim of the present study was to examine the associations between macronutrient intakes and the principal component representing the ALP. We examined 4301 healthy subjects (46–68 years old, 60 % women) at baseline in the MDC cohort. Dietary data were collected using a modified diet history method. Plasma lipoprotein subfractions were measured using a high-resolution ion mobility method. The principal component corresponding to the ALP was significantly associated with a higher intake of disaccharides, and inversely related to protein and alcohol consumption (P < 0·001 for all). The present findings indicate that the ALP may be improved by a low intake of disaccharides, and moderate intakes of protein and alcohol.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      High disaccharide intake associates with atherogenic lipoprotein profile
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      High disaccharide intake associates with atherogenic lipoprotein profile
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      High disaccharide intake associates with atherogenic lipoprotein profile
      Available formats
Corresponding author
*Corresponding author: E. Sonestedt, fax +46 40 39 13 22, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2RM Krauss & DJ Burke (1982) Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J Lipid Res 23, 97104.

3S Ip , AH Lichtenstein , M Chung , (2009) Systematic review: association of low-density lipoprotein subfractions with cardiovascular outcomes. Ann Intern Med 150, 474484.

4K Musunuru , M Orho-Melander , MP Caulfield , (2009) Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk. Arterioscler Thromb Vasc Biol 29, 19751980.

5RM Krauss (2010) Lipoprotein subfractions and cardiovascular disease risk. Curr Opin Lipidol 21, 305311.

6MA Austin , MC King , KM Vranizan , (1990) Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 82, 495506.

7FM Sacks & M Katan (2002) Randomized clinical trials on the effects of dietary fat and carbohydrate on plasma lipoproteins and cardiovascular disease. Am J Med 113, Suppl. 9B, 13S24S.

9DM Dreon , HA Fernstrom , H Campos , (1998) Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. Am J Clin Nutr 67, 828836.

10H Campos , E Blijlevens , JR McNamara , (1992) LDL particle size distribution. Results from the Framingham Offspring Study. Arterioscler Thromb 12, 14101419.

11PW Siri & RM Krauss (2005) Influence of dietary carbohydrate and fat on LDL and HDL particle distributions. Curr Atheroscler Rep 7, 455459.

12HL Taylor , DR Jacobs Jr, B Schucker , (1978) A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 31, 741755.

13C Li , CA Aronsson , B Hedblad , (2009) Ability of physical activity measurements to assess health-related risks. Eur J Clin Nutr 63, 14481451.

14E Callmer , E Riboli , R Saracci , (1993) Dietary assessment methods evaluated in the Malmo food study. J Intern Med 233, 5357.

15E Riboli , S Elmstahl , R Saracci , (1997) The Malmo Food Study: validity of two dietary assessment methods for measuring nutrient intake. Int J Epidemiol 26, Suppl. 1, S161S173.

17World Health Organization (1985) Energy and Protein Requirements: Report of a Joint FAO/WHO/UNU Expert Consultation. Geneva: WHO.

18AE Black (2000) Critical evaluation of energy intake using the Goldberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation, use and limitations. Int J Obes Relat Metab Disord 24, 11191130.

19MP Caulfield , S Li , G Lee , (2008) Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clin Chem 54, 13071316.

20MP Caulfield , S Li , G Lee , (2008) Concerns regarding lipoprotein particle measurement by ion mobility analysis. In reply. Clin Chem 54, 20882089.

22EB Rimm , P Williams , K Fosher , (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 319, 15231528.

23JD Otvos , LL Rudel & JP McConnell (2008) Concerns regarding lipoprotein particle measurement by ion mobility analysis. Clin Chem 54, 20862087; author reply 2088–2089.

24S Bingham , R Luben , A Welch , (2008) Associations between dietary methods and biomarkers, and between fruits and vegetables and risk of ischaemic heart disease, in the EPIC Norfolk Cohort Study. Int J Epidemiol 37, 978987.

25WC Willett (2008) Commentary: flawed study designs are not salvaged by large samples. Int J Epidemiol 37, 987989.

27W Becker & M Pearson (2002) Riksmaten 1997–98: kostvanor och näringsintag i Sverige: metod-och resultatanalys (Riksmaten 1997–98: Diet and Nutrition in Sweden: Methodological and Analytical Results). Uppsala: Livsmedelsverket.

28KL Stanhope , JM Schwarz , NL Keim , (2009) Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 119, 13221334.

29DA Lasker , EM Evans & DK Layman (2008) Moderate carbohydrate, moderate protein weight loss diet reduces cardiovascular disease risk compared to high carbohydrate, low protein diet in obese adults: a randomized clinical trial. Nutr Metab (Lond) 5, 30.

31RS Rosenson , JD Otvos & DS Freedman (2002) Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC-I) trial. Am J Cardiol 90, 8994.

32AC St-Pierre , B Cantin , GR Dagenais , (2005) Low-density lipoprotein subfractions and the long-term risk of ischemic heart disease in men: 13-year follow-up data from the Quebec Cardiovascular Study. Arterioscler Thromb Vasc Biol 25, 553559.

33S Mora , M Szklo , JD Otvos , (2007) LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis 192, 211217.

34BJ Arsenault , I Lemieux , JP Despres , (2007) Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study. Eur Heart J 28, 27702777.

35GJ Blake , JD Otvos , N Rifai , (2002) Low-density lipoprotein particle concentration and size as determined by nuclear magnetic resonance spectroscopy as predictors of cardiovascular disease in women. Circulation 106, 19301937.

36L Kuller , A Arnold , R Tracy , (2002) Nuclear magnetic resonance spectroscopy of lipoproteins and risk of coronary heart disease in the cardiovascular health study. Arterioscler Thromb Vasc Biol 22, 11751180.

37RP Mensink & MB Katan (1992) Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 12, 911919.

38PW Siri-Tarino , Q Sun , FB Hu , (2010) Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr 91, 535546.

40D Mozaffarian , A Aro & WC Willett (2009) Health effects of trans-fatty acids: experimental and observational evidence. Eur J Clin Nutr 63, Suppl. 2, S5S21.

41RM Krauss (2005) Dietary and genetic probes of atherogenic dyslipidemia. Arterioscler Thromb Vasc Biol 25, 22652272.

43PT Williams , RM Krauss , S Kindel-Joyce , (1986) Relationship of dietary fat, protein, cholesterol, and fiber intake to atherogenic lipoproteins in men. Am J Clin Nutr 44, 788797.

44K Wu , R Bowman , AA Welch , (2007) Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study. Eur Heart J 28, 29302936.

45S Kathiresan , CJ Willer , GM Peloso , (2009) Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41, 5665.

47S Kathiresan , O Melander , C Guiducci , (2008) Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40, 189197.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Type Description Title
Supplementary Materials

Sonestedt Supplementary Material

 Unknown (61 KB)
61 KB