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Homocysteine: a role in fetal programming?

  • Graham C. Burdge (a1)
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Fax +44 2380 594379, g.c.burdge@soton.ac.uk
References
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Bateson, P, Barker, D, Clutton-Brock, T, et al. (2004) Developmental plasticity and human health. Nature 430, 419421.
Bertram, C, Trowern, AR, Copin, N, Jackson, AA & Whorwood, CB (2001) The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 142, 28412853.
Bertram, CE & Hanson, MA (2001) Animal models and programming of the metabolic syndrome. Br Med Bull 60, 103121.
Bird, A (2002) DNA methylation patterns and epigenetic memory. Genes Dev 16, 621.
Bogdarina, I, Murphy, HC, Burns, SP & Clark, AJ (2004) Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming. Life Sci 74, 14071415.
Brawley, L, Torrens, C, Anthony, FW, Itoh, S, Wheeler, T, Jackson, AA, Clough, GF, Poston, L & Hanson, MA (2004) Glycine rectifies vascular dysfunction induced by dietary protein imbalance during pregnancy. J Physiol 554, 497504.
Brown, JC, Rosenquist, TH & Monaghan, DT (1998) ERK2 activation by homocysteine in vascular smooth muscle cells. Biochem Biophys Res Comm 251, 669676.
Burns, SP, Desai, M, Cohen, RD, Hales, CN, Iles, RA, Germain, JP, Going, TC & Bailey, RA (1997) Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest 100, 17681774.
Dalton, ML, Gadson, PF, Wrenn, RW & Rosenquist, TH (1997) Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells. FASEB J 11, 703711.
Godfrey, KM & Barker, DJ (2001) Fetal programming and adult health. Public Health Nutr 4, 611624.
Gluckman, PD & Hanson, MA (2004a) The developmental origins of the metabolic syndrome. Trends Endocrinol Metab 15, 183187.
Gluckman, PD & Hanson, MA (2004b) Living with the past: evolution, development, and patterns of disease. Science 305, 17331736.
Huxley, R (2006) Fatal flaw in the fetal argument. Br J Nutr 95, 441442.
Jackson, AA, Dunn, RL, Marchand, MC & Langley-Evans, SC (2002) Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Clin Sci (London) 103, 633639.
Kwong, WY, Wild, AE, Roberts, P, Willis, AC & Fleming, TP (2000) Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development 127, 41954202.
Langley-Evans, SC, Lilley, C & McMullen, S (2006) Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming. Br J Nutr 96, 578586.
Lillycrop, KA, Phillips, ES, Jackson, AA, Hanson, MA & Burdge, GC (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135, 13821386.
Malinow, MR, Nieto, FJ, Szklo, M, Chambless, LE & Bond, G (1993) Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults. The Atherosclerosis Risk in Communities Study. Circulation 87, 11071113.
Mujumdar, VS, Hayden, MR & Tyagi, SC (2000) Homocyst(e)ine induces calcium second messenger in vascular smooth muscle cells. J Cell Physiol 183, 2836.
Muskiet, FA (2005) The importance of (early) folate status to primary and secondary coronary artery disease prevention. Reprod Toxicol 20, 403410.
Nishimoto, S, Tawara, J, Toyoda, H, Kitamura, K & Komurasaki, T (2005) A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. Eur J Biochem 270, 25212531.
Petrie, L, Duthie, SJ, Rees, WD & McConnell, JM (2002) Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming. Br J Nutr 88, 471477.
Robert, K, Pages, C, Ledru, A, Delabar, J, Caboche, J & Janel, N (2005) Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus. Neuroscience 133, 925935.
Southern, FN, Cruz, N, Fink, LM, Cooney, CA, Barone, GW, Eidt, JF & Moursi, MM (1998) Hyperhomocysteinemia increases intimal hyperplasia in a rat carotid endarterectomy model. J Vasc Surg 28, 909918.
Tsai, JC, Perrella, MA, Yoshizumi, M, Hsieh, CM, Haber, E, Schlegel, R & Lee, ME (1994) Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci U S A 91, 63696373.
Woo, DK, Dudrick, SJ & Sumpio, BE (2000) Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells. Surgery 128, 5966.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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