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Impact of inulin and oligofructose on gastrointestinal peptides

  • Nathalie M. Delzenne (a1), Patrice D. Cani (a1), Catherine Daubioul (a1) and Audrey M. Neyrinck (a1)

In the present paper, we summarise the data supporting the following hypothesis: dietary inulin-type fructans extracted from chicory root may modulate the production of peptides, such as incretins, by endocrine cells present in the intestinal mucosa, this phenomenon being involved in the regulation of food intake and/or systemic effects. To test this hypothesis, male Wistar rats received for 3 weeks either a standard diet or the same diet supplemented with 10% inulin-type fructans with different degrees of polymerisation. All the effects were most pronounced with the diet containing oligofructose, and consisted of (i) a decrease in mean daily energy intake and in epididymal fat mass; (ii) a higher caecal pool of the anorexigenic glucagon-like peptide-1 (7–36) amide (GLP-1), and peptide YY (PYY), due to caecal tissue proliferation; (iii) an increase in GLP-1 and of its precursor – proglucagon mRNA – concentrations in the proximal colon; (iv) an increase in portal serum level of GLP-1 and PYY; (v) a decrease in serum orexigenic peptide ghrelin. Moreover, oligofructose supplementation improved glucose homeostasis (i.e. decreased glycaemia, increased pancreatic and serum insulin content) in diabetic rats previously treated with streptozotocin, a phenomenon that is partly linked to the reduction in food intake and that correlates with the increase in colic and portal GLP-1 content. Based on these results it appears justified to test, in human subjects, the hypothesis that dietary inulin-type fructans could play a role in the management of obesity and diabetes through their capacity to promote secretion of endogenous gastrointestinal peptides involved in appetite regulation.

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      Impact of inulin and oligofructose on gastrointestinal peptides
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Corresponding author
*Corresponding author: Dr N. M. Delzenne, fax +32 2 7647359, email
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Brubaker PL & Drucker DJ (2004) Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut and central nervous system. Endocrinology 145, 26532659.
Burcelin R, Da Costa A, Drucker D & Thorens B (2001) Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor. Diabetes 50, 17201728.
Cani PD, Dewever C & Delzenne NM (2004a) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92, 521526.
Cani PD, Daubioul C, Reusens B, Remacle C, Catillon G & Delzenne NM (2004b) Involvement of food restriction and endogenous GLP-1 (7–36) amide in glycemia-lowering effect of dietary oligofructose in streptozotocin diabetic rats. Regul Pept 122, 1213.
Daubioul C, De Wispelaere L, Taper H & Delzenne N (2000) Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats. J Nutr 130, 13141319.
Daubioul C, Rousseau N, Demeure R, Gallez B, Taper H, Declercq B & Delzenne N (2002) Dietary fructans, but not cellulose, decrease triglyceride accumulation in the liver of obese Zucker fa / fa rats. J Nutr 132, 967973.
Delzenne N (2003) Oligosaccharides: state of the art. Proc Nutr Soc 62, 177182.
Delzenne N & Kok N (2001) Effects of fructans-type prebiotics on lipid metabolism. Am J Clin Nutr 73, 456S458S.
Drozdowski LA, Dixon WT, McBurney MI & Thomson AB (2002) Short-chain fatty acids and total parenteral nutrition affect intestinal gene expression. J Parenter Enteral Nutr 26, 145150.
Druce MR, Small CJ & Bloom SR (2004) Gut peptides regulating satiety. Endocrinology 145, 26602665.
Drucker DJ (2002) Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122, 531544.
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H & Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402, 656660.
Lippl F, Kircher F, Erdmann J, Allescher HD & Schusdziarra V (2004) Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach. Regul Pept 119, 9398.
Massimino SP, McBurney MI, Field CJ, Thomson AB, Keelan M, Hayek MG & Sunvold GD (1998) Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs. J Nutr 128, 17861793.
Nie Y, Nakashima M, Brubaker PL, Li QL, Perfetti R, Jansen E, Zambre Y, Pipeleers D & Friedman TC (2000) Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. J Clin Invest 105, 955965.
Perrin IV, Marchesini M, Rochat FC, Schiffrin EJ & Schilter B (2003) Oligofructose does not affect the development of type 1 diabetes mellitus induced by dietary proteins in the diabetes-prone BB rat model. Diabetes Nutr Metab 16, 94101.
Piche T, des Varannes SB, Sacher-Huvelin S, Holst JJ, Cuber JC & Galmiche JP (2003) Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. Gastroenterology 124, 894902.
Reimer RA & McBurney MI (1996) Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats. Endocrinology 137, 39483956.
Roberfroid MB & Delzenne NM (1998) Dietary fructans. Annu Rev Nutr 18, 117143.
Robertson MD, Currie JM, Morgan LM, Jewell DP & Frayn KN (2003) Prior short-term consumption of resistant starch enhances post-prandial insulin sensitivity in healthy subjects. Diabetologia 46, 659665.
Schwartz GJ (2000) The role of gastrointestinal vagal afferents in the control of food intake: current prospects. Nutrition 16, 866873.
Stanley S, Wynne K & Bloom S (2004) Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am J Physiol (Gastrointest Liver Physiol) 286, G693G697.
Tappenden KA, Drozdowski LA, Thomson AB & McBurney MI (1998) Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats. Am J Clin Nutr 68, 118125.
Tourrel C, Bailbe D, Meile MJ, Kergoat M & Portha B (2001) Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in STZ-treated newborn rats resulting in persistently improved glucose homeostasis at adult age. Diabetes 50, 15621570.
Tschop M, Smiley DL & Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407, 908913.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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