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Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study

  • Raakel Luoto (a1) (a2), Kirsi Laitinen (a3) (a4), Merja Nermes (a1) and Erika Isolauri (a1) (a2)
Abstract

The perinatal nutritional environment impacts upon the health and well-being of mother and child also in the long term. The aim of the present study was to determine the safety and efficacy of perinatal probiotic-supplemented dietary counselling by evaluating pregnancy outcome and fetal and infant growth during the 24 months' follow-up. Altogether, 256 women were randomised at their first trimester of pregnancy into a control and a dietary intervention group. The intervention group received intensive dietary counselling provided by a nutritionist and were further randomised, double-blind to receive probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12; diet/probiotics) or placebo (diet/placebo). Firstly, probiotic intervention reduced the frequency of gestational diabetes mellitus (GDM); 13 % (diet/probiotics) v. 36 % (diet/placebo) and 34 % (control); P = 0·003. Secondly, the safety of this approach was attested by normal duration of pregnancies with no adverse events in mothers or children. No significant differences in prenatal or postnatal growth rates among the study groups were detected. Thirdly, distinctive effects of the two interventions were detected; probiotic intervention reduced the risk of GDM and dietary intervention diminished the risk of larger birth size in affected cases; P = 0·035 for birth weight and P = 0·028 for birth length. The results of the present study show that probiotic-supplemented perinatal dietary counselling could be a safe and cost-effective tool in addressing the metabolic epidemic. In view of the fact that birth size is a risk marker for later obesity, the present results are of significance for public health in demonstrating that this risk is modifiable.

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Corresponding author
*Corresponding author: Raakel Luoto, fax +358 2 313 1460, email raakel.luoto@utu.fi
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2 HT Sorensen , S Sabroe , KJ Rothman , (1997) Relation between weight and length at birth and body mass index in young adulthood: cohort study. BMJ 315, 1137.

3 TJ Parsons , C Power & O Manor (2001) Foetal and early life growth and body mass index from birth to early adulthood in 1958 British cohort: longitudinal study. BMJ 323, 13311335.

8 P Damm (2009) Future risk of diabetes in mother and child after gestational diabetes mellitus. Int J Gynaecol Obstet 104, Suppl. 1, 525526.

9 F Bäckhed , H Ding , T Wang , (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101, 1571815723.

10 PD Cani & NM Delzenne (2007) Gut microflora as a target for energy and metabolic homeostasis. Curr Opin Clin Nutr Metab Care 10, 729734.

11 RE Ley , PJ Turnbaugh , S Klein , (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 10221023.

13 M Kalliomäki , P Kirjavainen , E Eerola , (2001) Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol 107, 129134.

16 J Aaltonen , T Ojala , K Laitinen , (2008) Evidence of infant blood pressure programming by maternal nutrition during pregnancy: a prospective randomized controlled intervention study. J Pediatr 152, 7984.

17 W Becker , N Lyhne , AN Pedersen , (2004) Nordic nutrition recommendations 2004 – integrating nutrition and physical activity. Scand J Nutr 48, 178187.

20 J Schwager , MH Mohajeri , A Fowler , (2008) Challenges in discovering bioactives for the food industry. Curr Opin Biotechnol 19, 6672.

21 LC Douglas & ME Sanders (2008) Probiotics and prebiotics in dietetics practice. J Am Diet Assoc 108, 510521.

22 F He , H Morita , AC Ouwehand , (2002) Stimulation of the secretion of pro-inflammatory cytokines by Bifidobacterium strains. Microbial Immunol 46, 781785.

23 HR Christensen , H Frøkiær & JJ Pestka (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168, 171178.

24 MP Piccini , L Beloni , C Livi , (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nat Med 4, 10201024.

28 P Catalano (2002) The diabetogenic state of maternal metabolism in pregnancy. NeoReviews 3, e165e171.

30 C Druet & KK Ong (2008) Early childhood predictors of adult body composition. Best Pract Res Clin Endocrinol Metab 22, 489502.

31 CM Boney , A Verma , R Tucker , (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115, e290e296.

34 PD Cani , J Amar , MA Iglesias , (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 17611772.

36 PD Cani , S Possemiers , T Van de Wiele , (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58, 10911103.

41 ST Weiss (2005) Obesity: insight into the origins of asthma. Nat Immunol 6, 537539.

42 SA Shore (2008) Obesity and asthma: possible mechanism. J Allergy Clin Immunol 121, 10871093.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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