Skip to main content
×
Home
    • Aa
    • Aa

Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects

  • Anne C. Nilsson (a1), Elin V. Johansson-Boll (a1) and Inger M. E. Björck (a1)
Abstract
Abstract

Certain purified indigestible carbohydrates such as inulin have been shown to stimulate gut-derived hormones involved in glycaemic regulation and appetite regulation, and to counteract systemic inflammation through a gut microbiota-mediated mechanism. Less is known about the properties of indigestible carbohydrates intrinsic to food. The aim of this study was to investigate the possibility to affect release of endogenous gut hormones and ameliorate appetite control and glycaemic control by ingestion of a whole-grain cereal food product rich in NSP and resistant starch in healthy humans. In all, twenty middle-aged subjects were provided with a barley kernel-based bread (BB) or a reference white wheat bread during 3 consecutive days, respectively, in a randomised cross-over design study. At a standardised breakfast the following day (day 4), blood was collected for the analysis of blood (b) glucose regulation, gastrointestinal hormones, markers of inflammation and markers of colonic fermentation; 3 d of intervention with BB increased gut hormones in plasma (p) the next morning at fasting (p-glucagon-like peptide-1; 56 %) and postprandially (p-glucagon-like peptide-2; 13 % and p-peptide YY; 18 %). Breath H2 excretion and fasting serum (s) SCFA concentrations were increased (363 and 18 %, respectively), and b-glucose (22 %) and s-insulin responses (17 %) were decreased after BB intervention. Insulin sensitivity index (ISIcomposite) was also improved (25 %) after BB. In conclusion, 3 d of intervention with BB increased systemic levels of gut hormones involved in appetite regulation, metabolic control and maintenance of gut barrier function, as well as improved markers of glucose homoeostasis in middle-aged subjects, altogether relevant for the prevention of obesity and the metabolic syndrome.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: a randomised cross-over study in healthy middle-aged subjects
      Available formats
      ×
Copyright
Corresponding author
* Corresponding author: A. C. Nilsson, fax +46 46 222 45 32, email anne.nilsson@food-health-science.lu.se
References
Hide All
1. von RuestenA, FellerS, BergmannMM, et al. (2013) Diet and risk of chronic diseases: results from the first 8 years of follow-up in the EPIC-Potsdam study. Eur J Clin Nutr 67, 412419.
2. GroomsKN, OmmerbornMJ, PhamDQ, et al. (2013) Dietary fiber intake and cardiometabolic risks among US adults, NHANES 1999–2010. Am J Med 126, 10591067 (e1–4).
3. WuH, FlintAJ, QiQ, et al. (2015) Association between dietary whole grain intake and risk of mortality: two large prospective studies in US men and women. JAMA Intern Med 175, 373384.
4. Harris JacksonK, WestSG, Vanden HeuvelJP, et al. (2014) Effects of whole and refined grains in a weight-loss diet on markers of metabolic syndrome in individuals with increased waist circumference: a randomized controlled-feeding trial. Am J Clin Nutr 100, 577586.
5. CaniPD, EverardA & DuparcT (2013) Gut microbiota, enteroendocrine functions and metabolism. Curr Opin Pharmacol 13, 935940.
6. TolhurstG, HeffronH, LamYS, et al. (2012) Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes 61, 364371.
7. SamAH, TrokeRC, TanTM, et al. (2012) The role of the gut/brain axis in modulating food intake. Neuropharmacology 63, 4656.
8. HolstJJ (2007) The physiology of glucagon-like peptide 1. Physiol Rev 87, 14091439.
9. PersaudSJ & BewickGA (2014) Peptide YY: more than just an appetite regulator. Diabetologia 57, 17621769.
10. CaniPD, PossemiersS, Van de WieleT et al. (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58, 10911103.
11. DelzenneNM, NeyrinckAM & CaniPD (2013) Gut microbiota and metabolic disorders: how prebiotic can work? Br J Nutr 109, Suppl. 2, S81S85.
12. SchwartzTW & HolstB (2010) An enteroendocrine full package solution. Cell Metab 11, 445447.
13. PsichasA, SleethML, MurphyKG, et al. (2014) The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. Int J Obes (Lond) 39, 424429.
14. CaniPD, HosteS, GuiotY, et al. (2007) Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98, 3237.
15. CaniPD, LecourtE, DewulfEM, et al. (2009) Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal. Am J Clin Nutr 90, 12361243.
16. NilssonAC, ÖstmanEM, HolstJJ, et al. (2008) Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast. J Nutr 138, 732739.
17. JohanssonEV, NilssonAC, OstmanEM, et al. (2013) Effects of indigestible carbohydrates in barley on glucose metabolism, appetite and voluntary food intake over 16 h in healthy adults. Nutr J 12, 46.
18. NilssonA, JohanssonE, EkstromL, et al. (2013) Effects of a brown beans evening meal on metabolic risk markers and appetite regulating hormones at a subsequent standardized breakfast: a randomized cross-over study. PLoS ONE 8, e59985.
19. HolmJ, BjörckIME, DrewsA, et al. (1986) A rapid method for the analysis of starch. Starch/Stärke 38, 224226.
20. BjörckIME & SiljeströmMA (1992) In-vivo and in-vitro digestibility of starch in autoclaved pea and potato products. J Sci Food Agric 58, 541553.
21. ÅkerbergAK, LiljebergHG, GranfeldtYE, et al. (1998) An in vitro method, based on chewing, to predict resistant starch content in foods allows parallel determination of potentially available starch and dietary fiber. J Nutr 128, 651660.
22. AspN-G, JohanssonC-G, HallmerH, et al. (1983) Rapid enzymatic assay of insoluble and soluble dietary fiber. J Agric Food Chem 31, 476482.
23. BrighentiF (1998) Summary of the conclusion of the working group on profibre interlaboratory study on determination of short chain fatty acids in blood. In Functional Properties of Non-Digestible Carbohydrates, pp. 150153 [F Gullion, R Amadò, MT Amaral-Collaco, H Andersson, NG Asp, KEB Knudsen, M Champ, J Mathers, JA Robertson, I Rowland and JV Loo, editors]. Brussels: European Commission, DG XII, Science, Research and Development.
24. MatthewsDR, HoskerJP, RudenskiAS, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412419.
25. MatsudaM & DeFronzoRA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22, 14621470.
26. DeFronzoRA & MatsudaM (2010) Reduced time points to calculate the composite index. Diabetes Care 33, e93.
27. RobertsonMD, CurrieJM, MorganLM, et al. (2003) Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects. Diabetologia 46, 659665.
28. RobertsonMD, BickertonAS, DennisAL, et al. (2005) Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr 82, 559567.
29. WeickertMO, RodenM, IskenF, et al. (2011) Effects of supplemented isoenergetic diets differing in cereal fiber and protein content on insulin sensitivity in overweight humans. Am J Clin Nutr 94, 459471.
30. WeickertMO, MohligM, KoebnickC, et al. (2005) Impact of cereal fibre on glucose-regulating factors. Diabetologia 48, 23432353.
31. MansourA, HosseiniS, LarijaniB, et al. (2013) Nutrients related to GLP1 secretory responses. Nutrition 29, 813820.
32. HolstJJ & McGillMA (2012) Potential new approaches to modifying intestinal GLP-1 secretion in patients with type 2 diabetes mellitus: focus on bile acid sequestrants. Clin Drug Investig 32, 114.
33. EgerodKL, EngelstoftMS, GrunddalKV, et al. (2012) A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology 153, 57825795.
34. KajiI, KarakiS & KuwaharaA (2014) Short-chain fatty acid receptor and its contribution to glucagon-like peptide-1 release. Digestion 89, 3136.
35. FreelandKR & WoleverTMS (2010) Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α. Br J Nutr 103, 460466.
36. OrskovC, HartmannB, PoulsenSS, et al. (2005) GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors. Regul Pept 124, 105112.
37. CaniPD, AmarJ, IglesiasMA, et al. (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 17611772.
38. EverardA & CaniPD (2013) Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol 27, 7383.
39. CaniPD (2012) Crosstalk between the gut microbiota and the endocannabinoid system: impact on the gut barrier function and the adipose tissue. Clin Microbiol Infect 18, 5053.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 136
Total number of PDF views: 457 *
Loading metrics...

Abstract views

Total abstract views: 1531 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 22nd October 2017. This data will be updated every 24 hours.