1Giovannucci E (2002) Modifiable risk factors for colon cancer. Gastroenterol Clin North Am 31, 925–943.
2Martinez ME (2005) Primary prevention of colorectal cancer: lifestyle, nutrition, exercise. Recent Results Cancer Res 166, 177–211.
3Cummings JH & Bingham SA (1998) Diet and the prevention of cancer. Br Med J 317, 1636–1640.
4Food and Agriculture Organization of the United Nations and World Health Organization (2002) .
5Arimochi H, Kinouchi T, Kataoka K, Kuwahara T & Ohnishi Y (1997) Effect of intestinal bacteria on formation of azoxymethane-induced aberrant crypt foci in the rat colon. Biochem Biophys Res Commun 238, 753–757.
6Bolognani F, Rumney CJ, Pool-Zobel BL & Rowland IR (2001) Effect of lactobacilli, bifidobacteria and inulin on the formation of aberrant crypt foci in rats. Eur J Nutr 40, 293–300.
7Goldin BR, Gualtieri LJ & Moore RP (1996) The effect of Lactobacillus GG on the initiation and promotion of DMH-induced intestinal tumors in the rat. Nutr Cancer 25, 197–204.
8Marotta F, Naito Y, Minelli E, et al. (2003) Chemopreventive effect of a probiotic. Preparation on the development of preneoplastic and neoplastic colonic lesions: an experimental study. Hepato-gastroenterology 50, 1914–1918.
9McIntosh GH, Royle PJ & Playne MJ (1999) A probiotic strain of L-acidophilus reduces DMH-induced large intestinal tumors in male Sprague-Dawley rats. Nutr Cancer 35, 153–159.
10Yamazaki K, Tsunoda A, Sibusawa M, et al. (2000) The effect of an oral administration of Lactobacillus casei strain Shirota on azoxymethane-induced colonic aberrant crypt foci and colon cancer in the rat. Oncol Rep 7, 977–982.
11Wollowski I, Rechkemmer G & Pool-Zobel BL (2001) Protective role of probiotics and prebiotics in colon cancer. Am J Clin Nutr 73, 451S–455S.
12Hirayama K & Rafter J (2000) The role of probiotic bacteria in cancer prevention. Microbes Infect 2, 681–686.
13Commane D, Hughes R, Shortt C & Rowland I (2005) The potential mechanisms involved in the anti-carcinogenic action of probiotics. Mut Res 591, 276–289.
14Rafter J (2003) Probiotics and colon cancer. Best Pract Res Clin Gastroenterol 17, 849–859.
15Hanahan D & Weinberg RA (2000) The hallmarks of cancer. Cell 100, 57–70.
16Bedi A, Pasricha PJ, Akhtar AJ, et al. (1995) Inhibition of apoptosis during development of colorectal cancer. Cancer Res 55, 1811–1816.
17Baretton GB, Diebold J, Christoforis G, et al. (1996) Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas – aspects of carcinogenesis and prognostic significance. Cancer 77, 255–264.
18Moss SF, Scholes JV & Holt PR (1996) Abnormalities of epithelial apoptosis in multistep colorectal neoplasia demonstrated by terminal deoxyuridine nick end labeling. Dig Dis Sci 41, 2238–2247.
19Anti M, Armuzzi A, Morini S, et al. (2001) Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas. Gut 48, 238–246.
20Hughes R & Rowland IR (2001) Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon. Carcinogenesis 22, 43–47.
21Latham P, Lund EK & Johnson IT (1999) Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethylhydrazine, reduces mitosis and suppresses the induction of carcinogenesis in the rat colon. Carcinogenesis 20, 645–650.
22Le Leu RK, Brown IL, Hu Y, et al. (2005) A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon. J Nutr 135, 996–1001.
23Smith TK, Lund EK & Johnson IT (1998) Inhibition of dimethylhydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin. Carcinogenesis 19, 267–273.
24Jan G, Belzacq AS, Haouzi D, et al. (2002) Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria. Cell Death Differ 9, 179–188.
25Lan A, Lagadic-Gossmann D, Lemaire C, Brenner C & Jan G (2007) Acidic extracellular pH shifts colorectal cancer cell death from apoptosis to necrosis upon exposure to propionate and acetate, major end-products of the human probiotic propionibacteria. Apoptosis 12, 573–591.
26Lan A, Bruneau A, Philippe C, et al. (2007) Survival and metabolic activity of selected strains of Propionibacterium freudenreichii in the gastrointestinal tract of human microbiota-associated rats. Br J Nutr 97, 714–724.
27Coates ME (1968) The Germ-free Animal in Research. New York: Academic Press.
28Caderni G, Giannini A, Lancioni L, Luceri C, Biggeri A & Dolara P (1995) Characterisation of aberrant crypt foci in carcinogen-treated rats: association with intestinal carcinogenesis. Br J Cancer 71, 763–769.
29Hambly RJ, Saunders M, Rijken PJ & Rowland IR (2002) Influence of dietary components associated with high or low risk of colon cancer on apoptosis in the rat colon. Food Chem Toxicol 40, 801–808.
30Jan G, Leverrier P & Roland N (2002) Survival and beneficial effects of propionibacteria in the human gut: in vivo and in vitro investigations. Lait 82, 131–144.
31Rabot S, Szylit O, Nugon-Baudon L, et al. (2000) Variations in digestive physiology of rats after short duration flights aboard the US space shuttle. Dig Dis Sci 45, 1687–1695.
32Gavrieli Y, Sherman Y & Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119, 493–501.
33Hall PA, Levison DA, Woods AL, et al. (1990) Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J Pathol 162, 285–294.
34Gallaher DD & Khil J (1999) The effect of synbiotics on colon carcinogenesis in rats. J Nutr 129, 1483S–1487S.
35Davenport HW (1977) Physiology of the Digestive Tract, 4th ed.Chicago: Year Book Medical Publishers.
36Tsujitani S, Shirai H, Tatebe S, et al. (1996) Apoptotic cell death and its relationship to carcinogenesis in colorectal carcinoma. Cancer 77, 1711–1716.
37Johnson IT (2002) Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosa. Food Chem Toxicol 40, 1171–1178.
38Djouzi Z, Andrieux C, Degivry MC, Bouley C & Szylit O (1997) The association of yogurt starters with Lactobacillus casei DN 114.001 in fermented milk alters the composition and metabolism of intestinal microflora in germ-free rats and in human flora-associated rats. J Nutr 127, 2260–2266.
39Humblot C, Lhoste E, Knasmuller S, et al. (2004) Protective effects of Brussels sprouts, oligosaccharides and fermented milk towards 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced genotoxicity in the human flora associated F344 rat: role of xenobiotic metabolising enzymes and intestinal microflora. J Chromatogr B Analyt Technol Biomed Life Sci 802, 231–237.
40Imaoka A, Setoyama H, Takagi A, Matsumoto S & Umesaki Y (2004) Improvement of human faecal flora-associated mouse model for evaluation of the functional foods. J Appl Microbiol 96, 656–663.
41Kleessen B, Hartmann L & Blaut M (2001) Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora. Br J Nutr 86, 291–300.
42Nigro ND (1985) Animal model for colorectal cancer. Prog Clin Biol Res 186, 161–173.
43Smith TK, Mithen R & Johnson IT (2003) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcinogenesis 24, 491–495.
44Ijiri K (1989) Apoptosis (cell death) induced in mouse bowel by 1,2-dimethylhydrazine, methylazoxymethanol acetate, and gamma-rays. Cancer Res 49, 6342–6346.
45Sunter JP, Watson AJ & Appleton DR (1981) Kinetics of the non-neoplastic mucosa of the large bowel of dimethylhydrazine-treated rats. Br J Cancer 44, 35–44.
46Carter JW, Lancaster HK, Hardman WE & Cameron IL (1994) Distribution of intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of 1,2-dimethylhydrazine-treated mice. Cancer Res 54, 4304–4307.
47Riss TL (2001) Apoptosis as a biomarker in chemoprevention trials. Urology 57, 141–142.
48Potten CS (1992) The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev 11, 179–195.
49Bravo R & Donald-Bravo H (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 105, 1549–1554.
50Femia AP, Luceri C, Dolara P, et al. (2002) Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23, 1953–1960.
51Huang Y & Adams MC (2003) An in vitro model for investigating intestinal adhesion of potential dairy propionibacteria probiotic strains using cell line C2BBe1. Lett Appl Microbiol 36, 213–216.
52Zarate G, Morata D, Chaia AP & Gonzalez SN (2002) Adhesion of dairy propionibacteria to intestinal epithelial tissue in vitro and in vivo. J Food Prot 65, 534–539.
53Avice JC, Ourry A, Laine P, et al. (1999) A rapid and reliable method for NO quantification and 15NO/14NO determination using isotope ratio mass spectrometry: an application for the detection of NO synthesis in propionibacteria. Rapid Commun Mass Spectrom 13, 1197–1200.
54Monteiro HP, Silva EF & Stern A (2004) Nitric oxide: a potential inducer of adhesion-related apoptosis–anoikis. Nitric Oxide 10, 1–10.