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Indicators of zinc status at the population level: a review of the evidence

  • Rosalind S. Gibson (a1), Sonja Y. Hess (a2), Christine Hotz (a3) and Kenneth H. Brown (a2) (a4)
  • DOI:
  • Published online: 01 June 2008

The role of zinc deficiency as an important cause of morbidity and impaired linear growth has prompted the need to identify indicators of population zinc status. Three indicators have been recommended – prevalence of zinc intakes below the estimated average requirement (EAR), percentage with low serum zinc concentrations, and percentage of children aged < 5 years who are stunted. This review outlines steps to estimate the prevalence of inadequate intakes, and confirm their validity based on the EARs set by International Zinc Nutrition Collaborative Group. Next, the appropriateness of serum zinc as a biochemical marker for population zinc status is confirmed by a summary of: (a) the response of serum zinc concentrations to zinc intakes; (b) usefulness of serum zinc concentrations to predict functional responses to zinc interventions; (c) relationship between initial serum zinc and change in serum zinc in response to interventions. Height- or length-for-age was chosen as the best functional outcome after considering the responses of growth, infectious diseases (diarrhoea, pneumonia), and developmental outcomes in zinc supplementation trials and correlation studies. The potential of other zinc biomarkers such as zinc concentrations in hair, cells, zinc-metalloenzymes, and zinc-binding proteins, such as metallothionein, is also discussed. Molecular techniques employing reverse transcriptase (RT)-polymerase chain reaction to measure mRNA in metallothionein and ZIP1 transporter hold promise, as do kinetic markers such as exchangeable zinc pools (EZP) and plasma zinc turnover rates. More research is needed to establish the validity, specificity, sensitivity, and feasibility of these new biomarkers, especially in community-settings.

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*Corresponding author: Rosalind S. Gibson, fax +64-3-479-7958 (Office), email Rosalind.Gibson@Stonebow.Otago.AC.NZ
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3SH Zlotkin & MG Cherian (1988) Hepatic metallothionein as a source of zinc and cysteine during the first year of life. Pediatr Res 24, 326329.

6MS Houston , SL Summers & KS Soltesz (1997) Lifestyle and dietary practices influencing iron status in university students. Nutr Res 17, 922.

9UM Donovan & RS Gibson (1995) Iron and zinc status of young women aged 14 to 19 years consuming vegetarian and omnivorous diets. J Am Coll Nutr 14, 463472.

13JD Skinner , BR Carruth , KS Houck & F Coletta (1997) Longitudinal study of nutrient and food intakes of infants aged 2 to 24 months. JADA 97, 496505.

17C Hotz (2007) Dietary indicators for assessing the adequacy of population zinc intakes. Food Nutr Bull 28, S430S448.

22JP Liuzzi & RJ Cousins (2004) Mammalian zinc transporters. Ann Rev Nutr 24, 151172.

23SY Hess , JM Peerson , JC King & KH Brown (2007) Use of serum zinc concentration as an indicator of population zinc status. Food Nutr Bull 28, S403S429.

31S Van Biervliet , JP Van Biervliet , D Bernard , R Vercaemst & V Blaton (2003) Serum zinc in healthy Belgian children. Biol Trace Elem Res 94, 3340.

34CL Fischer Walker & RE Black (2007) Functional indicators for assessing zinc deficiency. Food Nutr Bull 28, S454S479.

36E Yokoi , NG Egger , VMS Ramanujam , NW Alcock , HH Dayal , JG Penland & HH Sandstead (2003) Association between plasma zinc concentration and zinc kinetic parameters in premenopausal women. Am J Physiol Endocrinol Metab 285, E1010E1020.

45CW Bales , RA DiSilvestro , KL Currie , CS Plaisted , H Joung , AN Galanos & PH Lin (1994) Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. J Am Coll Nutr 13, 455462.

48A Grider , LB Bailey & RJ Cousins (1990) Erythrocyte metallothionein as an index of zinc status in humans. Proc Natl Acad Sci USA 87, 12591262.

50AS Prasad , S Meftah , J Abdallah , J Kaplan , GJ Brewer , JF Bach & M Dardenne (1988) Serum thymulin in human zinc deficiency. J Clin Invest 82, 12021210.

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