Armitage, JA, Lakasing, L, Taylor, PD, Balachandran, AA, Jensen, RI, Dekou, V, Ashton, N, Nyengaard, JR & Poston, L (2005) Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy. J Physiol. 565, 171–184.
Bateson, P, Barker, D, Clutton-Brock, T, Deb, D, D'Udine, B, Foley, RA, Gluckman, P, Godfrey, K, Kirkwood, T, Lahr, MM, McNamara, J, Metcalfe, NB, Monaghan, P, Spencer, HG & Sultan, SE (2004) Developmental plasticity and human health. Nature 430, 419–421.
Benvenisty, N, Mencher, D, Meyuhas, O, Razin, A & Reshef, L (1985) Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development. Proc Natl Acad Sci USA 82, 267–271.
Bertram, C, Trowern, AR, Copin, N, Jackson, AA & Whorwood, CB (2001) The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11beta-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 142, 2841–2853.
Bird, A (2001) DNA methylation patterns and epigenetic memory. Genes Dev 16, 6–21.
Biniszkiewicz, D, Gribnau, J, Ramsahoye, B, Gaudet, F, Eggan, K, Humpherys, D, Mastrangelo, MA, Jun, Z, Walter, J & Jaenisch, R (2002) Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol 22, 2124–2135.
Boyd, KE & Farnham, P (1999) Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol Cell Biol 19, 8393–8399.
Burdge, GC, Phillips, ES, Dunn, RL, Jackson, AA & Lillycrop, KA (2004) Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferator-activated receptors in the liver and adipose tissue of the offspring. Nutr Res 24, 639–646.
Burns, SP, Desai, M, Cohen, RD, Hales, CN, Iles, RA, Germain, JP, Going, TC & Bailey, RA (1997) Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest 100, 1768–1774.
Bustin, SA (2000) Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25, 169–193.
Desai, M, Byrne, CD, Meeran, K, Martenz, ND, Bloom, SR & Hales, CN (1997) Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. Am J Physiol 273, G899–G904.
Detich, N, Theberge, J & Szyf, M (2002) Promoter-specific activation and demethylation by MBD2/demethylase. J Biol Chem 277, 35791–35794.
Fuks, F, Hurd, PJ, Wolf, D, Nan, X, Bird, AP & Kouzarides, T (2003) The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation. J Biol Chem 278, 4035–4040.
Ghoshal, K, Li, X, Datta, J, Bai, S, Pogribny, I, Pogribny, M, Huang, Y, Young, D & Jacob, ST (2006) A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr 136, 1522–1527.
Gidekel, S & Bergman, Y (2002) A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a cis-demodification element. J Biol Chem 277, 34521–34530.
Godfrey, KM & Barker, DJ (2001) Fetal programming and adult health. Public Health Nutr 4, 611–624.
Godfrey, K, Walker-Bone, K, Robinson, S, Taylor, P, Shore, S, Wheeler, T & Cooper, C (2001) Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Min Res 16, 1694–1703.
Grainger, RM, Hazard-Leonards, RM, Samaha, F, Hougan, LM, Lesk, MR & Thomsen, GH (1983) Is hypomethylation linked to activation of delta-crystallin genes during lens development? Nature 306, 88–91.
Harris, RG, White, E, Phillips, ES & Lillycrop, KA (2002) The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc. J Biol Chem 277, 34815–34825.
Hershko, AY, Kafri, T, Fainsod, A & Razin, A (2003) Methylation of HoxA5 and HoxB5 and its relevance to expression during mouse development. Gene 302, 65–72.
Jackson, AA, Dunn, RL, Marchand, MC & Langley-Evans, SC (2002) Increased systolic blood pressure in rats induced by a maternal low-protein diet is reversed by dietary supplementation with glycine. Clin Sci (Lond) 103, 633–639.
James, SJ, Melnyk, S, Pogribna, M, Pogribny, IP & Caudill, MA (2002) Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132, Suppl, 2361S–2366S.
Kwong, WY, Wild, AE, Roberts, P, Willis, AC & Fleming, TP (2000) Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension. Development 127, 4195–4202.
Lachner, M, O'Carroll, D, Rea, S, Mechtler, K & Jenuwein, T (2001) Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410, 116–120.
Langley, SC & Jackson, AA (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin Sci (Lond) 86, 217–222.
Langley-Evans, SC (1997) Hypertension induced by fetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. J Hypertens 15, 537–544.
Langley-Evans, SC, Gardner, DS & Jackson, AA (1996) Maternal protein restriction influences the programming of the rat hypothalamic-pituitary-adrenal axis. J Nutr 126, 1578–1585.
Leu, YW, Rahmatpanah, F, Shi, H, Wei, SH, Liu, JC, Yan, PS & Huang, TH (2003) Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. Cancer Res 63, 6110–6115.
Lillycrop, KA, Phillips, ES, Jackson, AA, Hanson, MA & Burdge, GC (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135, 1382–1386.
Litt, MD, Simpson, M, Gaszner, M, Allis, CD & Felsenfeld, G (2001) Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus. Science 293, 2453–2455.
Maloney, CA, Gosby, AK, Phuyal, JL, Denyer, GS, Bryson, JM & Caterson, ID (2003) Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in utero. Obes Res 11, 461–468.
McCormick, JA, Lyons, V, Jacobson, MD, Noble, J, Diorio, J, Nyirenda, M, Weaver, S, Ester, W, Yau, JL, Meaney, MJ, Seckl, JR & Chapman, KE (2000) 5′-Heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol Endocrinol 14, 506–517.
Milutinovic, S, Zhuang, Q, Niveleau, A & Szyf, M (2003) Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem 278, 14985–14995.
Nakayama, J, Rice, JC, Strahl, BD, Allis, CD & Grewal, SI (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292, 110–113.
Nyirenda, MJ, Lindsay, RS, Kenyon, CJ, Burchell, A & Seckl, JR (1998) Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 101, 2174–2181.
Petrie, L, Duthie, SJ, Rees, WD & McConnell, JM (2002) Serum concentrations of homocysteine are elevated during early pregnancy in rodent models of fetal programming. Br J Nutr 88, 471–477.
Ravelli, AC, van der Meulen, JH, Michels, RP, Osmond, C, Barker, DJ, Hales, CN & Bleker, OP (1998) Glucose tolerance in adults after prenatal exposure to famine. Lancet 351, 173–177.
Reik, W, Dean, W & Walter, J (2001) Epigenetic reprogramming in mammalian development. Science 293, 1089–1093.
Remacle, C, Bieswal, F & Reusens, B (2004) Programming of obesity and cardiovascular disease. Int J Obes Relat Metab Disord 28, Suppl 3, S46–S53.
Rhee, I, Jair, KW, Yen, RW, Lengauer, C, Herman, JG, Kinzler, KW, Vogelstein, B, Baylin, SB & Schuebel, KE (2000) CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404, 1003–1007.
Robertson, KD, Ait-Si-Ali, S, Yokochi, T, Wade, PA, Jones, PL & Wolffe, AP (2000) Dnmt1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25, 338–342.
Stancheva, I, Hensey, C & Meehan, RR (2001) Loss of the maintenance methyltransferase, xDnmt1, induces apoptosis in Xenopus embryos. EMBO J 20, 1963–1973.
Stancheva, I & Meehan, RR (2000) Transient depletion of xDnmt1 leads to premature gene activation in Xenopus embryos. Genes Dev 14, 313–327.
Strahl, BD, Ohba, R, Cook, RG & Allis, CD (1999) Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Proc Natl Acad Sci USA 96, 14967–14972.
Terzolo, M, Allasino, B, Bosio, S, Brusa, E, Daffara, F, Ventura, M, Aroasio, E, Sacchetto, G, Reimondo, G, Angeli, A & Camaschella, C (2004) Hyperhomocysteinemia in patients with Cushing's syndrome. J Clin Endocrinol Metab 89, 3745–3751.
Torrens, C, Brawley, L, Anthony, FW, Dance, CS, Dunn, R, Jackson, AA, Poston, L & Hanson, MA (2006) Folate supplementation during pregnancy improves offspring cardiovascular dysfunction induced by protein restriction. Hypertension 47, 982–987.
Turner, BM (2000) Histone acetylation and an epigenetic code. Bioessays 22, 836–845.
Turner, JD & Muller, CP (2005) Structure of the glucocorticoid receptor (NR3C1) gene 5′ untranslated region: identification, and tissue distribution of multiple new human exon 1. J Mol Endocrinol 35, 283–292.
Vickers, MH, Gluckman, PD, Coveny, AH, Hofman, PL, Cutfield, WS, Gertler, A, Breier, BH & Harris, M (2005) Neonatal leptin treatment reverses developmental programming. Endocrinology 146, 4211–4216.
Zegerman, P, Canas, B, Pappin, D & Kouzarides, T (2002) Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex. J Biol Chem 277, 11621–11624.