Hostname: page-component-7dd5485656-bt4hw Total loading time: 0 Render date: 2025-11-02T20:23:23.382Z Has data issue: false hasContentIssue false
  • English
  • Français

Influence of grapefruit-, orange- and apple-juice consumption on urinary variables and risk of crystallization

Published online by Cambridge University Press:  09 March 2007

Ruth Hönow ,
Norbert Laube ,
Anke Schneider ,
Torsten Keßler  and
Albrecht Hesse
Ruth Hönow*
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str 25, D-53 105 Bonn, Germany
Norbert Laube
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str 25, D-53 105 Bonn, Germany
Anke Schneider
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str 25, D-53 105 Bonn, Germany
Torsten Keßler
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str 25, D-53 105 Bonn, Germany
Albrecht Hesse
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str 25, D-53 105 Bonn, Germany
*
*Corresponding author: Dr Ruth Hönow, fax +49 228 287 6344, email Hoenow@uni-bonn.de
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Alkalizing beverages are highly effective in preventing the recurrence of calcium oxalate (Ox), uric acid and cystine lithiasis. The aim of the present study was to evaluate the influence of grapefruit-juice and apple-juice consumption on the excretion of urinary variables and the risk of crystallization in comparison with orange juice. All investigations were carried out on nine healthy female subjects without any history of stone formation and aged 26–35 years. Each juice was tested in a 5 d study. During the study, the subjects received a standardized diet. Fluid intake of 2·75 litres was composed of 2·25 litres neutral mineral water, 0·4 litre coffee and 0·1 litre milk. On the fourth and fifth day 0·5 litre mineral water was partly substituted by 0·5 or 1·0 litre juice under investigation respectively. The influence on urinary variables was evaluated in 24 h urine samples. In addition, the BONN risk index of CaOx, relative supersaturation (RS)CaOx crystallization was determined. Due to an increased pH value and an increased citric acid excretion after consumption of each juice, the RSCaOx decreased statistically significantly (P<0·05) for grapefruit juice, but not significantly for orange and apple juice. The BONN risk index yielded a distinct decrease in the crystallization risk. We showed that both grapefruit juice and apple juice reduce the risk of CaOx stone formation at a magnitude comparable with the effects obtained from orange juice.

Keywords

Grapefruit juiceApple juiceOrange juiceRelative supersaturationAlkalizing beveragesBONN risk index

Information

Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 2 , August 2003 , pp. 295 - 300
Copyright
Copyright © The Nutrition Society 2003

References

Ameer, B & Weintraub, RA (1997) Drug interaction with grapefruit juice. Clin Pharmacokinet 33, 102–121.CrossRefGoogle ScholarPubMed
Curhan, GC, Willett, WC, Rimm, EB, Spiegelman, D & Stampfer, MJ (1996) Prospective study of beverage use and the risk of kidney stones. Am J Epidemiol 143, 240–247.CrossRefGoogle ScholarPubMed
Curhan, GC, Willett, WC, Speizer, PE & Stampfer, MJ (1998) Beverage use and risk for kidney stones in women. Ann Int Med 128, 534–540.CrossRefGoogle ScholarPubMed
Deutsche Gesellschaft für Ernährung (1996) In Empfehlungen für die Nährstoffzufuhr (Recommendations for Nutrient Intakes). Frankfurt: Deutsche Gesellschaft für Ernährung.Google Scholar
Finlayson, B (1977) Calcium stones: some physical and clinical aspects. In Calcium Metabolism in Renal Failure and Nephrolithiasis. pp. 337–382. [David, DS, editor]. New York, London, Sydney, Toronto: J Wiley & Sons.Google Scholar
Fuhr, U & Kummert, AL (1995) The fate of naringin in humans: a key to grapefruit juice–drug interactions? Clin Pharm Ther 58, 365–373.CrossRefGoogle ScholarPubMed
Goldfarb, DS & Asplin, JR (2000) Effect of grapefruit on urinary lithogenicity. In Urolithiasis, pp. 317–318. [Rodgers, AL, Hibbert, BE, Hess, B, Khan, SR & Preminger, GM, editors]. Cape Town: University of Cape Town.Google Scholar
Goldfarb, DS & Asplin, JR (2001) Effect of grapefruit juice on urinary lithogenicity. J Urol 166, 263–267.CrossRefGoogle ScholarPubMed
Goldfarb, DS & Coe, FL (1999) Beverages, diet, and prevention of kidney stones. Am J Kidney Dis 33, 398–403.CrossRefGoogle ScholarPubMed
Hesse, A & Bach, D (1982) Harnsteine, pathochemie und klinische-chemische diagnostik (Urinary stones, pathochemistry and clinical chemical diagnostics). In Klinische Chemie und Einzeldarstellung V. pp. 33–38. [Breuer, H, Büttner, H & Stamm, D, editors]. Stuttgart, New York: Georg Thieme Verlag. ((Clinical Chemistry and Single Cases))Google Scholar
Hesse, A & Siener, R (1997) Current aspects of epidemiology and nutrition in urinary stone disease. World J Urol 15, 165–171.CrossRefGoogle ScholarPubMed
Hesse, A, Siener, R, Heynck, H & Jahnen, A (1993) The influence of dietary factors on the risk of urinary stone formation. Scanning Microsc 7, 1110–1128.Google ScholarPubMed
Hesse, A, Tiselius, HG & Jahnen, A (1997) In Urinary Stones, Diagnosis, Treatment and Prevention of Recurrence. Basel, Freiburg, Paris, London, New York, New Dehli, Bangkok, Singapore, Tokyo, Sydney: Karger.Google Scholar
Hönow, R, Bongartz, D & Hesse, A (1997) An improved HPLC-enzyme-reactor method for the determination of oxalic acid in complex matrices. Clin Chim Acta 261, 131–139.CrossRefGoogle ScholarPubMed
Laube, N, Hergarten, S & Hesse, A (2001) Testing the predictability of the relative urinary supersaturation from the BONN-Risk-Index for calcium-oxalate stone formation. Clin Chem Lab Med 39, 966–969.CrossRefGoogle ScholarPubMed
Laube, N, Hergarten, S & Hesse, A (2002) Comparison of laser-probe and photometer-based determinations of the urinary crystallization risk of calcium oxalate. Clin Chem Lab Med 40, 595–599.CrossRefGoogle ScholarPubMed
Laube, N, Schneider, A & Hesse, A (2000) A new approach to calculate the risk of calcium oxalate crystallization from unprepared native urine. Urol Res 28, 274–280.CrossRefGoogle ScholarPubMed
Nicar, MJ, Hill, K & Pak, CYC (1983) A simple technique for assessing the propensity for crystallization of calcium oxalate and brushite in urine from the increment in oxalate or calcium necessary to elicit precipitation. Metabolism 32, 906CrossRefGoogle ScholarPubMed
Trinchieri, A, Lizzano, R, Bernardini, P et al. (2002) Effect of acute load of grapefruit juice on urinary excretion of citrate and urinary risk factors for renal stone formation. Dig Liv Dis 34, pp. 160–161.CrossRefGoogle ScholarPubMed
Vahlensieck, W (1986) Review: The importance of diet in urinary stones. Urol Res 14, 283–288.CrossRefGoogle ScholarPubMed
Wabner, CL & Pak, CYC (1993) Effect of orange juice consumption on urinary stone risk factors. J Urol 149, 1405–1408.CrossRefGoogle ScholarPubMed
Weber, A, Jager, R & Borner, A (1996) Can grapefruit juice influence ethinylestradiol bioavailability? Contraception 53, 41–47.CrossRefGoogle ScholarPubMed
Werness, PG, Brown, CM, Smith, LH & Finlayson, B (1985) Equil 2: A basic computer program for the calculation of urinary saturation. J Urol 134, 1242–1244.CrossRefGoogle Scholar