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Ingestion of the soluble dietary fibre, polydextrose, increases calcium absorption and bone mineralization in normal and total-gastrectomized rats

Published online by Cambridge University Press:  09 March 2007

Hiroshi Hara ,
Takuya Suzuki  and
Yoritaka Aoyama
Hiroshi Hara*
Affiliation:
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
Takuya Suzuki
Affiliation:
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
Yoritaka Aoyama
Affiliation:
Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
*
*Corresponding author: Dr Hiroshi Hara, fax +81 11 706 2504 or +81 11 716 0879, email hara@chem.agr.hokudai.ac.jp
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Abstract

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We previously demonstrated that feeding a highly fermentable and water-soluble dietary fibre, guar-gum hydrolysate (GGH) increased intestinal absorption of insoluble Ca salts in total-gastrectomized rats. In the present study, we examined the effects of feeding a less fermentable and water-soluble fibre, polydextrose (PD), on Ca absorption and bone mineralization in the normal and total-gastrectomized rats in comparison with the effects of GGH. Apparent Ca absorption was severely lowered by gastrectomy, and PD feeding (50 g/kg diet) partially restored the reduction of Ca absorption similarly to GGH feeding (50 g/kg diet). PD feeding also increased the Ca absorption in normal rats, but not GGH feeding. Femur Ca concentration was reduced with gastrectomy. Feeding PD for 21 d increased the bone Ca concentration in both normal and gastrectomized rats, but GGH feeding did not. In rats fed PD, pH of the caecal contents was lower than in rats fed fibre-free and GGH diets; however, soluble Ca concentration in the caecal contents was not different between the diet groups. Short-chain fatty acid concentrations were much lower in the PD groups than in the GGH groups. We also examined in vitro Ca absorption by using everted sacs of the small intestine. Addition of PD to the serosal medium of the ileal sacs increased Ca absorption, but addition of GGH did not. These results suggest that the small intestine rather than the large intestine is responsible for the increase in Ca absorption in rats fed PD, and suggests that the mechanism for the increase by PD may be different from that by GGH.

Keywords

Calcium absorptionBone mineralizationPolydextroseDietary fibre
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 655 - 661
Copyright
Copyright © The Nutrition Society 2000

References

Achour, L, Fourie, B, Briet, F, Pellier, P, Marteau, P and Rambaud, JC (1994) Gastrointestinal effects and energy value of polydextrose in healthy nonobese men.American Journal of Clinical Nutrition 59, 1362–1368.CrossRefGoogle ScholarPubMed
American Institute of Nutrition(1977) Report of the American Institute of Nutrition. ad hoc committee on standards for nutritional studies.Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
American Institute of Nutrition(1980) Second report of the.ad hoc committee on standards for nutritional studies.Journal of Nutrition 110, 1726.CrossRefGoogle Scholar
Armbrecht, HJ and Wasserman, RH (1976) Enhancement of Ca++ uptake by lactose in the rat small intestine.Journal of Nutrition 106, 1265–1271.CrossRefGoogle ScholarPubMed
Bamba, T, Fuse, K, Chun, W and Hosoda, S (1993) Polydextrose and activities of brush-border membrane enzymes of small intestine in rats and glucose absorption in humans.Nutrition 9, 233–236.Google ScholarPubMed
Duncan, DB (1995) Multiple range and multiple F tests.Biometrics 11, 1–42.CrossRefGoogle Scholar
Goda, T, Takase, S and Hosoya, N (1993) Maltitol-induced increase of transepithelial transport of calcium in rat small intestine.Journal of Nutritional Science and Vitaminology 39, 589–595.CrossRefGoogle ScholarPubMed
Hara, H, Nagata, M, Ohta, A and Kasai, T (1996) Increases in calcium absorption with ingestion of soluble dietary fibre, guar-gum hydrolysate, depend on the caecum in partially nephrectomized and normal rats.British Journal of Nutrition 76, 773–784.CrossRefGoogle ScholarPubMed
Hara, H, Saito, Y, Nakashima, H and Kiriyama, S (1994) Evaluation of fermentability of acid-treated maize husk by rat caecal bacteria in vivo and in vitro.British Journal of Nutrition 71, 719–729.CrossRefGoogle ScholarPubMed
Hara, H, Suzuki, T, Kasai, T, Aoyama, Y and Ohta, A (1999) Ingestion of guar-gum hydrolysate partially restores calcium absorption in the large intestine lowered by suppression of gastric acid secretion in rats.British Journal of Nutrition 81, 315–321.CrossRefGoogle ScholarPubMed
Harper, AE (1959) Amino acid balance and imbalance. 1. Dietary level of protein and amino acid imbalance.Journal of Nutrition 68, 405–418.CrossRefGoogle Scholar
Juhr, NC and Franke, J (1992) A method for estimating the available energy of incompletely digested carbohydrates in rats.Journal of Nutrition 122, 1425–1433.CrossRefGoogle ScholarPubMed
Karbach, U and Feldmeier, H (1993) The cecum is the site with the highest calcium absorption in rat intestine.Digestive Diseases and Sciences 38, 1815–1824.CrossRefGoogle ScholarPubMed
Koga, S, Nishimura, O, Iwai, N, Kishi, K, Takeuchi, T, Hinohara, T and Okamoto, T (1979) Clinical evaluation of long-term survival after total gastrectomy.Americal Journal of Surgery 138, 635–639.CrossRefGoogle ScholarPubMed
Lambert, R (1965) Gastrectomy in the rat Surgery of the Digestive System in Rats,English version , pp. 327–365. Springfield, IL: Charles C Thomas.Google Scholar
Nilas, L, Christiansen, C and Christiansen, J (1985) Regulation of vitamin D and calcium metabolism after gastrectomy.Gut 26, 252–257.CrossRefGoogle ScholarPubMed
Ogata, S, Fujimoto, K, Iwakiri, R, Matsunaga, C, Ogawa, Y, Koyama, T and Sakai, T (1997) Effect of polydextrose on absorption of triglyceride and cholesterol in mesenteric lymph-fistula rats.Proceedings of the Society for Experimental Biology & Medicine 215, 53–58.CrossRefGoogle ScholarPubMed
Ohta, A, Baba, S, Ohtsuki, M, Takizawa, T, Adachi, T and Hara, H (1997) In vivo absorption of calcium carbonate and magnesium oxide from the large intestine in rats.Journal of Nutritional Science and Vitaminology 43, 35–46.CrossRefGoogle ScholarPubMed
Ohta, A, Ohtsuki, M, Hosono, A, Adachi, T, Hara, H and Sataka, T (1998) Dietary fructooligosaccharides prevent osteopenia after gastrectomy in rats.Journal of Nutrition 128, 106–110.CrossRefGoogle ScholarPubMed
Reeves, PG (1989) AIN-76 diet, should we change the formulation?.Journal of Nutrition 119, 1081–1082.CrossRefGoogle ScholarPubMed
Suzuki, T, Hara, H, Kasai, T and Tomita, F (1998) Effects of difructose anhydride III on calcium absorption in small and large intestines of rats.Bioscience Biotechnology and Biochemistry 62, 837–841.CrossRefGoogle ScholarPubMed
Takahashi, H, Yang, SI, Kim, M and Yamamoto, T (1994) Protein and energy utilization of growing rats fed on the diets containing intact or partially hydrolyzed guar gum.Comparative Biochemistry and Physiology 107A, 255–260.Google Scholar
Trinidad, TP, Wolever, TM and Thompson, LU (1996) Effect of acetate and propionate on calcium absorption from the rectum and distal colon of humans.American Journal of Clinical Nutrition 63, 574–578.CrossRefGoogle ScholarPubMed
Yoshioka, M, Shimomura, Y and Suzuki, M (1994) Dietary polydextrose affects the large intestine in rats.Journal of Nutrition 124, 539–547.CrossRefGoogle ScholarPubMed
Younes, H, Demigné C and Rémésy C (1996) Acidic fermentation in the caecum increases absorption of calcium and magnesium in the large intestine of the rat.British Journal of Nutrition 75, 301–314.CrossRefGoogle ScholarPubMed