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7 JW Miller , MG Garrod , AL Rockwood , MM Kushnir , LH Allen , MN Haan & R Green (2006) Measurement of total vitamin B12 and holotranscobalamin, singly and in combination, in screening for metabolic vitamin B12 deficiency. Clin Chem 52, 278–285.
9 AL Morkbak , RM Heimdal , K Emmens , A Molloy , AM Hvas , J Schneede , R Clarke , JM Scott , PM Ueland & E Nexo (2005) Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project. Clin Chem Lab Med 43, 1058–1064.
10 AM Hvas & E Nexo (2005) Holotranscobalamin – a first choice assay for diagnosing early vitamin B deficiency? J Intern Med 257, 289–298.
12 M Wolters , A Strohle & A Hahn (2004) Cobalamin: a critical vitamin in the elderly. Prev Med 39, 1256–1266.
17 S Liu , R West , E Randell , (2004) A comprehensive evaluation of food fortification with folic acid for the primary prevention of neural tube defects. BMC Pregnancy Childbirth 4, 20–29.
25 M Eichholzer , O Tonz & R Zimmermann (2006) Folic acid: a public-health challenge. Lancet 367, 1352–1361.
26 LD Botto , A Lisi , E Robert-Gnansia , (2005) International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working? BMJ 330, 571–576.
28 MA Honein , LJ Paulozzi , TJ Mathews , JD Erickson & L-YC Wong (2001) Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 285, 2981–2986.
29 P De Wals , F Tairou , MI Van Allen , (2007) Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357, 135–142.
30Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke. JAMA 288, 2015–2022.
31 DS Wald , M Law & JK Morris (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 325, 1202–1208.
32 P Frosst , HJ Blom , R Milos , (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10, 111–113.
33 B Wilcken , F Bamforth , Z Li , (2003) Geographical and ethnic variation of the 677C>T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet 40, 619–625.
34 M Klerk , P Verhoef , R Clarke , HJ Blom , FJ Kok & EG Schouten (2003) MTHFR 677C>T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 288, 2023–2031.
35 SJ Lewis , S Ebrahim & G Davey Smith (2005) Meta-analysis of MTHFR 677C → T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate. BMJ 331, 1053–1056.
36 Q Yang , LD Botto , JD Erickson , RJ Berry , C Sambell , H Johansen & JM Friedman (2006) Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation 113, 1335–1343.
37 X Wang , X Qin , H Demirtas , J Li , G Mao , Y Huo , N Sun , L Liu & X Xu (2007) Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Lancet 369, 1876–1882.
40 BF Cole , JA Baron , RS Sandler , (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297, 2351–2359.
41 JA McMahon , TJ Green , CM Skeaff , RG Knight , JI Mann & SM Williams (2006) A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 354, 2764–2772.
42 J Durga , MP van Boxtel , EG Schouten , FJ Kok , J Jolles , MB Katan & P Verhoef (2007) Effect of 3-year folic acid supplementation on cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 369, 208–216.
43 Y Sato , Y Honda , J Iwamoto , T Kanoko & K Satoh (2005) Effect of folate and mecobalamin on hip fractures in patients with stroke: a randomized controlled trial. JAMA 293, 1082–1088.
44Homocysteine Lowering Trialists' Collaboration (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. BMJ 316, 894–898.
45 SJPM Eussen , LCPGM de Groot , R Clarke , (2005) Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency. A dose finding trial. Arch Intern Med 165, 1167–1172.
47 H McNulty , LC Dowey , JJ Strain , A Dunne , M Ward , AM Molloy , LB McAnena , JP Hughes , M Hannon-Fletcher & JM Scott (2006) Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C → T polymorphism. Circulation 113, 74–80.
49 EP Quinlivan , J McPartlin , H McNulty , M Ward , JJ Strain , DG Weir & JM Scott (2002) Importance of both folic acid and vitamin B-12 in reduction of risk of vascular disease. Lancet 359, 227–228.
50 G Liaugaudas , PF Jacques , J Selhub , IH Rosenberg & AG Boston (2001) Renal insufficiency, vitamin B-12 status, and population attributable risk for mild hyperhomocysteinemia among coronary artery disease patients in the era of folic acid-fortified cereal grain flour. Arterioscler Thromb Vasc Biol 21, 849–851.
51 AM Molloy , S Daly , JL Mills , PN Kirke , AS Whitehead , D Ramsbottom , MR Conley , DG Weir & JM Scott (1997) Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 349, 1591–1593.
52 PF Jacques , AG Bostom , RR Williams , RC Ellison , JH Eckfeldt , IH Rosenberg , J Selhub & R Rozen (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93, 7–9.
53 K Yamada , Z Chen , R Rozen & RG Matthews (2001) Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. Proc Natl Acad Sci U S A 98, 14853–14858.