Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 30
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Shoaib, Muhammad Shehzad, Aamir Omar, Mukama Rakha, Allah Raza, Husnain Sharif, Hafiz Rizwan Shakeel, Azam Ansari, Anum and Niazi, Sobia 2016. Inulin: Properties, health benefits and food applications. Carbohydrate Polymers, Vol. 147, p. 444.


    Stamataki, Nikoleta S. Nikolidaki, Eirini K. Yanni, Amalia E. Stoupaki, Maria Konstantopoulos, Panagiotis Tsigkas, Alexandros-Pantelis Perrea, Despoina Tentolouris, Nikolaos and Karathanos, Vaios T. 2016. Evaluation of a high nutritional quality snack based on oat flakes and inulin: effects on postprandial glucose, insulin and ghrelin responses of healthy subjects. Food Funct., Vol. 7, Issue. 7, p. 3295.


    Bakker, Guido J. Zhao, Jing Herrema, Hilde and Nieuwdorp, Max 2015. Gut Microbiota and Energy Expenditure in Health and Obesity. Journal of Clinical Gastroenterology, Vol. 49, p. S13.


    Beski, S.S.M. and Al-Sardary, S.Y.T. 2015. Effects of Dietary Supplementation of Probiotic and Synbiotic on Broiler Chickens Hematology and Intestinal Integrity. International Journal of Poultry Science, Vol. 14, Issue. 1, p. 31.


    Mensink, Maarten A. Frijlink, Henderik W. van der Voort Maarschalk, Kees and Hinrichs, Wouter L.J. 2015. Inulin, a flexible oligosaccharide. II: Review of its pharmaceutical applications. Carbohydrate Polymers, Vol. 134, p. 418.


    Peshev, Darin and Van den Ende, Wim 2014. Fructans: Prebiotics and immunomodulators. Journal of Functional Foods, Vol. 8, p. 348.


    Zhou, Mengyi Pu, Chuanliang Xia, Lin Yu, Xiaohong Zhu, Bin Cheng, Rui Xu, Linxiang and Zhang, Jianfa 2014. Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum. Carbohydrate Polymers, Vol. 102, p. 772.


    Harrold, J.A. Hughes, G.M. O’Shiel, K. Quinn, E. Boyland, E.J. Williams, N.J. and Halford, J.C.G. 2013. Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice. Appetite, Vol. 62, p. 84.


    Lindsay, Karen L. Walsh, Colin A. Brennan, Lorraine and McAuliffe, Fionnuala M. 2013. Probiotics in pregnancy and maternal outcomes: a systematic review. The Journal of Maternal-Fetal & Neonatal Medicine, Vol. 26, Issue. 8, p. 772.


    Viladomiu, Monica Hontecillas, Raquel Yuan, Lijuan Lu, Pinyi and Bassaganya-Riera, Josep 2013. Nutritional protective mechanisms against gut inflammation. The Journal of Nutritional Biochemistry, Vol. 24, Issue. 6, p. 929.


    Das, Lipi Bhaumik, Eshani Raychaudhuri, Utpal and Chakraborty, Runu 2012. Role of nutraceuticals in human health. Journal of Food Science and Technology, Vol. 49, Issue. 2, p. 173.


    Ohashi, Yuji Harada, Keisuke Tokunaga, Makoto Ishihara, Noriyuki Okubo, Tsutomu Ogasawara, Yutaka Juneja, Lekh Raj and Fujisawa, Tomohiko 2012. Faecal fermentation of partially hydrolyzed guar gum. Journal of Functional Foods, Vol. 4, Issue. 1, p. 398.


    Papoff, Paola Ceccarelli, Giancarlo d'Ettorre, Gabriella Cerasaro, Carla Caresta, Elena Midulla, Fabio and Moretti, Corrado 2012. Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics. International Journal of Microbiology, Vol. 2012, p. 1.


    De Preter, Vicky Ghebretinsae, Aklilu Habteab Abrahantes, José Cortinas Windey, Karen Rutgeerts, Paul and Verbeke, Kristin 2011. Impact of the synbiotic combination of Lactobacillus casei shirota and oligofructose-enriched inulin on the fecal volatile metabolite profile in healthy subjects. Molecular Nutrition & Food Research, Vol. 55, Issue. 5, p. 714.


    Mandracchia, Delia Denora, Nunzio Franco, Massimo Pitarresi, Giovanna Giammona, Gaetano and Trapani, Giuseppe 2011. New Biodegradable Hydrogels Based on Inulin and α,β-Polyaspartylhydrazide Designed for Colonic Drug Delivery: In Vitro Release of Glutathione and Oxytocin. Journal of Biomaterials Science, Polymer Edition, Vol. 22, Issue. 1-3, p. 313.


    2011. A Guide to Evidence-based Integrative and Complementary Medicine.


    2011. General Practice.


    Chawla, R. and Patil, G.R. 2010. Soluble Dietary Fiber. Comprehensive Reviews in Food Science and Food Safety, Vol. 9, Issue. 2, p. 178.


    De Preter, Vicky Falony, Gwen Windey, Karen Hamer, Henrike M. De Vuyst, Luc and Verbeke, Kristin 2010. The prebiotic, oligofructose-enriched inulin modulates the faecal metabolite profile: An in vitro analysis. Molecular Nutrition & Food Research, Vol. 54, Issue. 12, p. 1791.


    Pouillart, Philippe R. Dépeint, Flore Abdelnour, Afif Deremaux, Laetitia Vincent, Odile Mazière, Jean-Claude Madec, Jean-Yves Chatelain, Denis Younes, Hassan Wils, Daniel Saniez, Marie-Hélène and Dupas, Jean-Louis 2010. Nutriose, a prebiotic low-digestible carbohydrate, stimulates gut mucosal immunity and prevents TNBS-induced colitis in piglets. Inflammatory Bowel Diseases, Vol. 16, Issue. 5, p. 783.


    ×

Inulin and oligofructose: impact on intestinal diseases and disorders

  • Francisco Guarner (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20041345
  • Published online: 01 March 2007
Abstract

A large and diverse variety of bacteria have evolved and adapted to live in the human intestinal habitat in a symbiotic arrangement that influences both physiology and pathology in the host. Symbiosis between host and flora can be optimised by prebiotics. Inulin-type fructans have been shown to improve the metabolic functions of the commensal flora. Clinical and experimental data suggest that they also improve the gut mucosal barrier. Furthermore, modulation of the trophic functions of the flora by these prebiotics could help in the prevention of inflammatory bowel diseases. The anti-inflammatory effects of inulin or oligofructose have been assessed in the rat model of distal colitis induced by dextran sodium sulphate, which histologically resembles human ulcerative colitis, and in the trinitrobenzene sulphonic acid model that resembles human Crohn's disease. Both inulin and oligofructose stimulate colonic production of SCFA and favour the growth of indigenous lactobacilli and/or bifidobacteria. These effects are associated with reduced mucosal inflammation and decreased mucosal lesion scores. Inulin has also been tested in a placebo-controlled clinical trial in patients with relapsing pouchitis. Treatment reduced endoscopic and histological parameters of inflammation of the pouch mucosa. Inulin and oligofructose may offer an opportunity to prevent chronic inflammatory intestinal disorders, and this potential should be tested in further clinical studies.

    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Inulin and oligofructose: impact on intestinal diseases and disorders
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Inulin and oligofructose: impact on intestinal diseases and disorders
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Inulin and oligofructose: impact on intestinal diseases and disorders
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author:, Dr Francisco Guarner, fax +34 934894456, email fguarnera@medynet.com
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A Aderem & RJ Ulevitch (2000) Toll-like receptors in the induction of the innate immune response. Nature 406, 782787.

JF Bach (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347, 911920.

N Borruel , M Carol , F Casellas , M Antolín , F de Lara , E Espín , J Naval , F Guarner & JR Malagelada (2002) Increased mucosal TNFα production in Crohn's disease can be downregulated ex vivo by probiotic bacteria. Gut 51, 659664.

N Borruel , F Casellas , M Antolín , M Carol , M Llopis , E Espín , J Naval , F Guarner & JR Malagelada (2003) Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa. Am J Gastroenterol 98, 865870.

M Carol , N Borruel , M Antolín , F Casellas , F Guarner , J-R Malagelada (2003) Lactobacillus casei can overcome resistance to apoptosis in lymphocytes from patients with Crohn's disease. Gastroenterology 124 A321

F Casellas , N Borruel , M Papo , F Guarner , M Antolín , S Videla & JR Malagelada (1998) Antiinflammatory effects of enterically coated amoxicillin–clavulanic acid in active ulcerative colitis. Inflamm Bowel Dis 4, 15.

JH Cummings , S Christie & TJ Cole (2001) A study of fructo oligosaccharides in the prevention of travellers' diarrhoea. Aliment Pharmacol Ther 15, 11391145.

GR D'Haens , K Geboes , M Peeters , F Baert , F Penninckx & P Rutgeerts (1998) Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum. Gastroenterology 114, 262267.

NM Delzenne , C Daubioul , A Neyrinck , M Lasa & HS Taper (2002) Inulin and oligofructose modulate lipid metabolism in animals: review of biochemical events and future prospects. Br J Nutr 87, Suppl. 2, S255S259.

S Fagarasan , M Muramatsu , K Suzuki , H Nagaoka , H Hiai & T Honjo (2002) Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora. Science 298, 14141427.

AP Femia , C Luceri , P Dolara , A Giannini , A Biggeri , M Salvadori , Y Clune , KJ Collins , M Paglierani & G Caderni (2002) Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis 23, 19531960.

F Guarner & JR Malagelada (2003) Gut flora in health and disease. Lancet 361, 512519.

LV Hooper , MH Wong , A Thelin , L Hansson , PG Falk & JI Gordon (2001) Molecular analysis of commensal host–microbial relationships in the intestine. Science 291, 881884.

MF Kagnoff & L Eckmann (1997) Epithelial cells as sensors for microbial infection. J Clin Invest 100, 610.

J McCarthy , L O'Mahony , L O'Callaghan (2003) Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut 52, 975980.

A Macpherson , UY Khoo , I Forgacs , J Philpott-Howard & I Bjarnason (1996) Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria. Gut 38, 365375.

KL Madsen , JS Doyle , LD Jewell , MM Tavernini & RN Fedorak (1999) Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterology 116, 11071114.

GP Morris , PL Beck , MS Herridge , WT Depew , MR Szewezuk & JL Wallace (1989) Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 96, 795803.

M Nyman (2002) Fermentation and bulking capacity of indigestible carbohydrates: the case of inulin and oligofructose. Br J Nutr 87, Suppl. 2 S163S168.

A Olah , T Belagyi , A Issekutz , ME Gamal & S Bengmark (2002) Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg 89, 11031107.

U Pirzer , A Schönhaar , B Fleischer , E Hermann , zum Meyer , KH Büschenfelde (1991) Reactivity of infiltrating T lymphocytes with microbial antigens in Crohn's disease. Lancet 338, 12381239.

N Rayes , D Seehofer , S Hansen , K Boucsein , AR Muller , S Serke , S Bengmark & P Neuhaus (2002) Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 74, 123127.

P Seksik , L Rigottier-Gois , G Gramet , M Sutren , P Pochart , P Marteau , R Jian , J Doré (2003) Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon. Gut 52, 237242.

F Shanahan (2001) Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. Gastroenterology 120, 622635.

L Steidler , W Hans , L Schotte , S Neirynck , F Obermeier , W Falk , W Fiers & E Remaut (2000) Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 289, 13521355.

A Swidsinski , A Ladhoff & A Pernthaler (2002) Mucosal flora in inflammatory bowel disease. Gastroenterology 122, 4454.

S Videla , J Vilaseca , M Antolín , A García-Lafuente , F Guarner , E Crespo , J Casalots , A Salas & JR Malagelada (2001) Dietary inulin improves distal colitis induced by dextran sodium sulfate in the rat. Am J Gastroenterol 96, 14861493.

CF Welters , E Heineman , FB Thunnissen , Bogaard AE van den , PB Soeters , CG Baeten (2002) Effect of dietary inulin supplementation on inflammation of pouch mucosa in patients with an ileal pouch–anal anastomosis. Dis Colon Rectum 45, 621627.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: