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Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats*

  • Patrice D. Cani (a1), Cédric Dewever (a1) and Nathalie M. Delzenne (a1)
Abstract

The hypothesis tested in the present study is that dietary fructans are able to modulate gastrointestinal peptides involved in the control of food intake, namely glucagon-like peptide (GLP)-1 (7-36) amide and ghrelin. After 3 weeks of treatment with a standard diet (control) or the same diet enriched with 100 g fructans varying in their degrees of polymerization (oligofructose (OFS), Synergy 1 (Syn) or long chain inulin)/kg, male Wistar rats were deprived of food for 8 h before sample collection. Dietary energy intake throughout the experiment was significantly lower (P>0·05) in fructans-fed rats than in control rats, leading to a significant decrease (P>0·01) in epidydimal fat mass at the end of the treatment in OFS- and Syn-treated rats. GLP-1 (7-36) amide concentration in portal vein serum was higher in OFS- and Syn-fed than in control rats. Both GLP-1 (7-36) amide concentration and proglucagon mRNA concentrations were significantly greater (P>0·05) in the proximal colonic mucosa of fructans-fed rats v. controls. Normally active ghrelin concentration in plasma increases during food deprivation and rapidly falls during a meal. In the present study, after 8 h of food deprivation, active ghrelin in the plasma remained significantly lower (P>0·05) in OFS and Syn-fed than in control rats. These results are in accordance with the modifications of dietary intake and fat-mass development in short-chain fructans-treated rats and demonstrate the potential modulation of GLP-1 (7-36) amide and ghrelin by fermentable fibres such as fructans, which are rapidly and extensively fermented in the proximal part of the colon.

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      Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats*
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Corresponding author
Corresponding author: fax +32 2 764 73 59, Email delzenne@pmnt.ucl.ac.be
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R Burcelin , A Da Costa , D Drucker & B Thorens Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor Diabetes (2001) 50 17201728

X Cao , G Flock , C Choi , DM Irwin & DJ Drucker Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line Endocrinology (2003) 144 20252033

P Chomczynski & N Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction Anal Biochem (1987) 162 156159

MA Cowley , RG Smith & S Diano The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis Neuron (2003) 37 649661

NM Delzenne Oligosaccharides: state of the art Proc Nutr Soc (2003) 62 177182

NM Delzenne & CM Williams Prebiotics and lipid metabolism Curr Opin Lipidol (2002) 13 6167

CB Djurhuus , TK Hansen , C Gravholt , L Orskov , H Hosoda , K Kangawa , JO Jorgensen , JJ Holst & O Schmitz Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion Horm Metab Res (2002) 34 411413

A Flint , A Raben , A Astrup & JJ Holst Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans J Clin Invest (1998) 101 515520

A Franck Technological functionality of inulin and oligofructose Br J Nutr (2002) 87 S287S291

JM Gee , W Lee-Finglas & IT Johnson Fermentable carbohydrate modulates postprandial enteroglucagon and gastrin release in rats Br J Nutr (1996) 75 757766

M Kojima , H Hosoda , Y Date , M Nakazato , H Matsuo & K Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature (1999) 402 656660

F Lippl , F Kircher , J Erdmann , HD Allescher & V Schusdziarra Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach Regul Pept (2004) 119 9398

JJ Meier , B Gallwitz , WE Schmidt & MA Nauck Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives Eur J Pharmacol (2002) 440 269279

E Naslund , B Barkeling , N King , M Gutniak , JE Blundell , JJ Holst , S Rossner & PM Hellstrom Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men Int J Obes Relat Metab Disord (1999) 23 304311

M Nyman Fermentation and bulking capacity of indigestible carbohydrates: the case of inulin and oligofructose Br J Nutr (2002) 87 S163S168

J Philippe , DJ Drucker , WL Chick & JF Habener Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line Mol Cell Biol (1987) 7 560563

F Preitner , M Ibberson & I Franklin Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors J Clin Invest (2004) 113 635645

RA Reimer & MI McBurney Dietary fiber modulates intestinal proglucagon messenger ribonucleic acid and postprandial secretion of glucagon-like peptide-1 and insulin in rats Endocrinology (1996) 137 39483956

AS Rocca & PL Brubacker Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion Endocrinology (1999) 140 16871694

M Tschop , DL Smiley & ML Heiman Ghrelin induces adiposity in rodents Nature (2000) 407 908913

AI Vinik & DJ Jenkins Dietary fiber in management of diabetes Diabetes Care Rev (1988) 11 160173

M Zander , S Madsbad , JL Madsen & JJ Holst Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study Lancet (2002) 359 824830

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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