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Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats*

Published online by Cambridge University Press:  09 March 2007

Patrice D. Cani ,
Cédric Dewever  and
Nathalie M. Delzenne
Patrice D. Cani
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Université Catholique de Louvain, B-1200 Brussels, Belgium
Cédric Dewever
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Université Catholique de Louvain, B-1200 Brussels, Belgium
Nathalie M. Delzenne*
Affiliation:
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Université Catholique de Louvain, B-1200 Brussels, Belgium
*
†Corresponding author: fax +32 2 764 73 59, Email delzenne@pmnt.ucl.ac.be
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Abstract

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The hypothesis tested in the present study is that dietary fructans are able to modulate gastrointestinal peptides involved in the control of food intake, namely glucagon-like peptide (GLP)-1 (7-36) amide and ghrelin. After 3 weeks of treatment with a standard diet (control) or the same diet enriched with 100 g fructans varying in their degrees of polymerization (oligofructose (OFS), Synergy 1 (Syn) or long chain inulin)/kg, male Wistar rats were deprived of food for 8 h before sample collection. Dietary energy intake throughout the experiment was significantly lower (P>0·05) in fructans-fed rats than in control rats, leading to a significant decrease (P>0·01) in epidydimal fat mass at the end of the treatment in OFS- and Syn-treated rats. GLP-1 (7-36) amide concentration in portal vein serum was higher in OFS- and Syn-fed than in control rats. Both GLP-1 (7-36) amide concentration and proglucagon mRNA concentrations were significantly greater (P>0·05) in the proximal colonic mucosa of fructans-fed rats v. controls. Normally active ghrelin concentration in plasma increases during food deprivation and rapidly falls during a meal. In the present study, after 8 h of food deprivation, active ghrelin in the plasma remained significantly lower (P>0·05) in OFS and Syn-fed than in control rats. These results are in accordance with the modifications of dietary intake and fat-mass development in short-chain fructans-treated rats and demonstrate the potential modulation of GLP-1 (7-36) amide and ghrelin by fermentable fibres such as fructans, which are rapidly and extensively fermented in the proximal part of the colon.

Keywords

Glugagon-like peptide-1 (7-36) amideGhrelinInulin-type fructansOligofructoseOrexigenicAnorexigenic
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 3 , September 2004 , pp. 521 - 526
Copyright
Copyright © The Nutrition Society 2004

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