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Iron absorption during normal human pregnancy: a study using stable isotopes

  • Paul G. Whittaker (a1), Tom Lind (a1) and John G. Williams (a2)
Abstract

The absorption of iron has been determined in nine healthy women studied serially during pregnancy and once post delivery. Following the oral administration of 5 mg aqueous 54FeSO4 plus ascorbic acid and the intravenous injection of 200 μg 57FeSO4, the isotope ratios of 54Fe: 56Fe and 57Fe:56Fe in serum were measured by the use of inductively-coupled-plasma mass spectrometry whereby metal ions are vaporized into an argon plasma without previous blood sample preparation. Mean oral Fe absorption was 7.6 (range 1–22) % at 12 weeks gestation, 21.1 (range 9–58) % at 24 weeks, 37.4 (range 18–56) % at 36 weeks and 26.3 (range 8–54) % at 12 weeks post delivery. All the other biochemical and haematological indices were within normal limits for pregnancy. The significant increase (P < 0.01) in Fe absorption during normal pregnancy suggests that most women would have the potential to meet the Fe demands of pregnancy without the need for supplementation if dietary Fe has similar availability to the aqueous preparation.

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References
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Bothwell T. H., Charlton R. W., Cook J. D. & Finch C. A. (1979 a). Iron nutrition. In Iron Metabolism in Man, pp. 742. London: Blackwell.
Bothwell T. H., Charlton R. W., Cook J. D. & Finch C. A. (1979 b). Measurement of iron absorption. In Iron Metabolism in Man, pp. 425438. London: Blackwell.
Bothwell T. H., Mallett B., Oliver R. & Smith M. D. (1955). The inability to assess the absorption of iron from plasma radioiron curves. British Journal of Haematology 1, 352357.
Dyer N. C. & Brill A. B. (1972). Use of the stable tracers 58Fe and 50Cr for the study of iron utilization in pregnant women. Nuclear Activation Techniques in the Life Sciences, pp. 469477. Vienna: IAEA.
Gibaldi M. & Perrier D. (1982). Absorption kinetics and bioavailability. Pharmacokinetics, pp. 145198. New York: Marcel Dekker.
Hahn P. F., Carothers E. L., Darby W. J., Martin M., Sheppard C. W., Cannon R. O., Beam A. S., Densen P. M., Peterson J. C. & McClellan G. S. (1951). Iron metabolism in early pregnancy as studied with the radioactive isotope 59Fe. American Journal of Obstetrics and Gynecology 61, 477486.
Heinrich H. C. (1970). Intestinal iron absorption in man. In Iron Deficiency, pp. 213296 [Hallberg L. Harwerth H. G. and Vannotti A., editors]. London: Academic Press.
Janghorbani M., Ting B. T. G. & Fomon S. J. (1986). Erythrocyte incorporation of ingested stable isotope of iron (58Fe). American Journal of Hematology 21, 277288.
Johnson P. E. (1982). A mass spectrometric method for use of stable isotopes as tracers in studies of iron, zinc and copper absorption in human subjects. Journal of Nutrition 112, 14141424.
King J. C., Raynolds W. L. & Margen S. (1978). Absorption of stable isotopes of iron, copper and zinc during oral contraceptive use. American Journal of Clinical Nutrition 31, 11981203.
Larsen L. & Milman N. (1975). Normal iron absorption determined by means of whole body counting and red cell incorporation of 59Fe. Acta Medica Scandinavica 198, 271274.
Lind T. (1983). Iron supplementation during pregnancy. In Nutrition in Pregnancy, pp. 181192 [Campbell D. M. and Gilmer R. D. G., editors]. London: Royal College of Obstetricians and Gynaecologists.
Miller D. D. & Van Campen D. (1979). A method for the detection and assay of iron stable isotopes in blood serum. American Journal of Clinical Nutrition 32, 23542361.
Schofield C., Stewart J. & Wheeler E. (1987). The diets of pregnant and post-pregnant women in different social groups in London and Edinburgh: energy, protein, fat and fibre. British Journal of Nutrition 58, 369381.
Schofield C., Stewart J. & Wheeler E. (1989). The diets of pregnant and post-pregnant women in different social groups in London and Edinburgh: calcium, iron, retinol, ascorbic acid and folic acid. British Journal of Nutrition 62, 363377.
Svanberg B. (1975). Iron absorption in early pregnancy - a study of the absorption of non-haem iron and ferrous iron in early pregnancy. Acta Obstetricia Gynecologia Scandinavica 48, Suppl. 6986.
Svanberg B., Arvidsson B., Bjorn-Rasmussen E., Hallberg L., Rossander L. & Swolin B. (1975 a). Dietary iron absorption in pregnancy - a longitudinal study with repeated measurements of non-haem iron absorption from whole diet. Acta Obstetricia Gynecologica Scandinavica 48, Suppl. 4368.
Svanberg B., Rossander L. & Isaksson B. (1975 b). Studies of dietary habits in pregnancy - with special reference to the intake of iron. Acta Obstetricia Gynecologica Scandinavica 48, Suppl. 2942.
Werner E., Hansen C., Roth P. & Kaltwasser J. P. (1983). Comparative evaluation of intestinal iron absorption by four different methods in man. In Structure and Function of Iron Storage and Transport Proteins, pp. 403408 [Urushizaki I. Aisen P. Listowsky I. and Drysdale J. W., editors]. Oxford: Elsevier Science.
Whittaker P. G., Lind T., Williams J. G. & Gray A. L. (1989). Inductively coupled plasma mass spectrometric determination of the absorption of iron in normal women. Analyst 114, 675678.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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