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Is coffee a functional food?

  • José G. Dórea (a1) and Teresa Helena M. da Costa (a1)

Definitions of functional food vary but are essentially based on foods' ability to enhance the quality of life, or physical and mental performance, of regular consumers. The worldwide use of coffee for social engagement, leisure, enhancement of work performance and well-being is widely recognised. Depending on the quantities consumed, it can affect the intake of some minerals (K, Mg, Mn, Cr), niacin and antioxidant substances. Epidemiological and experimental studies have shown positive effects of regular coffee-drinking on various aspects of health, such as psychoactive responses (alertness, mood change), neurological (infant hyperactivity, Alzheimer's and Parkinson's diseases) and metabolic disorders (diabetes, gallstones, liver cirrhosis), and gonad and liver function. Despite this, most reviews do not mention coffee as fulfilling the criteria for a functional food. Unlike other functional foods that act on a defined population with a special effect, the wide use of coffee-drinking impacts a broad demographic (from children to the elderly), with a wide spectrum of health benefits. The present paper discusses coffee-drinking and health benefits that support the concept of coffee as a functional food.

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Corresponding author
Corresponding author: Professor José G. Dórea, fax +55 61 368 5853, email
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Abbott RDWebster Ross G, White LR, Sanderson WT, Burchfiel CM, Kashon M, Sharp DS, Masaki KH, Curb JD & Petrovitch H (2003) Environmental, life-style, and physical precursors of clinical Parkinson's disease: recent findings from the Honolulu-Asia Aging Study. J Neurol 250, Suppl. 3III30III39.
Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K & Jequier E (1980) Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr 33, 989997.
Adrian J & Frangne R (1991) Synthesis and availability of niacin in roasted coffee. Adv Exp Med Biol 289, 4959.
Agardh EE, Carlsson S, Ahlbom A, Efendic S, Grill V, Hammar N, Hilding A & Ostenson CG (2004) Coffee consumption, type 2 diabetes and impaired glucose tolerance in Swedish men and women. J Intern Med 255, 645652.
Andueza SDe Pena MP & Cid C (2003) Chemical and sensorial characteristics of espresso coffee as affected by grinding and torrefacto roast. J Agric Food Chem 51, 70347039.
Anese M & Nicoli MC (2003) Antioxidant properties of ready-to-drink coffee brews. J Agric Food Chem 51, 942946.
Anonymous (2004) Coffee: for most it's safe. Harv Women's Health Watch 12, 24.
Arnesen E, Huseby NE, Brenn T & Try K (1986) The Tromso Heart Study: distribution of, and determinants for, gamma-glutamyltransferase in a free-living population. Scand J Clin Lab Invest 46, 6370.
Arnlov J, Vessby B & Riserus U (2004) Coffee consumption and insulin sensitivity. JAMA 291, 11991201.
Ascherio A, Chen H, Schwarzschild MA, Zhang SM, Colditz GA & Speizer FE (2003) Caffeine, postmenopausal estrogen, and risk of Parkinson's disease. Neurology 60, 790795.
Ascherio A, Zhang SM, Hernan MA, Kawachi I, Colditz GA, Speizer FE & Willett WC (2001) Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Ann Neurol 50, 5663.
Astier-Dumas M & Gounelle de Pantanel H (1974) Sur certains aspects nutritifs du café. Arch Sc Med 131, 1823.
Azam S, Hadi N, Khan NU & Hadi SM (2003) Antioxidant and prooxidant properties of caffeine, theobromine and xanthine. Med Sci Monit 9, BR325BR330.
Barone JJ & Roberts HR (1996) Caffeine consumption. Food Chem Toxicol 34, 119129.
Bell LN, Wetzel CR & Grand AN (1996) Caffeine content in coffee as influenced by grinding and brewing techniques. Food Res Intern 29, 785789.
Borrelli RC, Esposito F, Napolitano A, Ritieni A & Fogliano V (2004) Characterization of a new potential funcitonal ingredient: coffee silverskin. J Agric Food Chem 52, 13381343.
Borrelli RC, Visconti A, Mennella C, Anese M & Fogliano V (2002) Chemical characterization and antioxidant properties of coffee melanoidins. J Agric Food Chem 50, 65276533.
Bracco D, Ferrarra JM, Arnaud MJ, Jequier E & Schutz Y (1995) Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol 269, E671E678.
Carlsson S, Hammar N, Grill V & Kaprio J (2004) Coffee consumption and risk of type 2 diabetes in Finnish twins. Int J Epidemiol 33, 12.
Casal S, Oliveira MB, Alves MR & Ferreira MA (2000) Discriminate analysis of roasted coffee varieties for trigonelline, nicotinic acid, and caffeine content. J Agric Food Chem 48, 34203424.
Chodorowski Z (2002) Cappuccino coffee treatment of xerostomia in patients taking tricyclic antidepressants: preliminary report. Przegl Lek 59, 392393.
Cirilo MPG, Coelho AFS, Araujo CM, Goncalves FRB, Nogueira FD & Gloria MBA (2003) Profile and levels of bioactive amines in green and roasted coffee. Food Chem 82, 397402.
Corrao G, Zambon A, Bagnardi V, D'Amicis A & Klatsky A (2001) Coffee, caffeine, and the risk of liver cirrhosis. Ann Epidemiol 11, 458465.
Czok G (1977) Coffee and health. Z Ernahrungswiss 16, 248255.
Daglia M, Papetti A, Dacarro C & Gazzani G (1998) Isolation of an antibacterial component from roasted coffee. J Pharm Biomed Anal 18, 219225.
Daglia M, Racchi M, Papetti A, Lani C, Govoni S & Gazzani G (2004) In vitro and ex vivo antihydrosyl radical activity of green and roasted coffee. J Agric Food Chem 52, 17001704.
Daglia M, Tarsi R, Papetti A, Grisoli P, Dacarro C, Pruzzo C & Gazzani G (2002) Antiadhesive effect of green and roasted coffee on Streptococcus mutans ‘ adhesive properties on saliva-coated hydroxyapatite beads. J Agric Food Chem 50, 12251229.
del Castillo MD, Ames JM & Gordon MH (2002) Effect of roasting on the antioxidant activity of coffee brews. J Agric Food Chem 50, 36983703.
Dewey KG, Romero-Abal MEQuan de Serrano J, Bulux J, Peerson JM, Eagle P & Solomons NW (1997) Effects of discontinuing coffee intake on iron status of iron- deficient Guatemalan toddlers: a randomized intervention study. Am J Clin Nutr 66, 168176.
Diokno AC, Brown MB & Herzog AR (1990) Sexual function in the elderly. Arch Intern Med 150, 197200.
Dogasaki C, Shindo T, Furuhata K & Fukuyama M (2002) Identification of chemical structure of antibacterial components against Legionella pneumophila in a coffee beverage. Yakugaku Zasshi 122, 487494.
Dorea JG & Furumoto RAV (1992) Infant feeding practices among poor families of an urban squatter community. Ann Nutr Metabol 36, 257264.
Dye L & Blundell J (2002) Functional foods: psychological and behavioural functions. Br J Nutr 88, Suppl. 2S187S211.
Esposito F, Morisco F, Verde V, Ritieni A, Alezio A, Caporaso N & Fogliano V (2003) Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects. Aliment Pharmacol Ther 17, 595601.
Feijoo M & Bilbao J (1992) Seizures of sleep onset: clinical and therapeutical aspects. Clin Neuropharmacol 15, 5055.
Flores GB, Andrade F & Lima DR (2000) Can coffee help fighting the drug problem? Preliminary results of a Brazilian youth drug study. Acta Pharmacol Sin 21, 10591070.
Fortes C, Forastiere F, Farchi S, Rapiti E, Pastori G & Perucci CA (2000) Diet and overall survival in a cohort of very elderly people. Epidemiology 11, 440445.
Gallus S, Tavani A, Negri E & La Vecchia C (2002) Does coffee protect against liver cirrhosis? Ann Epidemiol 12, 202205.
Geleijnse JM, Kok FJ & Grobbee DE (2004) Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations. Eur J Pub Health 14, 235239.
Gillies ME & Birkbeck JA (1983) Tea and coffee as sources of some minerals in the New Zealand diet. Am J Clin Nutr 38, 936942.
Griffiths RR, Bigelow GE, Liebson IA, O'Keeffe MO'Leary D & Russ N (1986) Human coffee drinking: manipulation of concentration and caffeine dose. J Exp Anal Behav 45, 133148.
Halsted CH (2003) Dietary supplements and functional foods: 2 sides of a coin? Am J Clin Nutr 77, Suppl. 41001S1007S.
Hameleers PA, Van Boxtel MP, Hogervorst E, Riedel WJ, Houx PJ, Buntinx F & Jolles J (2000) Habitual caffeine consumption and its relation to memory, attention, planning capacity and psychomotor performance across multiple age groups. Hum Psychopharmacol 15, 573581.
Happonen P, Voutilainen S & Salonen JT (2004) Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men. J Nutr 134, 23812386.
Harland BF (2000) Caffeine and nutrition. Nutrition 16, 522526.
Harvey DH & Marsh RW (1978) The effects of de-caffeinated coffee versus whole coffee on hyperactive children. Dev Med Child Neurol 20, 8186.
Hasler CM (2000) The changing face of functional foods. J Am Coll Nutr 19, Suppl.499S506S.
Hasler CM (2002) Functional foods: benefits, concerns and challenges–a position paper from the American Council on Science and Health. J Nutr 132, 37723781.
Hernan MA, Takkouche BCaamano-Isorna F & Gestal-Otero JJ (2002) A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease. Ann Neurol 52, 276284.
Heuser I (2003) Prevention of dementias: state of the art. Dtsch Med Wochenschr 128, 421422.
Hildebrandt R & Gundert-Remy U (1983) Lack of pharmacological active saliva levels of caffeine in breast-fed infants. Pediatr Pharmacol 3, 237244.
Hodgson JM, Chan SY, Puddey IB, et al. (2004) Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects. Br J Nutr 91, 301306.
Hofer I & Battig K (1994) Cardiovascular, behavioral, and subjective effects of caffeine under field conditions. Pharmacol Biochem Behav 48, 899908.
Horne JA & Reyner LA (1995) Driver sleepiness. J Sleep Res 4, 2329.
Impellitteri CA, Allen HE, Lagos G & McLaughlin MJ (2000) Removal of soluble Cu and Pb by the automatic drip coffee brewing process: application to risk assessment. Hum Ecolog Risk Assess 6, 313322.
Isogawa A, Noda M, Takahashi Y, Kadowaki T & Tsugane S (2003) Coffee consumption and risk of type 2 diabetes mellitus. Lancet 361, 703704.
James JE (2004) Critical review of dietary caffeine and blood pressure: a relationship that should be taken more seriously. Psychosom Med 66, 6371.
Jarvis MJ (1993) Does caffeine intake enhance absolute levels of cognitive performance? Psychopharmacology 110, 4552.
Jodral-Segado AM, Navarro-Alarcon MLopez-Ga de la Serrana H & Lopez-Martinez MC (2003) Magnesium and calcium contents in foods from SE Spain: influencing factors and estimation of daily dietary intakes. Sci Total Environ 312, 4758.
Johnson-Kozlow M, Kritz-Silverstein DBarrett-Connor E & Morton D (2002) Coffee consumption and cognitive function among older adults. Am J Epidemiol 156, 842850.
Johnston KL, Clifford MN & Morgan LM (2003) Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. Am J Clin Nutr 78, 728733.
Karakaya S, El SN & Tas AA (2001) Antioxidant activity of some foods containing phenolic compounds. Int J Food Sci Nutr 52, 501508.
Karkal M (1975) Socio-cultural and economic aspects of infant-feeding. Indian Pediatr 12, 1319.
Kawachi I, Willett WC, Colditz GA, Stampfer MJ & Speizer FE (1996) A prospective study of coffee drinking and suicide in women. Arch Intern Med 156, 521525.
Klatsky AL & Armstrong MA (1992) Alcohol, smoking, coffee, and cirrhosis. Am J Epidemiol 136, 12481257.
Krause VM, Delisle H & Solomons NW (1998) Fortified foods contribute one half of recommended vitamin A intake in poor urban Guatemalan toddlers. J Nutr 128, 860864.
Krauss RM, Eckel RH, Howard B, et al. (2000) AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association. Circulation 102, 22842299.
Kubik A, Zatloukal P, Tomasek L, Kriz J, Petruzelka L & Plesko I (2001) Diet and the risk of lung cancer among women. A hospital-based case-control study. Neoplasma 48, 262266.
Kubo Shlonsky A, Klatsky AL & Armstrong MA (2003) Traits of persons who drink decaffeinated coffee. Ann Epidemiol 13, 273279.
Lammert F & Matern S (2004) Evidence based prevention of cholecystolithiasis. Deutsc Medizin Wochens 129, 15481550.
Lane JD (1997) Effects of brief caffeinated-beverage deprivation on mood, symptoms, and psychomotor performance. Pharmacol Biochem Behav 58, 203208.
Lawson CC, LeMasters GK & Wilson KA (2004) Changes in caffeine consumption as a signal of pregnancy. Reprod Toxicol 18, 625633.
Leitzmann MF, Stampfer MJ, Willett WC, Spiegelman D, Colditz GA & Giovannucci EL (2002) Coffee intake is associated with lower risk of symptomatic gallstone disease in women. Gastroenterology 123, 18231830.
Leitzmann MF, Willett WC, Rimm EB, Stampfer MJ, Spiegelman D, Colditz GA & Giovannucci E (1999) A prospective study of coffee consumption and the risk of symptomatic gallstone disease in men. JAMA 281, 21062112.
Lewis R (2004) Pursuing the perfect cup of coffee. Scientist 18, 56.
Lindahl B, Johansson I, Huhtasaari F, Hallmans G & Asplund K (1991) Coffee drinking and blood cholesterol: effects of brewing method, food intake and life style. J Intern Med 230, 299305.
Lindahl B, Stegmayr B, Johansson I, Weinehall L & Hallmans G (2003) Trends in lifestyle 1986–99 in a 25- to 64-year-old population of the Northern Sweden MONICA project. Scand J Public Health 61, Suppl.3137.
Lindsay J, Laurin D, Verreault R, Hebert R, Helliwell B, Hill GB & McDowell I (2002) Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156, 445453.
Lowik MR, van Dokkum W, Kistemaker C, Schaafsma G & Ockhuizen T (1993) Body composition, health status and urinary magnesium excretion among elderly people (Dutch Nutrition Surveillance System). Magnes Res 6, 223232.
McCusker RRGoldberger BA & Cone EJ (2003) Caffeine content of specialty coffees. J Anal Toxicol 27, 520522.
Manach C, Scalbert A, Morand C, Remesy C & Jimenez L (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79, 727747.
Martyn C & Gale C (2003) Tobacco, coffee, and Parkinson's disease. BMJ 326, 561562.
Mendilaharsu M, De Stefani E, Deneo-Pellegrini H, Carzoglio JC & Ronco A (1998) Consumption of tea and coffee and the risk of lung cancer in cigarette-smoking men: a case-control study in Uruguay. Lung Cancer 19, 101107.
Minamisawa M, Yoshida S & Takai N (2004) Determination of biologically active substances in roasted coffees using a diode-array HPLC system. Anal Sci 20, 325328.
Morales FJ, Jimenez-Perez S (2004) Peroxyl radical scavenging activity of melanoidins in aqueous systems. Eur Food Res Technol 218, 515520.
Morton C, Klatsky AL & Udaltsova N (2004) Smoking, coffee, and pancreatitis. Am J Gastroenterol 99, 731738.
Mosdol A, Christensen B, Retterstol L & Thelle DS (2002) Induced changes in the consumption of coffee alter ad libitum dietary intake and physical activity level. Br J Nutr 87, 261266.
Mougios V, Ring S, Petridou A & Nikolaidis MG (2003) Duration of coffee- and exercise- induced changes in the fatty acid profile of human serum. J Appl Physiol 94, 476484.
Mukamal KJ, Maclure M, Muller JE, Sherwood JB & Mittleman MA (2004) Caffeinated coffee consumption and mortality after acute myocardial infarction. Am Heart J 147, 9991004.
Munoz LM, Lonnerdal B, Keen CL & Dewey KG (1988) Coffee consumption as a factor in iron deficiency anemia among pregnant women and their infants in Costa Rica. Am J Clin Nutr 48, 645651.
Naismith DJ, Akinyanju PA, Szanto S & Yudkin J (1970) The effect, in volunteers, of coffee and decaffeinated coffee on blood glucose, insulin, plasma lipids and some factors involved in blood clotting. Nutr Metab 12, 144151.
Nakanishi N, Nakamura K, Nakajima K, Suzuki K & Tatara K (2000) Coffee consumption and decreased serum gamma-glutamyltransferase: a study of middle-aged Japanese men. Eur J Epidemiol 16, 419423.
Namba T & Matsuse T (2002) A historical study of coffee in Japanese and Asian countries: focusing the medicinal uses in Asian traditional medicines. Yakushigaku Zasshi 37, 6575.
Narod SADe Sanjose S & Victora C (1991) Coffee during pregnancy: a reproductive hazard? Am J Obstet Gynecol 164, 11091114.
Natella F, Nardini M, Giannetti I, Dattilo C & Scaccini C (2002) Coffee drinking influences plasma antioxidant capacity in humans. J Agric Food Chem 50, 62116216.
Navarini L, Ferrari M, Liverani FS, Liggieri L & Ravera F (2004) Dynamic tensiometric characterization of espresso coffee beverage. Food Hydrocol 18, 387393.
Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A & Feeley M (2003) Effects of caffeine on human health. Food Addit Contam 20, 130.
Nehlig A & Debry G (1994a) Consequences on the newborn of chronic maternal consumption of coffee during gestation and lactation: a review. J Am Coll Nutr 13, 621.
Nehlig A & Debry G (1994b) Caffeine and sports activity: a review. Int J Sports Med 15, 215223.
Nestler EJ & Malenka RC (2004) The addicted brain. Sci Am 290, 7885.
Neuhauser-Berthold M, Beine S, Verwied SC & Luhrmann PM (1997) Coffee consumption and total body water homeostasis as measured by fluid balance and bioelectrical impedance analysis. Ann Nutr Metab 41, 2936.
Nicoli MC, Anese M, Manzocco L & Lerici CR (1997) Antioxidant properties of coffee brews in relation to the roasting degree. Lebens Wiss Technol 30, 292297.
Nicoli MC, Anese M & Parpinel M (1999) Influence of processing on the antioxidant properties of fruit and vegetables. Trends Food Sci Technol 10, 94100.
Nilssen O & Forde OH (1994) Seven-year longitudinal population study of change in gamma-glutamyltransferase: the Tromso Study. Am J Epidemiol 139, 787792.
Ogita S, Uefuji H, Yamaguchi Y, Koizumi N & Sano H (2003) Producing decaffeinated coffee plants. Nature (Lond) 423, 823.
Ohayon MM (2004) Interactions between sleep normative data and sociocultural characteristics in the elderly. J Psychosom Res 56, 479486.
Olthof MR, Hollman PCH & Katan MB (2001) Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 131, 6671.
Pagano R, Negri E, Decarli A & La Vecchia C (1988) Coffee drinking and prevalence of bronchial asthma. Chest 94, 386389.
Panzella L, Napolitano A & d'ischia M (2003) Oxidative conjugation of chlorogenic acid with glutathione. Structural characterization of addition products and a new nitrite- promoted pathway. Bioorg Med Chem 11, 47974805.
Papadelis C, Kourtidou-Papadeli C, Vlachogiannis E, Skepastianos P, Bamidis P, Maglaveras N & Pappas K (2003) Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain Cogn 51, 143154.
Parazzini F, Chiaffarino F, Chatenoud L, Tozzi L, Cipriani S, Chiantera V & Fedele L (2004) Maternal coffee drinking in pregnancy and risk of small for gestational age birth. Eur J Clin Nutr online publication 29 September 2004; doi: 101038/sjejcn1602052.
Porta M, Vioque J, Ayude D, Alguacil J, Jariod M, Ruiz L & Murillol (2003) Coffee drinking: the rationale for treating it as a potential effect modifier of carcinogenic exposures. Eur J Epidemiol 18, 289298.
Pulido R, Hernandez-Garcia M & Saura-Calixto F (2003) Contribution of beverages to the intake of lipophilic and hydrophilic antioxidants in the Spanish diet. Eur J Clin Nutr 57, 12751282.
Quinlan P, Lane J & Aspinall L (1997) Effects of hot tea, coffee and water ingestion on physiological responses and mood: the role of caffeine, water and beverage type. Psychopharmacology 134, 164173.
Raaska K, Raitasuo V, Laitila J & Neuvonen PJ (2004) Effect of caffeine-containing versus decaffeinated coffee on serum clozapine concentrations in hospitalised patients. Pharmacol Toxicol 94, 1318.
Radtke J, Linseisen J & Wolfram G (1998) Phenolic acid intake of adults in a Bavarian subgroup of the national food consumption survey. Z Ernahrungswiss 37, 190197.
Ragonese P, Salemi G, Morgante L, Aridon P, Epifanio A, Buffa D, Scoppa F & Savettieri G (2003) A case-control study on cigarette, alcohol, and coffee consumption preceding Parkinson's disease. Neuroepidemiology 22, 297304.
Reunanen A, Heliovaara M & Aho K (2003) Coffee consumption and risk of type 2 diabetes mellitus. Lancet 361, 702703.
Rey de Castro J, Gallo J & Loureiro H (2004) Tiredness and sleepiness in bus drivers and road accidents in Peru: a quantitative study. Rev Panam Salud Pub 16, 1118.
Reyner LA & Horne JA (2000) Early morning driver sleepiness: effectiveness of 200 mg caffeine. Psychophysiology 37, 251256.
Richardson T, Rozkovec A, Thomas P, Ryder J, Meckes C & Kerr D (2004) Influence of caffeine on heart rate variability in patients with long-standing type-1 diabetes. Diabetes Care 27, 11271131.
Robertson D, Hollister AS, Kincaid D, Workman R, Goldberg MR, Tung CS & Smith B (1984) Caffeine and hypertension. Am J Med 77, 5460.
Robertson D, Wade D, Workman R, Woosley RL & Oates JA (1981) Tolerance to the humoral and hemodynamic effects of caffeine in man. J Clin Invest 67, 11111117.
Rogers PJ & Dernoncourt C (1998) Regular caffeine consumption: a balance of adverse and beneficial effects for mood and psychomotor performance. Pharmacol Biochem Behav 59, 10391045.
Rosengren A, Dotevall A, Wilhelmsen L, Thelle D & Johansson S (2004) Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study. J Intern Med 255, 8995.
Ross GW, Abbott RD, Petrovitch H, et al. (2000) Association of coffee and caffeine intake with the risk of Parkinson disease. JAMA 283, 26742679.
Ruhl CE & Everhart JE (2000) Association of coffee consumption with gallbladder disease. Am J Epidemiol 152, 10341038.
Ryu JE (1985) Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. Dev Pharmacol Ther 8, 355363.
Salazar-Martinez E, Willett WC, Ascherio A, Manson JE, Leitzmann MF, Stampfer MJ & Hu FB (2004) Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med 140, 18.
Santos RM & Lima DR (1989) Coffee as a medicinal plant and vitamin source for smokers. It J Chest Dis 43, 5658.
Santos EE, Lauria DC & Porto da Silveira CL (2004) Assessment of daily intake of trace elements due to consumption of foodstuffs by adult inhabitants of Rio de Janeiro city. Sci Total Env 327, 6979.
Santos RM, Oliveira D & Lima DR (1990) Smoking, drug addiction, opioid peptides and coffee intake. Yonago Acta Med 33, 7982.
Santos RM, Vieira S & Lima DR (1991) Effects of coffee in alcoholics. Ann Int Med 115, 499.
Saremi A, Tulloch-Reid M & Knowler WC (2003) Coffee consumption and the incidence of type 2 diabetes. Diabetes Care 26, 22112212.
Saris WHM, Verschuren PM & Harris S (eds.) (2002) Functional foods: scientific and global perspectives. Br J Nutr 88, Suppl. 2S123S235.
Schwartz J & Weiss ST (1992) Caffeine intake and asthma symptoms. Ann Epidemiol 2, 627635.
Shields DH, Corrales KM & Metallinos-Katsaras E (2004) Gourmet coffee beverage consumption among college women. J Am Diet Assoc 104, 650653.
Silvarolla MB, Mazzafera P & Fazuoli LC (2004) Plant biochemistry: a naturally decaffeinated arabica coffee. Nature 429, 826.
Smith A, Brice C, Nash J, Rich N & Nutt DJ (2003) Caffeine and central noradrenaline: effects on mood, cognitive performance, eye movements and cardiovascular function. J Psychopharmacol 17, 283292.
Smith AP, Clark R & Gallagher J (1999) Breakfast cereal and caffeinated coffee: effects on working memory, attention, mood, and cardiovascular function. Physiol Behav 67, 917.
Somoza V, Lindenmeier M, Wenzel E, Frank O, Erbersdobler HF & Hofmann T (2003) Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques. J Agric Food Chem 51, 68616869.
Soroko S, Chang J & Barrett-Connor E (1996) Reasons for changing caffeinated coffee consumption: the Rancho Bernardo Study. J Am Coll Nutr 15, 97101.
Sparaco P (1996) Combating fatigue to enhance safety. Aviat Week Space Technol 145, 5355.
Stavric B, Klassen R, Watkinson B, Karpinski K, Stapley R & Fried P (1988) Variability in caffeine consumption from coffee and tea: possible significance for epidemiological studies. Food Chem Toxicol 26, 111118.
Steptoe A & Wardle J (1999) Mood and drinking: a naturalistic diary study of alcohol, coffee and tea. Psychopharmacology 141, 315321.
Svartberg J, Midtby M, Bonaa KH, Sundsfjord J, Joakimsen RM & Jorde R (2003) The associations of age, lifestyle factors and chronic disease with testosterone in men: the Tromso Study. Eur J Endocrinol 149, 145152.
Svilaas A, Sakhi AK, Andersen LF, Svilaas T, Strom EC, Jacobs DR JrOse L & Blomhoff R (2004) Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans. J Nutr 134, 562567.
Tagliabue A, Terracina D, Cena H, Turconi G, Lanzola E & Montomoli C (1994) Coffee induced thermogenesis and skin temperature. Int J Obes Relat Metab Disord 18, 537541.
Tan EK, Tan C, Fook-Chong SM, et al. (2003) Dose-dependent protective effect of coffee, tea, and smoking in Parkinson's disease: a study in ethnic Chinese. J Neurol Sci 216, 163167.
Tavani A, Bertuzzi M, Gallus S, Negri E & La Vecchia C (2004) Risk factors for non-fatal acute myocardial infarction in Italian women. Prev Med 39, 128134.
Tieges ZRichard Ridderinkhof K, Snel J & Kok A (2004) Caffeine strengthens action monitoring: evidence from the error-related negativity. Brain Res Cogn Brain Res 21, 8793.
Tuomilehto J, Hu G, Bidel S, Lindstrom J & Jousilahti P (2004) Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women. JAMA 291, 12131219.
Tverdal A & Skurtveit S (2003) Coffee intake and mortality from liver cirrhosis. Ann Epidemiol 13, 419423.
Urgert R & de Groot CP (1996) Consumption of unfiltered coffee brews in elderly Europeans. Eur J Clin Nutr 50, Suppl. 2S101S104.
van Dam RM & Feskens EJ (2002) Coffee consumption and risk of type 2 diabetes mellitus. Lancet 360, 14771478.
Van Deventer G, Kamemoto E, Kuznicki JT, Heckert DC & Schulte MC (1992) Lower esophageal sphincter pressure, acid secretion, and blood gastrin after coffee consumption. Dig Dis Sci 37, 558569.
Vatten LJ, Solvoll K & Loken EB (1990) Coffee consumption and the risk of breast cancer. A prospective study of 14,593 Norwegian women. Br J Cancer 62, 267270.
Verschuren PM (2002) Functional foods: scientific and global perspectives. Br J Nutr 88, Suppl. 2S125S130.
Wahllander A, Renner E & Preisig R (1985) Fasting plasma caffeine concentration: a guide to the severity of chronic liver disease. Scand J Gastroenterol 20, 11331141.
Wynne KN, Familari M, Boublik JH, Drummer OH, Rae ID & Funder JW (1987) Isolation of opiate receptor ligands in coffee. Clin Exp Pharmacol Physiol 14, 785790.
Yanagimoto K, Ochi H, Lee KG & Shibamoto T (2004) Antioxidative activities of fractions obtained from brewed coffee. J Agric Food Chem 52, 592596.
Yoshioka M, Doucet E, Drapeau V, Dionne I & Tremblay A (2001) Combined effects of red pepper and caffeine consumption on 24 h energy balance in subjects given free access to foods. Br J Nutr 85, 203211.
Yukawa GS, Mune M, Otani H, Tone Y, Liang XM, Iwahashi H & Sakamoto W (2004) Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans. Biochemistry 69, 7074.
Zahorska-Markiewicz B (1980) The thermic effect of caffeinated and decaffeinated coffee ingested with breakfast. Acta Physiol Pol 31, 1720.
Zampelas A, Panagiotakos DB, Pitsavos C, Chrysohoou C & Stefanadis C (2004) Associations between coffee consumption and inflammatory markers in healthy persons: the ATTICA study. Am J Clin Nutr 80, 862867.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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