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    Virtanen, Suvi M 2016. Dietary factors in the development of type 1 diabetes. Pediatric Diabetes, Vol. 17, p. 49.


    Niinistö, S. Takkinen, H.-M. Uusitalo, L. Rautanen, J. Vainio, N. Ahonen, S. Nevalainen, J. Kenward, M. G. Lumia, M. Simell, O. Veijola, R. Ilonen, J. Knip, M. and Virtanen, S. M. 2015. Maternal intake of fatty acids and their food sources during lactation and the risk of preclinical and clinical type 1 diabetes in the offspring. Acta Diabetologica, Vol. 52, Issue. 4, p. 763.


    Yessoufou, Akadiri Nekoua, Magloire P. Gbankoto, Adam Mashalla, Yohana and Moutairou, Kabirou 2015. Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity. Journal of Diabetes Research, Vol. 2015, p. 1.


    Hakola, L. Takkinen, H-M. Niinistö, S. Ahonen, S. Erlund, I. Rautanen, J. Veijola, R. Ilonen, J. Toppari, J. Knip, M. Virtanen, S. M. and Lehtinen-Jacks, S. 2016. Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study. Pediatric Obesity,


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Maternal dietary fatty acid intake during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring

  • Sari Niinistö (a1) (a2), Hanna-Mari Takkinen (a3), Liisa Uusitalo (a1), Jenna Rautanen (a1), Jaakko Nevalainen (a4), Michael G. Kenward (a5), Mirka Lumia (a1) (a3), Olli Simell (a6), Riitta Veijola (a7), Jorma Ilonen (a8) (a9), Mikael Knip (a10) (a11) (a12) and Suvi M. Virtanen (a1) (a3) (a13)
  • DOI: http://dx.doi.org/10.1017/S0007114513003073
  • Published online: 02 October 2013
Abstract

The aim of the present study was to examine the associations between the maternal intake of fatty acids during pregnancy and the risk of preclinical and clinical type 1 diabetes in the offspring. The study included 4887 children with human leucocyte antigen (HLA)-conferred type 1 diabetes susceptibility born during the years 1997–2004 from the Finnish Type 1 Diabetes Prediction and Prevention Study. Maternal diet was assessed with a validated FFQ. The offspring were observed at 3- to 12-month intervals for the appearance of type 1 diabetes-associated autoantibodies and development of clinical type 1 diabetes (average follow-up period: 4·6 years (range 0·5–11·5 years)). Altogether, 240 children developed preclinical type 1 diabetes and 112 children developed clinical type 1 diabetes. Piecewise linear log-hazard survival model and Cox proportional-hazards regression were used for statistical analyses. The maternal intake of palmitic acid (hazard ratio (HR) 0·82, 95 % CI 0·67, 0·99) and high consumption of cheese during pregnancy (highest quarter v. intermediate half HR 0·52, 95 % CI 0·31, 0·87) were associated with a decreased risk of clinical type 1 diabetes. The consumption of sour milk products (HR 1·14, 95 % CI 1·02, 1·28), intake of protein from sour milk (HR 1·15, 95 % CI 1·02, 1·29) and intake of fat from fresh milk (HR 1·43, 95 % CI 1·04, 1·96) were associated with an increased risk of preclinical type 1 diabetes, and the intake of low-fat margarines (HR 0·67, 95 % CI 0·49, 0·92) was associated with a decreased risk. No conclusive associations between maternal fatty acid intake or food consumption during pregnancy and the development of type 1 diabetes in the offspring were detected.

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*Corresponding author: S. Niinistö, email sari.niinisto@thl.fi
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1V Harjutsalo , L Sjoberg & J Tuomilehto (2008) Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 371, 17771782.

2O Vaarala , MA Atkinson & J Neu (2008) The “perfect storm” for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 57, 25552562.

3N Blumer , PI Pfefferle & H Renz (2007) Development of mucosal immune function in the intrauterine and early postnatal environment. Curr Opin Gastroenterol 23, 655660.

4 SLPrescott & JADunstan (2007) Prenatal fatty acid status and immune development: the pathways and the evidence. Lipids 42, 801810.

6LC Stene , J Ulriksen , P Magnus , et al. (2000) Use of cod liver oil during pregnancy associated with lower risk of type I diabetes in the offspring. Diabetologia 43, 10931098.

7 CMFronczak , AEBaron , HPChase , et al. (2003) In utero dietary exposures and risk of islet autoimmunity in children. Diabetes Care 26, 32373242.

9 JMNorris , XYin , MMLamb , et al. (2007) Omega-3 polyunsaturated fatty acid intake and islet autoimmunity in children at increased risk for type 1 diabetes. JAMA 298, 14201428.

10 YKagohashi , NAbiru , MKobayashi , et al. (2010) Maternal dietary n-6/n-3 fatty acid ratio affects type 1 diabetes development in the offspring of non-obese diabetic mice. Congenit Anom (Kyoto) 50, 212220.

11D Wei , J Li , M Shen , et al. (2010) Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death. Diabetes 59, 471478.

12 SMVirtanen , SNiinisto , JNevalainen , et al. (2010) Serum fatty acids and risk of advanced beta-cell autoimmunity: a nested case–control study among children with HLA-conferred susceptibility to type I diabetes. Eur J Clin Nutr 64, 792799.

13SM Virtanen , J Nevalainen , C Kronberg-Kippila , et al. (2012) Food consumption and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes: a nested case–control design. Am J Clin Nutr 95, 471478.

14A Giacca , C Xiao , AI Oprescu , et al. (2011) Lipid-induced pancreatic {beta}-cell dysfunction: focus on in vivo studies. Am J Physiol Endocrinol Metab 300, E255E262.

15NG Morgan & S Dhayal (2010) Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell. Prostaglandins Leukot Essent Fatty Acids 82, 231236.

16A Kupila , P Muona , T Simell , et al. (2001) Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 44, 290297.

17M Erkkola , M Karppinen , J Javanainen , et al. (2001) Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women. Am J Epidemiol 154, 466476.

18 MKukko , TKimpimaki , SKorhonen , et al. (2005) Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population. J Clin Endocrinol Metab 90, 27122717.

20HT Siljander , S Simell , A Hekkala , et al. (2009) Predictive characteristics of diabetes-associated autoantibodies among children with HLA-conferred disease susceptibility in the general population. Diabetes 58, 28352842.

21M Erkkola , C Kronberg-Kippila , E Savilahti , et al. (2005) Maternal consumption of dairy products during pregnancy and lactation, and the development of cow's milk antibodies in the offspring. Acta Paediatr 94, 696704.

22 KLuopajarvi , ESavilahti , SMVirtanen , et al. (2008) Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes 9, 434441.

23M Knip , SM Virtanen & HK Akerblom (2010) Infant feeding and the risk of type 1 diabetes. Am J Clin Nutr 91, 1506S1513S.

24M Knip , SM Virtanen , K Seppa , et al. (2010) Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 363, 19001908.

25E Savilahti & KM Saarinen (2009) Early infant feeding and type 1 diabetes. Eur J Nutr 48, 243249.

26C Galli & PC Calder (2009) Effects of fat and fatty acid intake on inflammatory and immune responses: a critical review. Ann Nutr Metab 55, 123139.

27 SMVirtanen , LUusitalo , MGKenward , et al. (2011) Maternal food consumption during pregnancy and risk of advanced beta-cell autoimmunity in the offspring. Pediatr Diabetes 12, 9599.


29M Lumia , P Luukkainen , H Tapanainen , et al. (2011) Dietary fatty acid composition during pregnancy and the risk of asthma in the offspring. Pediatr Allergy Immunol 22, 827835.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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