Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 24
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Chang, Huailong Wang, Mu Xia, Wei Chen, Tian Huo, Wenqian Mao, Zhenxing Zhu, Yingshuang Li, Yuanyuan and Xu, Shunqing 2016. Perinatal exposure to low-dose bisphenol A disrupts learning/memory and DNA methylation of estrogen receptor alpha in the hippocampus. Toxicol. Res., Vol. 5, Issue. 3, p. 828.


    Handal, Marte Skurtveit, Svetlana Roth, Christine Hernandez-Diaz, Sonia and Selmer, Randi 2016. Prenatal Exposure to Folic Acid and Antidepressants and Language Development. Journal of Clinical Psychopharmacology, Vol. 36, Issue. 4, p. 333.


    Irwin, Rachelle E Pentieva, Kristina Cassidy, Tony Lees-Murdock, Diane J McLaughlin, Marian Prasad, Girijesh McNulty, Helene and Walsh, Colum P 2016. The interplay between DNA methylation, folate and neurocognitive development. Epigenomics, Vol. 8, Issue. 6, p. 863.


    De-Regil, Luz Maria Peña-Rosas, Juan Pablo Fernández-Gaxiola, Ana C Rayco-Solon, Pura and De-Regil, Luz Maria 2015. Cochrane Database of Systematic Reviews.


    McGarel, C. Pentieva, K. Strain, J. J. and McNulty, H. 2015. Emerging roles for folate and related B-vitamins in brain health across the lifecycle. Proceedings of the Nutrition Society, Vol. 74, Issue. 01, p. 46.


    Polańska, Kinga Muszyński, Paweł Sobala, Wojciech Dziewirska, Emila Merecz-Kot, Dorota and Hanke, Wojciech 2015. Maternal lifestyle during pregnancy and child psychomotor development — Polish Mother and Child Cohort study. Early Human Development, Vol. 91, Issue. 5, p. 317.


    Spann, Marisa N. Smerling, Jennifer Gustafsson, Hanna Foss, Sophie Altemus, Margaret and Monk, Catherine 2015. Deficient maternal zinc intake—but not folate—is associated with lower fetal heart rate variability. Early Human Development, Vol. 91, Issue. 3, p. 169.


    Steenweg-de Graaff, Jolien Roza, Sabine J. Walstra, Alette N. El Marroun, Hanan Steegers, Eric A. P. Jaddoe, Vincent W. V. Hofman, Albert Verhulst, Frank C. Tiemeier, Henning and White, Tonya 2015. Associations of maternal folic acid supplementation and folate concentrations during pregnancy with foetal and child head growth: the Generation R Study. European Journal of Nutrition,


    de Theije, Caroline G. M. Bavelaar, Bas M. Lopes da Silva, Sofia Korte, Sijmen Mechiel Olivier, Berend Garssen, Johan and Kraneveld, Aletta D. 2014. Food allergy and food-based therapies in neurodevelopmental disorders. Pediatric Allergy and Immunology, Vol. 25, Issue. 3, p. 218.


    Lyall, K. Schmidt, R. J. and Hertz-Picciotto, I. 2014. Maternal lifestyle and environmental risk factors for autism spectrum disorders. International Journal of Epidemiology, Vol. 43, Issue. 2, p. 443.


    McGarel, C. McNulty, H. Strain, J. J. Cassidy, T. McLoughlin, M. McNulty, B. Rollins, M. Marshall, B. Ward, M. Molloy, A. M. and Pentieva, K. 2014. Effect of folic acid supplementation during pregnancy on cognitive development of the child at 6 years: preliminary results from the FASSTT Offspring Trial. Proceedings of the Nutrition Society, Vol. 73, Issue. OCE2,


    Rauh-Pfeiffer, Astrid Handel, Uschi Demmelmair, Hans Peissner, Wolfgang Niesser, Mareile Moretti, Diego Martens, Vanessa Wiseman, Sheila Weichert, Judith Heene, Moritz Bühner, Markus and Koletzko, Berthold 2014. Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance. European Journal of Nutrition, Vol. 53, Issue. 7, p. 1445.


    van Mil, N. H. Bouwland-Both, M. I. Stolk, L. Verbiest, M. M. P. J. Hofman, A. Jaddoe, V. W. V. Verhulst, F. C. Eilers, P. H. C. Uitterlinden, A. G. Steegers, E. A. P. Tiemeier, H. and Steegers-Theunissen, R. P. M. 2014. Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles. Reproduction, Vol. 148, Issue. 6, p. 581.


    Anjos, Tania Altmäe, Signe Emmett, Pauline Tiemeier, Henning Closa-Monasterolo, Ricardo Luque, Verónica Wiseman, Sheila Pérez-García, Miguel Lattka, Eva Demmelmair, Hans Egan, Bernadette Straub, Niels Szajewska, Hania Evans, Jayne Horton, Claire Paus, Tomas Isaacs, Elizabeth van Klinken, Jan Willem Koletzko, Berthold and Campoy, Cristina 2013. Nutrition and neurodevelopment in children: focus on NUTRIMENTHE project. European Journal of Nutrition, Vol. 52, Issue. 8, p. 1825.


    Lyall, Kristen Schmidt, Rebecca J. and Hertz-Picciotto, Irva 2013. The Neuroscience of Autism Spectrum Disorders.


    Ghassabian, Akhgar Bongers-Schokking, Jacoba J. de Rijke, Yolanda B. van Mil, Nina Jaddoe, Vincent W.V. de Muinck Keizer-Schrama, Sabine M.P.F. Hooijkaas, Herbert Hofman, Albert Visser, Willy Roman, Gustavo C. Visser, Theo J. Verhulst, Frank C. and Tiemeier, Henning 2012. Maternal Thyroid Autoimmunity During Pregnancy and the Risk of Attention Deficit/Hyperactivity Problems in Children: The Generation R Study. Thyroid, Vol. 22, Issue. 2, p. 178.


    Horton, C. 2012. An overview of the NUTRIMENTHE project. Nutrition Bulletin, Vol. 37, Issue. 2, p. 152.


    Skórka, Agata Gieruszczak-Białek, Dorota Pieścik, Małgorzata and Szajewska, Hania 2012. Effects of Prenatal and/or Postnatal (Maternal and/or Child) Folic Acid Supplementation on the Mental Performance of Children. Critical Reviews in Food Science and Nutrition, Vol. 52, Issue. 11, p. 959.


    Villamor, Eduardo Rifas-Shiman, Sheryl L. Gillman, Matthew W. and Oken, Emily 2012. Maternal Intake of Methyl-Donor Nutrients and Child Cognition at 3 Years of Age. Paediatric and Perinatal Epidemiology, Vol. 26, Issue. 4, p. 328.


    GHASSABIAN, AKHGAR BONGERS-SCHOKKING, JACOBA J. HENRICHS, JENS JADDOE, VINCENT W.V. VISSER, THEO J. VISSER, WILLY DE MUINCK KEIZER-SCHRAMA, SABINE M.P.F. HOOIJKAAS, HERBERT STEEGERS, ERIC A.P. HOFMAN, ALBERT VERHULST, FRANK C. VAN DER ENDE, JAN DE RIJKE, YOLANDA B. and TIEMEIER, HENNING 2011. Maternal Thyroid Function During Pregnancy and Behavioral Problems in the Offspring: The Generation R Study. Pediatric Research, Vol. 69, Issue. 5 Part 1, p. 454.


    ×

Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study

  • Sabine J. Roza (a1) (a2), Tamara van Batenburg-Eddes (a1) (a2), Eric A. P. Steegers (a3), Vincent W. V. Jaddoe (a1) (a4) (a5), Johan P. Mackenbach (a6), Albert Hofman (a5), Frank C. Verhulst (a2) and Henning Tiemeier (a2) (a5)
  • DOI: http://dx.doi.org/10.1017/S0007114509991954
  • Published online: 22 September 2009
Abstract

Folate deficiency during embryogenesis is an established risk factor for neural tube defects in the fetus. An adequate folate nutritional status is also important for normal fetal growth and brain development. The aim of the present research was to study the association between folic acid use of the mother during pregnancy and child behavioural development. Within a population-based cohort, we prospectively assessed folic acid supplement use during the first trimester by questionnaire. Child behavioural and emotional problems were assessed with the Child Behaviour Checklist at the age of 18 months in 4214 toddlers. Results showed that children of mothers who did not use folic acid supplements in the first trimester had a higher risk of total problems (OR 1·44; 95 % CI 1·12, 1·86). Folic acid supplement use protected both from internalising (OR of no supplement use 1·65; 95 % CI 1·24, 2·19) and externalising problems (OR 1·45; 95 % CI 1·17, 1·80), even when adjusted for maternal characteristics. Birth weight and size of the fetal head did not mediate the association between folic acid use and child behaviour. In conclusion, inadequate use of folic acid supplements during early pregnancy may be associated with a higher risk of behavioural problems in the offspring. Folic acid supplementation in early pregnancy, aimed to prevent neural tube defects, may also reduce mental health problems in children.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Henning Tiemeier, fax +31 10 7044657, email h.tiemeier@erasmusmc.nl
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2Anonymous (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 338, 131137.

4L Iyengar & K Rajalakshmi (1975) Effect of folic acid supplement on birth weights of infants. Am J Obstet Gynecol 122, 332336.

6S Xiao , DK Hansen , ET Horsley , (2005) Maternal folate deficiency results in selective upregulation of folate receptors and heterogeneous nuclear ribonucleoprotein-E1 associated with multiple subtle aberrations in fetal tissues. Birth Defects Res A Clin Mol Teratol 73, 628.

7S Zammit , S Lewis , D Gunnell , (2007) Schizophrenia and neural tube defects: comparisons from an epidemiological perspective. Schizophr Bull 33, 853858.

9RE Erbe (1975) Inborn errors of folate metabolism (first of two parts). N Engl J Med 293, 753757.

11T Tamura , RL Goldenberg , VR Chapman , (2005) Folate status of mothers during pregnancy and mental and psychomotor development of their children at five years of age. Pediatrics 116, 703708.

12VW Jaddoe , JP Mackenbach , HA Moll , (2006) The Generation R Study: design and cohort profile. Eur J Epidemiol 21, 475484.

14NT Tick , J van der Ende , HM Koot , (2007) 14-Year changes in emotional and behavioural problems of very young Dutch children. J Am Acad Child Adolesc Psychiatry 46, 13331340.

15A Reichenberg , R Gross , M Weiser , (2006) Advancing paternal age and autism. Arch Gen Psychiatry 63, 10261032.

16D Malaspina , S Harlap , S Fennig , (2001) Advancing paternal age and the risk of schizophrenia. Arch Gen Psychiatry 58, 361367.

19S Timmermans , VW Jaddoe , JP Mackenbach , (2008) Determinants of folic acid use in early pregnancy in a multi-ethnic urban population in the Netherlands: The Generation R Study. Prev Med (Epublication ahead of print version 2 July 2008).

21AS Brown , ES Susser , PD Butler , (1996) Neurobiological plausibility of prenatal nutritional deprivation as a risk factor for schizophrenia. J Nerv Ment Dis 184, 7185.

25YJ Kelly , JY Nazroo , A McMunn , (2001) Birthweight and behavioural problems in children: a modifiable effect? Int J Epidemiol 30, 8894.

26JM McClellan , E Susser & M King (2006) Maternal famine, de novo mutations, and schizophrenia. JAMA 296, 582584.

28AL Brantsaeter , M Haugen , TA Hagve , (2007) Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa). Ann Nutr Metab 51, 146154.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: