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Maternal low-protein diet-induced delayed reflex ontogeny is attenuated by moderate physical training during gestation in rats

  • Filippe Falcão-Tebas (a1), Adriano Bento-Santos (a2), Marco Antônio Fidalgo (a3), Marcelus Brito de Almeida (a3), José Antônio dos Santos (a2), Sandra Lopes de Souza (a1) (a2), Raul Manhães-de-Castro (a1) (a2) and Carol Góis Leandro (a1) (a3)...
Abstract

We evaluated the effects of moderate- to low-intensity physical training during gestation on reflex ontogeny in neonate rats whose mothers were undernourished. Virgin female Wistar rats were divided into four groups as follows: untrained (NT, n 7); trained (T, n 7); untrained with a low-protein diet (NT+LP, n 7); trained with a low-protein diet (T+LP, n 4). Trained rats were subjected to a protocol of moderate physical training on a treadmill over a period of 4 weeks (5 d/week and 60 min/d, at 65 % of VO2max). After confirming the pregnancy, the intensity and duration of the exercise were reduced. Low-protein groups were provided with an 8 % casein diet, and controls were provided with a 17 % casein diet. Their respective offspring were evaluated (during the 10th–17th days of postnatal life) in terms of physical feature maturation, somatic growth and reflex ontogeny. Pups born to mothers provided with the low-protein diet during gestation and lactation showed delayed physical feature and reflex maturation and a deficit in somatic growth when compared with controls. However, most of these deficiencies were attenuated in pups of undernourished mothers undergoing training. In conclusion, physical training during gestation attenuates the effects of perinatal undernutrition on some patterns of maturation in the central nervous system during development.

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Corresponding author
*Corresponding author: F. Falcão-Tebas, fax +55 81 21268473, email filippe_oliveira@hotmail.com
References
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1 Dauncey, MJ & Bicknell, RJ (1999) Nutrition and neurodevelopment: mechanisms of developmental dysfunction and disease in later life. Nutr Res Rev 12, 231253.
2 Bennis-Taleb, N, Remacle, C, Hoet, JJ, et al. (1999) A low-protein isocaloric diet during gestation affects brain development and alters permanently cerebral cortex blood vessels in rat offspring. J Nutr 129, 16131619.
3 Lodygensky, GA, Seghier, ML, Warfield, SK, et al. (2008) Intrauterine growth restriction affects the preterm infant's hippocampus. Pediatr Res 63, 438443.
4 Smart, JL & Dobbing, J (1971) Vulnerability of developing brain. II. Effects of early nutritional deprivation on reflex ontogeny and development of behaviour in the rat. Brain Res 28, 8595.
5 Barros, KM, Manhaes-De-Castro, R, Lopes-De-Souza, S, et al. (2006) A regional model (Northeastern Brazil) of induced mal-nutrition delays ontogeny of reflexes and locomotor activity in rats. Nutr Neurosci 9, 99104.
6 Lopes de Souza, S, Orozco-Solis, R, Grit, I, et al. (2008) Perinatal protein restriction reduces the inhibitory action of serotonin on food intake. Eur J Neurosci 27, 14001408.
7 Gallagher, EA, Newman, JP, Green, LR, et al. (2005) The effect of low protein diet in pregnancy on the development of brain metabolism in rat offspring. J Physiol 568, 553558.
8 Clapp, JF 3rd (2003) The effects of maternal exercise on fetal oxygenation and feto-placental growth. Eur J Obstet Gynecol Reprod Biol 110, Suppl. 1, S80S85.
9 Wolfe, LA & Weissgerber, TL (2003) Clinical physiology of exercise in pregnancy: a literature review. J Obstet Gynaecol Can 25, 473483.
10 Parnpiansil, P, Jutapakdeegul, N, Chentanez, T, et al. (2003) Exercise during pregnancy increases hippocampal brain-derived neurotrophic factor mRNA expression and spatial learning in neonatal rat pup. Neurosci Lett 352, 4548.
11 Kim, H, Lee, SH, Kim, SS, et al. (2007) The influence of maternal treadmill running during pregnancy on short-term memory and hippocampal cell survival in rat pups. Int J Dev Neurosci 25, 243249.
12 Amorim, MF, dos Santos, JA, Hirabara, SM, et al. (2009) Can physical exercise during gestation attenuate the effects of a maternal perinatal low-protein diet on oxygen consumption in rats? Exp Physiol 94, 906913.
13 Bayne, K (1996) Revised Guide for the Care and Use of Laboratory Animals available. American Physiological Society. Physiologist 39, 208–111.
14 Bayol, S, Jones, D, Goldspink, G, et al. (2004) The influence of undernutrition during gestation on skeletal muscle cellularity and on the expression of genes that control muscle growth. Br J Nutr 91, 331339.
15 Dobbing, J & Hopewell, JW (1971) Permanent deficit of neurones in cerebral and cerebellar cortex following early mild undernutrition. Arch Dis Child 46, 736737.
16 Dobbing, J (1964) The influence of early nutrition on the development and myelination of the brain. Proc R Soc Lond B Biol Sci 159, 503509.
17 Smart, JL (1981) Under nutrition during early life and its effects on animal development and behaviour. Neuropharmacology 20, 12511252.
18 Morgane, PJ, Austin-LaFrance, R, Bronzino, J, et al. (1993) Prenatal malnutrition and development of the brain. Neurosci Biobehav Rev 17, 91128.
19 Barreto Medeiros, JM, Cabral Filho, JE, De Souza, SL, et al. (2002) Early malnourished rats are not affected by anorexia induced by a selective serotonin reuptake inhibitor in adult life. Nutr Neurosci 5, 211214.
20 Pine, AP, Jessop, NS, Allan, GF, et al. (1994) Maternal protein reserves and their influence on lactational performance in rats. 4. Tissue protein synthesis and turnover associated with mobilization of maternal protein. Br J Nutr 72, 831844.
21 Zamenhof, S (1981) Maternal nutrient storage and efficiency in production of fetal brain tissue in rats. Biol Neonate 39, 4551.
22 Moita, L, Lustosa, MF, Tobias Silva, AT, et al. (2011) Moderate physical training attenuates the effects of perinatal undernutrition on the morphometry of the splenic lymphoid follicles in endotoxemic adult rats. Neuroimmunomodulation 18, 103110.
23 Chandler, KD & Bell, AW (1981) Effects of maternal exercise on fetal and maternal respiration and nutrient metabolism in the pregnant ewe. J Dev Physiol 3, 161176.
24 Dauge, V (2003) Neurobiological impact of separating mothers from newborns in rodents. Med Sci (Paris) 19, 607611.
25 Passos, MC, Toste, FP, Dutra, SC, et al. (2009) Role of neonatal hyperleptinaemia on serum adiponectin and suppressor of cytokine signalling-3 expression in young rats. Br J Nutr 101, 250256.
26 May, LE, Glaros, A, Yeh, HW, et al. (2010) Aerobic exercise during pregnancy influences fetal cardiac autonomic control of heart rate and heart rate variability. Early Hum Dev 86, 213217.
27 Clapp, JF 3rd (2008) Long-term outcome after exercising throughout pregnancy: fitness and cardiovascular risk. Am J Obstet Gynecol 199, 489e1489e6.
28 Deiro, TC, Manhaes-de-Castro, R, Cabral-Filho, JE, et al. (2006) Sertraline delays the somatic growth and reflex ontogeny in neonate rats. Physiol Behav 87, 338344.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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