Skip to main content
×
Home
    • Aa
    • Aa

Metabolism of erythritol in humans: Comparison with glucose and lactitol

  • Martin Hiele (a1), Yvo Ghoos (a1), Paul Rutgeerts (a1) and Gaston Vantrappen (a1)
Abstract

The metabolism of erythritol was assessed in six normal volunteers by measuring the amount of 13CO2 excretion and H2 excretion in breath, and erythritol in urine after intake of 25 g 13C-labelled erythritol. The results were compared with the same variables obtained after intake of 25 g 13C-labelled glucose and13C-labelled lactitol. In addition, the H2 production by faecal flora supplemented with small amounts of erythritol, glucose and lactitol was measured in vitro, as an index of bacterial metabolism of non-absorbed substrate. In contrast to the results obtained after intake of glucose and lactitol, no increase in breath 13CO2 and H2 was observed after intake of erythritol, and erythritol was nearly completely recovered in urine. The in vitro experiments showed that no H2 was formed by faecal flora from erythritol as compared with glucose and lactitol. It is concluded that erythritol is a substrate that is readily absorbed, and undergoes no metabolism by the host. If part of it escapes absorption, it is not metabolized by faecal flora.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Metabolism of erythritol in humans: Comparison with glucose and lactitol
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Metabolism of erythritol in humans: Comparison with glucose and lactitol
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Metabolism of erythritol in humans: Comparison with glucose and lactitol
      Available formats
      ×
Copyright
References
Hide All
Ebiner J. R., Acheson K. J., Doerner A., Maeder E., Arnaud M. J., Jéquier E. & Felber J. P. (1979). Comparison of carbohydrate utilization in man using indirect calorimetry and mass spectrometry after an oral load of 100 g naturally-labelled [13C]glucose. British Journal of Nutrition 41, 419429.
Grimble G. K., Patil D. H. & Silk D. B. A. (1988). Assimilation of lactitol, an ‘unabsorbed’ disaccharide in the normal human colon. Gut 29, 16661671.
Haycock G. B., Schwatz G. J. & Wisotsky D. H. (1978). Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. Journal of Pediatrics 93, 6266.
Hiele M., Ghoos Y., Rutgeerts P. & Vantrappen G. (1988 a). Measurements of the rate of assimilation of oligo- and polysaccharides by 13CO2, breath tests and isotope ratio mass spectrometry. Biomedical and Environmental Mass Spectrometry 16, 133135.
Hiele M., Ghoos Y., Rutgeerts P., Vantrappen G., Carchon H. & Eggermont E. (1988 b). 13CO2, breath test using naturally 13C-enriched lactose for detection of lactose deficiency in patients with gastrointestinal symptoms. Journal of Laboratory and Clinical Medicine 112, 193200.
Hiele M., Ghoos Y., Rutgeerts P. & Vantrappen G. (1989). Starch digestion in normal subjects and patients with pancreatic disease, using a 13CO2, breath test. Gastroenterology 96, 503509.
Klein P. D. & Klein E. R. (1985). Applications of stable isotopes to pediatric nutrition and gastroenterology: measurement of nutrient absorption and digestion using 13C. Journal of Pediatric Gastroenterology and Nutrition 4, 919.
Lacroix M., Mosord F., Pontus M., Lefebvre P., Luyckx A. & Lopez-Habib G. (1973). Glucose naturally labelled with carbon-13: use for metabolic studies in man. Science 181, 445446.
McGaw B. A., Milne E. & Duncan G. J. (1988). A rapid method for the preparation of combustion samples for stable carbon isotope analysis by isotope ratio mass spectrometry. Biomedical and Environmental Mass Spectrometry 16, 269273.
Miller T. L. & Wolin M. J. (1979). Fermentations by saccharolytic intestinal bacteria. American Journal of Clinical Nutrition 32, 164172.
Oku T. & Noda J. (1990). Influence of chronic ingestion of newly developed sweetener, erythritol on growth and gastrointestinal function of the rats. Nutrition Research 10, 987996.
SAS Institute Inc. (1988). SAS/STAT User's Guide, releuse 6.03 ed. Cary, NC: SAS Institute Inc.
Schoeller D. A., Klein P. D., Watkins J. B., Heim T. & MacLean W. C. (1980). 13C abundances of nutrients and the effect of variations in 13C isotopic abundances of test meals formulated for l3CO, breath tests. American Journal of Clinical Nutrition 33, 23752385.
Shreeve W. W., Cerasi E. & Luft R. (1970). Metabolism of [2-14C]-pyruvate in normal, acromegalic and HGH- treated human subjects. Acta Endocrinologica 65, 155169.
Shulman R. J., Wong W. W., Irving C. S., Nichols B. L. & Klein P. D. (1983). Utilization of dietary cereal by young infants. Journal of Pediatrics 103, 2328.
Van Es A. J. H. (1987). Energy utilization of low digestibility carbohydrates. In Low Digestibility Carbohydrates, pp. 121127 [Leegwater D. C., Feron V. J. and Hermus R. J. J., editors]. Wageningen: Pudoc.
Van Es A. J. H., De Groot L. & Vogt J. E. (1986). Energy balances of eight volunteers fed on diets supplemented with either lactitol or saccharose. British Journal of Nutrition 56, 545554.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 1
Total number of PDF views: 221 *
Loading metrics...

Abstract views

Total abstract views: 1024 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd October 2017. This data will be updated every 24 hours.